Search Results - "JAUTELAT, ROLF" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure

Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure

by Follmann, Markus, Ackerstaff, Jens, Redlich, Gorden, Wunder, Frank, Lang, Dieter, Kern, Armin, Fey, Peter, Griebenow, Nils, Kroh, Walter, Becker-Pelster, Eva-Maria, Kretschmer, Axel, Geiss, Volker, Li, Volkhart, Straub, Alexander, Mittendorf, Joachim, Jautelat, Rolf, Schirok, Hartmut, Schlemmer, Karl-Heinz, Lustig, Klemens, Gerisch, Michael, Knorr, Andreas, Tinel, Hanna, Mondritzki, Thomas, Trübel, Hubert, Sandner, Peter, Stasch, Johannes-Peter
Published in Journal of medicinal chemistry (22.06.2017)

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Journal Article

Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors

Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors

by Sommer, Anette, Kopitz, Charlotte, Schatz, Christoph A, Nising, Carl F, Mahlert, Christoph, Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Hammer, Stefanie, Greven, Simone, Schuhmacher, Joachim, Braun, Manuela, Zierz, Ruprecht, Wittemer-Rump, Sabine, Harrenga, Axel, Dittmer, Frank, Reetz, Frank, Apeler, Heiner, Jautelat, Rolf, Huynh, Hung, Ziegelbauer, Karl, Kreft, Bertolt
Published in Cancer research (Chicago, Ill.) (01.11.2016)

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Preclinical Antitumor Efficacy of BAY 1129980-a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody-Drug Conjugate for the Treatment of Non-Small Cell Lung Cancer

Preclinical Antitumor Efficacy of BAY 1129980-a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody-Drug Conjugate for the Treatment of Non-Small Cell Lung Cancer

by Willuda, Jörg, Linden, Lars, Lerchen, Hans-Georg, Kopitz, Charlotte, Stelte-Ludwig, Beatrix, Pena, Carol, Lange, Claudia, Golfier, Sven, Kneip, Christoph, Carrigan, Patricia E, Mclean, Kirk, Schuhmacher, Joachim, von Ahsen, Oliver, Müller, Jörg, Dittmer, Frank, Beier, Rudolf, El Sheikh, Sherif, Tebbe, Jan, Leder, Gabriele, Apeler, Heiner, Jautelat, Rolf, Ziegelbauer, Karl, Kreft, Bertolt
Published in Molecular cancer therapeutics (01.05.2017)

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Studies towards Trichodimerol: Novel Cascade Reactions and Polycyclic Frameworks

Studies towards Trichodimerol: Novel Cascade Reactions and Polycyclic Frameworks

by Nicolaou, K. C., Jautelat, Rolf, Vassilikogiannakis, Georgios, Baran, Phil S., Simonsen, Klaus B.
Published in Chemistry : a European journal (03.12.1999)

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Journal Article

The Lab Oddity Prevails: Discovery of Pan-CDK Inhibitor (R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the Treatment of Cancer

The Lab Oddity Prevails: Discovery of Pan-CDK Inhibitor (R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the Treatment of Cancer

by Lücking, Ulrich, Jautelat, Rolf, Krüger, Martin, Brumby, Thomas, Lienau, Philip, Schäfer, Martina, Briem, Hans, Schulze, Julia, Hillisch, Alexander, Reichel, Andreas, Wengner, Antje Margret, Siemeister, Gerhard
Published in ChemMedChem (01.07.2013)

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Journal Article

Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

by Schulze, Volker K, Klar, Ulrich, Kosemund, Dirk, Wengner, Antje M, Siemeister, Gerhard, Stöckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Holton, Simon J, Briem, Hans, Marquardt, Tobias, Schirok, Hartmut, Jautelat, Rolf, Bohlmann, Rolf, Nguyen, Duy, Fernández-Montalván, Amaury E, Bömer, Ulf, Eberspaecher, Uwe, Brüning, Michael, Döhr, Olaf, Raschke, Marian, Kreft, Bertolt, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael, von Nussbaum, Franz, Koppitz, Marcus
Published in Journal of medicinal chemistry (13.08.2020)

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New Generation of sGC Stimulators: Discovery of Imidazo[1,2‑a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension

