TrkB-ICD fragment, originating from BDNF receptor cleavage, is translocated to cell nucleus and phosphorylates nuclear and axonal proteins
Fonseca-Gomes, João, Jerónimo-Santos, André, Lesnikova, Angelina, Casarotto, Plinio, Castrén, Eero, Sebastião, Ana M, de Oliveira Diógenes Nogueira, Maria José
Published in Frontiers in molecular neuroscience (01.02.2019)
Published in Frontiers in molecular neuroscience (01.02.2019)
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Brain-derived neurotrophic factor mediates neuroprotection against Aβ-induced toxicity through a mechanism independent on adenosine 2A receptor activation
Jerónimo-Santos, André, Fonseca-Gomes, João, Guimarães, Diogo Andrade, Tanqueiro, Sara Ramalho, Ramalho, Rita Mira, Ribeiro, Joaquim Alexandre, Sebastião, Ana Maria, Diógenes, Maria José
Published in Growth factors (Chur, Switzerland) (01.01.2015)
Published in Growth factors (Chur, Switzerland) (01.01.2015)
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Journal Article
Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice
Kemppainen, Susanna, Rantamäki, Tomi, Jerónimo-Santos, André, Lavasseur, Gregoire, Autio, Henri, Karpova, Nina, Kärkkäinen, Elisa, Stavén, Saara, Miranda, Hugo Vicente, Outeiro, Tiago F, Diógenes, Maria J, Laroche, Serge, Davis, Sabrina, Sebastião, Ana M, Castrén, Eero, Tanila, Heikki
Published in Neurobiology of aging (01.06.2012)
Published in Neurobiology of aging (01.06.2012)
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Journal Article
Impact of in vivo chronic blockade of adenosine A sub(2A) receptors on the BDNF-mediated facilitation of LTP
Jeronimo-Santos, Andre, Batalha, Vania L, Mueller, Christa E, Baqi, Younis, Sebastiao, Ana Maria, Lopes, Luisa V, Diogenes, Maria Jose
Published in Neuropharmacology (01.08.2014)
Published in Neuropharmacology (01.08.2014)
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Journal Article
Dysregulation of TrkB receptors and BDNF function by amyloid-β peptide is mediated by calpain
Jerónimo-Santos, André, Henriques Vaz, Sandra Cristina, Parreira, Sara, Lerias, Sofia, Caetano, António P., Buée-Scherrer, Valérie, Castrén, Eero, Valente, Cláudia, Blum, David, Sebastião, Ana M, de Oliveira Diógenes Nogueira, Maria José
Published in Cerebral cortex (New York, N.Y. 1991) (01.09.2015)
Published in Cerebral cortex (New York, N.Y. 1991) (01.09.2015)
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Journal Article
Enhancement of LTP in Aged Rats is Dependent on Endogenous BDNF
DIOGENES, Maria J, COSTENLA, Ana R, LOPES, Luisa V, JERONIMO-SANTOS, Andre, SOUSA, Vasco C, FONTINHA, Bruno M, RIBEIRO, Joaquim A, SEBASTIAO, Ana M
Published in Neuropsychopharmacology (01.08.2011)
Published in Neuropsychopharmacology (01.08.2011)
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Journal Article
Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP
Jerónimo-Santos, André, Batalha, Vânia L., Müller, Christa E., Baqi, Younis, Sebastião, Ana Maria, Lopes, Luisa V., Diógenes, Maria José
Published in Neuropharmacology (01.08.2014)
Published in Neuropharmacology (01.08.2014)
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Journal Article
THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS, AND ASSOCIATED BIOMARKERS BASED ON TRK-B
