TIGIT: A Key Inhibitor of the Cancer Immunity Cycle
Manieri, Nicholas A, Chiang, Eugene Y, Grogan, Jane L
Published in Trends in immunology (01.01.2017)
Published in Trends in immunology (01.01.2017)
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The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+ T Cell Effector Function
Johnston, Robert J., Comps-Agrar, Laetitia, Hackney, Jason, Yu, Xin, Huseni, Mahrukh, Yang, Yagai, Park, Summer, Javinal, Vincent, Chiu, Henry, Irving, Bryan, Eaton, Dan L., Grogan, Jane L.
Published in Cancer cell (08.12.2014)
Published in Cancer cell (08.12.2014)
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Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer
Patil, Namrata S., Nabet, Barzin Y., Müller, Sören, Koeppen, Hartmut, Zou, Wei, Giltnane, Jennifer, Au-Yeung, Amelia, Srivats, Shyam, Cheng, Jason H., Takahashi, Chikara, de Almeida, Patricia E., Chitre, Avantika S., Grogan, Jane L., Rangell, Linda, Jayakar, Sangeeta, Peterson, Maureen, Hsia, Allison W., O’Gorman, William E., Ballinger, Marcus, Banchereau, Romain, Shames, David S.
Published in Cancer cell (14.03.2022)
Published in Cancer cell (14.03.2022)
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Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses
Banta, Karl L., Xu, Xiaozheng, Chitre, Avantika S., Au-Yeung, Amelia, Takahashi, Chikara, O’Gorman, William E., Wu, Thomas D., Mittman, Stephanie, Cubas, Rafael, Comps-Agrar, Laetitia, Fulzele, Amit, Bennett, Eric J., Grogan, Jane L., Hui, Enfu, Chiang, Eugene Y., Mellman, Ira
Published in Immunity (Cambridge, Mass.) (08.03.2022)
Published in Immunity (Cambridge, Mass.) (08.03.2022)
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High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE
Li, Tianbo, Lu, Gang, Chiang, Eugene Y, Chernov-Rogan, Tania, Grogan, Jane L, Chen, Jun
Published in PloS one (06.07.2017)
Published in PloS one (06.07.2017)
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Peripheral T cell expansion predicts tumour infiltration and clinical response
Wu, Thomas D., Madireddi, Shravan, de Almeida, Patricia E., Banchereau, Romain, Chen, Ying-Jiun J., Chitre, Avantika S., Chiang, Eugene Y., Iftikhar, Hina, O’Gorman, William E., Au-Yeung, Amelia, Takahashi, Chikara, Goldstein, Leonard D., Poon, Chungkee, Keerthivasan, Shilpa, de Almeida Nagata, Denise E., Du, Xiangnan, Lee, Hyang-Mi, Banta, Karl L., Mariathasan, Sanjeev, Das Thakur, Meghna, Huseni, Mahrukh A., Ballinger, Marcus, Estay, Ivette, Caplazi, Patrick, Modrusan, Zora, Delamarre, Lélia, Mellman, Ira, Bourgon, Richard, Grogan, Jane L.
Published in Nature (London) (01.03.2020)
Published in Nature (London) (01.03.2020)
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High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade
Yuen, Kobe C., Liu, Li-Fen, Gupta, Vinita, Madireddi, Shravan, Keerthivasan, Shilpa, Li, Congfen, Rishipathak, Deepali, Williams, Patrick, Kadel, Edward E., Koeppen, Hartmut, Chen, Ying-Jiun, Modrusan, Zora, Grogan, Jane L., Banchereau, Romain, Leng, Ning, Thastrom, AnnChristine, Shen, Xiadong, Hashimoto, Kenji, Tayama, Darren, van der Heijden, Michiel S., Rosenberg, Jonathan E., McDermott, David F., Powles, Thomas, Hegde, Priti S., Huseni, Mahrukh A., Mariathasan, Sanjeev
Published in Nature medicine (01.05.2020)
Published in Nature medicine (01.05.2020)
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The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
Harden, Kristin, Yu, Xin, C Gonzalez, Lino, Grogan, Jane L, Chiang, Eugene, Irving, Bryan, Refino, Canio J, Francesco, Michelle, Tom, Irene, Clark, Hilary, Eaton, Dan, Ivelja, Sinisa
Published in Nature immunology (01.01.2009)
Published in Nature immunology (01.01.2009)
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Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC + CD127 + natural killer-like cells
Cupedo, Tom, Crellin, Natasha K, Papazian, Natalie, Rombouts, Elwin J, Weijer, Kees, Grogan, Jane L, Fibbe, Willem E, Cornelissen, Jan J, Spits, Hergen
Published in Nature immunology (01.01.2009)
Published in Nature immunology (01.01.2009)
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Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice
Lau, Janet, Cheung, Jeanne, Navarro, Armando, Lianoglou, Steve, Haley, Benjamin, Totpal, Klara, Sanders, Laura, Koeppen, Hartmut, Caplazi, Patrick, McBride, Jacqueline, Chiu, Henry, Hong, Rebecca, Grogan, Jane, Javinal, Vincent, Yauch, Robert, Irving, Bryan, Belvin, Marcia, Mellman, Ira, Kim, Jeong M., Schmidt, Maike
Published in Nature communications (21.02.2017)
Published in Nature communications (21.02.2017)
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Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions
Chiang, Eugene Y., Li, Tianbo, Jeet, Surinder, Peng, Ivan, Zhang, Juan, Lee, Wyne P., DeVoss, Jason, Caplazi, Patrick, Chen, Jun, Warming, Søren, Hackos, David H., Mukund, Susmith, Koth, Christopher M., Grogan, Jane L.
