Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases
Clark, James D, Flanagan, Mark E, Telliez, Jean-Baptiste
Published in Journal of medicinal chemistry (26.06.2014)
Published in Journal of medicinal chemistry (26.06.2014)
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Journal Article
JAK inhibition using tofacitinib for inflammatory bowel disease treatment: a hub for multiple inflammatory cytokines
Danese, Silvio, Grisham, Matthew, Hodge, Jennifer, Telliez, Jean-Baptiste
Published in American journal of physiology: Gastrointestinal and liver physiology (01.02.2016)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.02.2016)
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Journal Article
The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis
Veale, Douglas J, McGonagle, Dennis, McInnes, Iain B, Krueger, James G, Ritchlin, Christopher T, Elewaut, Dirk, Kanik, Keith S, Hendrikx, Thijs, Berstein, Gabriel, Hodge, Jennifer, Telliez, Jean-Baptiste
Published in Rheumatology (Oxford, England) (01.02.2019)
Published in Rheumatology (Oxford, England) (01.02.2019)
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Journal Article
Parsing the Interferon Transcriptional Network and Its Disease Associations
Mostafavi, Sara, Yoshida, Hideyuki, Moodley, Devapregasan, LeBoité, Hugo, Rothamel, Katherine, Raj, Towfique, Ye, Chun Jimmie, Chevrier, Nicolas, Zhang, Shen-Ying, Feng, Ting, Lee, Mark, Casanova, Jean-Laurent, Clark, James D., Hegen, Martin, Telliez, Jean-Baptiste, Hacohen, Nir, De Jager, Philip L., Regev, Aviv, Mathis, Diane, Benoist, Christophe
Published in Cell (28.01.2016)
Published in Cell (28.01.2016)
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Journal Article
Target Occupancy and Functional Inhibition of JAK3 and TEC Family Kinases by Ritlecitinib in Healthy Adults: An Open-Label, Phase 1 Study
Martin, David A, Telliez, Jean-Baptiste, Pleasic-Williams, Susan, Zhang, Ying, Tierney, Brendan, Blatnik, Matthew, Gale, Jeremy D, Banfield, Chris, Zhou, Yifan, Lejeune, Alexandre, Zwillich, Samuel H, Stevens, Erin, Tiwari, Neeraj, Kieras, Elizabeth, Karanam, Ashwin
Published in Journal of clinical pharmacology (01.01.2024)
Published in Journal of clinical pharmacology (01.01.2024)
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Journal Article
Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors
Casimiro-Garcia, Agustin, Trujillo, John I, Vajdos, Felix, Juba, Brian, Banker, Mary Ellen, Aulabaugh, Ann, Balbo, Paul, Bauman, Jonathan, Chrencik, Jill, Coe, Jotham W, Czerwinski, Robert, Dowty, Martin, Knafels, John D, Kwon, Soojin, Leung, Louis, Liang, Sidney, Robinson, Ralph P, Telliez, Jean-Baptiste, Unwalla, Ray, Yang, Xin, Thorarensen, Atli
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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Journal Article
Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition
Dowty, Martin E., Lin, Tsung H., Jesson, Michael I., Hegen, Martin, Martin, David A., Katkade, Vaibhav, Menon, Sujatha, Telliez, Jean‐Baptiste
Published in Pharmacology research & perspectives (01.12.2019)
Published in Pharmacology research & perspectives (01.12.2019)
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Journal Article
Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1‑((2S,5R)‑5-((7H‑Pyrrolo[2,3‑d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans
Thorarensen, Atli, Dowty, Martin E, Banker, Mary Ellen, Juba, Brian, Jussif, Jason, Lin, Tsung, Vincent, Fabien, Czerwinski, Robert M, Casimiro-Garcia, Agustin, Unwalla, Ray, Trujillo, John I, Liang, Sidney, Balbo, Paul, Che, Ye, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Leung, Louis, Yang, Xin, Soucy, Sarah, Hegen, Martin, Coe, Jotham, Langille, Jonathan, Vajdos, Felix, Chrencik, Jill, Telliez, Jean-Baptiste
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Journal Article
Inhibition of T-cell activity in alopecia areata: recent developments and new directions
Passeron, Thierry, King, Brett, Seneschal, Julien, Steinhoff, Martin, Jabbari, Ali, Ohyama, Manabu, Tobin, Desmond J, Randhawa, Simran, Winkler, Aaron, Telliez, Jean-Baptiste, Martin, David, Lejeune, Alexandre
Published in Frontiers in immunology (2023)
Published in Frontiers in immunology (2023)
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Journal Article
MAPKAP Kinase 2-Deficient Mice Are Resistant to Collagen-Induced Arthritis
Hegen, Martin, Gaestel, Matthias, Nickerson-Nutter, Cheryl L, Lin, Lih-Ling, Telliez, Jean-Baptiste
Published in Journal of Immunology (01.08.2006)
Published in Journal of Immunology (01.08.2006)
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Journal Article
