In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435
LENZ, Oliver, VERBINNEN, Thierry, VERMEIREN, Katrien, IVENS, Tania, RABOISSON, Pierre, EDLUND, Michael, STORM, Susan, VRANG, Lotta, DE KOCK, Herman, FANNING, Gregory C, SIMMEN, Kenneth A, LIN, Tse-I, VIJGEN, Leen, CUMMINGS, Maxwell D, LINDBERG, Jimmy, MARTIN BERKE, Jan, DEHERTOGH, Pascale, FRANSEN, Els, SCHOLLIERS, Annick
Published in Antimicrobial Agents and Chemotherapy (01.05.2010)
Published in Antimicrobial Agents and Chemotherapy (01.05.2010)
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Novel Potent Capsid Assembly Modulators Regulate Multiple Steps of the Hepatitis B Virus Life Cycle
Lahlali, Thomas, Berke, Jan Martin, Vergauwen, Karen, Foca, Adrien, Vandyck, Koen, Pauwels, Frederik, Zoulim, Fabien, Durantel, David
Published in Antimicrobial agents and chemotherapy (01.10.2018)
Published in Antimicrobial agents and chemotherapy (01.10.2018)
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Virology analysis of chronic hepatitis B virus–infected patients treated for 28 days with JNJ‐56136379 monotherapy
Verbinnen, Thierry, Hodari, Moana, Talloen, Willem, Berke, Jan Martin, Blue, David, Yogaratnam, Jeysen, Vandenbossche, Joris, Shukla, Umesh, De Meyer, Sandra, Lenz, Oliver
Published in Journal of viral hepatitis (01.11.2020)
Published in Journal of viral hepatitis (01.11.2020)
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Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase
MARTIN BERKE, Jan, VIJGEN, Leen, VAN DEN EYNDE, Christel, LECLERCQ, Laurent, JONCKERS, Tim H. M, RABOISSON, Pierre, NILSSON, Magnus, SAMUELSSON, Bertil, ROSENQUIST, Asa, FANNING, Gregory C, LIN, Tse-I, LACHAU-DURAND, Sophie, POWDRILL, Megan H, RAWE, Svea, SJUVARSSON, Elena, ERIKSSON, Staffan, GÖTTE, Matthias, FRANSEN, Els, DEHERTOGH, Pascale
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
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Molecular elucidation of drug-induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR
Lecoq, Lauriane, Brigandat, Louis, Huber, Rebecca, Fogeron, Marie-Laure, Wang, Shishan, Dujardin, Marie, Briday, Mathilde, Wiegand, Thomas, Callon, Morgane, Malär, Alexander, Durantel, David, Burdette, Dara, Berke, Jan Martin, Meier, Beat H., Nassal, Michael, Böckmann, Anja
Published in Nature communications (28.01.2023)
Published in Nature communications (28.01.2023)
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Structural Determinants for Membrane Association and Dynamic Organization of the Hepatitis C Virus NS3-4A Complex
Brass, Volker, Berke, Jan Martin, Montserret, Roland, Blum, Hubert E., Penin, François, Moradpour, Darius
Published in Proceedings of the National Academy of Sciences - PNAS (23.09.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (23.09.2008)
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Combining Cell-Free Protein Synthesis and NMR Into a Tool to Study Capsid Assembly Modulation
Wang, Shishan, Fogeron, Marie-Laure, Schledorn, Maarten, Dujardin, Marie, Penzel, Susanne, Burdette, Dara, Berke, Jan Martin, Nassal, Michael, Lecoq, Lauriane, Meier, Beat H, Böckmann, Anja
Published in Frontiers in molecular biosciences (08.08.2019)
Published in Frontiers in molecular biosciences (08.08.2019)
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Journal Article
TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage
DEVOGELAERE, Benoit, BERKE, Jan Martin, LENZ, Oliver, CUMMINGS, Maxwell D, CLAYTON, Reginald F, VENDEVILLE, Sandrine, RABOISSON, Pierre, SIMMEN, Kenneth A, FANNING, Gregory C, LIN, Tse-I, VIJGEN, Leen, DEHERTOGH, Pascale, FRANSEN, Els, CLEIREN, Erna, VAN DER HELM, Liesbet, NYANGUILE, Origène, TAHRI, Abdellah, AMSSOMS, Katie
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
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Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055
Vendeville, Sandrine, Lin, Tse-I., Hu, Lili, Tahri, Abdellah, McGowan, David, Cummings, Maxwell D., Amssoms, Katie, Canard, Maxime, Last, Stefaan, Van den Steen, Iris, Devogelaere, Benoit, Rouan, Marie-Claude, Vijgen, Leen, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Cleiren, Erna, van der Helm, Liesbet, Fanning, Gregory, Van Emelen, Kristof, Nyanguile, Origène, Simmen, Kenny, Raboisson, Pierre
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
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Upregulation of Protein Phosphatase 2Ac by Hepatitis C Virus Modulates NS3 Helicase Activity through Inhibition of Protein Arginine Methyltransferase 1
