Defining and Combating the Mechanisms of Triclosan Resistance in Clinical Isolates of Staphylococcus aureus
FAN, Frank, KANG YAN, SEEFELD, Mark A, NEWLANDER, Kenneth A, JAKAS, Dalia R, HEAD, Martha S, PAYNE, David J, WALLIS, Nicola G, REED, Shannon, MOORE, Terrance D, RITTENHOUSE, Stephen F, DEWOLF, Walter E, JIANZHONG HUANG, MCDEVITT, Damien, MILLER, William H
Published in Antimicrobial Agents and Chemotherapy (01.11.2002)
Published in Antimicrobial Agents and Chemotherapy (01.11.2002)
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Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity
Kingsbury, William D, Boehm, Jeffrey C, Jakas, Dalia R, Holden, Kenneth G, Hecht, Sidney M, Gallagher, Gregory, Caranfa, Mary Jo, McCabe, Francis L, Faucette, Leo F, Johnson, Randall K, Hertzberg, Robert P
Published in Journal of medicinal chemistry (01.01.1991)
Published in Journal of medicinal chemistry (01.01.1991)
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Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK
Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, DeWolf, Walter E, Elkins, Patricia A, Head, Martha S, Jakas, Dalia R, Janson, Cheryl A, Keller, Paul M, Manley, Peter J, Moore, Terrance D, Payne, David J, Pearson, Stewart, Polizzi, Brian J, Qiu, Xiayang, Rittenhouse, Stephen F, Uzinskas, Irene N, Wallis, Nicola G, Huffman, William F
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Published in Journal of medicinal chemistry (24.04.2003)
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(E)-3-[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic Acid and Related Compounds: High Affinity Leukotriene B4 Receptor Antagonists
Daines, Robert A, Chambers, Pamela A, Eggleston, Drake S, Foley, James J, Griswold, Don E, Haltiwanger, R. Curtis, Jakas, Dalia R, Kingsbury, William D, Martin, Lenox D
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
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Preclinical Pharmacokinetics and Interspecies Scaling of a Novel Vitronectin Receptor Antagonist
WARD, K. W, AZZARANO, L. M, MUMAW, J. A, NEWLANDER, K. A, PIRHALLA, J. L, ROETHKE, T. J, SALYERS, K. L, SOUDER, P. R, STELMAN, G. J, SMITH, B. R, BONDINELL, W. E, COUSINS, R. D, HUFFMAN, W. F, JAKAS, D. R, KEENAN, R. M, KU, T. W, LUNDBERG, D, MILLER, W. H
Published in Drug metabolism and disposition (01.11.1999)
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Published in Drug metabolism and disposition (01.11.1999)
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The use of rabbit intestinal permeability as an in vitro assay in the search for orally active GPIIb/IIIa antagonists
Samanen, James M., Lee, Chao-Pin, Smith, Philip L., Bondinell, William E., Calvo, Raul R., Jakas, Dalia R., Newlander, Kenneth A., Parker, Michael, Uzinskas, Irene, Yellin, Tobias O., Nichols, Andrew J.
Published in Advanced drug delivery reviews (15.01.1997)
Published in Advanced drug delivery reviews (15.01.1997)
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Trisubstituted pyridine leukotriene B4 receptor antagonists: synthesis and structure-activity relationships
Daines, Robert A, Chambers, Pamela A, Pendrak, Israil, Jakas, Dalia R, Sarau, Henry M, Foley, James J, Schmidt, Dulcie B, Kingsbury, William D
Published in Journal of medicinal chemistry (01.10.1993)
Published in Journal of medicinal chemistry (01.10.1993)
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(E)-3-[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic acid: a novel high-affinity leukotriene B4 receptor antagonist
Daines, Robert A, Chambers, Pamela A, Pendrak, Israil, Jakas, Dalia R, Sarau, Henry M, Foley, James J, Schmidt, Dulcie B, Griswold, Don E, Martin, Lenox D
Published in Journal of medicinal chemistry (01.09.1993)
Published in Journal of medicinal chemistry (01.09.1993)
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Modification of the hydroxylactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity
Hertzberg, Robert P, Caranfa, Mary Jo, Holden, Kenneth G, Jakas, Dalia R, Gallagher, Gregory, Mattern, Michael R, Mong, Shau Ming, Bartus, Joan O'Leary, Johnson, Randall K, Kingsbury, William D
Published in Journal of medicinal chemistry (01.03.1989)
Published in Journal of medicinal chemistry (01.03.1989)
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Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists
Keenan, Richard M, Callahan, James F, Samanen, James M, Bondinell, William E, Calvo, Raul R, Chen, Lichong, DeBrosse, Charles, Eggleston, Drake S, Haltiwanger, R. Curtis, Hwang, Shing Mei, Jakas, Dalia R, Ku, Thomas W, Miller, William H, Newlander, Kenneth A, Nichols, Andrew, Parker, Michael F, Southhall, Linda S, Uzinskas, Irene, Vasko-Moser, Janice A, Venslavsky, Joseph W, Wong, Angela S, Huffman, William F
Published in Journal of medicinal chemistry (25.02.1999)
Published in Journal of medicinal chemistry (25.02.1999)
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Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity
HERTZBERG, R. P, CARANFA, M. J, HOLDEN, K. G, JAKAS, D. R, GALLAGHER, G, MATTERN, M. R, SHAU-MING MONG, OLEARY BARTUS, J, JOHNSON, R. K, KINGSBURY, W. D
Published in Journal of medicinal chemistry (01.03.1989)
Published in Journal of medicinal chemistry (01.03.1989)
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Direct design of a potent non-peptide fibrinogen receptor antagonist based on the structure and conformation of a highly constrained cyclic RGD peptide
Ku, Thomas W, Ali, Fadia E, Barton, Linda S, Bean, John W, Bondinell, William E, Burgess, Joelle L, Callahan, James F, Calvo, Raul R, Chen, Lichong
Published in Journal of the American Chemical Society (01.09.1993)
Published in Journal of the American Chemical Society (01.09.1993)
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Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model
Miller, William H., Bondinell, William E., Cousins, Russell D., Erhard, Karl F., Jakas, Dalia R., Keenan, Richard M., Ku, Thomas W., Newlander, Kenneth A., Ross, Stephen T., Haltiwanger, R.Curtis, Bradbeer, Jeremy, Drake, Fred H., Gowen, Maxine, Hoffman, Sandra J., Hwang, Shing-Mei, James, Ian E., Lark, Michael W., Lechowska, Beata, Rieman, David J., Stroup, George B., Vasko-Moser, Janice A., Zembryki, Denise L., Azzarano, Leonard M., Adams, Paula C., Salyers, Kevin L., Smith, Brian R., Ward, Keith W., Johanson, Kyung O., Huffaman, William F.
