Discovery of a Potential Allosteric Ligand Binding Site in CDK2
Betzi, Stephane, Alam, Riazul, Martin, Mathew, Lubbers, Donna J, Han, Huijong, Jakkaraj, Sudhakar R, Georg, Gunda I, Schönbrunn, Ernst
Published in ACS chemical biology (20.05.2011)
Published in ACS chemical biology (20.05.2011)
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Journal Article
The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease
Sundar, Shirin V, Zhou, Julie Xia, Magenheimer, Brenda S, Reif, Gail A, Wallace, Darren P, Georg, Gunda I, Jakkaraj, Sudhakar R, Tash, Joseph S, Yu, Alan S L, Li, Xiaogang, Calvet, James P
Published in American journal of physiology. Renal physiology (01.10.2022)
Published in American journal of physiology. Renal physiology (01.10.2022)
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Journal Article
N -Butyldeoxygalactonojirimycin Induces Reversible Infertility in Male CD Rats
Gupta, Vijayalaxmi, Hild, Sheri A, Jakkaraj, Sudhakar R, Carlson, Erick J, Wong, Henry L, Allen, C. Leigh, Georg, Gunda I, Tash, Joseph S
Published in International journal of molecular sciences (31.12.2019)
Published in International journal of molecular sciences (31.12.2019)
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Journal Article
Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases
Schonbrunn, Ernst, Betzi, Stephane, Alam, Riazul, Martin, Mathew P, Becker, Andreas, Han, Huijong, Francis, Rawle, Chakrasali, Ramappa, Jakkaraj, Sudhakar, Kazi, Aslamuzzaman, Sebti, Said M, Cubitt, Christopher L, Gebhard, Anthony W, Hazlehurst, Lori A, Tash, Joseph S, Georg, Gunda I
Published in Journal of medicinal chemistry (23.05.2013)
Published in Journal of medicinal chemistry (23.05.2013)
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Journal Article
Novel Potent Indazole Carboxylic Acid Derivative Blocks Spermatogenesis and Is Contraceptive in Rats after a Single Oral Dose
Tash, Joseph S, Attardi, Barbara, Hild, Sheri A, Chakrasali, Ramappa, Jakkaraj, Sudhakar R, Georg, Gunda I
Published in Biology of reproduction (01.06.2008)
Published in Biology of reproduction (01.06.2008)
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Journal Article
Gamendazole, an Orally Active Indazole Carboxylic Acid Male Contraceptive Agent, Targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and Stimulates Il1a Transcription in Rat Sertoli Cells
Tash, Joseph S, Chakrasali, Ramappa, Jakkaraj, Sudhakar R, Hughes, Jennifer, Smith, S. Kendall, Hornbaker, Kaori, Heckert, Leslie L, Ozturk, Sedide B, Hadden, M. Kyle, Kinzy, Terri Goss, Blagg, Brian S.J, Georg, Gunda I
Published in Biology of reproduction (01.06.2008)
Published in Biology of reproduction (01.06.2008)
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Journal Article
Scalable syntheses of the BET bromodomain inhibitor JQ1
Syeda, Shameem Sultana, Jakkaraj, Sudhakar, Georg, Gunda I.
Published in Tetrahedron letters (03.06.2015)
Published in Tetrahedron letters (03.06.2015)
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Journal Article
Effect of H2-Gamendazole and Other Indazole Carboxylic Acid (ICA) Analogs on Primary Rat Sertoli Cells Cytoskeletal Structure and Elongation Factor 1 Alpha (EEF1A1) Expression and Function
Holets, Lesya M., Cottita, Julie, Jakkaraj, Sudhakar, Chakrasali, Ramappa, Kinzy, Terri, Georg, Gunda, Tash, Joseph
Published in Biology of reproduction (01.07.2011)
Published in Biology of reproduction (01.07.2011)
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Journal Article
In Vitro Versus In Vivo Effects of NB-DGJ and NB-DNJ as Lead Compounds for Development of Non-Hormonal Reversible Oral Male Contraceptives
Gupta, Vijayalaxmi G., Hild, Sheri, Jakkaraj, Sudhakar, Georg, Gunda I., Tash, Joseph S.
