Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington's Disease
Peng, Qi, Wu, Bin, Jiang, Mali, Jin, Jing, Hou, Zhipeng, Zheng, Jennifer, Zhang, Jiangyang, Duan, Wenzhen
Published in PloS one (09.02.2016)
Published in PloS one (09.02.2016)
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Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
Jiang, Mali, Wang, Jiawei, Fu, Jinrong, Du, Lin, Jeong, Hyunkyung, West, Tim, Xiang, Lan, Peng, Qi, Hou, Zhipeng, Cai, Huan, Seredenina, Tamara, Arbez, Nicolas, Zhu, Shanshan, Sommers, Katherine, Qian, Jennifer, Zhang, Jiangyang, Mori, Susumu, Yang, X William, Tamashiro, Kellie L K, Aja, Susan, Moran, Timothy H, Luthi-Carter, Ruth, Martin, Bronwen, Maudsley, Stuart, Mattson, Mark P, Cichewicz, Robert H, Ross, Christopher A, Holtzman, David M, Krainc, Dimitri, Duan, Wenzhen
Published in Nature medicine (01.01.2012)
Published in Nature medicine (01.01.2012)
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Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease
Jin, Jing, Peng, Qi, Hou, Zhipeng, Jiang, Mali, Wang, Xin, Langseth, Abraham J, Tao, Michael, Barker, Peter B, Mori, Susumu, Bergles, Dwight E, Ross, Christopher A, Detloff, Peter J, Zhang, Jiangyang, Duan, Wenzhen
Published in Human molecular genetics (01.05.2015)
Published in Human molecular genetics (01.05.2015)
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The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model
Peng, Qi, Masuda, Naoki, Jiang, Mali, Li, Qing, Zhao, Ming, Ross, Christopher A., Duan, Wenzhen
Published in Experimental neurology (01.03.2008)
Published in Experimental neurology (01.03.2008)
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Metformin Protects Cells from Mutant Huntingtin Toxicity Through Activation of AMPK and Modulation of Mitochondrial Dynamics
Jin, Jing, Gu, Hao, Anders, Nicole M., Ren, Tianhua, Jiang, Mali, Tao, Michael, Peng, Qi, Rudek, Michelle A., Duan, Wenzhen
Published in Neuromolecular medicine (01.12.2016)
Published in Neuromolecular medicine (01.12.2016)
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Baicalein reduces E46K α-synuclein aggregation in vitro and protects cells against E46K α-synuclein toxicity in cell models of familiar Parkinsonism
Jiang, Mali, Porat-Shliom, Yair, Pei, Zhong, Cheng, Yong, Xiang, Lan, Sommers, Katherine, Li, Qing, Gillardon, Frank, Hengerer, Bastian, Berlinicke, Cynthia, Smith, Wanli W, Zack, Donald J, Poirier, Michelle A, Ross, Christopher A, Duan, Wenzhen
Published in Journal of neurochemistry (01.07.2010)
Published in Journal of neurochemistry (01.07.2010)
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Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin
Waldron-Roby, Elaine, Ratovitski, Tamara, Wang, XiaoFang, Jiang, Mali, Watkin, Erin, Arbez, Nikolas, Graham, Rona K, Hayden, Michael R, Hou, Zhipeng, Mori, Susumu, Swing, Deborah, Pletnikov, Mikhail, Duan, Wenzhen, Tessarollo, Lino, Ross, Christopher A
Published in The Journal of neuroscience (04.01.2012)
Published in The Journal of neuroscience (04.01.2012)
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Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease
Masuda, Naoki, Peng, Qi, Li, Qing, Jiang, Mali, Liang, Yideng, Wang, Xiaofang, Zhao, Ming, Wang, Wenfei, Ross, Christopher A, Duan, Wenzhen
Published in Neurobiology of disease (01.06.2008)
Published in Neurobiology of disease (01.06.2008)
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trans-(−)-ε-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease
Fu, Jinrong, Jin, Jing, Cichewicz, Robert H., Hageman, Serena A., Ellis, Trevor K., Xiang, Lan, Peng, Qi, Jiang, Mali, Arbez, Nicolas, Hotaling, Katelyn, Ross, Christopher A., Duan, Wenzhen
Published in The Journal of biological chemistry (13.07.2012)
Published in The Journal of biological chemistry (13.07.2012)
