Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL
Lai, Ashton C., Toure, Momar, Hellerschmied, Doris, Salami, Jemilat, Jaime-Figueroa, Saul, Ko, Eunhwa, Hines, John, Crews, Craig M.
Published in Angewandte Chemie (International ed.) (11.01.2016)
Published in Angewandte Chemie (International ed.) (11.01.2016)
Get full text
Journal Article
Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury
Chase, Davis H., Bebenek, Adrian M., Nie, Pengju, Jaime‐Figueroa, Saul, Butrin, Arseniy, Castro, Danielle A., Hines, John, Linhares, Brian M., Crews, Craig M.
Published in Angewandte Chemie International Edition (02.04.2024)
Published in Angewandte Chemie International Edition (02.04.2024)
Get full text
Journal Article
Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure–Degradation Relationships
Burslem, George M., Ottis, Philipp, Jaime‐Figueroa, Saul, Morgan, Alicia, Cromm, Philipp M., Toure, Momar, Crews, Craig M.
Published in ChemMedChem (10.08.2018)
Published in ChemMedChem (10.08.2018)
Get full text
Journal Article
Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
Smith, Blake E, Wang, Stephen L, Jaime-Figueroa, