Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity
Yu, Wensheng, Liu, Jian, Clausen, Dane, Yu, Younong, Duffy, Joseph L, Wang, Ming, Xu, Shouning, Deng, Lin, Suzuki, Takao, Chung, Christine C, Myers, Robert W, Klein, Daniel J, Fells, James I, Holloway, M. Katharine, Wu, Jin, Wu, Guoxin, Howell, Bonnie J, Barnard, Richard J. O, Kozlowski, Joseph
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Journal Article
Identification of free fatty acid receptor 2 agonists using virtual screening
Fells, James I., Ai, Xi, Weinglass, Adam, Feng, Wen, Lei, Ying, Finley, Michael, Hoveyda, Hamid R., Fraser, Graeme L., Machacek, Michelle
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
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Journal Article
Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/ Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo
HONGLU ZHANG, XIAOYU XU, PRESTWICH, Glenn D, GAJEWIAK, Joanna, TSUKAHARA, Ryoko, FUJIWARA, Yuko, LIU, Jianxiong, FELLS, James I, PERYGIN, Donna, PARRILL, Abby L, TIGYI, Gabor
Published in Cancer research (Chicago, Ill.) (01.07.2009)
Published in Cancer research (Chicago, Ill.) (01.07.2009)
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Journal Article
Unique Ligand Selectivity of the GPR92/LPA5 Lysophosphatidate Receptor Indicates Role in Human Platelet Activation
Williams, Jesica R., Khandoga, Anna L., Goyal, Pankaj, Fells, James I., Perygin, Donna H., Siess, Wolfgang, Parrill, Abby L., Tigyi, Gabor, Fujiwara, Yuko
Published in The Journal of biological chemistry (19.06.2009)
Published in The Journal of biological chemistry (19.06.2009)
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Journal Article
Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles
Sanders, John M, Beshore, Douglas C, Culberson, J Christopher, Fells, James I, Imbriglio, Jason E, Gunaydin, Hakan, Haidle, Andrew M, Labroli, Marc, Mattioni, Brian E, Sciammetta, Nunzio, Shipe, William D, Sheridan, Robert P, Suen, Linda M, Verras, Andreas, Walji, Abbas, Joshi, Elizabeth M, Bueters, Tjerk
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Journal Article
Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis
Gotoh, Mari, Fujiwara, Yuko, Yue, Junming, Liu, Jianxiong, Lee, SueChin, Fells, James, Uchiyama, Ayako, Murakami-Murofushi, Kimiko, Kennel, Stephen, Wall, Jonathan, Patil, Renukadevi, Gupte, Renuka, Balazs, Louisa, Miller, Duane D, Tigyi, Gabor J
Published in Biochemical Society transactions (01.02.2012)
Published in Biochemical Society transactions (01.02.2012)
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Journal Article
Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions
Kiss, Gyöngyi N, Fells, James I, Gupte, Renuka, Lee, Sue-Chin, Liu, Jianxiong, Nusser, Nóra, Lim, Keng G, Ray, Ramesh M, Lin, Fang-Tsyr, Parrill, Abby L, Sümegi, Balázs, Miller, Duane D, Tigyi, Gabor
Published in Molecular pharmacology (01.12.2012)
Published in Molecular pharmacology (01.12.2012)
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Journal Article
Workflows and performances in the ranking prediction of 2016 D3R Grand Challenge 2: lessons learned from a collaborative effort
Gao, Ying-Duo, Hu, Yuan, Crespo, Alejandro, Wang, Deping, Armacost, Kira A., Fells, James I., Fradera, Xavier, Wang, Hongwu, Wang, Huijun, Sherborne, Brad, Verras, Andreas, Peng, Zhengwei
Published in Journal of computer-aided molecular design (2018)
Published in Journal of computer-aided molecular design (2018)
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Journal Article
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface
Fells, James I, Lee, Sue Chin, Fujiwara, Yuko, Norman, Derek D, Lim, Keng Gat, Tsukahara, Ryoko, Liu, Jianxiong, Patil, Renukadevi, Miller, Duane D, Kirby, R Jason, Nelson, Sandra, Seibel, William, Papoian, Ruben, Parrill, Abby L, Baker, Daniel L, Bittman, Robert, Tigyi, Gabor
Published in Molecular pharmacology (01.09.2013)
Published in Molecular pharmacology (01.09.2013)
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Journal Article
Performance of multiple docking and refinement methods in the pose prediction D3R prospective Grand Challenge 2016
Fradera, Xavier, Verras, Andreas, Hu, Yuan, Wang, Deping, Wang, Hongwu, Fells, James I., Armacost, Kira A., Crespo, Alejandro, Sherborne, Brad, Wang, Huijun, Peng, Zhengwei, Gao, Ying-Duo
Published in Journal of computer-aided molecular design (2018)
