P170 - Microtracer bioavailability, biotransformation mechanisms, and excretion of the covalent BTK inhibitor acalabrutinib in humans
Podoll, Terry, Pearson, Paul G., Evarts, Jerry, Ingallinera, Tim, Bibikova, Elena, Sun, Hao, Gohdes, Mark, Byard, Stephen, Cardinal, Kristen, Sanghvi, Mitesh, Slatter, J. Greg
Published in Drug metabolism and pharmacokinetics (2020)
Published in Drug metabolism and pharmacokinetics (2020)
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Journal Article
Allylic Sulfones in Solid-Phase Synthesis: Preparation of Cyclobutylidenes
Cheng, Wei-Chieh, Halm, Chris, Evarts, Jerry B, Olmstead, Marilyn M, Kurth, Mark J
Published in Journal of organic chemistry (12.11.1999)
Published in Journal of organic chemistry (12.11.1999)
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Journal Article
Use of allylic triflones for allylation of C-H bonds
Xiang, Jason, Evarts, Jerry, Rivkin, Alexey, Curran, Dennis P., Fuchs, P.L.
Published in Tetrahedron letters (01.06.1998)
Published in Tetrahedron letters (01.06.1998)
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Journal Article
Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans
Podoll, Terry, Pearson, Paul G, Evarts, Jerry, Ingallinera, Tim, Bibikova, Elena, Sun, Hao, Gohdes, Mark, Cardinal, Kristen, Sanghvi, Mitesh, Slatter, J Greg
Published in Drug metabolism and disposition (01.02.2019)
Published in Drug metabolism and disposition (01.02.2019)
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Journal Article
Identification and Characterization of ACP-5862, the Major Circulating Active Metabolite of Acalabrutinib: Both Are Potent and Selective Covalent Bruton Tyrosine Kinase Inhibitors
Podoll, Terry, Pearson, Paul G, Kaptein, Allard, Evarts, Jerry, de Bruin, Gerjan, Emmelot-van Hoek, Maaike, de Jong, Anouk, van Lith, Bart, Sun, Hao, Byard, Stephen, Fretland, Adrian, Hoogenboom, Niels, Barf, Tjeerd, Slatter, J Greg
Published in The Journal of pharmacology and experimental therapeutics (01.01.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2023)
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Journal Article
Abstract 13: Structure elucidation, metabolism, and drug interaction potential of ACP-5862, an active, major, circulating metabolite of acalabrutinib
Podoll, Terry, Pearson, Paul G., Evarts, Jerry, Ingallinera, Tim, Sun, Hao, Byard, Stephen, Fretland, Adrian J., Slatter, J. Greg
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Development of Commercial Manufacturing Processes for Acalabrutinib
Bethel, Paul A., Chan, Lai Chun, Cooper, Katie, Ensor, Gareth J., Evarts, Jerry, Garrey, Rustam, Ford, J. Gair, Harding, Daniel, Hughes, Shaun, Jackson, Lucy, Golden, Michael, Millard, Kirsty, Phillips, Andrew, Robbins, Andrew, Short, David, Telford, Alex, Whittaker, David T. E.
Published in Organic process research & development (16.12.2022)
Published in Organic process research & development (16.12.2022)
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Journal Article
Discovery of a Phosphoinositide 3‑Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856
Perreault, Stephane, Chandrasekhar, Jayaraman, Cui, Zhi-Hua, Evarts, Jerry, Hao, Jia, Kaplan, Joshua A, Kashishian, Adam, Keegan, Kathleen S, Kenney, Thomas, Koditek, David, Lad, Latesh, Lepist, Eve-Irene, McGrath, Mary E, Patel, Leena, Phillips, Bart, Therrien, Joseph, Treiberg, Jennifer, Yahiaoui, Anella, Phillips, Gary
Published in Journal of medicinal chemistry (23.02.2017)
Published in Journal of medicinal chemistry (23.02.2017)
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Journal Article
Discovery of Orally Efficacious Phosphoinositide 3‑Kinase δ Inhibitors with Improved Metabolic Stability
Patel, Leena, Chandrasekhar, Jayaraman, Evarts, Jerry, Forseth, Kristen, Haran, Aaron C, Ip, Carmen, Kashishian, Adam, Kim, Musong, Koditek, David, Koppenol, Sandy, Lad, Latesh, Lepist, Eve-Irene, McGrath, Mary E, Perreault, Stephane, Puri, Kamal D, Villaseñor, Armando G, Somoza, John R, Steiner, Bart H, Therrien, Joseph, Treiberg, Jennifer, Phillips, Gary
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
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Journal Article
2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors
Patel, Leena, Chandrasekhar, Jayaraman, Evarts, Jerry, Haran, Aaron C, Ip, Carmen, Kaplan, Joshua A, Kim, Musong, Koditek, David, Lad, Latesh, Lepist, Eve-Irene, McGrath, Mary E, Novikov, Nikolai, Perreault, Stephane, Puri, Kamal D, Somoza, John R, Steiner, Bart H, Stevens, Kirk L, Therrien, Joseph, Treiberg, Jennifer, Villaseñor, Armando G, Yeung, Arthur, Phillips, Gary
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
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Journal Article
PROCESSES FOR PREPARATION OF 4-{8-AMINO-3-[(2S)-1-(BUT-2-YNOYL)-PYRROLIDIN-2-YL]IMIDAZO[1,5-A]-PYRAZIN-1-YL}N-(PYRIDIN-2-YL)-BENZAMIDE
FRANK L M VOS, PETER JOHANNES SERVAAS SAVIO VAN EIJK, MICHAEL DAVID GOLDEN, WANG ANGANG, LUCINDA VICTORIA JACKSON, CHAN LAI CHUN, KIRSTY JANE MILLARD, MICHAEL JOSEPH LAWLER, REMY E J N LITJENS, MATHILDA MARIA HENRICA VERSTAPPEN, ALEXANDER JAMES TELFORD, JERRY EVARTS, SHAUN ALAN HUGHES, RUSTAM FERDINAND GARREY, QIU JUNYING, ERIC JURRIEN ZIJP, ROBERT JOHN COX, KATIE GRACE COOPER, DAVID ALLEN SHORT, PAUL ALLEN BETHEL, ANDREW JOHN PHILLIPS
Year of Publication 19.03.2024
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Year of Publication 19.03.2024
Patent
ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
JERRY EVARTS, JENNIFER A TREIBERG, STEPHANE PERREAULT, GARY PHILLIPS, LEENA PATEL, JOSHUA KAPLAN
Year of Publication 18.01.2018
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Year of Publication 18.01.2018
Patent
Syntheses of highly substituted enantiopure C6 and C7 enones
EVARTS, Jerry, TORRES, Eduardo, FUCHS, Philip L
Published in Journal of the American Chemical Society (18.09.2002)
Published in Journal of the American Chemical Society (18.09.2002)
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Journal Article
PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
JERRY EVARTS, JENNIFER A TREIBERG, KIM MUSONG, DEVAN NADUTHAMBI, STEPHANE PERREAULT, GARY PHILLIPS, LEENA PATEL, KIRK L STEVENS, LAFE J PURVIS II, JOSHUA KAPLAN
Year of Publication 14.06.2018
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Year of Publication 14.06.2018
Patent
Syntheses of Highly Substituted Enantiopure C6 and C7 Enones 1
Evarts, Jerry, Torres, Eduardo, Fuchs, Philip L.
Published in Journal of the American Chemical Society (01.09.2002)
Published in Journal of the American Chemical Society (01.09.2002)
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Journal Article