New Generation of sGC Stimulators: Discovery of Imidazo[1,2‑a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension

by Vakalopoulos, Alexandros, Wunder, Frank, Hartung, Ingo V., Redlich, Gorden, Jautelat, Rolf, Buchgraber, Philipp, Hassfeld, Jorma, Gromov, Alexey V., Lindner, Niels, Bierer, Donald, Gries, Jörg, Kroh, Walter, Paulsen, Holger, Mittendorf, Joachim, Lang, Dieter, Becker-Pelster, Eva, Brockschnieder, Damian, Geiss, Volker, Li, Volkhart, Straub, Alexander, Knorr, Andreas, Mondritzki, Thomas, Trübel, Hubert, Raschke, Marian, Schaefer, Martina, Thomas, Dirk, Sandner, Peter, Stasch, Johannes-Peter, Follmann, Markus
Published in Journal of medicinal chemistry (08.06.2023)

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Discovery of Rogaratinib (BAY 1163877): a pan‐FGFR Inhibitor

Discovery of Rogaratinib (BAY 1163877): a pan‐FGFR Inhibitor

by Collin, Marie‐Pierre, Lobell, Mario, Hübsch, Walter, Brohm, Dirk, Schirok, Hartmut, Jautelat, Rolf, Lustig, Klemens, Bömer, Ulf, Vöhringer, Verena, Héroult, Mélanie, Grünewald, Sylvia, Hess‐Stumpp, Holger
Published in ChemMedChem (06.03.2018)

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Abstract 46: Preclinical activity of novel antibody-drug conjugates with pyrrole-based kinesin spindle protein inhibitors targeting different tumor antigens

Abstract 46: Preclinical activity of novel antibody-drug conjugates with pyrrole-based kinesin spindle protein inhibitors targeting different tumor antigens

by Sommer, Anette, Berndt, Sandra, Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Wittrock, Sven, Rebstock, Anne-Sophie, Dietz, Lisa, Mahlert, Christoph, Greven, Simone, Griebenow, Nils, Cancho-Grande, Yolanda, Jautelat, Rolf, Apeler, Heiner, Kreft, Bertolt
Published in Cancer research (Chicago, Ill.) (01.07.2017)

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Abstract 3234: Development of potent and selective antibody-drug conjugates with pyrrole-based KSP inhibitors as novel payload class

Abstract 3234: Development of potent and selective antibody-drug conjugates with pyrrole-based KSP inhibitors as novel payload class

by Lerchen, Hans-Georg, Wittrock, Sven, Griebenow, Nils, Lobell, Mario, Rebstock, Anne-Sophie, Cancho-Grande, Yolanda, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Sommer, Anette, Berndt, Sandra, Terjung, Carsten, Apeler, Heiner, Kreft, Bertolt, Jautelat, Rolf
Published in Cancer research (Chicago, Ill.) (01.07.2017)

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Abstract 4332: Discovery of BAY 1163877 - A pan-FGFR inhibitor: De novo structure-based design and lead optimization of benzothiophenyl-pyrrolotriazines

Abstract 4332: Discovery of BAY 1163877 - A pan-FGFR inhibitor: De novo structure-based design and lead optimization of benzothiophenyl-pyrrolotriazines

by Collin, Marie-Pierre L., Lobell, Mario, Huebsch, Walter, Brohm, Dirk, Héroult, Mélanie, Lustig, Klemens, Gruenewald, Sylvia, Boemer, Ulf, Jautelat, Rolf, Hess-Stump, Holger, Jaroch, Stefan, Brands, Michael, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (15.07.2016)

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Abstract 1739: Preclinical profile of BAY 1163877 - a selective pan-FGFR inhibitor in phase 1 clinical trial

by Heroult, Melanie, Ellinghaus, Peter, Sieg, Christian, Brohm, Dirk, Gruenewald, Sylvia, Collin, Marie-Pierre, Boemer, Ulf, Lobell, Mario, Huebsch, Walter, Ocker, Matthias, Ince, Stuart, Haegebarth, Andrea, Jautelat, Rolf, Hess-Stumpp, Holger, Brands, Michael, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (01.10.2014)

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Abstract 4491: FGFR2-ADC potently and selectively inhibits growth of gastric and breast cancer xenograft models

Abstract 4491: FGFR2-ADC potently and selectively inhibits growth of gastric and breast cancer xenograft models

by Sommer, Anette, Nising, Carl F., Mahlert, Christoph, Kopitz, Charlotte C., Lerchen, Hans-Georg, Greven, Simone, Stelte-Ludwig, Beatrix, Schuhmacher, Joachim, Zierz, Ruprecht, Wittemer-Rump, Sabine, Schatz, Christoph, Reetz, Frank, Apeler, Heiner, Jautelat, Rolf, Kreft, Bertolt, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (01.10.2014)

