Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state
Smajić, Semra, Prada-Medina, Cesar A, Landoulsi, Zied, Ghelfi, Jenny, Delcambre, Sylvie, Dietrich, Carola, Jarazo, Javier, Henck, Jana, Balachandran, Saranya, Pachchek, Sinthuja, Morris, Christopher M, Antony, Paul, Timmermann, Bernd, Sauer, Sascha, Pereira, Sandro L, Schwamborn, Jens C, May, Patrick, Grünewald, Anne, Spielmann, Malte
Published in Brain (London, England : 1878) (29.04.2022)
Published in Brain (London, England : 1878) (29.04.2022)
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Automated microfluidic cell culture of stem cell derived dopaminergic neurons
Kane, Khalid I. W., Moreno, Edinson Lucumi, Hachi, Siham, Walter, Moriz, Jarazo, Javier, Oliveira, Miguel A. P., Hankemeier, Thomas, Vulto, Paul, Schwamborn, Jens C., Thoma, Martin, Fleming, Ronan M. T.
Published in Scientific reports (11.02.2019)
Published in Scientific reports (11.02.2019)
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PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons
Brown, Sarah J., Boussaad, Ibrahim, Jarazo, Javier, Fitzgerald, Julia C., Antony, Paul, Keatinge, Marcus, Blechman, Janna, Schwamborn, Jens C., Krüger, Rejko, Placzek, Marysia, Bandmann, Oliver
Published in Scientific reports (23.03.2021)
Published in Scientific reports (23.03.2021)
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Journal Article
Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells
Monzel, Anna S., Smits, Lisa M., Hemmer, Kathrin, Hachi, Siham, Moreno, Edinson Lucumi, van Wuellen, Thea, Jarazo, Javier, Walter, Jonas, Brüggemann, Inga, Boussaad, Ibrahim, Berger, Emanuel, Fleming, Ronan M.T., Bolognin, Silvia, Schwamborn, Jens C.
Published in Stem cell reports (09.05.2017)
Published in Stem cell reports (09.05.2017)
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Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient‐Derived Neurons
Hanss, Zoé, Larsen, Simone B., Antony, Paul, Mencke, Pauline, Massart, François, Jarazo, Javier, Schwamborn, Jens C., Barbuti, Peter A., Mellick, George D., Krüger, Rejko
Published in Movement disorders (01.03.2021)
Published in Movement disorders (01.03.2021)
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CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons
Qing, Xiaobing, Walter, Jonas, Jarazo, Javier, Arias-Fuenzalida, Jonathan, Hillje, Anna-Lena, Schwamborn, Jens C.
Published in Stem cell research (01.10.2017)
Published in Stem cell research (01.10.2017)
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Journal Article
3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing
Bolognin, Silvia, Fossépré, Marie, Qing, Xiaobing, Jarazo, Javier, Ščančar, Janez, Moreno, Edinson Lucumi, Nickels, Sarah L., Wasner, Kobi, Ouzren, Nassima, Walter, Jonas, Grünewald, Anne, Glaab, Enrico, Salamanca, Luis, Fleming, Ronan M. T., Antony, Paul M. A., Schwamborn, Jens C.
Published in Advanced science (09.01.2019)
Published in Advanced science (09.01.2019)
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Journal Article
FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling
Arias-Fuenzalida, Jonathan, Jarazo, Javier, Qing, Xiaobing, Walter, Jonas, Gomez-Giro, Gemma, Nickels, Sarah Louise, Zaehres, Holm, Schöler, Hans Robert, Schwamborn, Jens Christian
Published in Stem cell reports (14.11.2017)
Published in Stem cell reports (14.11.2017)
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Journal Article
Generalising from conventional pipelines using deep learning in high-throughput screening workflows
Garcia Santa Cruz, Beatriz, Slter, Jan, Gomez-Giro, Gemma, Saraiva, Claudia, Sabate-Soler, Sonia, Modamio, Jennifer, Barmpa, Kyriaki, Schwamborn, Jens Christian, Hertel, Frank, Jarazo, Javier, Husch, Andreas
Published in Scientific reports (06.07.2022)
Published in Scientific reports (06.07.2022)
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Journal Article
Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality
Walter, Jonas, Bolognin, Silvia, Antony, Paul M.A., Nickels, Sarah L., Poovathingal, Suresh K., Salamanca, Luis, Magni, Stefano, Perfeito, Rita, Hoel, Fredrik, Qing, Xiaobing, Jarazo, Javier, Arias-Fuenzalida, Jonathan, Ignac, Tomasz, Monzel, Anna S., Gonzalez-Cano, Laura, Pereira de Almeida, Luis, Skupin, Alexander, Tronstad, Karl J., Schwamborn, Jens C.
