Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron‑2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA)
Cheung, Atwood K, Hurley, Brian, Kerrigan, Ryan, Shu, Lei, Chin, Donovan N, Shen, Yiping, O’Brien, Gary, Sung, Moo Je, Hou, Ying, Axford, Jake, Cody, Emma, Sun, Robert, Fazal, Aleem, Tomlinson, Ronald C, Jain, Monish, Deng, Lin, Hoffmaster, Keith, Song, Cheng, Van Hoosear, Mailin, Shin, Youngah, Servais, Rebecca, Towler, Christopher, Hild, Marc, Curtis, Daniel, Dietrich, William F, Hamann, Lawrence G, Briner, Karin, Chen, Karen S, Kobayashi, Dione, Sivasankaran, Rajeev, Dales, Natalie A
Published in Journal of medicinal chemistry (27.12.2018)
Published in Journal of medicinal chemistry (27.12.2018)
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Journal Article
Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines
Hunt, Thomas, Atherton-Watson, Hazel C., Axford, Jake, Collingwood, Stephen P., Coote, Kevin J., Cox, Brian, Czarnecki, Sarah, Danahay, Henry, Devereux, Nick, Howsham, Catherine, Hunt, Peter, Paddock, Victoria, Paisley, Derek, Young, Alice
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Journal Article
Use of Intramolecular 1,5-Sulfur–Oxygen and 1,5-Sulfur–Halogen Interactions in the Design of N‑Methyl-5-aryl‑N‑(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine SMN2 Splicing Modulators
Axford, Jake, Sung, Moo Je, Manchester, John, Chin, Donovan, Jain, Monish, Shin, Youngah, Dix, Ina, Hamann, Lawrence G, Cheung, Atwood K, Sivasankaran, Rajeev, Briner, Karin, Dales, Natalie A, Hurley, Brian
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Journal Article
Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors
Regard, Jean B., Harrison, Tyler J., Axford, Jake, Axford, Laura, Lee, Lac, Ren, Xianglin, Deng, Lin, Reynolds, Aimee, Mao, Justin, Liu, Qian, Patnaik, Anup, Cohick, Evan, Hollis-Symynkywicz, Micah, Loi, Sally, Riek, Simone, McKeever, Una, Dunstan, David, Sung, MooJe, Ware, Nathaniel F., Brown, Alan P., Hamann, Lawrence G., Marcinkeviciene, Jovita, Patterson, Andrew W., Marro, Martin L.
Published in Biochemical pharmacology (01.03.2023)
Published in Biochemical pharmacology (01.03.2023)
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Journal Article
Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase
Hoegenauer, Klemens, An, Shaojian, Axford, Jake, Benander, Christina, Bergsdorf, Christian, Botsch, Josephine, Chau, Suzanne, Fernández, César, Gleim, Scott, Hassiepen, Ulrich, Hunziker, Juerg, Joly, Emilie, Keller, Aramis, Lopez Romero, Sandra, Maher, Robert, Mangold, Anne-Sophie, Mickanin, Craig, Mihalic, Manuel, Neuner, Philippe, Patterson, Andrew W., Perruccio, Francesca, Roggo, Silvio, Scesa, Julien, Schröder, Martin, Shkoza, Dojna, Thai, Binh, Vulpetti, Anna, Renatus, Martin, Reece-Hoyes, John S.
Published in ACS medicinal chemistry letters (14.12.2023)
Published in ACS medicinal chemistry letters (14.12.2023)
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Journal Article
TECHNOLOGIES TARGETING CELL STATES
AXFORD, Jake Charles, MILLAN, David Simon, MCRINER, Andrew John, NEEF, James Anthony
Year of Publication 24.10.2024
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Year of Publication 24.10.2024
Patent
Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease
SMITH, Nichola, SHEN, Yiping, STANLEY, Emily, ADCOCK, Claire, KIM, Hyungchul, WHITEHEAD, Lewis, MAZZACANI, Alessandro, SOLOVAY, Catherine Fooks, LIGHTFOOT, Megan, AXFORD, Jake, HOU, Ying, SUNG, Moo Je
Year of Publication 23.11.2023
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Year of Publication 23.11.2023
Patent
SUBSTITUTED 1,3-PHENYL HETEROARYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
SMITH, Nichola, SHEN, Yiping, STANLEY, Emily, ADCOCK, Claire, KIM, Hyungchul, WHITEHEAD, Lewis, MAZZACANI, Alessandro, SOLOVAY, Catherine Fooks, LIGHTFOOT, Megan, AXFORD, Jake, HOU, Ying, SUNG, Moo Je
Year of Publication 29.09.2022
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Year of Publication 29.09.2022
Patent
SUBSTITUTED 1,3-PHENYL HETEROARYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
SMITH, Nichola, SHEN, Yiping, STANLEY, Emily, ADCOCK, Claire, KIM, Hyungchul, WHITEHEAD, Lewis, MAZZACANI, Alessandro, SOLOVAY, Catherine Fooks, LIGHTFOOT, Megan, AXFORD, Jake, HOU, Ying, SUNG, Moo Je
Year of Publication 06.07.2022
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Year of Publication 06.07.2022
Patent