Distinct Cellular Functions of MK2
Kotlyarov, Alexey, Yannoni, Yvonne, Fritz, Susann, Laaß, Kathrin, Telliez, Jean-Baptiste, Pitman, Deborah, Lin, Lih-Ling, Gaestel, Matthias
Published in Molecular and Cellular Biology (01.07.2002)
Published in Molecular and Cellular Biology (01.07.2002)
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Journal Article
Identification and SAR of a new series of thieno[3,2- d]pyrimidines as Tpl2 kinase inhibitors
Ni, Yike, Gopalsamy, Ariamala, Cole, Derek, Hu, Yonghan, Denny, Rajiah, Ipek, Manus, Liu, Julie, Lee, Julie, Hall, J. Perry, Luong, Michael, Telliez, Jean-Baptiste, Lin, Lih-Ling
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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Journal Article
Pharmacologic Inhibition of Tpl2 Blocks Inflammatory Responses in Primary Human Monocytes, Synoviocytes, and Blood
Hall, J. Perry, Kurdi, Yahya, Hsu, Sang, Cuozzo, John, Liu, Julie, Telliez, Jean-Baptiste, Seidl, Katherine J., Winkler, Aaron, Hu, Yonghan, Green, Neal, Askew, G. Roger, Tam, Steve, Clark, James D., Lin, Lih-Ling
Published in The Journal of biological chemistry (16.11.2007)
Published in The Journal of biological chemistry (16.11.2007)
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Journal Article
The mechanism of action of tofacitinib - an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis
Hodge, Jennifer A, Kawabata, Thomas T, Krishnaswami, Sriram, Clark, James D, Telliez, Jean-Baptiste, Dowty, Martin E, Menon, Sujatha, Lamba, Manisha, Zwillich, Samuel
Published in Clinical and experimental rheumatology (01.03.2016)
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Published in Clinical and experimental rheumatology (01.03.2016)
Journal Article
The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR optimization
Thorarensen, Atli, Balbo, Paul, Banker, Mary E., Czerwinski, Robert M., Kuhn, Max, Maurer, Tristan S., Telliez, Jean-Baptiste, Vincent, Fabien, Wittwer, Arthur J.
Published in Bioorganic & medicinal chemistry (01.01.2021)
Published in Bioorganic & medicinal chemistry (01.01.2021)
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Journal Article
Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases
Vazquez, Michael L, Kaila, Neelu, Strohbach, Joseph W, Trzupek, John D, Brown, Matthew F, Flanagan, Mark E, Mitton-Fry, Mark J, Johnson, Timothy A, TenBrink, Ruth E, Arnold, Eric P, Basak, Arindrajit, Heasley, Steven E, Kwon, Soojin, Langille, Jonathan, Parikh, Mihir D, Griffin, Sarah H, Casavant, Jeffrey M, Duclos, Brian A, Fenwick, Ashley E, Harris, Thomas M, Han, Seungil, Caspers, Nicole, Dowty, Martin E, Yang, Xin, Banker, Mary Ellen, Hegen, Martin, Symanowicz, Peter T, Li, Li, Wang, Lu, Lin, Tsung H, Jussif, Jason, Clark, James D, Telliez, Jean-Baptiste, Robinson, Ralph P, Unwalla, Ray
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Journal Article
PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor
Xu, Hua, Jesson, Michael I, Seneviratne, Uthpala I, Lin, Tsung H, Sharif, M. Nusrat, Xue, Liang, Nguyen, Chuong, Everley, Robert A, Trujillo, John I, Johnson, Douglas S, Point, Gary R, Thorarensen, Atli, Kilty, Iain, Telliez, Jean-Baptiste
Published in ACS chemical biology (21.06.2019)
Published in ACS chemical biology (21.06.2019)
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Journal Article
Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1)
Giese, Karl Peter, Friedman, Eugenia, Telliez, Jean-Baptiste, Fedorov, Nikolai B, Wines, Mary, Feig, Larry A, Silva, Alcino J
Published in Neuropharmacology (01.11.2001)
Published in Neuropharmacology (01.11.2001)
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Journal Article
Network pharmacology of JAK inhibitors
Moodley, Devapregasan, Yoshida, Hideyuki, Mostafavi, Sara, Asinovski, Natasha, Ortiz-Lopez, Adriana, Symanowicz, Peter, Telliez, Jean-Baptiste, Hegen, Martin, Clark, James D., Mathis, Diane, Benoist, Christophe
Published in Proceedings of the National Academy of Sciences - PNAS (30.08.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (30.08.2016)
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Journal Article
The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
Bauman, Jonathan N, Doran, Angela C, King-Ahmad, Amanda, Sharma, Raman, Walker, Gregory S, Lin, Jian, Lin, Tsung H, Telliez, Jean-Baptiste, Tripathy, Sakambari, Goosen, Theunis C, Banfield, Christopher, Malhotra, Bimal K, Dowty, Martin E
Published in Drug metabolism and disposition (01.08.2022)
Published in Drug metabolism and disposition (01.08.2022)
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Journal Article