Published in Journal of computer-aided molecular design (2018)
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Journal Article
Structural Determinants of the Transient Receptor Potential 1 (TRPV1) Channel Activation by Phospholipid Analogs
Morales-Lázaro, Sara L., Serrano-Flores, Barbara, Llorente, Itzel, Hernández-García, Enrique, González-Ramírez, Ricardo, Banerjee, Souvik, Miller, Duane, Gududuru, Veeresh, Fells, James, Norman, Derek, Tigyi, Gabor, Escalante-Alcalde, Diana, Rosenbaum, Tamara
Published in The Journal of biological chemistry (29.08.2014)
Published in The Journal of biological chemistry (29.08.2014)
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Journal Article
Mitigation of radiation injury by selective stimulation of the LPA(2) receptor
Kiss, Gyöngyi N, Lee, Sue-Chin, Fells, James I, Liu, Jianxiong, Valentine, William J, Fujiwara, Yuko, Thompson, Karin Emmons, Yates, Charles R, Sümegi, Balázs, Tigyi, Gabor
Published in Biochimica et biophysica acta (01.01.2013)
Published in Biochimica et biophysica acta (01.01.2013)
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Journal Article
Design and Synthesis of Sulfamoyl Benzoic Acid Analogues with Subnanomolar Agonist Activity Specific to the LPA2 Receptor
Patil, Renukadevi, Fells, James I, Szabó, Erzsébet, Lim, Keng G, Norman, Derek D, Balogh, Andrea, Patil, Shivaputra, Strobos, Jur, Miller, Duane D, Tigyi, Gábor J
Published in Journal of medicinal chemistry (28.08.2014)
Published in Journal of medicinal chemistry (28.08.2014)
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Journal Article
Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles: Miniperspective
Sanders, John M, Beshore, Douglas C, Culberson, J. Christopher, Fells, James I, Imbriglio, Jason E, Gunaydin, Hakan, Haidle, Andrew M, Labroli, Marc, Mattioni, Brian E, Sciammetta, Nunzio, Shipe, William D, Sheridan, Robert P, Suen, Linda M, Verras, Andreas, Walji, Abbas, Joshi, Elizabeth M, Bueters, Tjerk
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Journal Article
Structure-based drug design identifies novel LPA3 antagonists
FELLS, James I, TSUKAHARA, Ryoko, JIANXIONG LIU, TIGYI, Gabor, PARRILL, Abby L
Published in Bioorganic & medicinal chemistry (01.11.2009)
Published in Bioorganic & medicinal chemistry (01.11.2009)
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Journal Article
Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif
Fells, James I., Lee, Sue Chin, Norman, Derek D., Tsukahara, Ryoko, Kirby, Jason R., Nelson, Sandra, Seibel, William, Papoian, Ruben, Patil, Renukadevi, Miller, Duane D., Parrill, Abby L., Pham, Truc‐Chi, Baker, Daniel L., Bittman, Robert, Tigyi, Gabor
Published in The FEBS journal (01.02.2014)
Published in The FEBS journal (01.02.2014)
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Journal Article
Subtype-specific Residues Involved in Ligand Activation of the Endothelial Differentiation Gene Family Lysophosphatidic Acid Receptors
Valentine, William J., Fells, James I., Perygin, Donna H., Mujahid, Sana, Yokoyama, Kazuaki, Fujiwara, Yuko, Tsukahara, Ryoko, Van Brocklyn, James R., Parrill, Abby L., Tigyi, Gabor
Published in The Journal of biological chemistry (02.05.2008)
Published in The Journal of biological chemistry (02.05.2008)
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Journal Article
Mitigation of radiation injury by selective stimulation of the LPA2 receptor
Kiss, Gyöngyi N., Lee, Sue-Chin, Fells, James I., Liu, Jianxiong, Valentine, William J., Fujiwara, Yuko, Thompson, Karin Emmons, Yates, Charles R., Sümegi, Balázs, Tigyi, Gabor
Published in Biochimica et biophysica acta (01.01.2013)
Published in Biochimica et biophysica acta (01.01.2013)
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Journal Article
Identification of non-lipid LPA3 antagonists by virtual screening
FELLS, James I, TSUKAHARA, Ryoko, FUJIWARA, Yuko, JIANXIONG LIU, PERYGIN, Donna H, OSBORNE, Daniel A, TIGYI, Gabor, PARRILL, Abby L
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Journal Article
2D binary QSAR modeling of LPA3 receptor antagonism
Fells, James I, Tsukahara, Ryoko, Liu, Jianxiong, Tigyi, Gabor, Parrill, Abby L
Published in Journal of molecular graphics & modelling (01.06.2010)
Published in Journal of molecular graphics & modelling (01.06.2010)
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