Structure−Activity Studies and Analgesic Efficacy of N-(3-Pyridinyl)-Bridged Bicyclic Diamines, Exceptionally Potent Agonists at Nicotinic Acetylcholine Receptors
Bunnelle, William H, Daanen, Jerome F, Ryther, Keith B, Schrimpf, Michael R, Dart, Michael J, Gelain, Arianna, Meyer, Michael D, Frost, Jennifer M, Anderson, David J, Buckley, Michael, Curzon, Peter, Cao, Ying-Jun, Puttfarcken, Pamela, Searle, Xenia, Ji, Jianguo, Putman, C. Brent, Surowy, Carol, Toma, Lucio, Barlocco, Daniela
Published in Journal of medicinal chemistry (26.07.2007)
Published in Journal of medicinal chemistry (26.07.2007)
Get full text
Journal Article
Gram Scale Synthesis of the Glucuronide Metabolite of ABT-724
Engstrom, Kenneth M, Daanen, Jerome F, Wagaw, Seble, Stewart, Andrew O
Published in Journal of organic chemistry (27.10.2006)
Published in Journal of organic chemistry (27.10.2006)
Get full text
Journal Article
Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature
Reilly, Regina M, McDonald, Heath A, Puttfarcken, Pamela S, Joshi, Shailen K, Lewis, LaGeisha, Pai, Madhavi, Franklin, Pamela H, Segreti, Jason A, Neelands, Torben R, Han, Ping, Chen, Jun, Mantyh, Patrick W, Ghilardi, Joseph R, Turner, Teresa M, Voight, Eric A, Daanen, Jerome F, Schmidt, Robert G, Gomtsyan, Arthur, Kort, Michael E, Faltynek, Connie R, Kym, Philip R
Published in The Journal of pharmacology and experimental therapeutics (01.08.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2012)
Get full text
Journal Article
Discovery of (R)‑1-(7-Chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): A Temperature-Neutral Transient Receptor Potential Vanilloid‑1 (TRPV1) Antagonist with Analgesic Efficacy
Voight, Eric A, Gomtsyan, Arthur R, Daanen, Jerome F, Perner, Richard J, Schmidt, Robert G, Bayburt, Erol K, DiDomenico, Stanley, McDonald, Heath A, Puttfarcken, Pamela S, Chen, Jun, Neelands, Torben R, Bianchi, Bruce R, Han, Ping, Reilly, Regina M, Franklin, Pamela H, Segreti, Jason A, Nelson, Richard A, Su, Zhi, King, Andrew J, Polakowski, James S, Baker, Scott J, Gauvin, Donna M, Lewis, LaGeisha R, Mikusa, Joseph P, Joshi, Shailen K, Faltynek, Connie R, Kym, Philip R, Kort, Michael E
Published in Journal of medicinal chemistry (11.09.2014)
Published in Journal of medicinal chemistry (11.09.2014)
Get full text
Journal Article
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain
Frost, Jennifer M, DeGoey, David A, Shi, Lei, Gum, Rebecca J, Fricano, Meagan M, Lundgaard, Greta L, El-Kouhen, Odile F, Hsieh, Gin C, Neelands, Torben, Matulenko, Mark A, Daanen, Jerome F, Pai, Madhavi, Ghoreishi-Haack, Nayereh, Zhan, Cenchen, Zhang, Xu-Feng, Kort, Michael E
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
Get full text
Journal Article
Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia
Honore, Prisca, Chandran, Prasant, Hernandez, Gricelda, Gauvin, Donna M., Mikusa, Joseph P., Zhong, Chengmin, Joshi, Shailen K., Ghilardi, Joseph R., Sevcik, Molly A., Fryer, Ryan M., Segreti, Jason A., Banfor, Patricia N., Marsh, Kennan, Neelands, Torben, Bayburt, Erol, Daanen, Jerome F., Gomtsyan, Arthur, Lee, Chih-Hung, Kort, Michael E., Reilly, Regina M., Surowy, Carol S., Kym, Philip R., Mantyh, Patrick W., Sullivan, James P., Jarvis, Michael F., Faltynek, Connie R.
Published in Pain (Amsterdam) (01.03.2009)
Published in Pain (Amsterdam) (01.03.2009)
Get full text
Journal Article
Synthesis of Oxazolo[4,5-c]quinoline TRPV1 Antagonists
Voight, Eric A, Daanen, Jerome F, Kort, Michael E
Published in Journal of organic chemistry (17.12.2010)
Published in Journal of organic chemistry (17.12.2010)
Get full text
Journal Article
Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists
Schmidt, Robert G., Bayburt, Erol K., Latshaw, Steven P., Koenig, John R., Daanen, Jerome F., McDonald, Heath A., Bianchi, Bruce R., Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Marsh, Kennan C., Lee, Chih-Hung, Faltynek, Connie R., Gomtsyan, Arthur
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Get full text
Journal Article
TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats
Gomtsyan, Arthur, McDonald, Heath A, Schmidt, Robert G, Daanen, Jerome F, Voight, Eric A, Segreti, Jason A, Puttfarcken, Pamela S, Reilly, Regina M, Kort, Michael E, Dart, Michael J, Kym, Philip R
Published in Temperature (Austin) (30.06.2015)
Published in Temperature (Austin) (30.06.2015)
Get full text
Journal Article
Efficient and general asymmetric syntheses of ( R)-chroman-4-amine salts
Voight, Eric A., Daanen, Jerome F., Hannick, Steven M., Shelat, Bhadra H., Kerdesky, Francis A., Plata, Daniel J., Kort, Michael E.
