Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2
Lee, Taeweon, Schwandner, Ralf, Swaminath, Gayathri, Weiszmann, Jennifer, Cardozo, Mario, Greenberg, Joanne, Jaeckel, Peter, Ge, Hongfei, Wang, Yingcai, Jiao, Xianyun, Liu, Jiwen, Kayser, Frank, Tian, Hui, Li, Yang
Published in Molecular pharmacology (01.12.2008)
Published in Molecular pharmacology (01.12.2008)
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Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors
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Published in Bioorganic & medicinal chemistry letters (01.10.2012)
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
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The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators
Wang, Yingcai, Jiao, Xianyun, Kayser, Frank, Liu, Jiwen, Wang, Zhongyu, Wanska, Malgorzata, Greenberg, Joanne, Weiszmann, Jennifer, Ge, Hongfei, Tian, Hui, Wong, Simon, Schwandner, Ralf, Lee, Taeweon, Li, Yang
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles
Wang, Yingcai, Liu, Jiwen (Jim), Dransfield, Paul J, Zhu, Liusheng, Wang, Zhongyu, Du, Xiaohui, Jiao, Xianyun, Su, Yongli, Li, An-rong, Brown, Sean P, Kasparian, Annie, Vimolratana, Marc, Yu, Ming, Pattaropong, Vatee, Houze, Jonathan B, Swaminath, Gayathri, Tran, Thanhvien, Nguyen, Khanh, Guo, Qi, Zhang, Jane, Zhuang, Run, Li, Frank, Miao, Lynn, Bartberger, Michael D, Correll, Tiffany L, Chow, David, Wong, Simon, Luo, Jian, Lin, Daniel C.-H, Medina, Julio C
Published in ACS medicinal chemistry letters (13.06.2013)
Published in ACS medicinal chemistry letters (13.06.2013)
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Discovery and optimization of a series of liver X receptor antagonists
Jiao, XianYun, Kopecky, David J., Fisher, Ben, Piper, Derek E., Labelle, Marc, McKendry, Sharon, Harrison, Martin, Jones, Stuart, Jaen, Juan, Shiau, Andrew K., Escaron, Patrick, Danao, Jean, Chai, Anne, Coward, Peter, Kayser, Frank
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
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CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity
Assimon, Victoria A, Tang, Yangzhong, Vargas, Jesse D, Lee, Grace J, Wu, Zhi Yong, Lou, Kenny, Yao, Bing, Menon, Mary-Kamala, Pios, Ariel, Perez, Kristy C, Madriaga, Antonett, Buchowiecki, Peter K, Rolfe, Mark, Shawver, Laura, Jiao, Xianyun, Le Moigne, Ronan, Zhou, Han-Jie, Anderson, Daniel J
Published in ACS chemical biology (15.02.2019)
Published in ACS chemical biology (15.02.2019)
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Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction
Rew, Yosup, Sun, Daqing, Gonzalez-Lopez De Turiso, Felix, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Deignan, Jeffrey, Fox, Brian M, Gustin, Darin, Huang, Xin, Jiang, Min, Jiao, Xianyun, Jin, Lixia, Kayser, Frank, Kopecky, David J, Li, Yihong, Lo, Mei-Chu, Long, Alexander M, Michelsen, Klaus, Oliner, Jonathan D, Osgood, Tao, Ragains, Mark, Saiki, Anne Y, Schneider, Steve, Toteva, Maria, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist
Brown, Sean P, Dransfield, Paul J, Vimolratana, Marc, Jiao, XianYun, Zhu, Liusheng, Pattaropong, Vatee, Sun, Ying, Liu, Jinqian, Luo, Jian, Zhang, Jane, Wong, Simon, Zhuang, Run, Guo, Qi, Li, Frank, Medina, Julio C, Swaminath, Gayathri, Lin, Daniel C.-H, Houze, Jonathan B
Published in ACS medicinal chemistry letters (13.09.2012)
Published in ACS medicinal chemistry letters (13.09.2012)
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Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates
Brown, Sean P., Dransfield, Paul, Vimolratana, Marc, Zhu, Liusheng, Luo, Jian, Zhang, Jane, Jiao, XianYun, Pattaropong, Vatee, Wong, Simon, Zhuang, Run, Swaminath, Gayathri, Houze, Jonathan B., Lin, Daniel C.-H.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Synthesis of benzimidazoles from 1,1-dibromoethenes
