Small-Molecule Ghrelin Receptor Antagonists Improve Glucose Tolerance, Suppress Appetite, and Promote Weight Loss
Esler, William P, Rudolph, Joachim, Claus, Thomas H, Tang, Weifeng, Barucci, Nicole, Brown, Su-Ellen, Bullock, William, Daly, Michelle, DeCarr, Lynn, Li, Yaxin, Milardo, Lucinda, Molstad, David, Zhu, Jian, Gardell, Stephen J, Livingston, James N, Sweet, Laurel J
Published in Endocrinology (Philadelphia) (01.11.2007)
Published in Endocrinology (Philadelphia) (01.11.2007)
Get full text
Journal Article
The Effects of NT-1044, a Novel AMPK Activator, on Endometrial Cancer Cell Proliferation, Apoptosis, Cell Stress and In Vivo Tumor Growth
Roque, Dario R, Zhang, Lu, Wysham, Weiya Z, Han, Jianjun, Sun, Wenchuan, Yin, Yajie, Livingston, James N, Batchelor, Ken W, Zhou, Chunxiao, Bae-Jump, Victoria L
Published in Frontiers in oncology (05.08.2021)
Published in Frontiers in oncology (05.08.2021)
Get full text
Journal Article
A Novel Long-Acting Selective Neuropeptide Y2 Receptor Polyethylene Glycol-Conjugated Peptide Agonist Reduces Food Intake and Body Weight and Improves Glucose Metabolism in Rodents
Ortiz, Astrid A, Milardo, Lucinda F, DeCarr, Lynn B, Buckholz, Thomas M, Mays, Michelle R, Claus, Thomas H, Livingston, James N, Mahle, Cathy D, Lumb, Kevin J
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
Get full text
Journal Article
Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetes
Claus, Thomas H, Pan, Clark Q, Buxton, Joanne M, Yang, Ling, Reynolds, Jennifer C, Barucci, Nicole, Burns, Michael, Ortiz, Astrid A, Roczniak, Steve, Livingston, James N, Clairmont, Kevin B, Whelan, James P
Published in Journal of endocrinology (01.02.2007)
Published in Journal of endocrinology (01.02.2007)
Get full text
Journal Article
Indanylacetic Acid Derivatives Carrying 4-Thiazolyl-phenoxy Tail Groups, a New Class of Potent PPAR α/γ/δ Pan Agonists: Synthesis, Structure−Activity Relationship, and In Vivo Efficacy
Rudolph, Joachim, Chen, Libing, Majumdar, Dyuti, Bullock, William H, Burns, Michael, Claus, Thomas, Dela Cruz, Fernando E, Daly, Michelle, Ehrgott, Frederick J, Johnson, Jeffrey S, Livingston, James N, Schoenleber, Robert W, Shapiro, Jeffrey, Yang, Ling, Tsutsumi, Manami, Ma, Xin
Published in Journal of medicinal chemistry (08.03.2007)
Published in Journal of medicinal chemistry (08.03.2007)
Get full text
Journal Article
A potent and highly selective VPAC2 agonist enhances glucose-induced insulin release and glucose disposal: A potential therapy for type 2 diabetes
TSUTSUMI, Manami, CLAUS, Thomas H, HAMREN, Sarah, LIVINGSTON, James N, PAN, Clark Q, YIN LIANG, YAXIN LI, LING YANG, JIAN ZHU, DELA CRUZ, Fernando, XIANBU PENG, HONGXING CHEN, YUNG, Stephanie L
Published in Diabetes (New York, N.Y.) (01.05.2002)
Published in Diabetes (New York, N.Y.) (01.05.2002)
Get full text
Journal Article
PDE-10A inhibitors as insulin secretagogues
Cantin, Louis-David, Magnuson, Steven, Gunn, David, Barucci, Nicole, Breuhaus, Marina, Bullock, William H., Burke, Jennifer, Claus, Thomas H., Daly, Michelle, DeCarr, Lynn, Gore-Willse, Ann, Hoover-Litty, Helana, Kumarasinghe, Ellalahewage S., Li, Yaxin, Liang, Sidney X., Livingston, James N., Lowinger, Timothy, MacDougall, Margit, Ogutu, Herbert O., Olague, Alan, Ott-Morgan, Ronda, Schoenleber, Robert W., Tersteegen, Adrian, Wickens, Philip, Zhang, Zhonghua, Zhu, Jian, Zhu, Lei, Sweet, Laurel J.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Get full text
Journal Article
Indanylacetic acids as PPAR-δ activator insulin sensitizers
Wickens, Philip, Zhang, Chengzhi, Ma, Xin, Zhao, Qian, Amatruda, John, Bullock, William, Burns, Michael, Cantin, Louis-David, Chuang, Chih-Yuan, Claus, Thomas, Dai, Miao, Dela Cruz, Fernando, Dickson, David, Ehrgott, Frederick J., Fan, Dongping, Heald, Sarah, Hentemann, Martin, Iwuagwu, Christiana I., Johnson, Jeffrey S., Kumarasinghe, Ellalahewage, Ladner, David, Lavoie, Rico, Liang, Sidney, Livingston, James N., Lowe, Derek, Magnuson, Steve, Mannelly, Gretchen, Mugge, Ingo, Ogutu, Herbert, Pleasic-Williams, Susan, Schoenleber, Robert W., Shapiro, Jeff, Shelekhin, Tatiana, Sweet, Laurel, Town, Christopher, Tsutsumi, Manami
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Get full text
Journal Article
Indanylacetic acid derivatives carrying aryl-pyridyl and aryl-pyrimidinyl tail groups—new classes of PPAR γ/δ and PPAR α/γ/δ agonists
Cantin, Louis-David, Liang, Sidney, Ogutu, Herbert, Iwuagwu, Christiana I., Boakye, Ken, Bullock, William H., Burns, Michael, Clark, Roger, Claus, Thomas, delaCruz, Fernando E., Daly, Michelle, Ehrgott, Frederick J., Johnson, Jeffrey S., Keiper, Christine, Livingston, James N., Schoenleber, Robert W., Shapiro, Jeffrey, Town, Christopher, Yang, Ling, Tsutsumi, Manami, Ma, Xin
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
Get full text
Journal Article
Discovery of 5-Hydroxyalkyl-4-phenylpyridines as a New Class of Glucagon Receptor Antagonists
Ladouceur, Gaetan H., Cook, James H., Doherty, Elizabeth M., Schoen, William R., MacDougall, Margit L., Livingston, James N.
