Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration
Ryan, Sean K., Zelic, Matija, Han, Yingnan, Teeple, Erin, Chen, Luoman, Sadeghi, Mahdiar, Shankara, Srinivas, Guo, Lilu, Li, Cong, Pontarelli, Fabrizio, Jensen, Elizabeth H., Comer, Ashley L., Kumar, Dinesh, Zhang, Mindy, Gans, Joseph, Zhang, Bailin, Proto, Jonathan D., Saleh, Jacqueline, Dodge, James C., Savova, Virginia, Rajpal, Deepak, Ofengeim, Dimitry, Hammond, Timothy R.
Published in Nature neuroscience (01.01.2023)
Published in Nature neuroscience (01.01.2023)
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Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models
Sardi, S. Pablo, Viel, Catherine, Clarke, Jennifer, Treleaven, Christopher M., Richards, Amy M., Park, Hyejung, Olszewski, Maureen A., Dodge, James C., Marshall, John, Makino, Elina, Wang, Bing, Sidman, Richard L., Cheng, Seng H., Shihabuddin, Lamya S.
Published in Proceedings of the National Academy of Sciences - PNAS (07.03.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (07.03.2017)
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Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies
Sardi, S. Pablo, Clarke, Jennifer, Viel, Catherine, Chan, Monyrath, Tamsett, Thomas J., Treleaven, Christopher M., Bu, Jie, Sweet, Lindsay, Passini, Marco A., Dodge, James C., Yu, W. Haung, Sidman, Richard L., Cheng, Seng H., Shihabuddin, Lamya S.
Published in Proceedings of the National Academy of Sciences - PNAS (26.02.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (26.02.2013)
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Journal Article
Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis
Dodge, James C, Christopher M. Treleaven, Joshua Pacheco, Samantha Cooper, Channa Bao, Marissa Abraham, Mandy Cromwell, S. Pablo Sardi, Wei-Lien Chuang, Richard L. Sidman, Seng H. Cheng, Lamya S. Shihabuddin
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2015)
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Journal Article
Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral Sclerosis
Dodge, James C, Jensen, Elizabeth H, Yu, Jinlong, Sardi, S Pablo, Bialas, Allison R, Taksir, Tatyana V, Bangari, Dinesh S, Shihabuddin, Lamya S
Published in The Journal of neuroscience (18.11.2020)
Published in The Journal of neuroscience (18.11.2020)
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Artificial axons as a biomimetic 3D myelination platform for the discovery and validation of promyelinating compounds
Jagielska, Anna, Radzwill, Kristin, Espinosa-Hoyos, Daniela, Yang, Mingyu, Kowsari, Kavin, Farley, Jonathan E., Giera, Stefanie, Byrne, Ann, Sheng, Guoqing, Fang, Nicholas X., Dodge, James C., Pedraza, Carlos E., Van Vliet, Krystyn J.
Published in Scientific reports (09.11.2023)
Published in Scientific reports (09.11.2023)
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Metabolic signatures of amyotrophic lateral sclerosis reveal insights into disease pathogenesis
Dodge, James C., Treleaven, Christopher M., Fidler, Jonathan A., Tamsett, Thomas J., Bao, Channa, Searles, Michelle, Taksir, Tatyana V., Misra, Kuma, Sidman, Richard L., Cheng, Seng H., Shihabuddin, Lamya S.