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Abstract 5445: Preclinical anti-tumor efficacy of an anti-C4.4a (LYPD3) antibody drug conjugate for the treatment of lung squamous cell carcinoma

Abstract 5445: Preclinical anti-tumor efficacy of an anti-C4.4a (LYPD3) antibody drug conjugate for the treatment of lung squamous cell carcinoma

by Willuda, Joerg, Linden, Lars, Lerchen, Hans-Georg, Kopitz, Charlotte, Golfier, Sven, Bach, Ute, Schumacher, Joachim, Stelte-Ludwig, Beatrix, Ahsen, Oliver Von, Schneider, Claudia, Dittmer, Frank, Beier, Rudolf, El-Sheik, Sherif, Tebbe, Jan, Leder, Gabriele, Apeler, Heiner, Jautelat, Rolf, Kreft, Bertolt, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (01.10.2014)

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Journal Article

From the Insoluble Dye Indirubin towards Highly Active, Soluble CDK2-Inhibitors

From the Insoluble Dye Indirubin towards Highly Active, Soluble CDK2-Inhibitors

by Jautelat, Rolf, Brumby, Thomas, Schäfer, Martina, Briem, Hans, Eisenbrand, Gerhard, Schwahn, Stefan, Krüger, Martin, Lücking, Ulrich, Prien, Olaf, Siemeister, Gerhard
Published in Chembiochem : a European journal of chemical biology (01.03.2005)

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Journal Article

Macrocyclic Aminopyrimidines as Multitarget CDK and VEGF-R Inhibitors with Potent Antiproliferative Activities

Macrocyclic Aminopyrimidines as Multitarget CDK and VEGF-R Inhibitors with Potent Antiproliferative Activities

by Lücking, Ulrich, Siemeister, Gerhard, Schäfer, Martina, Briem, Hans, Krüger, Martin, Lienau, Philip, Jautelat, Rolf
Published in ChemMedChem (15.01.2007)

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Journal Article

Cover Picture: The Lab Oddity Prevails: Discovery of Pan-CDK Inhibitor (R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the Treatment of Cancer (ChemMedChem 7/2013)

Cover Picture: The Lab Oddity Prevails: Discovery of Pan-CDK Inhibitor (R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the Treatment of Cancer (ChemMedChem 7/2013)

by Lücking, Ulrich, Jautelat, Rolf, Krüger, Martin, Brumby, Thomas, Lienau, Philip, Schäfer, Martina, Briem, Hans, Schulze, Julia, Hillisch, Alexander, Reichel, Andreas, Wengner, Antje Margret, Siemeister, Gerhard
Published in ChemMedChem (01.07.2013)

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Journal Article

17alpha-alkyl-17beta-oxy-estratrienes, uses thereof and pharmaceutical preparations

17alpha-alkyl-17beta-oxy-estratrienes, uses thereof and pharmaceutical preparations

by BOHLMANN ROLF,JAUTELAT ROLF,PETROV ORLIN,HOFFMANNJENS,HEINRICH NIKOLAUS,KROLL JORG,REICHEL ANDREAS,LICHTNER ROSEMARIE
Year of Publication 11.07.2007

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Patent

SULFONE-SUBSTITUTED ANILINOPYRIMIDINE DERIVATIVES AS CDK INHIBITORS, THE PRODUCTION THEREOF, AND USE AS A MEDICINE

SULFONE-SUBSTITUTED ANILINOPYRIMIDINE DERIVATIVES AS CDK INHIBITORS, THE PRODUCTION THEREOF, AND USE AS A MEDICINE

by LIENAU PHILIP, SIEMEISTER GERHARD, JAUTELAT ROLF, SCHULZE JULIA, LUECKING ULRICH
Year of Publication 11.07.2011

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Patent

SULFOXIMINE-SUBSTITUTED ANILINOPYRIMIDINE DERIVATIVES AS CDK INHIBITORS, THE PRODUCTION THEREOF, AND USE AS MEDICINE

SULFOXIMINE-SUBSTITUTED ANILINOPYRIMIDINE DERIVATIVES AS CDK INHIBITORS, THE PRODUCTION THEREOF, AND USE AS MEDICINE

by LIENAU PHILIP, SIEMEISTER GERHARD, JAUTELAT ROLF, SCHULZE JULIA, LUECKING ULRICH
Year of Publication 22.06.2011

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Patent

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