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
Get full text
Journal Article
Insulin signaling in mice expressing reduced levels of syp
Arrandale, J.M, Gore-Willse, A, Rocks, S, Ren, J.M, Zhu, J, Davis, A, Livingston, J.N, Rabin, D.U
Published in The Journal of biological chemistry (30.08.1996)
Published in The Journal of biological chemistry (30.08.1996)
Get full text
Journal Article
Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists
Ladouceur, Gaetan H., Cook, James H., Hertzog, Donald L., Jones, J.Howard, Hundertmark, Thomas, Korpusik, Mary, Lease, Timothy G., Livingston, James N., MacDougall, Margit L., Osterhout, Martin H., Phelan, Kathleen, Romero, Romulo H., Schoen, William R., Shao, Chunning, Smith, Roger A.
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
Get full text
Journal Article
Optimization of the 4-aryl group of 4-aryl-pyridine glucagon antagonists: development of an efficient, alternative synthesis
Smith, Roger A., Hertzog, Donald L., Osterhout, Martin H., Ladouceur, Gaetan H., Korpusik, Mary, Bobko, Mark A., Jones, J.Howard, Phelan, Kathleen, Romero, Romulo H., Hundertmark, Thomas, MacDougall, Margit L., Livingston, James N., Schoen, William R.
Published in Bioorganic & medicinal chemistry letters (06.05.2002)
Published in Bioorganic & medicinal chemistry letters (06.05.2002)
Get full text
Journal Article
A Potent and Highly Selective VPAC2 Agonist Enhances Glucose-Induced Insulin Release and Glucose Disposal
Tsutsumi, Manami, Claus, Thomas H., Liang, Yin, Li, Yaxin, Yang, Ling, Zhu, Jian, Dela Cruz, Fernando, Peng, Xianbu, Chen, Hongxing, Yung, Stephanie L., Hamren, Sarah, Livingston, James N., Pan, Clark Q.
Published in Diabetes (New York, N.Y.) (01.05.2002)
Published in Diabetes (New York, N.Y.) (01.05.2002)
Get full text
Journal Article
Quinazolinone Derivatives as Orally Available Ghrelin Receptor Antagonists for the Treatment of Diabetes and Obesity
Rudolph, Joachim, Esler, William P, O'Connor, Stephen, Coish, Philip D. G, Wickens, Philip L, Brands, Michael, Bierer, Donald E, Bloomquist, Brian T, Bondar, Georgiy, Chen, Libing, Chuang, Chih-Yuan, Claus, Thomas H, Fathi, Zahra, Fu, Wenlang, Khire, Uday R, Kristie, James A, Liu, Xiao-Gao, Lowe, Derek B, McClure, Andrea C, Michels, Martin, Ortiz, Astrid A, Ramsden, Philip D, Schoenleber, Robert W, Shelekhin, Tatiana E, Vakalopoulos, Alexandros, Tang, Weifeng, Wang, Lei, Yi, Lin, Gardell, Stephen J, Livingston, James N, Sweet, Laurel J, Bullock, William H
Published in Journal of medicinal chemistry (18.10.2007)
Published in Journal of medicinal chemistry (18.10.2007)
Get full text
Journal Article
Deletion of Lysine 121 Creates a Temperature-sensitive Alteration in Insulin Binding by the Insulin Receptor (∗)
Liu, Ruichun, Zhu, Jian, Jospe, Nicholas, Furlanetto, Richard W., Bastian, William, Livingston, James N.
Published in The Journal of biological chemistry (06.01.1995)
Published in The Journal of biological chemistry (06.01.1995)
Get full text
Journal Article