Osimertinib in Pretreated T790M-Positive Advanced Non-Small-Cell Lung Cancer: AURA Study Phase II Extension Component
Yang, James Chih-Hsin, Ahn, Myung-Ju, Kim, Dong-Wan, Ramalingam, Suresh S, Sequist, Lecia V, Su, Wu-Chou, Kim, Sang-We, Kim, Joo-Hang, Planchard, David, Felip, Enriqueta, Blackhall, Fiona, Haggstrom, Daniel, Yoh, Kiyotaka, Novello, Silvia, Gold, Kathryn, Hirashima, Tomonori, Lin, Chia-Chi, Mann, Helen, Cantarini, Mireille, Ghiorghiu, Serban, Jänne, Pasi A
Published in Journal of clinical oncology (20.04.2017)
Published in Journal of clinical oncology (20.04.2017)
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Efficacy and Safety of Patritumab Deruxtecan (HER3-DXd) in EGFR Inhibitor-Resistant, EGFR -Mutated Non-Small Cell Lung Cancer
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A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies
Boettcher, Steffen, Miller, Peter G, Sharma, Rohan, McConkey, Marie, Leventhal, Matthew, Krivtsov, Andrei V, Giacomelli, Andrew O, Wong, Waihay, Kim, Jesi, Chao, Sherry, Kurppa, Kari J, Yang, Xiaoping, Milenkowic, Kirsten, Piccioni, Federica, Root, David E, Rücker, Frank G, Flamand, Yael, Neuberg, Donna, Lindsley, R Coleman, Jänne, Pasi A, Hahn, William C, Jacks, Tyler, Döhner, Hartmut, Armstrong, Scott A, Ebert, Benjamin L
Published in Science (American Association for the Advancement of Science) (09.08.2019)
Published in Science (American Association for the Advancement of Science) (09.08.2019)
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Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
Koyama, Shohei, Akbay, Esra A, Li, Yvonne Y, Herter-Sprie, Grit S, Buczkowski, Kevin A, Richards, William G, Gandhi, Leena, Redig, Amanda J, Rodig, Scott J, Asahina, Hajime, Jones, Robert E, Kulkarni, Meghana M, Kuraguchi, Mari, Palakurthi, Sangeetha, Fecci, Peter E, Johnson, Bruce E, Janne, Pasi A, Engelman, Jeffrey A, Gangadharan, Sidharta P, Costa, Daniel B, Freeman, Gordon J, Bueno, Raphael, Hodi, F Stephen, Dranoff, Glenn, Wong, Kwok-Kin, Hammerman, Peter S
Published in Nature communications (17.02.2016)
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Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C
Zeng, Mei, Lu, Jia, Li, Lianbo, Feru, Frederic, Quan, Chunshan, Gero, Thomas W., Ficarro, Scott B., Xiong, Yuan, Ambrogio, Chiara, Paranal, Raymond M., Catalano, Marco, Shao, Jay, Wong, Kwok-Kin, Marto, Jarrod A., Fischer, Eric S., Jänne, Pasi A., Scott, David A., Westover, Kenneth D., Gray, Nathanael S.
Published in Cell chemical biology (17.08.2017)
Published in Cell chemical biology (17.08.2017)
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Association of High Tumor Mutation Burden in Non-Small Cell Lung Cancers With Increased Immune Infiltration and Improved Clinical Outcomes of PD-L1 Blockade Across PD-L1 Expression Levels
Ricciuti, Biagio, Wang, Xinan, Alessi, Joao V, Rizvi, Hira, Mahadevan, Navin R, Li, Yvonne Y, Polio, Andrew, Lindsay, James, Umeton, Renato, Sinha, Rileen, Vokes, Natalie I, Recondo, Gonzalo, Lamberti, Giuseppe, Lawrence, Marissa, Vaz, Victor R, Leonardi, Giulia C, Plodkowski, Andrew J, Gupta, Hersh, Cherniack, Andrew D, Tolstorukov, Michael Y, Sharma, Bijaya, Felt, Kristen D, Gainor, Justin F, Ravi, Arvind, Getz, Gad, Schalper, Kurt A, Henick, Brian, Forde, Patrick, Anagnostou, Valsamo, Jänne, Pasi A, Van Allen, Eliezer M, Nishino, Mizuki, Sholl, Lynette M, Christiani, David C, Lin, Xihong, Rodig, Scott J, Hellmann, Matthew D, Awad, Mark M
Published in JAMA oncology (01.08.2022)
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Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion-Positive Lung Cancer by Combining Selpercatinib with Crizotinib
