The Latest Research and Development into the Antibody–Drug Conjugate, [fam-] Trastuzumab Deruxtecan (DS-8201a), for HER2 Cancer Therapy
Nakada, Takashi, Sugihara, Kiyoshi, Jikoh, Takahiro, Abe, Yuki, Agatsuma, Toshinori
Published in Chemical & pharmaceutical bulletin (01.03.2019)
Published in Chemical & pharmaceutical bulletin (01.03.2019)
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Journal Article
Visualization of Intratumor Pharmacokinetics of [fam-] Trastuzumab Deruxtecan (DS-8201a) in HER2 Heterogeneous Model Using Phosphor-integrated Dots Imaging Analysis
Suzuki, Mikiko, Yagishita, Shigehiro, Sugihara, Kiyoshi, Ogitani, Yusuke, Nishikawa, Tadaaki, Ohuchi, Mayu, Teishikata, Takashi, Jikoh, Takahiro, Yatabe, Yasushi, Yonemori, Kan, Tamura, Kenji, Hasegawa, Kosei, Hamada, Akinobu
Published in Clinical cancer research (15.07.2021)
Published in Clinical cancer research (15.07.2021)
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Journal Article
Single agent activity of DS-8201a, a HER2-targeting antibody-drug conjugate, in heavily pretreated HER2 expressing solid tumors
Doi, Toshihiko, Iwata, Hiroji, Tsurutani, Junji, Takahashi, Shunji, Park, Haeseong, Redfern, Charles H., Shitara, Kohei, Shimizu, Chikako, Taniguchi, Hiroya, Iwasa, Tsutomu, Taira, Shinichiro, Lockhart, Albert C., Fisher, Jennifer M., Jikoh, Takahiro, Fujisaki, Yoshihiko, Lee, Caleb C., Yver, Antoine, Tamura, Kenji
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
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Journal Article
FGF-2-Responsive and Spinal Cord-Resident Cells Improve Locomotor Function after Spinal Cord Injury
Kasai, Masaki, Jikoh, Takahiro, Fukumitsu, Hidefumi, Furukawa, Shoei
Published in Journal of neurotrauma (15.09.2014)
Published in Journal of neurotrauma (15.09.2014)
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Journal Article
Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody–drug conjugate, in patients with advanced breast and gastric or gastro-oesophageal tumours: a phase 1 dose-escalation study
Doi, Toshihiko, Shitara, Kohei, Naito, Yoichi, Shimomura, Akihiko, Fujiwara, Yasuhiro, Yonemori, Kan, Shimizu, Chikako, Shimoi, Tatsunori, Kuboki, Yasutoshi, Matsubara, Nobuaki, Kitano, Atsuko, Jikoh, Takahiro, Lee, Caleb, Fujisaki, Yoshihiko, Ogitani, Yusuke, Yver, Antoine, Tamura, Kenji
Published in The lancet oncology (01.11.2017)
Published in The lancet oncology (01.11.2017)
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Journal Article
Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive breast cancer previously treated with trastuzumab emtansine: a dose-expansion, phase 1 study
Tamura, Kenji, Tsurutani, Junji, Takahashi, Shunji, Iwata, Hiroji, Krop, Ian E, Redfern, Charles, Sagara, Yasuaki, Doi, Toshihiko, Park, Haeseong, Murthy, Rashmi K, Redman, Rebecca A, Jikoh, Takahiro, Lee, Caleb, Sugihara, Masahiro, Shahidi, Javad, Yver, Antoine, Modi, Shanu
Published in The lancet oncology (01.06.2019)
Published in The lancet oncology (01.06.2019)
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Journal Article
Targeting HER2 with Trastuzumab Deruxtecan: A Dose-Expansion, Phase I Study in Multiple Advanced Solid Tumors
Tsurutani, Junji, Iwata, Hiroji, Krop, Ian, Jänne, Pasi A, Doi, Toshihiko, Takahashi, Shunji, Park, Haeseong, Redfern, Charles, Tamura, Kenji, Wise-Draper, Trisha M, Saito, Kaku, Sugihara, Masahiro, Singh, Jasmeet, Jikoh, Takahiro, Gallant, Gilles, Li, Bob T
Published in Cancer discovery (01.05.2020)
Published in Cancer discovery (01.05.2020)
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Journal Article
Co-Clinical Study of [fam-] Trastuzumab Deruxtecan (DS8201a) in Patient-Derived Xenograft Models of Uterine Carcinosarcoma and Its Association with Clinical Efficacy
Yagishita, Shigehiro, Nishikawa, Tadaaki, Yoshida, Hiroshi, Shintani, Daisuke, Sato, Sho, Miwa, Maiko, Suzuki, Mikiko, Yasuda, Masanori, Ogitani, Yusuke, Jikoh, Takahiro, Yonemori, Kan, Hasegawa, Kosei, Hamada, Akinobu
Published in Clinical cancer research (13.06.2023)
Published in Clinical cancer research (13.06.2023)
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Journal Article
FGF-2-responsive and spinal cord-resident cells improve locomotor function after spinal cord injury
Kasai, Masaki, Jikoh, Takahiro, Fukumitsu, Hidefumi, Furukawa, Shoei
Published in Journal of neurotrauma (15.09.2014)
Published in Journal of neurotrauma (15.09.2014)
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Journal Article
HER2 - THERAPY FOR DRUG-RESISTANT CANCER BY ADMINISTRATION OF ANTI-HER2 ANTIBODY/DRUG CONJUGATE
