The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties
Goepfert, Arnaud, Lehmann, Sylvie, Wirth, Emmanuelle, Rondeau, Jean-Michel
Published in Scientific reports (21.08.2017)
Published in Scientific reports (21.08.2017)
Get full text
Journal Article
The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease
Neumann, Ulf, Ufer, Mike, Jacobson, Laura H, Rouzade‐Dominguez, Marie‐Laure, Huledal, Gunilla, Kolly, Carine, Lüönd, Rainer M, Machauer, Rainer, Veenstra, Siem J, Hurth, Konstanze, Rueeger, Heinrich, Tintelnot‐Blomley, Marina, Staufenbiel, Matthias, Shimshek, Derya R, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean‐Michel, Beckmann, Nicolau, Hartmann, Andreas, Vormfelde, Stefan, David, Olivier J, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina
Published in EMBO molecular medicine (01.11.2018)
Published in EMBO molecular medicine (01.11.2018)
Get full text
Journal Article
Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β
Hommel, Ulrich, Hurth, Konstanze, Rondeau, Jean-Michel, Vulpetti, Anna, Ostermeier, Daniela, Boettcher, Andreas, Brady, Jacob Peter, Hediger, Michael, Lehmann, Sylvie, Koch, Elke, Blechschmidt, Anke, Yamamoto, Rina, Tundo Dottorello, Valentina, Haenni-Holzinger, Sandra, Kaiser, Christian, Lehr, Philipp, Lingel, Andreas, Mureddu, Luca, Schleberger, Christian, Blank, Jutta, Ramage, Paul, Freuler, Felix, Eder, Joerg, Bornancin, Frédéric
Published in Nature communications (07.09.2023)
Published in Nature communications (07.09.2023)
Get full text
Journal Article
Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria
Nishimura, Jun-Ichi, Ando, Kiyoshi, Masuko, Masayoshi, Noji, Hideyoshi, Ito, Yoshikazu, Mayer, Jiri, Griskevicius, Laimonas, Bucher, Christoph, Müllershausen, Florian, Gergely, Peter, Rozenberg, Izabela, Schubart, Anna, Chawla, Raghav, Rondeau, Jean-Michel, Roguska, Michael, Splawski, Igor, Keating, Mark T, Johnson, Leslie, Danekula, Rambabu, Bagger, Morten, Watanabe, Yoko, Haraldsson, Börje, Kanakura, Yuzuru
Published in Haematologica (Roma) (01.06.2022)
Published in Haematologica (Roma) (01.06.2022)
Get full text
Journal Article
A General Strategy for Targeting Drugs to Bone
Jahnke, Wolfgang, Bold, Guido, Marzinzik, Andreas L., Ofner, Silvio, Pellé, Xavier, Cotesta, Simona, Bourgier, Emmanuelle, Lehmann, Sylvie, Henry, Chrystelle, Hemmig, René, Stauffer, Frédéric, Hartwieg, J. Constanze D., Green, Jonathan R., Rondeau, Jean-Michel
Published in Angewandte Chemie (International ed.) (23.11.2015)
Published in Angewandte Chemie (International ed.) (23.11.2015)
Get full text
Journal Article
Protein crystallization in stirred systems-scale-up via the maximum local energy dissipation
Smejkal, Benjamin, Helk, Bernhard, Rondeau, Jean-Michel, Anton, Sabine, Wilke, Angelika, Scheyerer, Peter, Fries, Jacqueline, Hekmat, Dariusch, Weuster-Botz, Dirk
Published in Biotechnology and bioengineering (01.07.2013)
Published in Biotechnology and bioengineering (01.07.2013)
Get full text
Journal Article
Structural Basis for the Exceptional in vivo Efficacy of Bisphosphonate Drugs
Rondeau, Jean-Michel, Bitsch, Francis, Bourgier, Emmanuelle, Geiser, Martin, Hemmig, Rene, Kroemer, Markus, Lehmann, Sylvie, Ramage, Paul, Rieffel, Sebastien, Strauss, André, Green, Jonathan R., Jahnke, Wolfgang
Published in ChemMedChem (13.02.2006)
Published in ChemMedChem (13.02.2006)
Get full text
Journal Article
Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling
Goepfert, Arnaud, Lehmann, Sylvie, Blank, Jutta, Kolbinger, Frank, Rondeau, Jean-Michel
Published in Immunity (Cambridge, Mass.) (17.03.2020)
Published in Immunity (Cambridge, Mass.) (17.03.2020)
Get full text
Journal Article
Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors
Rueeger, Heinrich, Rondeau, Jean-Michel, McCarthy, Clive, Möbitz, Henrik, Tintelnot-Blomley, Marina, Neumann, Ulf, Desrayaud, Sandrine
Published in Bioorganic & medicinal chemistry letters (01.04.2011)
Published in Bioorganic & medicinal chemistry letters (01.04.2011)
Get full text
Journal Article
Redirecting an anti-IL-1β antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A
Fischman, Sharon, Levin, Itay, Rondeau, Jean-Michel, Štrajbl, Marek, Lehmann, Sylvie, Huber, Thomas, Nimrod, Guy, Cebe, Régis, Omer, Dotan, Kovarik, Jiri, Bernstein, Shmuel, Sasson, Yehezkel, Demishtein, Alik, Shlamkovich, Tomer, Bluvshtein, Olga, Grossman, Noam, Barak-Fuchs, Reut, Zhenin, Michael, Fastman, Yair, Twito, Shir, Vana, Tal, Zur, Nevet, Ofran, Yanay