Rosen, Ezra Y, Johnson, Melissa L, Clifford, Sarah E, Somwar, Romel, Kherani, Jennifer F, Son, Jieun, Bertram, Arrien A, Davare, Monika A, Gladstone, Eric, Ivanova, Elena V, Henry, Dahlia N, Kelley, Elaine M, Lin, Mika, Milan, Marina S D, Nair, Binoj C, Olek, Elizabeth A, Scanlon, Jenna E, Vojnic, Morana, Ebata, Kevin, Hechtman, Jaclyn F, Li, Bob T, Sholl, Lynette M, Taylor, Barry S, Ladanyi, Marc, Jänne, Pasi A, Rothenberg, S Michael, Drilon, Alexander, Oxnard, Geoffrey R
Published in Clinical cancer research (01.01.2021)
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EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody-Drug Conjugate HER3-DXd
Haikala, Heidi M, Lopez, Timothy, Köhler, Jens, Eser, Pinar O, Xu, Man, Zeng, Qing, Teceno, Tyler J, Ngo, Kenneth, Zhao, Yutong, Ivanova, Elena V, Bertram, Arrien A, Leeper, Brittaney A, Chambers, Emily S, Adeni, Anika E, Taus, Luke J, Kuraguchi, Mari, Kirschmeier, Paul T, Yu, Channing, Shiose, Yoshinobu, Kamai, Yasuki, Qiu, Yang, Paweletz, Cloud P, Gokhale, Prafulla C, Jänne, Pasi A
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Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors
Akbay, Esra A, Koyama, Shohei, Carretero, Julian, Altabef, Abigail, Tchaicha, Jeremy H, Christensen, Camilla L, Mikse, Oliver R, Cherniack, Andrew D, Beauchamp, Ellen M, Pugh, Trevor J, Wilkerson, Matthew D, Fecci, Peter E, Butaney, Mohit, Reibel, Jacob B, Soucheray, Margaret, Cohoon, Travis J, Janne, Pasi A, Meyerson, Matthew, Hayes, D Neil, Shapiro, Geoffrey I, Shimamura, Takeshi, Sholl, Lynette M, Rodig, Scott J, Freeman, Gordon J, Hammerman, Peter S, Dranoff, Glenn, Wong, Kwok-Kin
Published in Cancer discovery (01.12.2013)
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Amplification of Wild-type KRAS Imparts Resistance to Crizotinib in MET Exon 14 Mutant Non-Small Cell Lung Cancer
Bahcall, Magda, Awad, Mark M, Sholl, Lynette M, Wilson, Frederick H, Xu, Man, Wang, Stephen, Palakurthi, Sangeetha, Choi, Jihyun, Ivanova, Elena V, Leonardi, Giulia C, Ulrich, Bryan C, Paweletz, Cloud P, Kirschmeier, Paul T, Watanabe, Masayuki, Baba, Hideo, Nishino, Mizuki, Nagy, Rebecca J, Lanman, Richard B, Capelletti, Marzia, Chambers, Emily S, Redig, Amanda J, VanderLaan, Paul A, Costa, Daniel B, Imamura, Yu, Jänne, Pasi A
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MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer
Yoshida, Ryohei, Saigi, Maria, Tani, Tetsuo, Springer, Benjamin F, Shibata, Hirofumi, Kitajima, Shunsuke, Mahadevan, Navin R, Campisi, Marco, Kim, William, Kobayashi, Yoshihisa, Thai, Tran C, Haratani, Koji, Yamamoto, Yurie, Sundararaman, Shriram K, Knelson, Erik H, Vajdi, Amir, Canadas, Israel, Uppaluri, Ravindra, Paweletz, Cloud P, Miret, Juan J, Lizotte, Patrick H, Gokhale, Prafulla C, Jänne, Pasi A, Barbie, David A
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Use of Ex Vivo Patient-Derived Tumor Organotypic Spheroids to Identify Combination Therapies for HER2 Mutant Non-Small Cell Lung Cancer
Ivanova, Elena, Kuraguchi, Mari, Xu, Man, Portell, Andrew J, Taus, Luke, Diala, Irmina, Lalani, Alshad S, Choi, Jihyun, Chambers, Emily S, Li, Shuai, Liu, Shengwu, Chen, Ting, Barbie, Thanh U, Oxnard, Geoffrey R, Haworth, Jacob J, Wong, Kwok-Kin, Dahlberg, Suzanne E, Aref, Amir A, Barbie, David A, Bahcall, Magda, Paweletz, Cloud P, Jänne, Pasi A
Published in Clinical cancer research (15.05.2020)
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Unique Clinicopathologic Features Characterize ALK-Rearranged Lung Adenocarcinoma in the Western Population
RODIG, Scott J, MINO-KENUDSON, Mari, JANNE, Pasi A, LYNCH, Thomas, JOHNSON, Bruce E, LAFRATE, A. John, CHIRIEAC, Lucian R, DACIC, Sanja, YEAP, Beow Y, SHAW, Alice, BARLETTA, Justine A, STUBBS, Hannah, LAW, Kenny, LINDEMAN, Neal, MARK, Eugene
Published in Clinical cancer research (15.08.2009)
Published in Clinical cancer research (15.08.2009)
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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