Duong, Francois H T, Christen, Verena, Berke, Jan Martin, Penna, Sabina Hernandez, Moradpour, Darius, Heim, Markus H
Published in Journal of Virology (01.12.2005)
Published in Journal of Virology (01.12.2005)
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Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series
McGowan, David, Vendeville, Sandrine, Lin, Tse-I, Tahri, Abdellah, Hu, Lili, Cummings, Maxwell D., Amssoms, Katie, Berke, Jan Martin, Canard, Maxime, Cleiren, Erna, Dehertogh, Pascale, Last, Stefaan, Fransen, Els, Van Der Helm, Elisabeth, Van den Steen, Iris, Vijgen, Leen, Rouan, Marie-Claude, Fanning, Gregory, Nyanguile, Origène, Van Emelen, Kristof, Simmen, Kenneth, Raboisson, Pierre
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
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MAPPIT as a high-throughput screening assay for modulators of protein-protein interactions in HIV and HCV
Van Schoubroeck, Bertrand, Van Acker, Koen, Dams, Géry, Jochmans, Dirk, Clayton, Reginald, Berke, Jan Martin, Lievens, Sam, Van der Heyden, José, Tavernier, Jan
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2012)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2012)
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Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary Human Hepatocytes Infected with Hepatitis B Virus
Berke, Jan Martin, Dehertogh, Pascale, Vergauwen, Karen, Van Damme, Ellen, Mostmans, Wendy, Vandyck, Koen, Pauwels, Frederik
Published in Antimicrobial agents and chemotherapy (01.08.2017)
Published in Antimicrobial agents and chemotherapy (01.08.2017)
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Journal Article
Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379
Berke, Jan Martin, Dehertogh, Pascale, Vergauwen, Karen, Mostmans, Wendy, Vandyck, Koen, Raboisson, Pierre, Pauwels, Frederik
Published in Antimicrobial agents and chemotherapy (21.04.2020)
Published in Antimicrobial agents and chemotherapy (21.04.2020)
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Journal Article
Characterization of Nonstructural Protein Membrane Anchor Deletion Mutants Expressed in the Context of the Hepatitis C Virus Polyprotein
GOSERT, Rainer, JENDRSCZOK, Wiebke, BERKE, Jan Martin, BRASS, Volker, BLUM, Hubert E, MORADPOUR, Darius
Published in Journal of Virology (01.06.2005)
Published in Journal of Virology (01.06.2005)
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Anti-HBV activity of the HBV capsid assembly modulator JNJ-56136379 across full-length genotype A–H clinical isolates and core site-directed mutants in vitro
Verbinnen, Thierry, Tan, Ying, Wang, Gengyan, Dehertogh, Pascale, Vergauwen, Karen, Neefs, Jean-Marc, Jacoby, Edgar, Lenz, Oliver, Berke, Jan Martin
Published in Journal of antimicrobial chemotherapy (01.09.2020)
Published in Journal of antimicrobial chemotherapy (01.09.2020)
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Synthesis and Evaluation of N‑Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV)
Vandyck, Koen, Rombouts, Geert, Stoops, Bart, Tahri, Abdellah, Vos, Ann, Verschueren, Wim, Wu, Yiming, Yang, Jingmei, Hou, Fuliang, Huang, Bing, Vergauwen, Karen, Dehertogh, Pascale, Berke, Jan Martin, Raboisson, Pierre
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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Antiviral profiling of the capsid assembly modulator BAY41-4109 on full-length HBV genotype A-H clinical isolates and core site-directed mutants in vitro
Berke, Jan Martin, Tan, Ying, Verbinnen, Thierry, Dehertogh, Pascale, Vergauwen, Karen, Vos, Ann, Lenz, Oliver, Pauwels, Frederik
Published in Antiviral research (01.08.2017)
Published in Antiviral research (01.08.2017)
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Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation
Berke, Jan Martin, Tan, Ying, Sauviller, Sarah, Wu, Dai-Tze, Zhang, Ke, Conceição-Neto, Nádia, Blázquez Moreno, Alfonso, Kong, Desheng, Kukolj, George, Li, Chris, Zhu, Ren, Nájera, Isabel, Pauwels, Frederik
Published in Journal of virology (19.03.2024)
Published in Journal of virology (19.03.2024)
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Journal Article
Virologic response and characterisation of HCV genotype 2–6 in patients receiving TMC435 monotherapy (study TMC435-C202)
Lenz, Oliver, Vijgen, Leen, Berke, Jan Martin, Cummings, Maxwell D, Fevery, Bart, Peeters, Monika, Smedt, Goedele De, Moreno, Christophe, Picchio, Gaston
Published in Journal of hepatology (01.03.2013)
Published in Journal of hepatology (01.03.2013)
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