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Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease
Zhou, Xiao, Li, Gang, Kaplan, Anna, Gaschler, Michael M, Zhang, Xiaoyan, Hou, Zhipeng, Jiang, Mali, Zott, Roseann, Cremers, Serge, Stockwell, Brent R, Duan, Wenzhen
Published in Human molecular genetics (01.05.2018)
Published in Human molecular genetics (01.05.2018)
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Arginine methylation of RNA-binding proteins is impaired in Huntington’s disease
Ratovitski, Tamara, Kamath, Siddhi V, O'Meally, Robert N, Gosala, Keerthana, Holland, Chloe D, Jiang, Mali, Cole, Robert N, Ross, Christopher A
Published in Human molecular genetics (04.10.2023)
Published in Human molecular genetics (04.10.2023)
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Interaction of huntingtin with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity
Ratovitski, Tamara, Jiang, Mali, O'Meally, Robert N, Rauniyar, Priyanka, Chighladze, Ekaterine, Faragó, Anikó, Kamath, Siddhi V, Jin, Jing, Shevelkin, Alexey V, Cole, Robert N, Ross, Christopher A
Published in Human molecular genetics (19.05.2022)
Published in Human molecular genetics (19.05.2022)
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Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease
Jiang, Mali, Peng, Qi, Liu, Xia, Jin, Jing, Hou, Zhipeng, Zhang, Jiangyang, Mori, Susumu, Ross, Christopher A, Ye, Keqiang, Duan, Wenzhen
Published in Human molecular genetics (15.06.2013)
Published in Human molecular genetics (15.06.2013)
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Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats
Ratovitski, Tamara, O’Meally, Robert N, Jiang, Mali, Chaerkady, Raghothama, Chighladze, Ekaterine, Stewart, Jacqueline C, Wang, Xiaofang, Arbez, Nicolas, Roby, Elaine, Alexandris, Athanasios, Duan, Wenzhen, Vijayvargia, Ravi, Seong, Ihn Sik, Lavery, Daniel J, Cole, Robert N, Ross, Christopher A
Published in Journal of proteome research (04.08.2017)
Published in Journal of proteome research (04.08.2017)
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Immortalized striatal precursor neurons from Huntington’s disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics
Akimov, Sergey S, Jiang, Mali, Kedaigle, Amanda J, Arbez, Nicolas, Marque, Leonard O, Eddings, Chelsy R, Ranum, Paul T, Whelan, Emma, Tang, Anthony, Wang, Ronald, DeVine, Lauren R, Talbot, Conover C, Cole, Robert N, Ratovitski, Tamara, Davidson, Beverly L, Fraenkel, Ernest, Ross, Christopher A
Published in Human molecular genetics (30.11.2021)
Published in Human molecular genetics (30.11.2021)
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Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington’s disease
Jiang, Mali, Zhang, Xiaoyan, Liu, Hongshuai, LeBron, Jared, Alexandris, Athanasios, Peng, Qi, Gu, Hao, Yang, Fanghan, Li, Yuchen, Wang, Ruiling, Hou, Zhipeng, Arbez, Nicolas, Ren, Qianwei, Dong, Jen-Li, Whela, Emma, Wang, Ronald, Ratovitski, Tamara, Troncoso, Juan C, Mori, Susumu, Ross, Christopher A, Lim, Janghoo, Duan, Wenzhen
Published in Human molecular genetics (28.05.2020)
Published in Human molecular genetics (28.05.2020)
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Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images
Zhang, Jiangyang, Peng, Qi, Li, Qing, Jahanshad, Neda, Hou, Zhipeng, Jiang, Mali, Masuda, Naoki, Langbehn, Douglas R., Miller, Michael I., Mori, Susumu, Ross, Christopher A., Duan, Wenzhen
Published in NeuroImage (Orlando, Fla.) (01.02.2010)
Published in NeuroImage (Orlando, Fla.) (01.02.2010)
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Long-Term Potentiation of Excitatory Synapses on Neocortical Somatostatin-Expressing Interneurons
Chen, Huan-Xin, Jiang, Mali, Akakin, Dilek, Roper, Steven N
Published in Journal of neurophysiology (01.12.2009)
Published in Journal of neurophysiology (01.12.2009)
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