Published in Nature communications (01.03.2017)
Published in Nature communications (01.03.2017)
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A Platform for Extracellular Interactome Discovery Identifies Novel Functional Binding Partners for the Immune Receptors B7-H3/CD276 and PVR/CD155
Husain, Bushra, Ramani, Sree R., Chiang, Eugene, Lehoux, Isabelle, Paduchuri, Sairupa, Arena, Tia A., Patel, Ashka, Wilson, Blair, Chan, Pamela, Franke, Yvonne, Wong, Athena W., Lill, Jennie R., Turley, Shannon J., Gonzalez, Lino C., Grogan, Jane L., Martinez-Martin, Nadia
Published in Molecular & cellular proteomics (01.11.2019)
Published in Molecular & cellular proteomics (01.11.2019)
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CD96 functions as a co‐stimulatory receptor to enhance CD8+ T cell activation and effector responses
Chiang, Eugene Y., Almeida, Patricia E., Almeida Nagata, Denise E., Bowles, Kristin Harden, Du, Xiangnan, Chitre, Avantika S., Banta, Karl L., Kwon, Youngsu, McKenzie, Brent, Mittman, Stephanie, Cubas, Rafael, Anderson, Keith R., Warming, Søren, Grogan, Jane L.
Published in European journal of immunology (01.06.2020)
Published in European journal of immunology (01.06.2020)
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Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell–cell adhesion and signaling mechanism that requires cis-trans receptor clustering
Stengel, Katharina F, Harden-Bowles, Kristin, Yu, Xin, Rouge, Lionel, Yin, Jianping, Comps-Agrar, Laëtitia, Wiesmann, Christian, Bazan, J. Fernando, Eaton, Dan L, Grogan, Jane L
Published in Proceedings of the National Academy of Sciences - PNAS (03.04.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (03.04.2012)
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HPK1 citron homology domain regulates phosphorylation of SLP76 and modulates kinase domain interaction dynamics
Chitre, Avantika S., Wu, Ping, Walters, Benjamin T., Wang, Xiangdan, Bouyssou, Alexandre, Du, Xiangnan, Lehoux, Isabelle, Fong, Rina, Arata, Alisa, Chan, Joyce, Wang, Die, Franke, Yvonne, Grogan, Jane L., Mellman, Ira, Comps-Agrar, Laetitia, Wang, Weiru
Published in Nature communications (02.05.2024)
Published in Nature communications (02.05.2024)
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The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function
Hernandez, Sairy, Qing, Jing, Thibodeau, Rebecca Hong, Du, Xiangnan, Park, Summer, Lee, Hyang-Mi, Xu, Min, Oh, Soyoung, Navarro, Armando, Roose-Girma, Meron, Newman, Robert J., Warming, Soren, Nannini, Michelle, Sampath, Deepak, Kim, Jeong M., Grogan, Jane L., Mellman, Ira
Published in Cell reports (Cambridge) (02.10.2018)
Published in Cell reports (Cambridge) (02.10.2018)
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CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1
Du, Xiangnan, de Almeida, Patricia, Manieri, Nick, de Almeida Nagata, Denise, Wu, Thomas D., Bowles, Kristin Harden, Arumugam, Vidhyalakshmi, Schartner, Jill, Cubas, Rafael, Mittman, Stephanie, Javinal, Vincent, Anderson, Keith R., Warming, Søren, Grogan, Jane L., Chiang, Eugene Y.
Published in Proceedings of the National Academy of Sciences - PNAS (11.12.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (11.12.2018)
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