Published in Proceedings of the National Academy of Sciences - PNAS (25.06.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (25.06.2013)
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Journal Article
Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease
Rockenstein, Edward, Clarke, Jennifer, Viel, Catherine, Panarello, Nicholas, Treleaven, Christopher M, Kim, Changyoun, Spencer, Brian, Adame, Anthony, Park, Hyejung, Dodge, James C, Cheng, Seng H, Shihabuddin, Lamya S, Masliah, E, Sardi, S Pablo
Published in Human molecular genetics (01.07.2016)
Published in Human molecular genetics (01.07.2016)
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Journal Article
AAV4-mediated Expression of IGF-1 and VEGF Within Cellular Components of the Ventricular System Improves Survival Outcome in Familial ALS Mice
Dodge, James C, Treleaven, Christopher M, Fidler, Jonathan A, Hester, Mark, Haidet, Amanda, Handy, Chalonda, Rao, Meghan, Eagle, Amy, Matthews, Jennifer C, Taksir, Tatyana V, Cheng, Seng H, Shihabuddin, Lamya S, Kaspar, Brian K
Published in Molecular therapy (01.12.2010)
Published in Molecular therapy (01.12.2010)
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Journal Article
Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer's disease
Dodge, James C, Tamsett, Thomas J, Treleaven, Christopher M, Taksir, Tatyana V, Piepenhagen, Peter, Sardi, S Pablo, Cheng, Seng H, Shihabuddin, Lamya S
Published in Alzheimer's research & therapy (01.02.2022)
Published in Alzheimer's research & therapy (01.02.2022)
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Journal Article
Intraventricular Enzyme Replacement Improves Disease Phenotypes in a Mouse Model of Late Infantile Neuronal Ceroid Lipofuscinosis
Chang, Michael, Cooper, Jonathan D, Sleat, David E, Cheng, Seng H, Dodge, James C, Passini, Marco A, Lobel, Peter, Davidson, Beverly L
Published in Molecular therapy (01.04.2008)
Published in Molecular therapy (01.04.2008)
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Systemic Administration of a Recombinant AAV1 Vector Encoding IGF-1 Improves Disease Manifestations in SMA Mice
Tsai, Li-Kai, Chen, Chien-Lin, Ting, Chen-Hung, Lin-Chao, Sue, Hwu, Wuh-Liang, Dodge, James C, Passini, Marco A, Cheng, Seng H
Published in Molecular therapy (01.08.2014)
Published in Molecular therapy (01.08.2014)
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Journal Article
Delivery of AAV-IGF-1 to the CNS Extends Survival in ALS Mice Through Modification of Aberrant Glial Cell Activity
Dodge, James C, Haidet, Amanda M, Yang, Wendy, Passini, Marco A, Hester, Mark, Clarke, Jennifer, Roskelley, Eric M, Treleaven, Christopher M, Rizo, Liza, Martin, Heather, Kim, Soo H, Kaspar, Rita, Taksir, Tatyana V, Griffiths, Denise A, Cheng, Seng H, Shihabuddin, Lamya S, Kaspar, Brian K
Published in Molecular therapy (01.06.2008)
Published in Molecular therapy (01.06.2008)
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High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells
Li, Weifeng, Berlinicke, Cynthia, Huang, Yinyin, Giera, Stefanie, McGrath, Anna G., Fang, Weixiang, Chen, Chaoran, Takaesu, Felipe, Chang, Xiaoli, Duan, Yukan, Kumar, Dinesh, Chang, Calvin, Mao, Hai-Quan, Sheng, Guoqing, Dodge, James C., Ji, Hongkai, Madden, Stephen, Zack, Donald J., Chamling, Xitiz
Published in iScience (17.03.2023)
Published in iScience (17.03.2023)
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Journal Article
IGF-1 delivery to CNS attenuates motor neuron cell death but does not improve motor function in type III SMA mice
Tsai, Li-Kai, Chen, Yi-Chun, Cheng, Wei-Cheng, Ting, Chen-Hung, Dodge, James C, Hwu, Wuh-Liang, Cheng, Seng H, Passini, Marco A
Published in Neurobiology of disease (01.01.2012)
Published in Neurobiology of disease (01.01.2012)
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Journal Article
Merits of Combination Cortical, Subcortical, and Cerebellar Injections for the Treatment of Niemann-Pick Disease Type A
Bu, Jie, Ashe, Karen M, Bringas, John, Marshall, John, Dodge, James C, Cabrera-Salazar, Mario A, Forsayeth, John, Schuchman, Edward H, Bankiewicz, Krystof S, Cheng, Seng H, Shihabuddin, Lamya S., Passini, Marco A
Published in Molecular therapy (01.10.2012)
Published in Molecular therapy (01.10.2012)
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Journal Article
Intracerebroventricular infusion of acid sphingomyelinase corrects CNS manifestations in a mouse model of Niemann–Pick A disease
Dodge, James C., Clarke, Jennifer, Treleaven, Christopher M., Taksir, Tatyana V., Griffiths, Denise A., Yang, Wendy, Fidler, Jonathan A., Passini, Marco A., Karey, Kenneth P., Schuchman, Edward H., Cheng, Seng H., Shihabuddin, Lamya S.
Published in Experimental neurology (01.02.2009)
Published in Experimental neurology (01.02.2009)
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Journal Article
Relationship between neuropathology and disease progression in the SOD1(G93A) ALS mouse
Yang, Wendy W, Sidman, Richard L, Taksir, Tatyana V, Treleaven, Christopher M, Fidler, Jonathan A, Cheng, Seng H, Dodge, James C, Shihabuddin, Lamya S
Published in Experimental neurology (01.02.2011)
Published in Experimental neurology (01.02.2011)
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