Shen, Wang, Kohn, Todd, Fu, Zice, Jiao, XianYun, Lai, Sujen, Schmitt, Michael
Published in Tetrahedron letters (15.12.2008)
Published in Tetrahedron letters (15.12.2008)
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 14.11.2023
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Year of Publication 14.11.2023
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5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties
Kohn, Todd J, Du, Xiaohui, Lai, SuJen, Xiong, YuMei, Komorowski, Renee, Veniant, Murielle, Fu, Zice, Jiao, Xianyun, Pattaropong, Vatee, Chow, David, Cardozo, Mario, Jin, Lixia, Conn, Marion, DeWolf, Walter E, Kraser, Christopher F, Hinklin, Ronald J, Boys, Mark L, Medina, Julio C, Houze, Jonathan, Dransfield, Paul, Coward, Peter
Published in ACS medicinal chemistry letters (14.07.2016)
Published in ACS medicinal chemistry letters (14.07.2016)
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 20.06.2022
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Year of Publication 20.06.2022
Patent
Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists
Du, Xiaohui, Dransfield, Paul J, Lin, Daniel C.-H, Wong, Simon, Wang, Yingcai, Wang, Zhongyu, Kohn, Todd, Yu, Ming, Brown, Sean P, Vimolratana, Marc, Zhu, Liusheng, Li, An-Rong, Su, Yongli, Jiao, Xianyun, Liu, Jiwen (Jim), Swaminath, Gayathri, Tran, Thanhvien, Luo, Jian, Zhuang, Run, Zhang, Jane, Guo, Qi, Li, Frank, Connors, Richard, Medina, Julio C, Houze, Jonathan B
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 08.06.2021
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Year of Publication 08.06.2021
Patent
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators
Du, Xiaohui, Hinklin, Ronald J, Xiong, Yumei, Dransfield, Paul, Park, Jaehyeon, Kohn, Todd J, Pattaropong, Vatee, Lai, SuJen, Fu, Zice, Jiao, Xianyun, Chow, David, Jin, Lixia, Davda, Jasmine, Veniant, Murielle M, Anderson, Deborah A, Baer, Brian R, Bencsik, Josef R, Boyd, Steven A, Chicarelli, Mark Joseph, Mohr, Peter J, Wang, Bin, Condroski, Kevin R, DeWolf, Walter E, Conn, Marion, Tran, Thanhvien, Yang, Jerry, Aicher, Thomas D, Medina, Julio C, Coward, Peter, Houze, Jonathan B
Published in ACS medicinal chemistry letters (11.12.2014)
Published in ACS medicinal chemistry letters (11.12.2014)
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Aminopyrazole–Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies
Yu, Ming, Lizarzaburu, Mike, Motani, Alykhan, Fu, Zice, Du, Xiaohui, Liu, Jiwen (Jim), Jiao, Xianyun, Lai, SuJen, Fan, Peter, Fu, Angela, Liu, Qingxiang, Murakoshi, Michiko, Nara, Futoshi, Oda, Kozo, Okuyama, Ryo, Reagan, Jeff D, Watanabe, Nobuaki, Yamazaki, Mami, Xiong, Yumei, Zhang, Ying, Zhuang, Run, Lin, Daniel C.-H, Houze, Jonathan B, Medina, Julio C, Li, Leping
Published in ACS medicinal chemistry letters (12.09.2013)
Published in ACS medicinal chemistry letters (12.09.2013)
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 04.06.2020
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Year of Publication 04.06.2020
Patent
PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 29.05.2019
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Year of Publication 29.05.2019
Patent
An ultrasensitive high-throughput electrochemiluminescence immunoassay for the Cdc42-associated protein tyrosine kinase ACK1
Xiao, Shou-Hua, Farrelly, Ellyn, Anzola, John, Crawford, Daniel, Jiao, XianYun, Liu, Jinqian, Ayres, Merrill, Li, Shyun, Huang, Linda, Sharma, Rajiv, Kayser, Frank, Wesche, Holger, Young, Stephen W.
Published in Analytical biochemistry (15.08.2007)
Published in Analytical biochemistry (15.08.2007)
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