Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir
Belema, Makonen, Nguyen, Van N., Bachand, Carol, Deon, Dan H., Goodrich, Jason T., James, Clint A., Lavoie, Rico, Lopez, Omar D., Martel, Alain, Romine, Jeffrey L., Ruediger, Edward H., Snyder, Lawrence B., Laurent, Denis R. St, Yang, Fukang, Zhu, Juliang, Wong, Henry S., Langley, David R., Adams, Stephen P., Cantor, Glenn H., Chimalakonda, Anjaneya, Fura, Aberra, Johnson, Benjamin M., Knipe, Jay O., Parker, Dawn D., Santone, Kenneth S., Fridell, Robert A., Lemm, Julie A., O’Boyle, Donald R., Colonno, Richard J., Gao, Min, Meanwell, Nicholas A., Hamann, Lawrence G.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Combined Directed ortho and Remote Metalation−Suzuki Cross-Coupling Strategies. Efficient Synthesis of Heteroaryl-Fused Benzopyranones from Biaryl O-Carbamates
James, Clint A, Coelho, Antonio Luiz, Gevaert, Matt, Forgione, Pat, Snieckus, Victor
Published in Journal of organic chemistry (05.06.2009)
Published in Journal of organic chemistry (05.06.2009)
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Nucleotide competing reverse transcriptase inhibitors: Discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors
James, Clint A., DeRoy, Patrick, Duplessis, Martin, Edwards, Paul J., Halmos, Teddy, Minville, Joannie, Morency, Louis, Morin, Sébastien, Simoneau, Bruno, Tremblay, Martin, Bethell, Richard, Cordingley, Michael, Duan, Jianmin, Lamorte, Louie, Pelletier, Alex, Rajotte, Daniel, Salois, Patrick, Tremblay, Sonia, Sturino, Claudio F.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors
Tremblay, Martin, Bethell, Richard C., Cordingley, Michael G., DeRoy, Patrick, Duan, Jianmin, Duplessis, Martin, Edwards, Paul J., Faucher, Anne-Marie, Halmos, Ted, James, Clint A., Kuhn, Cyrille, Lacoste, Jean-Éric, Lamorte, Louie, LaPlante, Steven R., Malenfant, Éric, Minville, Joannie, Morency, Louis, Morin, Sébastien, Rajotte, Daniel, Salois, Patrick, Simoneau, Bruno, Tremblay, Sonia, Sturino, Claudio F.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: In vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors
Sturino, Claudio F., Bousquet, Yves, James, Clint A., DeRoy, Patrick, Duplessis, Martin, Edwards, Paul J., Halmos, Ted, Minville, Joannie, Morency, Louis, Morin, Sébastien, Thavonekham, Bounkham, Tremblay, Martin, Duan, Jianmin, Ribadeneira, Maria, Garneau, Michel, Pelletier, Alex, Tremblay, Sonia, Lamorte, Louie, Bethell, Richard, Cordingley, Michael G., Rajotte, Daniel, Simoneau, Bruno
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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2-Arylaminothiazoles as high-affinity corticotropin-Releasing factor 1 receptor (CRF 1R) antagonists: synthesis, binding studies and behavioral efficacy
Dubowchik, Gene M., Michne, Jodi A., Zuev, Dmitry, Schwartz, Wendy, Scola, Paul M., James, Clint A., Ruediger, Edward H., Pin, Sokhom S., Burris, Kevin D., Balanda, Lynn A., Gao, Qi, Wu, Dedong, Fung, Lawrence, Fiedler, Tracey, Browman, Kaitlin E., Taber, Matthew T., Zhang, Jie
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, ST LAURENT DENIS R, GOODRICH JASON, BELEMA MAKONEN, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN
Year of Publication 01.10.2015
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Year of Publication 01.10.2015
Patent
HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, GOODRICH JASON, BELEMA MAKONEN, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN, ST. LAURENT DENIS R
Year of Publication 02.06.2014
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Year of Publication 02.06.2014
Patent
HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, GOODRICH JASON, BELEMA MAKONEN, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN, ST. LAURENT DENIS R
Year of Publication 26.11.2010
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Year of Publication 26.11.2010
Patent
HETEROCYCLIC DERIVATIVES AS HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, GOODRICH JASON, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, MAKONEN BELEMA, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN, ST. LAURENT DENIS R
Year of Publication 24.11.2010
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Year of Publication 24.11.2010
Patent
CONFORMATIONALLY RESTRICTED BIPHENYL DERIVATIVES FOR USE AS HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, GOODRICH JASON, BELEMA MAKONEN, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN, ST. LAURENT DENIS R
Year of Publication 18.11.2010
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Year of Publication 18.11.2010
Patent
HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, GOODRICH JASON, BELEMA MAKONEN, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN, ST. LAURENT DENIS R
Year of Publication 26.10.2010
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Year of Publication 26.10.2010
Patent
IMIDAZOLYL BIPHENYL IMIDAZOLES AS HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, GOODRICH JASON, BELEMA MAKONEN, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN, ST. LAURENT DENIS R
Year of Publication 21.10.2010
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Year of Publication 21.10.2010
Patent
General synthesis of tetrasubstituted alkenyl-1,3,4-oxadiazoles
James, Clint A., Poirier, Brigitte, Grisé, Christiane, Martel, Alain, Ruediger, Edward H.
Published in Tetrahedron letters (23.01.2006)
Published in Tetrahedron letters (23.01.2006)
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