Su, Wenjing, Mukherjee, Radha, Yaeger, Rona, Son, Jieun, Xu, Jianing, Na, Na, Merna Timaul, Neilawattie, Hechtman, Jaclyn, Paroder, Viktoriya, Lin, Mika, Mattar, Marissa, Qiu, Juan, Chang, Qing, Zhao, Huiyong, Zhang, Jonathan, Little, Megan, Adachi, Yuta, Han, Sae-Won, Taylor, Barry S, Ebi, Hiromichi, Abdel-Wahab, Omar, de Stanchina, Elisa, Rudin, Charles M, Jänne, Pasi A, McCormick, Frank, Yao, Zhan, Rosen, Neal
Published in Molecular cell (07.07.2022)
Published in Molecular cell (07.07.2022)
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Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations
Sholl, Lynette M., Nishino, Mizuki, Pokharel, Saraswati, Mino-Kenudson, Mari, French, Christopher A., Janne, Pasi A., Lathan, Christopher
Published in Journal of thoracic oncology (01.06.2015)
Published in Journal of thoracic oncology (01.06.2015)
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An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer
To, Ciric, Beyett, Tyler S, Jang, Jaebong, Feng, William W, Bahcall, Magda, Haikala, Heidi M, Shin, Bo H, Heppner, David E, Rana, Jaimin K, Leeper, Brittaney A, Soroko, Kara M, Poitras, Michael J, Gokhale, Prafulla C, Kobayashi, Yoshihisa, Wahid, Kamal, Kurppa, Kari J, Gero, Thomas W, Cameron, Michael D, Ogino, Atsuko, Mushajiang, Mierzhati, Xu, Chunxiao, Zhang, Yanxi, Scott, David A, Eck, Michael J, Gray, Nathanael S, Jänne, Pasi A
Published in Nature cancer (01.04.2022)
Published in Nature cancer (01.04.2022)
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Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors
Kobayashi, Yoshihisa, Oxnard, Geoffrey R, Cohen, Elizabeth F, Mahadevan, Navin R, Alessi, Joao V, Hung, Yin P, Bertram, Arrien A, Heppner, David E, Ribeiro, Mauricio F, Sacardo, Karina P, Saddi, Rodrigo, Macedo, Mariana P, Blasco, Rafael B, Li, Jiaqi, Kurppa, Kari J, Nguyen, Tom, Voligny, Emma, Ananda, Guruprasad, Chiarle, Roberto, Katz, Artur, Tolstorukov, Michael Y, Sholl, Lynette M, Jänne, Pasi A
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Published in Nature communications (24.09.2022)
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The Combined Effect of FGFR Inhibition and PD-1 Blockade Promotes Tumor-Intrinsic Induction of Antitumor Immunity
Palakurthi, Sangeetha, Kuraguchi, Mari, Zacharek, Sima J, Zudaire, Enrique, Huang, Wei, Bonal, Dennis M, Liu, Jeffrey, Dhaneshwar, Abha, DePeaux, Kristin, Gowaski, Martha R, Bailey, Dyane, Regan, Samuel N, Ivanova, Elena, Ferrante, Catherine, English, Jessie M, Khosla, Aditya, Beck, Andrew H, Rytlewski, Julie A, Sanders, Catherine, Laquerre, Sylvie, Bittinger, Mark A, Kirschmeier, Paul T, Packman, Kathryn, Janne, Pasi A, Moy, Christopher, Wong, Kwok-Kin, Verona, Raluca I, Lorenzi, Matthew V
Published in Cancer immunology research (01.09.2019)
Published in Cancer immunology research (01.09.2019)
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Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
QINGSONG LIU, CHUNXIAO XU, ERCAN, Dalia, NIEPEL, Mario, THOREEN, Carson C, KANG, Seong A, PATRICELLI, Matthew P, YUCHUAN WANG, TUPPER, Tanya, ALTABEF, Abigail, KAWAMURA, Hidemasa, HELD, Kathryn D, KIRUBAKARAN, Sivapriya, CHOU, Danny M, ELLEDGE, Stephen J, JANNE, Pasi A, WONG, Kwok-Kin, SABATINI, David M, GRAY, Nathanael S, XIN ZHANG, HUR, Wooyoung, YAN LIU, KWIATKOWSKI, Nicholas P, JINHUA WANG, WESTOVER, Kenneth D, PENG GAO
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
Engelman, Jeffrey A, Mukohara, Toru, Zejnullahu, Kreshnik, Lifshits, Eugene, Borrás, Ana M, Gale, Christopher-Michael, Naumov, George N, Yeap, Beow Y, Jarrell, Emily, Sun, Jason, Tracy, Sean, Zhao, Xiaojun, Heymach, John V, Johnson, Bruce E, Cantley, Lewis C, Jänne, Pasi A
Published in The Journal of clinical investigation (01.10.2006)
Published in The Journal of clinical investigation (01.10.2006)
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