Evolution of Cereblon-Mediated Protein Degradation as a Therapeutic Modality
Chamberlain, Philip P, D’Agostino, Laura A, Ellis, J. Michael, Hansen, Joshua D, Matyskiela, Mary E, McDonald, Joseph J, Riggs, Jennifer R, Hamann, Lawrence G
Published in ACS medicinal chemistry letters (12.12.2019)
Published in ACS medicinal chemistry letters (12.12.2019)
Get full text
Journal Article
Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115
Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Shevlin, Graziella, Elsner, Jan, Zhao, Jingjing, Whitefield, Brandon, Tehrani, Lida, Sapienza, John, Riggs, Jennifer R., Parnes, Jason S., Papa, Patrick, Packard, Garrick, Lee, Branden G.S., Harris, Roy, Correa, Matthew, Bahmanyar, Sogole, Richardson, Samantha J., Peng, Sophie X., Leisten, Jim, Khambatta, Godrej, Hickman, Matt, Gamez, James C., Bisonette, René R., Apuy, Julius, Cathers, Brian E., Canan, Stacie S., Moghaddam, Mehran F., Raymon, Heather K., Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
Get full text
Journal Article
Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors
Packard, Garrick K., Papa, Patrick, Riggs, Jennifer R., Erdman, Paul, Tehrani, Lida, Robinson, Dale, Harris, Roy, Shevlin, Graziella, Perrin-Ninkovic, Sophie, Hilgraf, Robert, McCarrick, Margaret A., Tran, Tam, Fleming, Yuedi, Bai, April, Richardson, Samantha, Katz, Jason, Tang, Yang, Leisten, Jim, Moghaddam, Mehran, Cathers, Brian, Zhu, Dan, Sakata, Steven
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Get full text
Journal Article
The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen
Riggs, Jennifer R, Nagy, Mark, Elsner, Jan, Erdman, Paul, Cashion, Dan, Robinson, Dale, Harris, Roy, Huang, Dehua, Tehrani, Lida, Deyanat-Yazdi, Gordafaried, Narla, Rama Krishna, Peng, Xiaohui, Tran, Tam, Barnes, Leo, Miller, Terra, Katz, Jason, Tang, Yang, Chen, Ming, Moghaddam, Mehran F, Bahmanyar, Sogole, Pagarigan, Barbra, Delker, Silvia, LeBrun, Laurie, Chamberlain, Philip P, Calabrese, Andrew, Canan, Stacie S, Leftheris, Katerina, Zhu, Dan, Boylan, John F
Published in Journal of medicinal chemistry (09.11.2017)
Published in Journal of medicinal chemistry (09.11.2017)
Get full text
Journal Article
Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1–S Checkpoint
Zhu, Dan, Xu, Shuichan, Deyanat-Yazdi, Gordafaried, Peng, Sophie X., Barnes, Leo A., Narla, Rama Krishna, Tran, Tam, Mikolon, David, Ning, Yuhong, Shi, Tao, Jiang, Ning, Raymon, Heather K., Riggs, Jennifer R., Boylan, John F.
Published in Molecular cancer therapeutics (01.08.2018)
Published in Molecular cancer therapeutics (01.08.2018)
Get full text
Journal Article
Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity
Elsner, Jan, Cashion, Dan, Robinson, Dale, Bahmanyar, Sogole, Tehrani, Lida, Fultz, Kimberly E, Narla, Rama Krishna, Peng, Xiaohui, Tran, Tam, Apuy, Julius, LeBrun, Laurie, Leftheris, Katerina, Boylan, John F, Zhu, Dan, Riggs, Jennifer R
Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
Get full text
Journal Article
Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G 1 -S Checkpoint
Zhu, Dan, Xu, Shuichan, Deyanat-Yazdi, Gordafaried, Peng, Sophie X, Barnes, Leo A, Narla, Rama Krishna, Tran, Tam, Mikolon, David, Ning, Yuhong, Shi, Tao, Jiang, Ning, Raymon, Heather K, Riggs, Jennifer R, Boylan, John F
Published in Molecular cancer therapeutics (01.08.2018)
Published in Molecular cancer therapeutics (01.08.2018)
Get full text
Journal Article
Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy
Riggs, Jennifer R, Elsner, Jan, Cashion, Dan, Robinson, Dale, Tehrani, Lida, Nagy, Mark, Fultz, Kimberly E, Krishna Narla, Rama, Peng, Xiaohui, Tran, Tam, Kulkarni, Ashutosh, Bahmanyar, Sogole, Condroski, Kevin, Pagarigan, Barbra, Fenalti, Gustavo, LeBrun, Laurie, Leftheris, Katerina, Zhu, Dan, Boylan, John F
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
Get full text
Journal Article
Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223
Mortensen, Deborah S, Perrin-Ninkovic, Sophie M, Shevlin, Graziella, Zhao, Jingjing, Packard, Garrick, Bahmanyar, Sogole, Correa, Matthew, Elsner, Jan, Harris, Roy, Lee, Branden G. S, Papa, Patrick, Parnes, Jason S, Riggs, Jennifer R, Sapienza, John, Tehrani, Lida, Whitefield, Brandon, Apuy, Julius, Bisonette, René R, Gamez, James C, Hickman, Matt, Khambatta, Godrej, Leisten, Jim, Peng, Sophie X, Richardson, Samantha J, Cathers, Brian E, Canan, Stacie S, Moghaddam, Mehran F, Raymon, Heather K, Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E, Sankar, Sabita
Published in Journal of medicinal chemistry (09.07.2015)
Published in Journal of medicinal chemistry (09.07.2015)
Get full text
Journal Article
Comparison of Diesel Fuel Oxygenate Additives to the Composition-Explicit Distillation Curve Method. Part 1: Linear Compounds with One to Three Oxygens
Bruno, Thomas J, Lovestead, Tara M, Riggs, Jennifer R, Jorgenson, Erica L, Huber, Marcia L
Published in Energy & fuels (16.06.2011)
Published in Energy & fuels (16.06.2011)
Get full text
Journal Article
Frailty and Advanced Heart Failure in Older Adults
Riggs, Jennifer R., Reyentovich, Alex, Maurer, Mathew S., Dodson, John A.
Published in Current cardiovascular risk reports (01.05.2017)
Published in Current cardiovascular risk reports (01.05.2017)
Get full text
Journal Article
Effect of Intramolecular Paterno-Buchi Reaction on the Thermodynamics and Kinetics of Nearly Degenerate [3,3]-Sigmatropic Shift in Fluxional Polycycles
Valiulin, Roman A., Dressen, Donald G., Riggs, Jennifer R., Habte, Faven M., Kutateladze, Andrei G.
Published in Journal of organic chemistry (01.05.2009)
Published in Journal of organic chemistry (01.05.2009)
Get full text
Journal Article
Potent 4-amino-5-azaindole factor VIIa inhibitors
Hu, Huiyong, Kolesnikov, Aleksandr, Riggs, Jennifer R., Wesson, Kieron E., Stephens, Robin, Leahy, Ellen M., Shrader, William D., Sprengeler, Paul A., Green, Michael J., Sanford, Ellen, Nguyen, Margaret, Gjerstad, Erik, Cabuslay, Ronnel, Young, Wendy B.
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Get full text
Journal Article
Factor VIIa inhibitors: A prodrug strategy to improve oral bioavailability
Riggs, Jennifer R., Kolesnikov, Aleksandr, Hendrix, John, Young, Wendy B., Shrader, William D., Vijaykumar, Dange, Stephens, Robin, Liu, Liang, Pan, Lin, Mordenti, Joyce, Green, Michael J., Sukbuntherng, Juthamas
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Get full text
Journal Article
Novel 5-azaindole factor VIIa inhibitors
Riggs, Jennifer R., Hu, Huiyong, Kolesnikov, Aleksandr, Leahy, Ellen M., Wesson, Kieron E., Shrader, William D., Vijaykumar, Dange, Wahl, Troy A., Tong, Zhiwei, Sprengeler, Paul A., Green, Michael J., Yu, Christine, Katz, Brad A., Sanford, Ellen, Nguyen, Margaret, Cabuslay, Ronnel, Young, Wendy B.
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
Get full text
Journal Article
Efforts toward oral bioavailability in factor VIIa inhibitors
Vijaykumar, Dange, Rai, Roopa, Shaghafi, Michael, Ton, Tony, Torkelson, Steve, Leahy, Ellen M., Riggs, Jennifer R., Hu, Huiyong, Sprengeler, Paul A., Shrader, William D., O’Bryan, Colin, Cabuslay, Ronnell, Sanford, Ellen, Gjerstadt, Erik, Liu, Liang, Sukbuntherng, Juthamas, Young, Wendy B.
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Get full text
Journal Article
Abstract A043: Identification of a patient enrichment strategy supporting development of a potent and selective dual TTK/CLK2 inhibitor CC-671
Xu, Shuichan, Tran, Tam, Shi, Tao, Jiang, Ning, Zhu, Dan, Riggs, Jennifer R., Boylan, John
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
Get full text
Journal Article