FONSECA GOMES, JOAO FILIPE, FERREIRA DE SOUSA SEBASTIAO, ANA MARIA, BANDEIRA DUARTE, CARLOS, DE OLIVEIRA DIOGENES NOGUEIRA, MARIA JOSE, SANTOS, ANDRE JERONIMO
Year of Publication 07.10.2021
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Year of Publication 07.10.2021
Patent
Impaired TrkB receptor signaling contributes to memory impairement in APP/PS1 mice
Kemppainen, Susanna, Rantamäki, Tomi, Jeronimo-Santos, André, Levasseur, Grégoire, Autio, Henri, Karpova, Nina, Kärkkäinen, Elisa, Stavén, Saara, Miranda, Hugo Vicente, Outeiro, Tiago F., Diogenes, Maria J., Laroche, Serge, Davis, Sabrina, Sebastiao, Ana M., Castrén, Eero, Tanila, Heikki
Published in Neurobiology of aging (05.06.2012)
Published in Neurobiology of aging (05.06.2012)
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Journal Article
A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease
Fonseca-Gomes, João, Costa-Coelho, Tiago, Ferreira-Manso, Mafalda, Inteiro-Oliveira, Sara, Vaz, Sandra H., Alemãn-Serrano, Nuno, Atalaia-Barbacena, Henrique, Ribeiro-Rodrigues, Leonor, Ramalho, Rita M., Pinto, Rui, Vicente Miranda, Hugo, Tanqueiro, Sara R., de Almeida-Borlido, Carolina, Ramalho, Maria João, Miranda-Lourenço, Catarina, Belo, Rita F., Ferreira, Catarina B., Neves, Vera, Rombo, Diogo M., Viais, Ricardo, Martins, Ivo C., Jerónimo-Santos, André, Caetano, António, Manso, Nuno, Mäkinen, Petra, Marttinen, Mikael, Takalo, Mari, Bremang, Michael, Pike, Ian, Haapasalo, Annakaisa, Loureiro, Joana A., Pereira, Maria Carmo, Santos, Nuno C., Outeiro, Tiago F., Castanho, Miguel A.R.B., Fernandes, Adelaide, Hiltunen, Mikko, Duarte, Carlos B., Castrén, Eero, de Mendonça, Alexandre, Sebastião, Ana M., Rodrigues, Tiago M., Diógenes, Maria José
Published in Molecular therapy (02.10.2024)
Published in Molecular therapy (02.10.2024)
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Journal Article
THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS, AND ASSOCIATED BIOMARKERS BASED ON TRK-B
FERREIRA DE SOUSA SEBASTIÃO, Ana Maria, DE OLIVEIRA DIÓGENES NOGUEIRA, Maria José, SANTOS, André Jerónimo, FONSECA GOMES, João Filipe, BANDEIRA DUARTE, Carlos
Year of Publication 12.10.2023
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Year of Publication 12.10.2023
Patent
THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS, AND ASSOCIATED BIOMARKERS BASED ON TRK-B
FERREIRA DE SOUSA SEBASTIÃO, Ana Maria, DE OLIVEIRA DIÓGENES NOGUEIRA, Maria José, SANTOS, André Jerónimo, FONSECA GOMES, João Filipe, BANDEIRA DUARTE, Carlos
Year of Publication 08.02.2023
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Year of Publication 08.02.2023
Patent
Therapeutic Agents, Pharmaceutical Compositions, and Associated Biomarkers based on Trk-B
FERREIRA DE SOUSA SEBASTIÃO, Ana Maria, DE OLIVEIRA DIÓGENES NOGUEIRA, Maria José, SANTOS, André Jerónimo, FONSECA GOMES, João Filipe, BANDEIRA DUARTE, Carlos
Year of Publication 03.11.2022
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Year of Publication 03.11.2022
Patent
THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS, AND ASSOCIATED BIOMARKERS BASED ON TRK-B
FERREIRA DE SOUSA SEBASTIÃO, Ana Maria, DE OLIVEIRA DIÓGENES NOGUEIRA, Maria José, SANTOS, André Jerónimo, FONSECA GOMES, João Filipe, BANDEIRA DUARTE, Carlos
Year of Publication 07.10.2021
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Year of Publication 07.10.2021
Patent