Bicyclic Derivatives of the Potent Dual Aromatase-Steroid Sulfatase Inhibitor 2-Bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenylsulfamate: Synthesis, SAR, Crystal Structure, and in vitro and in vivo Activities
Wood, Paul M., Woo, L. W. Lawrence, Labrosse, Jean-Robert, Thomas, Mark P., Mahon, Mary F., Chander, Surinder K., Purohit, Atul, Reed, Michael J., Potter, Barry V. L.
Published in ChemMedChem (03.09.2010)
Published in ChemMedChem (03.09.2010)
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Discovery of (2S)‑8-[(3R)‑3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro‑2H‑pyrimido[1,2‑a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors
Pasquier, Benoit, El-Ahmad, Youssef, Filoche-Rommé, Bruno, Dureuil, Christine, Fassy, Florence, Abecassis, Pierre-Yves, Mathieu, Magali, Bertrand, Thomas, Benard, Tsiala, Barrière, Cédric, El Batti, Samira, Letallec, Jean-Philippe, Sonnefraud, Véronique, Brollo, Maurice, Delbarre, Laurence, Loyau, Véronique, Pilorge, Fabienne, Bertin, Luc, Richepin, Patrick, Arigon, Jérôme, Labrosse, Jean-Robert, Clément, Jacques, Durand, Florence, Combet, Romain, Perraut, Pierre, Leroy, Vincent, Gay, Frédéric, Lefrançois, Dominique, Bretin, François, Marquette, Jean-Pierre, Michot, Nadine, Caron, Anne, Castell, Christelle, Schio, Laurent, McCort, Gary, Goulaouic, Hélène, Garcia-Echeverria, Carlos, Ronan, Baptiste
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Pd-Catalyzed annulation of benzene-1,2-diol and propargylic carbonates: a new example of asymmetric catalysis
Damez, Céline, Labrosse, Jean-Robert, Lhoste, Paul, Sinou, Denis
Published in Tetrahedron letters (01.01.2003)
Published in Tetrahedron letters (01.01.2003)
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Asymmetric palladium-catalyzed annulation of benzene-1,2-diol and racemic secondary propargylic carbonates bearing two different substituents
Dominczak, Norbert, Damez, Céline, Rhers, Bouchra, Labrosse, Jean-Robert, Lhoste, Paul, Kryczka, Boguslaw, Sinou, Denis
Published in Tetrahedron (07.03.2005)
Published in Tetrahedron (07.03.2005)
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Journal Article
Discovery of (2 S )-8-[(3 R )-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2 H -pyrimido[1,2- a ]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors
Pasquier, Benoit, El-Ahmad, Youssef, Filoche-Rommé, Bruno, Dureuil, Christine, Fassy, Florence, Abecassis, Pierre-Yves, Mathieu, Magali, Bertrand, Thomas, Benard, Tsiala, Barrière, Cédric, El Batti, Samira, Letallec, Jean-Philippe, Sonnefraud, Véronique, Brollo, Maurice, Delbarre, Laurence, Loyau, Véronique, Pilorge, Fabienne, Bertin, Luc, Richepin, Patrick, Arigon, Jérôme, Labrosse, Jean-Robert, Clément, Jacques, Durand, Florence, Combet, Romain, Perraut, Pierre, Leroy, Vincent, Gay, Frédéric, Lefrançois, Dominique, Bretin, François, Marquette, Jean-Pierre, Michot, Nadine, Caron, Anne, Castell, Christelle, Schio, Laurent, McCort, Gary, Goulaouic, Hélène, Garcia-Echeverria, Carlos, Ronan, Baptiste
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Asymmetric Palladium-Catalyzed Annulation of Benzene-1,2-diols and Propargylic Carbonates
Labrosse, Jean-Robert, Lhoste, Paul, Sinou, Denis
Published in European journal of organic chemistry (01.06.2002)
Published in European journal of organic chemistry (01.06.2002)
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Journal Article
Chiral Aromatase and Dual Aromatase−Steroid Sulfatase Inhibitors from the Letrozole Template: Synthesis, Absolute Configuration, and In Vitro Activity
Wood, Paul M, Woo, L. W. Lawrence, Labrosse, Jean-Robert, Trusselle, Melanie N, Abbate, Sergio, Longhi, Giovanna, Castiglioni, Ettore, Lebon, France, Purohit, Atul, Reed, Michael J, Potter, Barry V. L
Published in Journal of medicinal chemistry (24.07.2008)
Published in Journal of medicinal chemistry (24.07.2008)
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Asymmetric palladium(0)-mediated synthesis of 2-vinylchroman
Labrosse, Jean-Robert, Poncet, Cécilia, Lhoste, Paul, Sinou, Denis
Published in Tetrahedron: asymmetry (26.03.1999)
Published in Tetrahedron: asymmetry (26.03.1999)
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IMPROVED PROCESSES FOR PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS
LOIC PATRICK LE HIR DE FALLOIS, LEE HYOUNG IK, ZHAN XINXI, MICHEL MULHAUSER, CHARLES Q MENG, JEAN-ROBERT LABROSSE
Year of Publication 16.11.2017
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Year of Publication 16.11.2017
Patent
Concise Preparation of a Stable Cyclic Sulfamidate Intermediate in the Synthesis of a Enantiopure Chiral Active Diamine Derivative
Rousseau, Jean-Francois, Chekroun, Isaac, Ferey, Vincent, Labrosse, Jean Robert
Published in Organic process research & development (17.04.2015)
Published in Organic process research & development (17.04.2015)
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Palladium–catalyzed synthesis of 2,3-dihydro-2-substituted-2-vinyl-1,4-benzodioxins
Labrosse, Jean–Robert, Pichon, Nathalie, Goux–Henry, Catherine, Lhoste, Paul, Sinou, Denis
Published in ARKIVOC (19.03.2002)
Published in ARKIVOC (19.03.2002)
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Web Resource
Asymmetric Palladium-Catalyzed Annulation of Benzene-1,2-diol and Racemic Secondary Propargylic Carbonates Bearing Two Different Substituents
Dominczak, Norbert, Damez, Celine, Rhers, Bouchra, Labrosse, Jean-Robert, Lhoste, Paul, Kryczka, Boguslaw, Sinou, Denis
Published in ChemInform (19.07.2005)
Published in ChemInform (19.07.2005)
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Palladium-Catalyzed Synthesis of 2,3-Dihydro-2-ylidene-1,4-benzodioxins
Labrosse, Jean-Robert, Lhoste, Paul, Sinou, Denis
Published in Journal of organic chemistry (05.10.2001)
Published in Journal of organic chemistry (05.10.2001)
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Journal Article
Pd-Catalyzed Annulation of Benzene-1,2-diol and Propargylic Carbonates: A New Example of Asymmetric Catalysis
Damez, Celine, Labrosse, Jean-Robert, Lhoste, Paul, Sinou, Denis
Published in ChemInform (08.04.2003)
Published in ChemInform (08.04.2003)
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Journal Article
PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS
MENG, CHARLES Q, LE HIR DE FALLOIS, LOIC PATRICK, ZHAN, XINXI, MULHAUSER, MICHEL, LEE, HYOUNG IK, LABROSSE, JEAN-ROBERT
Year of Publication 29.09.2020
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Year of Publication 29.09.2020
Patent