YOSHIHARA KAZUTAKA, ENDO SEIKO, FUJISAKI YOSHIHIKO, OGITANI YUSUKE, JIKOH TAKAHIRO
Year of Publication 20.11.2023
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Year of Publication 20.11.2023
Patent
Abstract GS1-05: Datopotamab deruxtecan in advanced/metastatic HER2- breast cancer: Results from the phase 1 TROPION-PanTumor01 study
Krop, Ian, Juric, Dejan, Shimizu, Toshio, Tolcher, Anthony, Spira, Alexander, Mukohara, Toru, Lisberg, Aaron E., Kogawa, Takahiro, Papadopoulos, Kyriakos P., Hamilton, Erika, Damodaran, Senthil, Greenberg, Jonathan, Gu, Wen, Kobayashi, Fumiaki, Guevara, Ferdinand, Jikoh, Takahiro, Kawasaki, Yui, Meric-Bernstam, Funda, Bardia, Aditya
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Published in Cancer research (Chicago, Ill.) (15.02.2022)
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Journal Article
A phase 2, multicenter, open-label study of trastuzumab deruxtecan (DS-8201a) in subjects with HER2-positive, unresectable and/or metastatic breast cancer previously treated with T-DM1
Baselga, Jose, Tamura, Kenji, Yamashita, Toshinari, Modi, Shanu, Tokunaga, Eriko, Ito, Yoshinori, Iwata, Hiroji, Charif, Mahmoud, Lee, Caleb C., Sugihara, Masahiro, Jikoh, Takahiro, Andre, Fabrice
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Journal Article
Phase I study of Efatutazone, an oral PPARγ agonist, in patients with metastatic solid tumors
Murakami, Haruyasu, Ono, Akira, Takahashi, Toshiaki, Onozawa, Yusuke, Tsushima, Takahiro, Yamazaki, Kentaro, Jikoh, Takahiro, Boku, Narikazu, Yamamoto, Nobuyuki
Published in Anticancer research (01.09.2014)
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Published in Anticancer research (01.09.2014)
Journal Article
Impact of race on dose selection of molecular-targeted agents in early-phase oncology trials
Yokota, Tomoya, Bendell, Johanna, LoRusso, Patricia, Tsushima, Takahiro, Desai, Ved, Kenmotsu, Hirotsugu, Watanabe, Junichiro, Ono, Akira, Murugesan, Bhavani, Silva, Joseph, Naito, Tateaki, Greenberg, Jonathan, Kumar, Prasanna, Wang, Yibin, Jikoh, Takahiro, Shiga, Ryota, Hyman, David M., Ho, Alan Loh, Spriggs, David R., Schwartz, Gary K., Gounder, Mrinal M.
Published in British journal of cancer (01.06.2018)
Published in British journal of cancer (01.06.2018)
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Journal Article
A call for global harmonization of phase I oncology trials: Results from two parallel, first-in-human phase I studies of DS-7423, an oral PI3K/mTOR dual inhibitor in advanced solid tumors conducted in the United States and Japan
Yokota, Tomoya, Bendell, Johanna C., LoRusso, Patricia, Tsushima, Takahiro, Desai, Ved, Kenmotsu, Hirotsugu, Watanabe, Junichiro, Ono, Akira, Murugesan, Bhavani G., Silva, Joseph, Naito, Tateaki, Greenberg, Jonathan, Kumar, Prasanna, Wang, Yibin, Jikoh, Takahiro, Shiga, Ryota, Ho, Alan Loh, Gounder, Mrinal M.
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
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Journal Article
항 HER2 항체-약물 콘주게이트 투여에 의한 내성암의 치료
YOSHIHARA KAZUTAKA, ENDO SEIKO, FUJISAKI YOSHIHIKO, OGITANI YUSUKE, JIKOH TAKAHIRO
Year of Publication 12.06.2019
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Year of Publication 12.06.2019
Patent
항 HER2 항체-약물 콘쥬게이트 투여에 의한 HER2 변이암의 치료
SAITO KAKU, SERIZAWA YUI, SHIGA RYOTA, TOKUHIRO SHINYA, FUJISAKI YOSHIHIKO, SATO YUTA, JIKOH TAKAHIRO
Year of Publication 09.02.2021
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Year of Publication 09.02.2021
Patent
Abstract A145: DS-8201a, a novel HER2-targeting ADC with a novel DNA topoisomerase I inhibitor, demonstrates a potent anti-tumor efficacy with differentiation from T-DM1 in preclinical studies
Ogitani, Yusuke, Yamaguchi, Junko, Ishii, Chiaki, Hirai, Takehiro, Atsumi, Ryo, Morita, Koji, Hayakawa, Ichiro, Naito, Hiroyuki, Masuda, Takeshi, Nakada, Takashi, Jikoh, Takahiro
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
THERAPY FOR DRUG-RESISTANT CANCER BY ADMINISTRATION OF ANTI-HER2 ANTIBODY/DRUG CONJUGATE
JIKOH Takahiro, OGITANI Yusuke, ENDO Seiko, FUJISAKI Yoshihiko, YOSHIHARA Kazutaka
Year of Publication 12.04.2018
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Year of Publication 12.04.2018
Patent
TREATMENT OF HER2-MUTATED CANCER BY ADMINISTERING ANTI-HER2 ANTIBODY-DRUG CONJUGATE
TOKUHIRO Shinya, SERIZAWA Yui, SAITO Kaku, JIKOH Takahiro, SATO Yuta, FUJISAKI Yoshihiko, SHIGA Ryota
Year of Publication 05.12.2019
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Year of Publication 05.12.2019
Patent