Scale-Up Preparation of Best-In-Class Orally Bioavailable CXCR4 Antagonist EMU-116 in an Academic Setting
Jacobs, Leon, Miller, Eric J., Wilson, Robert J., Jecs, Edgars, Joseph Tholath, Paul, Nguyen, Huy H., Saindane, Manohar T., Altas-Tahirovic, Yesim, Wilson, Lawrence J., Liotta, Dennis C.
Published in Organic process research & development (18.10.2024)
Published in Organic process research & development (18.10.2024)
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Journal Article
Small molecule and peptide-based CXCR4 modulators as therapeutic agents. A patent review for the period from 2010 to 2018
Tahirovic, Yesim A, Pelly, Sameshnee, Jecs, Edgars, Miller, Eric J, Sharma, Savita K, Liotta, Dennis C, Wilson, Lawrence J
Published in Expert opinion on therapeutic patents (01.02.2020)
Published in Expert opinion on therapeutic patents (01.02.2020)
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Journal Article
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties
Nguyen, Huy H., Kim, Michelle B., Wilson, Robert J., Butch, Christopher J., Kuo, Katie M., Miller, Eric J., Tahirovic, Yesim A., Jecs, Edgars, Truax, Valarie M., Wang, Tao, Sum, Chi S., Cvijic, Mary E., Schroeder, Gretchen M., Wilson, Lawrence J., Liotta, Dennis C.
Published in Journal of medicinal chemistry (23.08.2018)
Published in Journal of medicinal chemistry (23.08.2018)
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Journal Article
Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles
Jecs, Edgars, Tahirovic, Yesim A, Wilson, Robert J, Miller, Eric J, Kim, Michelle, Truax, Valarie, Nguyen, Huy H, Akins, Nicholas S, Saindane, Manohar, Wang, Tao, Sum, Chi S, Cvijic, Mary E, Schroeder, Gretchen M, Burton, Samantha L, Derdeyn, Cynthia A, Xu, Lingjie, Jiang, Yi, Wilson, Lawrence J, Liotta, Dennis C
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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Journal Article
Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties
Miller, Eric J, Jecs, Edgars, Truax, Valarie M, Katzman, Brooke M, Tahirovic, Yesim A, Wilson, Robert J, Kuo, Katie M, Kim, Michelle B, Nguyen, Huy H, Saindane, Manohar T, Zhao, Huanyu, Wang, Tao, Sum, Chi S, Cvijic, Mary E, Schroeder, Gretchen M, Wilson, Lawrence J, Liotta, Dennis C
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Journal Article
Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings
Nguyen, Huy H, Tahirovic, Yesim A, Truax, Valarie M, Wilson, Robert J, Jecs, Edgars, Miller, Eric J, Kim, Michelle B, Akins, Nicholas S, Xu, Lingjie, Jiang, Yi, Wang, Tao, Sum, Chi S, Cvijic, Mary E, Schroeder, Gretchen M, Wilson, Lawrence J, Liotta, Dennis C
Published in ACS medicinal chemistry letters (14.10.2021)
Published in ACS medicinal chemistry letters (14.10.2021)
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Journal Article
PYRROLIDINE MAIN PROTEASE INHIBITORS AS ANTIVIRAL AGENTS
MILLER R. ERIC, HARDEE J. DAVID, GFESSER A. GREGORY, LI X. HUAN QIU, SCHMIDT G. ROBERT, SCHRIMPF R. MICHAEL, MUNOZ ALBERTO, DEGOEY A. DAVID, NOEY L. ELIZABETH, NOCEK P. BOGUSLAW, LUDWIG JACOB, PERLMUTTER J. SARAH, DIETRICH D. JUSTIN, JECS EDGARS, JANG ALVIN, SEARLE B. XENIA, HODGES R. TIMOTHY, BOGDAN ANDREW
Year of Publication 23.04.2024
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Year of Publication 23.04.2024
Patent
Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains
Jecs, Edgars, Miller, Eric J, Wilson, Robert J, Nguyen, Huy H, Tahirovic, Yesim A, Katzman, Brook M, Truax, Valarie M, Kim, Michelle B, Kuo, Katie M, Wang, Tao, Sum, Chi S, Cvijic, Mary E, Schroeder, Gretchen M, Wilson, Lawrence J, Liotta, Dennis C
Published in ACS medicinal chemistry letters (08.02.2018)