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
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Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonists
Keenan, Richard M., Miller, William H., Lago, M.Amparo, Ali, Fadia E., Bondinell, William E., Callahan, James F., Calvo, Raul R., Cousins, Russell D., Hwang, Shing-Mei, Jakas, Dalia R., Ku, Thomas W., Kwon, Chet, Nguyen, Thomas T., Reader, Valerie A., Rieman, David J., Ross, Steven T., Takata, Dennis T., Uzinskas, Irene N., Yuan, Catherine C.K., Smith, Brian R.
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
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Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonist with efficacy in a restenosis model
Keenan, Richard M., Lago, M.Amparo, Miller, William H., Ali, Fadia E., Cousins, Russell D., Hall, Leon B., Hwang, Shing-Mei, Jakas, Dalia R., Kwon, Chet, Louden, Calvert, Nguyen, Thomas T., Ohlstein, Eliot H., Rieman, David J., Ross, Steven T., Samanen, James M., Smith, Brian R., Stadel, Jeffrey, Takata, Dennis T., Vickery, Lynne, Yuan, Catherine C.K., Yue, Tian-Li
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
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DEWOLF WALTER E.JR, JAKAS DALIA R, NEWLANDER KENNETH A, MILLER WILLIAM H, SEEFELD MARK A, UZINSKAS IRENE N
Year of Publication 28.05.2015
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Year of Publication 28.05.2015
Patent
Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist
Bondinell, William E., Keenan, Richard M., Miller, William H., Ali, Fadia E., Allen, Andrew C., De Brosse, Charles W., Eggleston, Drake S., Erhard, Karl F., Haltiwanger, R.Curtis, Huffman, William F., Hwang, Shing-Mei, Jakas, Dalia R., Koster, Paul F., Ku, Thomas W., Lee, Chao Pin, Nichols, Andrew J., Ross, Stephen T., Samanen, James M., Valocik, Richard E., Vasko-Moser, Janice A., Venslavsky, Joseph W., Wong, Angela S., Yuan, Chuan-Kui
Published in Bioorganic & medicinal chemistry (01.09.1994)
Published in Bioorganic & medicinal chemistry (01.09.1994)
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Additions and Corrections - (E)-3-[[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octy-1]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic Acid: A Novel High-Affinity Leukotriene B 4 Receptor Antagonist
Daines, Robert, Chambers, Pamela, Pendrak, Israil, Jakas, Dalia, Sarau, Henry, Foley, James, Schmidt, Dulcie, Griswold, Don, Martin, Lenox, Tzimas, Maritsa, Kingsbury, William
Published in Journal of medicinal chemistry (01.12.1993)
Published in Journal of medicinal chemistry (01.12.1993)
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Journal Article
Additions and Corrections - (E)-3-[[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octy-1]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic Acid: A Novel High-Affinity Leukotriene B4 Receptor Antagonist
Daines, Robert, Chambers, Pamela, Pendrak, Israil, Jakas, Dalia, Sarau, Henry, Foley, James, Schmidt, Dulcie, Griswold, Don, Martin, Lenox, Tzimas, Maritsa, Kingsbury, William
Published in Journal of medicinal chemistry (01.12.1993)
Published in Journal of medicinal chemistry (01.12.1993)
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Structure-activity relationships in 3-oxo-1,4-benzodiazepine-2-acetic acid GPIIb/IIIa antagonists. The 2-benzazepine series
Miller, William H., Ali, Fadia E., Bondinell, William E., Callahan, James F., Calvo, Raul R., Eggleston, Drake S., Curtis Haltiwanger, R., Huffman, William F., Hwang, Shing-Mei, Jakas, Dalia R., Keenan, Richard M., Koster, Paul F., Ku, Thomas W., Kwon, Chet, Newlander, Kenneth A., Nichols, Andrew J., Parker, Michael F., Samanen, James M., Southall, Linda S., Takata, Dennis T., Uzinskas, Irene N., Valocik, Richard E., Vasko-Moser, Janice A., Wong, Angela S., Yellin, Tobias O., Yuan, Catherine C.K.
Published in Bioorganic & medicinal chemistry letters (05.11.1996)
Published in Bioorganic & medicinal chemistry letters (05.11.1996)
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