Quality Control Autophagy Degrades Soluble ERAD-Resistant Conformers of the Misfolded Membrane Protein GnRHR
Houck, Scott A., Ren, Hong Yu, Madden, Victoria J., Bonner, Jacob N., Conlin, Michael P., Janovick, Jo Ann, Conn, P. Michael, Cyr, Douglas M.
Published in Molecular cell (10.04.2014)
Published in Molecular cell (10.04.2014)
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Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy
Jo Ann Janovick, Stewart, M. David, Jacob, Darla, Martin, L. D., Deng, Jian Min, Stewart, C. Allison, Wang, Ying, Cornea, Anda, Chavali, Lakshmi, Lopez, Suhujey, Mitalipov, Shoukhrat, Kang, Eunju, Lee, Hyo-Sang, Manna, Pulak R., Stocco, Douglas M., Behringer, Richard R., Conn, P. Michael
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2013)
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Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity
Smith, Emery, Janovick, Jo Ann, Bannister, Thomas D., Shumate, Justin, Ganapathy, Vadivel, Scampavia, Louis, Spicer, Timothy P.
Published in Scientific reports (29.06.2020)
Published in Scientific reports (29.06.2020)
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Rescue of Hypogonadotropic Hypogonadism-Causing and Manufactured GnRH Receptor Mutants by a Specific Protein-Folding Template: Misrouted Proteins as a Novel Disease Etiology and Therapeutic Target
Janovick, Jo Ann, Maya-Nunez, Guadalupe, Conn, P. Michael
Published in The journal of clinical endocrinology and metabolism (01.07.2002)
Published in The journal of clinical endocrinology and metabolism (01.07.2002)
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Salt bridge integrates GPCR activation with protein trafficking
Janovick, Jo Ann, Conn, P. Michael
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2010)
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Rescue of Misrouted GnRHR Mutants Reveals Its Constitutive Activity
Janovick, Jo Ann, Pogozheva, Irina D, Mosberg, Henry I, Cornea, Anda, Conn, P. Michael
Published in Molecular endocrinology (Baltimore, Md.) (01.07.2012)
Published in Molecular endocrinology (Baltimore, Md.) (01.07.2012)
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Structure-Activity Relations of Successful Pharmacologic Chaperones for Rescue of Naturally Occurring and Manufactured Mutants of the Gonadotropin-Releasing Hormone Receptor
Janovick, Jo Ann, Goulet, Mark, Bush, Eugene, Greer, Jonathan, Wettlaufer, David G, Conn, P Michael
Published in The Journal of pharmacology and experimental therapeutics (01.05.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2003)
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Human Loss-of-Function Gonadotropin-Releasing Hormone Receptor Mutants Retain Wild-Type Receptors in the Endoplasmic Reticulum: Molecular Basis of the Dominant-Negative Effect
Brothers, Shaun P, Cornea, Anda, Janovick, Jo Ann, Conn, P. Michael
Published in Molecular endocrinology (Baltimore, Md.) (01.07.2004)
Published in Molecular endocrinology (Baltimore, Md.) (01.07.2004)
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Calnexin regulated gonadotropin-releasing hormone receptor plasma membrane expression
Brothers, Shaun P, Janovick, Jo Ann, Conn, P Michael
Published in Journal of molecular endocrinology (01.12.2006)
Published in Journal of molecular endocrinology (01.12.2006)
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Parallel Regulation of Membrane Trafficking and Dominant-negative Effects by Misrouted Gonadotropin-releasing Hormone Receptor Mutants
Knollman, Paul E., Janovick, Jo Ann, Brothers, Shaun P., Conn, P. Michael
Published in The Journal of biological chemistry (01.07.2005)
Published in The Journal of biological chemistry (01.07.2005)
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A Novel Mouse Model of Hypogonadotrophic Hypogonadism: N-Ethyl-N-Nitrosourea-Induced Gonadotropin-Releasing Hormone Receptor Gene Mutation
Pask, Andrew J, Kanasaki, Haruhiko, Kaiser, Ursula B, Conn, P. Michael, Janovick, Jo Ann, Stockton, David W, Hess, David L, Justice, Monica J, Behringer, Richard R
Published in Molecular endocrinology (Baltimore, Md.) (01.04.2005)
Published in Molecular endocrinology (Baltimore, Md.) (01.04.2005)
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Addition of Catfish Gonadotropin-Releasing Hormone (GnRH) Receptor Intracellular Carboxyl-Terminal Tail to Rat GnRH Receptor Alters Receptor Expression and Regulation
Lin, Xinwei, Janovick, Jo Ann, Brothers, Shaun, Blömenrohr, Marion, Bogerd, Jan, Conn, P. Michael
Published in Molecular endocrinology (Baltimore, Md.) (01.02.1998)
Published in Molecular endocrinology (Baltimore, Md.) (01.02.1998)
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