Published in ACS medicinal chemistry letters (08.02.2018)
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Journal Article
Abstract 2649: Orally bioavailable small molecule CXCR4 antagonists with enhanced efficacy in mouse models of genitourinary cancers
Miller, Eric J., Sun, Carrie Q., Gregorova, Petra, Jecs, Edgars, Tahirovic, Yesim Altas, Wilson, Robert J., Nguyen, Huy H., Sharma, Savita K., Bartsch, Perry, Sticher, Zachary, Moellering, Levi, Davidson, Priscilla, Jajosky, Ryan, D'Erasmo, Michael, Saindane, Manohar, Sahin, Zafer, Akins, Nicholas S., Kolykhalov, Alexander A., Wilson, Lawrence, Arnold, Rebecca S., Petros, John A., Kissick, Haydn, Xu, Lingjie, Jiang, Yi, Liotta, Dennis C.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists
Wilson, Robert J, Jecs, Edgars, Miller, Eric J, Nguyen, Huy H, Tahirovic, Yesim A, Truax, Valarie M, Kim, Michelle B, Kuo, Katie M, Wang, Tao, Sum, Chi Shing, Cvijic, Mary E, Paiva, Anthony A, Schroeder, Gretchen M, Wilson, Lawrence J, Liotta, Dennis C
Published in ACS medicinal chemistry letters (11.01.2018)
Published in ACS medicinal chemistry letters (11.01.2018)
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Journal Article
Discovery of N‑Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties
Tahirovic, Yesim A, Truax, Valarie M, Wilson, Robert J, Jecs, Edgars, Nguyen, Huy H, Miller, Eric J, Kim, Michelle B, Kuo, Katie M, Wang, Tao, Sum, Chi S, Cvijic, Mary E, Schroeder, Gretchen M, Wilson, Lawrence J, Liotta, Dennis C
Published in ACS medicinal chemistry letters (10.05.2018)
Published in ACS medicinal chemistry letters (10.05.2018)
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Journal Article
Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus
Pribut, Nicole, Kaiser, Thomas M, Wilson, Robert J, Jecs, Edgars, Dentmon, Zackery W, Pelly, Stephen C, Sharma, Savita, Bartsch, Perry W, Burger, Pieter B, Hwang, Soyon S, Le, Thalia, Sourimant, Julien, Yoon, Jeong-Joong, Plemper, Richard K, Liotta, Dennis C
Published in ACS infectious diseases (08.05.2020)
Published in ACS infectious diseases (08.05.2020)
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Journal Article
Geminal Alkene–Alkyne Cross Metathesis Using a Relay Strategy
Clark, Joseph R, French, Jonathan M, Jecs, Edgars, Diver, Steven T
Published in Organic letters (17.08.2012)
Published in Organic letters (17.08.2012)
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Journal Article
Inhibitors of RSV replication and applications thereof
Jecs, Edgars, Liotta, Dennis, Wilson, Robert, Dentmon, Zackery Will, Sourimant, Julien, Plemper, Richard, Pelly, Stephen
Year of Publication 25.06.2024
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Year of Publication 25.06.2024
Patent
CXCR4 MODULATORS AND USES RELATED THERETO
JECS, Edgars, MILLER, Eric, WILSON, Lawrence, LIOTTA, Dennis, ALTAS TAHIROVIC, Yesim
Year of Publication 29.05.2024
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Year of Publication 29.05.2024
Patent
Pan-Tropic Entry Inhibitors
Jecs, Edgars, Liotta, Dennis, Wilson, Lawrence, Altas Tahirovic, Yesim, Pelly, Stephen
Year of Publication 31.08.2023
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Year of Publication 31.08.2023
Patent
Pan-tropic entry inhibitors
Jecs, Edgars, Liotta, Dennis, Wilson, Lawrence, Altas Tahirovic, Yesim, Pelly, Stephen
Year of Publication 16.05.2023
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Year of Publication 16.05.2023
Patent
CXCR4 MODULATORS AND USES RELATED THERETO
JECS, Edgars, MILLER, Eric, WILSON, Lawrence, LIOTTA, Dennis, ALTAS TAHIROVIC, Yesim
Year of Publication 26.01.2023
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Year of Publication 26.01.2023
Patent