1,2,4-Triazolo-[1,5‑a]pyridine HIF Prolylhydroxylase Domain‑1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction
Ahmed, Saleh, Ayscough, Andrew, Barker, Greg R, Canning, Hannah E, Davenport, Richard, Downham, Robert, Harrison, David, Jenkins, Kerry, Kinsella, Natasha, Livermore, David G, Wright, Susanne, Ivetac, Anthony D, Skene, Robert, Wilkens, Steven J, Webster, Natalie A, Hendrick, Alan G
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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The Discovery of Potent, Selective, and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma
Newton, Gary K, Perrior, Trevor R, Jenkins, Kerry, Major, Meriel R, Key, Rebekah E, Stewart, Mark R, Firth-Clark, Stuart, Lloyd, Steven M, Zhang, Jihui, Francis-Newton, Nicola J, Richardson, Jonathan P, Chen, Jie, Lai, Pei, Garrod, David R, Robinson, Clive
Published in Journal of medicinal chemistry (26.11.2014)
Published in Journal of medicinal chemistry (26.11.2014)
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Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy
Zhang, Jihui, Chen, Jie, Richardson, Jonathan P., Francis-Newton, Nicola-Jane, Lai, Pei F., Jenkins, Kerry, Major, Meriel R., Key, Rebekah E., Stewart, Mark E., Firth-Clark, Stuart, Lloyd, Steven M., Newton, Gary K., Perrior, Trevor R., Garrod, David R., Robinson, Clive
Published in ACS pharmacology & translational science (09.09.2022)
Published in ACS pharmacology & translational science (09.09.2022)
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Journal Article
IRAK-4 inhibitors. Part III: A series of imidazo[1,2- a]pyridines
Buckley, George M., Fosbeary, Richard, Fraser, Joanne L., Gowers, Lewis, Higueruelo, Alicia P., James, Lynwen A., Jenkins, Kerry, Mack, Stephen R., Morgan, Trevor, Parry, David M., Pitt, William R., Rausch, Oliver, Richard, Marianna D., Sabin, Verity
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
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IRAK-4 inhibitors. Part II: A structure-based assessment of imidazo[1,2- a]pyridine binding
Buckley, George M., Ceska, Thomas A., Fraser, Joanne L., Gowers, Lewis, Groom, Colin R., Higueruelo, Alicia Perez, Jenkins, Kerry, Mack, Stephen R., Morgan, Trevor, Parry, David M., Pitt, William R., Rausch, Oliver, Richard, Marianna D., Sabin, Verity
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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PHD 저해제로서의 활성을 갖는 융합된 바이시클릭 헤테로아릴 유도체
AHMED SALEH, BARKER GREGORY, JENKINS KERRY, WRIGHT SUSANNE, CANNING HANNAH, LIVERMORE DAVID, HARRISON DAVID, KINSELLA NATASHA, DAVENPORT RICHARD
Year of Publication 27.11.2017
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Year of Publication 27.11.2017
Patent
IRAK-4 inhibitors. Part 1: A series of amides
Buckley, George M., Gowers, Lewis, Higueruelo, Alicia Perez, Jenkins, Kerry, Mack, Stephen R., Morgan, Trevor, Parry, David M., Pitt, William R., Rausch, Oliver, Richard, Marianna D., Sabin, Verity, Fraser, Joanne L.
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Journal Article
Optimization of a series of multi-isoform PI3 kinase inhibitors
Perry, Benjamin, Beevers, Rebekah, Bennett, Gavin, Buckley, George, Crabbe, Tom, Gowers, Lewis, James, Lynwen, Jenkins, Kerry, Lock, Chris, Sabin, Verity, Wright, Sara
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
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Journal Article
Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines
Perry, Benjamin, Alexander, Rikki, Bennett, Gavin, Buckley, George, Ceska, Tom, Crabbe, Tom, Dale, Verity, Gowers, Lewis, Horsley, Helen, James, Lynwen, Jenkins, Kerry, Crépy, Karen, Kulisa, Claire, Lightfoot, Helen, Lock, Chris, Mack, Stephen, Morgan, Trevor, Nicolas, Anne-Lise, Pitt, Will, Sabin, Verity, Wright, Sara
Published in Bioorganic & medicinal chemistry (15.08.2008)
Published in Bioorganic & medicinal chemistry (15.08.2008)
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Journal Article
Future inhaled drugs by virtual innovation: allergen delivery inhibitors
Robinson, Clive, Zhang, Jihui, Garrod, David R, Newton, Gary K, Jenkins, Kerry, Perrior, Trevor R
Published in Future medicinal chemistry (01.10.2011)
Published in Future medicinal chemistry (01.10.2011)
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Journal Article
Novel indole inhibitors of IMPDH from fragments: Synthesis and initial structure–activity relationships
Beevers, Rebekah E., Buckley, George M., Davies, Natasha, Fraser, Joanne L., Galvin, Francis C., Hannah, Duncan R., Haughan, Alan F., Jenkins, Kerry, Mack, Stephen R., Pitt, William R., Ratcliffe, Andrew J., Richard, Marianna D., Sabin, Verity, Sharpe, Andrew, Williams, Sophie C.
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Journal Article
Low molecular weight indole fragments as IMPDH inhibitors
Beevers, Rebekah E., Buckley, George M., Davies, Natasha, Fraser, Joanne L., Galvin, Francis C., Hannah, Duncan R., Haughan, Alan F., Jenkins, Kerry, Mack, Stephen R., Pitt, William R., Ratcliffe, Andrew J., Richard, Marianna D., Sabin, Verity, Sharpe, Andrew, Williams, Sophie C.
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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