Published in Communications biology (29.09.2023)
Published in Communications biology (29.09.2023)
Get full text
Journal Article
Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding
Marzinzik, Andreas L., Amstutz, René, Bold, Guido, Bourgier, Emmanuelle, Cotesta, Simona, Glickman, J. Fraser, Götte, Marjo, Henry, Christelle, Lehmann, Sylvie, Hartwieg, J. Constanze D., Ofner, Silvio, Pellé, Xavier, Roddy, Thomas P., Rondeau, Jean-Michel, Stauffer, Frédéric, Stout, Steven J., Widmer, Armin, Zimmermann, Johann, Zoller, Thomas, Jahnke, Wolfgang
Published in ChemMedChem (01.11.2015)
Published in ChemMedChem (01.11.2015)
Get full text
Journal Article
SEC-TID: A Label-Free Method for Small-Molecule Target Identification
Salcius, Michael, Bauer, Andras J, Hao, Qin, Li, Shu, Tutter, Antonin, Raphael, Jacob, Jahnke, Wolfgang, Rondeau, Jean-Michel, Bourgier, Emmanuelle, Tallarico, John, Michaud, Gregory A
Published in Journal of biomolecular screening (01.07.2014)
Published in Journal of biomolecular screening (01.07.2014)
Get full text
Journal Article
Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy
Morvan, Frederic, Rondeau, Jean-Michel, Zou, Chao, Minetti, Giulia, Scheufler, Clemens, Scharenberg, Meike, Jacobi, Carsten, Brebbia, Pascale, Ritter, Veronique, Toussaint, Gauthier, Koelbing, Claudia, Leber, Xavier, Schilb, Alain, Witte, Florian, Lehmann, Sylvie, Koch, Elke, Geisse, Sabine, Glass, David J., Lach-Trifilieff, Estelle
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2017)
Get full text
Journal Article
Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious beta-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease
Machauer, Rainer, Lueoend, Rainer, Hurth, Konstanze, Veenstra, Siem J., Rueeger, Heinrich, Voegtle, Markus, Tintelnot-Blomley, Marina, Rondeau, Jean-Michel, Jacobson, Laura H., Laue, Grit, Beltz, Karen, Neumann, Ulf
Published in Journal of medicinal chemistry (28.10.2021)
Published in Journal of medicinal chemistry (28.10.2021)
Get full text
Journal Article
Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides
Rueeger, Heinrich, Lueoend, Rainer, Rogel, Olivier, Rondeau, Jean-Michel, Möbitz, Henrik, Machauer, Rainer, Jacobson, Laura, Staufenbiel, Matthias, Desrayaud, Sandrine, Neumann, Ulf
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
Get full text
Journal Article
Synthesis of the Potent, Selective, and Efficacious β‑Secretase (BACE1) Inhibitor NB-360
Rueeger, Heinrich, Lueoend, Rainer, Machauer, Rainer, Veenstra, Siem J, Holzer, Philipp, Hurth, Konstanze, Voegtle, Markus, Frederiksen, Mathias, Rondeau, Jean-Michel, Tintelnot-Blomley, Marina, Jacobson, Laura H, Staufenbiel, Matthias, Laue, Grit, Neumann, Ulf
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
Get full text
Journal Article
Secukinumab for the treatment of psoriasis, psoriatic arthritis, and axial spondyloarthritis: Physical and pharmacological properties underlie the observed clinical efficacy and safety
Kolbinger, Frank, Di Padova, Franco, Deodhar, Atul, Hawkes, Jason E., Huppertz, Christine, Kuiper, Torsten, McInnes, Iain B., Ritchlin, Christopher T., Rosmarin, David, Schett, Georg, Carballido, José M., Häusermann, Peter, Calonder, Claudio, Vogel, Beate, Rondeau, Jean-Michel, Bruin, Gerard
Published in Pharmacology & therapeutics (Oxford) (01.01.2022)
Published in Pharmacology & therapeutics (Oxford) (01.01.2022)
Get full text
Journal Article
IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling
Goepfert, Arnaud, Barske, Carmen, Lehmann, Sylvie, Wirth, Emmanuelle, Willemsen, Joschka, Gudjonsson, Johann E., Ward, Nicole L., Sarkar, Mrinal K., Hemmig, René, Kolbinger, Frank, Rondeau, Jean-Michel
Published in Cell reports (Cambridge) (18.10.2022)
Published in Cell reports (Cambridge) (18.10.2022)
Get full text
Journal Article
Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches
Vulpetti, Anna, Rondeau, Jean-Michel, Bellance, Marie-Hélène, Blank, Jutta, Boesch, Ralf, Boettcher, Andreas, Bornancin, Frédéric, Buhr, Sylvia, Connor, Lauren E., Dumelin, Christoph E., Esser, Oliver, Hediger, Michael, Hintermann, Samuel, Hommel, Ulrich, Koch, Elke, Lapointe, Guillaume, Leder, Lukas, Lehmann, Sylvie, Lehr, Philipp, Meier, Peter, Muller, Lionel, Ostermeier, Daniela, Ramage, Paul, Schiebel-Haddad, Sihame, Smith, Alexander Baxter, Stojanovic, Aleksandar, Velcicky, Juraj, Yamamoto, Rina, Hurth, Konstanze
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
Get full text
Journal Article