Published in Stem cell reports (14.05.2019)
Published in Stem cell reports (14.05.2019)
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Journal Article
The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1
Walter, Jonas, Bolognin, Silvia, Poovathingal, Suresh K., Magni, Stefano, Gérard, Deborah, Antony, Paul M.A., Nickels, Sarah L., Salamanca, Luis, Berger, Emanuel, Smits, Lisa M., Grzyb, Kamil, Perfeito, Rita, Hoel, Fredrik, Qing, Xiaobing, Ohnmacht, Jochen, Bertacchi, Michele, Jarazo, Javier, Ignac, Tomasz, Monzel, Anna S., Gonzalez-Cano, Laura, Krüger, Rejko, Sauter, Thomas, Studer, Michèle, de Almeida, Luis Pereira, Tronstad, Karl J., Sinkkonen, Lasse, Skupin, Alexander, Schwamborn, Jens C.
Published in Cell reports (Cambridge) (19.10.2021)
Published in Cell reports (Cambridge) (19.10.2021)
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Automated high-throughput high-content autophagy and mitophagy analysis platform
Arias-Fuenzalida, Jonathan, Jarazo, Javier, Walter, Jonas, Gomez-Giro, Gemma, Forster, Julia I., Krueger, Rejko, Antony, Paul M. A., Schwamborn, Jens C.
Published in Scientific reports (01.07.2019)
Published in Scientific reports (01.07.2019)
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Journal Article
Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis
Gomez-Giro, Gemma, Arias-Fuenzalida, Jonathan, Jarazo, Javier, Zeuschner, Dagmar, Ali, Muhammad, Possemis, Nina, Bolognin, Silvia, Halder, Rashi, Jäger, Christian, Kuper, Willemijn F E, van Hasselt, Peter M, Zaehres, Holm, Del Sol, Antonio, van der Putten, Herman, Schöler, Hans R, Schwamborn, Jens C
Published in Acta neuropathologica communications (30.12.2019)
Published in Acta neuropathologica communications (30.12.2019)
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Journal Article
Generation of isogenic control DJ-1-delP GC13 for the genetic Parkinson‘s disease-patient derived iPSC line DJ-1-delP (LCSBi008-A-1)
Mencke, Pauline, Hanss, Zoé, Jarazo, Javier, Massart, François, Rybicki, Arkadiusz, Petkovski, Elizabet, Glaab, Enrico, Boussaad, Ibrahim, Bonifati, Vincenzo, Christian Schwamborn, Jens, Mandemakers, Wim, Krüger, Rejko
Published in Stem cell research (01.07.2022)
Published in Stem cell research (01.07.2022)
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Journal Article
Quality Control Strategy for CRISPR-Cas9-Based Gene Editing Complicated by a Pseudogene
Hanss, Zoé, Boussaad, Ibrahim, Jarazo, Javier, Schwamborn, Jens C, Krüger, Rejko
Published in Frontiers in genetics (08.01.2020)
Published in Frontiers in genetics (08.01.2020)
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Journal Article
Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids
Rosety, Isabel, Zagare, Alise, Saraiva, Claudia, Nickels, Sarah, Antony, Paul, Almeida, Catarina, Glaab, Enrico, Halder, Rashi, Velychko, Sergiy, Rauen, Thomas, Schöler, Hans R., Bolognin, Silvia, Sauter, Thomas, Jarazo, Javier, Krüger, Rejko, Schwamborn, Jens C.
Published in NPJ Parkinson's Disease (18.12.2023)
Published in NPJ Parkinson's Disease (18.12.2023)
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Journal Article
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
Sabate‐Soler, Sonia, Nickels, Sarah Louise, Saraiva, Cláudia, Berger, Emanuel, Dubonyte, Ugne, Barmpa, Kyriaki, Lan, Yan Jun, Kouno, Tsukasa, Jarazo, Javier, Robertson, Graham, Sharif, Jafar, Koseki, Haruhiko, Thome, Christian, Shin, Jay W., Cowley, Sally A., Schwamborn, Jens C.
Published in Glia (01.07.2022)
Published in Glia (01.07.2022)
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Journal Article
Impaired mitochondrial–endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson’s disease
Berenguer-Escuder, Clara, Grossmann, Dajana, Antony, Paul, Arena, Giuseppe, Wasner, Kobi, Massart, François, Jarazo, Javier, Walter, Jonas, Schwamborn, Jens C, Grünewald, Anne, Krüger, Rejko
Published in Human molecular genetics (28.05.2020)
Published in Human molecular genetics (28.05.2020)
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Equine Cloning: In Vitro and In Vivo Development of Aggregated Embryos
GAMBINI, Andres, JARAZO, Javier, OLIVERA, Ramiro, SALAMONE, Daniel F
Published in Biology of reproduction (01.07.2012)
Published in Biology of reproduction (01.07.2012)
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