In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine)
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Published in Journal of medicinal chemistry (24.03.2005)
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Concentration and pH Dependent Aggregation of Hydrophobic Drug Molecules and Relevance to Oral Bioavailability
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Published in Journal of medicinal chemistry (24.03.2005)
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SYNOPSIS: SYNthesize and OPtimize System in Silico
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Published in Journal of medicinal chemistry (19.06.2003)
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Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants
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Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives
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Published in Nature (London) (01.02.1990)
Published in Nature (London) (01.02.1990)
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Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1
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Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Design, Synthesis, and SAR of a Novel Pyrazinone Series with Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitory Activity
Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Daeyaert, Frits F. D, Vinkers, Maarten, Van Aken, Koen J. A, Arnold, Eddy, Das, Kalyan, Kilonda, Amuri, Hoornaert, Georges J, Compernolle, Frans, Cegla, Marek, Azzam, Rasha A, Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, Lewi, Paul J, Janssen, Paul A. J
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Pre-incubation of cell-free HIV-1 group M isolates with non-nucleoside reverse transcriptase inhibitors blocks subsequent viral replication in co-cultures of dendritic cells and T cells
NJAI, Harr F, LEWI, Paul J, JANSSEN, Cornelus G. M, GARCIA, Sergio, FRANSEN, Katrien, KESTENS, Luc, VANHAM, Guido, JANSSEN, Paul A. J
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Prediction of Binding Affinities for TIBO Inhibitors of HIV-1 Reverse Transcriptase Using Monte Carlo Simulations in a Linear Response Method
Smith, Richard H, Jorgensen, William L, Tirado-Rives, Julian, Lamb, Michelle L, Janssen, Paul A. J, Michejda, Christopher J, Kroeger Smith, Marilyn B
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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New antihistaminic N-heterocyclic 4-piperidinamines. 3. Synthesis and antihistaminic activity of N-(4-piperidinyl)-3H-imidazo[4,5-b]pyridin-2-amines
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Published in Journal of medicinal chemistry (01.12.1985)
Published in Journal of medicinal chemistry (01.12.1985)
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New antihistaminic N-heterocyclic 4-piperidinamines. 2. Synthesis and antihistaminic activity of 1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amines
Janssens, Frans, Torremans, Joseph, Janssen, Marcel, Stokbroekx, Raymond A, Luyckx, Marcel, Janssen, Paul A. J
Published in Journal of medicinal chemistry (01.12.1985)
Published in Journal of medicinal chemistry (01.12.1985)
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Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 2
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Published in Journal of medicinal chemistry (01.11.1991)
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Synthetic analgesics. Synthesis and pharmacology of the diastereoisomers of N-[3-methyl-1-(2-phenylethyl)-4-piperidyl]-N-phenylpropanamide and N-[3-methyl-1-(1-methyl-2-phenylethyl)-4-piperidyl]-N-phenylpropanamide
Van Bever, Willem F. M, Niemegeers, Carlos J. E, Janssen, Paul A. J
Published in Journal of medicinal chemistry (01.10.1974)
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Functional role of 5-HT2 receptors in the regulation of sleep and wakefulness in the rat
Dugovic, C, Wauquier, A, Leysen, J E, Marrannes, R, Janssen, P A
Published in Psychopharmacology (01.04.1989)
Published in Psychopharmacology (01.04.1989)
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Preparation and antimycotic properties of derivatives of 1-phenethylimidazole
Godefroi, Erik F, Heeres, Jan, Van Cutsem, Jan, Janssen, Paul A. J
Published in Journal of medicinal chemistry (01.09.1969)
Published in Journal of medicinal chemistry (01.09.1969)
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Mode of action studies. Basis for the search of new antifungal drugs
Vanden Bossche, H, Marichal, P, Gorrens, J, Geerts, H, Janssen, P A
Published in Annals of the New York Academy of Sciences (01.12.1988)
Published in Annals of the New York Academy of Sciences (01.12.1988)
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