Published in Tetrahedron letters (10.11.2010)
Published in Tetrahedron letters (10.11.2010)
Get full text
Journal Article
Capsaicin-induced inhibition of platelet aggregation is not mediated by transient receptor potential vanilloid type 1
Mittelstadt, Scott W, Nelson, Richard A, Daanen, Jerome F, King, Andrew J, Kort, Michael E, Kym, Philip R, Lubbers, Nathan L, Cox, Bryan F, Lynch, 3rd, James J
Published in Blood coagulation & fibrinolysis (01.01.2012)
Published in Blood coagulation & fibrinolysis (01.01.2012)
Get more information
Journal Article
Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists
XUEQING WANG, BHATIA, Pramila A, MILLER, Loan N, RENJIE CHANG, MORELAND, Robert B, BRIONI, Jorge D, STEWART, Andrew O, DAANEN, Jerome F, LATSAW, Steve P, ROHDE, Jeffrey, KOLASA, Teodozyi, HAKEEM, Ahmed A, MATULENKO, Mark A, NAKANE, Masaki, UCHIC, Marie E
Published in Bioorganic & medicinal chemistry (01.08.2005)
Published in Bioorganic & medicinal chemistry (01.08.2005)
Get full text
Journal Article
Discovery of 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a Dopaminergic Agent with a Novel Mode of Action for the Potential Treatment of Erectile Dysfunction
Cowart, Marlon, Latshaw, Steven P, Bhatia, Pramila, Daanen, Jerome F, Rohde, Jeffrey, Nelson, Sherry L, Patel, Meena, Kolasa, Teodozyi, Nakane, Masaki, Uchic, Marie E, Miller, Loan N, Terranova, Marc A, Chang, Renjie, Donnelly-Roberts, Diana L, Namovic, Marian T, Hollingsworth, Peter R, Martino, Brenda R, Lynch, James J, Sullivan, James P, Hsieh, Gin C, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O
Published in Journal of medicinal chemistry (15.07.2004)
Published in Journal of medicinal chemistry (15.07.2004)
Get full text
Journal Article
Synthesis and Structure−Activity Relationships of 3,8-Diazabicyclo[4.2.0]octane Ligands, Potent Nicotinic Acetylcholine Receptor Agonists
Frost (née Pac, Jennifer M, Bunnelle, William H, Tietje, Karin R, Anderson, David J, Rueter, Lynne E, Curzon, Peter, Surowy, Carol S, Ji, Jianquo, Daanen, Jerome F, Kohlhaas, Kathy L, Buckley, Michael J, Henry, Rodger F, Dyhring, Tino, Ahring, Philip K, Meyer, Michael D
Published in Journal of medicinal chemistry (28.12.2006)
Published in Journal of medicinal chemistry (28.12.2006)
Get full text
Journal Article
Dopamine D4 Ligands and Models of Receptor Activation: 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and Related Heteroarylmethylarylpiperazines Exhibit a Substituent Effect Responsible for Additional Efficacy Tuning
Stewart, Andrew O, Cowart, Marlon D, Moreland, Robert B, Latshaw, Steve P, Matulenko, Mark A, Bhatia, Pramila A, Wang, Xueqing, Daanen, Jerome F, Nelson, Sherry L, Terranova, Marc A, Namovic, Marian T, Donnelly-Roberts, Diana L, Miller, Loan N, Nakane, Masaki, Sullivan, James P, Brioni, Jorge D
Published in Journal of medicinal chemistry (22.04.2004)
Published in Journal of medicinal chemistry (22.04.2004)
Get full text
Journal Article
ABT-089 [2-Methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A Novel Cholinergic Channel Modulator with Effects on Cognitive Performance in Rats and Monkeys
Decker, M W, Bannon, A W, Curzon, P, Gunther, K L, Brioni, J D, Holladay, M W, Lin, N H, Li, Y, Daanen, J F, Buccafusco, J J, Prendergast, M A, Jackson, W J, Arneric, S P
Published in The Journal of pharmacology and experimental therapeutics (01.10.1997)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.10.1997)
Journal Article
Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors
Lee, Chih-Hung, Daanen, Jerome F, Jiang, Meiqun, Yu, Haixia, Kohlhaas, Kathy L, Alexander, Karen, Jarvis, Michael F, Kowaluk, Elizabeth L, Bhagwat, Shripad S
Published in Bioorganic & medicinal chemistry letters (17.09.2001)
Published in Bioorganic & medicinal chemistry letters (17.09.2001)
Get full text
Journal Article
Substituted Indazoles as Na(v)1.7 Blockers for the Treatment of Pain
Frost, Jennifer M., DeGoey, David A., Shi, Lei, Gum, Rebecca J., Fricano, Meagan M., Lundgaard, Greta L., El-Kouhen, Odile F., Hsieh, Gin C., Neelands, Torben, Matulenko, Mark A., Daanen, Jerome F., Pai, Madhavi, Ghoreishi-Haack, Nayereh, Zhan, Cenchen, Zhang, Xu-Feng, Kort, Michael E.
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
Get full text
Journal Article