Published in Biology of reproduction (01.11.2010)
Published in Biology of reproduction (01.11.2010)
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Journal Article
KU-AS-272, a Potential Single-Dose Sterilant for Cats and Dogs, Shows Safety and Ability to Block Spermatogenesis in Testis to Sertoli Cells Only after a Single Subcutaneous Injection in Male Rat
Gupta, Vijayalaxmi G., Roby, Katherine F., Kern, Brian, Hall, Todd, Jakkaraj, Sudhakar, Chakrasali, Ramappa, Georg, Gunda I., Broward, Melinda, Wood, Robyn, Weir, Scott, Tash, Joseph S.
Published in Biology of reproduction (01.08.2012)
Published in Biology of reproduction (01.08.2012)
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Journal Article
Anti-Spermatogenic Efficacy of Nonhormonal Male Contraceptive Agent, H2-Gamendazole, in Mice, Rats, Rabbits, and Nonhuman Primates (Rhesus), and a Multiple Low Dose Oral Regimen That Gives 100% Infertility with Complete Reversibility
Gupta, Vijayalaxmi G., Zelinski, Mary, Steinmetz, Karen, Miklos, Andras, Broward, Melinda, Jakkaraj, Sudhakar, Chakrasali, Ramappa, Georg, Gunda I., Tash, Joseph S.
Published in Biology of reproduction (01.07.2011)
Published in Biology of reproduction (01.07.2011)
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Journal Article
A Novel Potent Indazole Carboxylic Acid Derivative Blocks Spermatogenesis and Is Contraceptive in Rats after a Single Oral Dose1
Tash, Joseph S., Attardi, Barbara, Hild, Sheri A., Chakrasali, Ramappa, Jakkaraj, Sudhakar R., Georg, Gunda I.
Published in Biology of reproduction (01.06.2008)
Published in Biology of reproduction (01.06.2008)
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Journal Article
Exploiting the Potential of Iminosugars as Novel Reversible Non-Hormonal Male Contraceptive
Gupta, Vijayalaxmi G., Jakkaraj, Sudhakar, Georg, Gunda I., Tash, Joseph S.
Published in Biology of reproduction (01.05.2008)
Published in Biology of reproduction (01.05.2008)
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Journal Article
The Candidate Male Contraceptive Agent, Gamendazole, Affects Actin Organization and Vinculin Based Focal Contact Distribution in Sertoli Cells In Vitro
Cotitta, Jeffrey, Ozturk, Sedide, Kinzy, Terri, Jakkaraj, Sudhakar, Chakrasali, Ramappa, Gross, Stephane, Georg, Gunda, Tash, Joseph
Published in Biology of reproduction (01.05.2008)
Published in Biology of reproduction (01.05.2008)
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Journal Article
LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT
CHAKRASALI RAMAPPA, JAKKARAJ SUDHAKAR RAO, GEORG INGRID GUNDA, ROBY KATHERINE, TASH JOSEPH S
Year of Publication 10.06.2014
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Year of Publication 10.06.2014
Patent
LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT
CHAKRASALI RAMAPPA, JAKKARAJ SUDHAKAR RAO, GEORG INGRID GUNDA, ROBY KATHERINE, TASH JOSEPH S
Year of Publication 28.06.2012
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Year of Publication 28.06.2012
Patent
Gamendazole, an Orally Active Indazole Carboxylic Acid Male Contraceptive Agent, Targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and Stimulates Il1a Transcription in Rat Sertoli Cells1
Tash, Joseph S., Chakrasali, Ramappa, Jakkaraj, Sudhakar R., Hughes, Jennifer, Smith, S. Kendall, Hornbaker, Kaori, Heckert, Leslie L., Ozturk, Sedide B., Hadden, M. Kyle, Kinzy, Terri Goss, Blagg, Brian S.J., Georg, Gunda I.
Published in Biology of reproduction (01.06.2008)
Published in Biology of reproduction (01.06.2008)
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Journal Article
THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF
JAKKARAJ, Sudhakar, CHERYALA, Narsihmulu, GEORG, Gunda Ingrid, DUDLEY, Samuel
Year of Publication 27.04.2023
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Year of Publication 27.04.2023
Patent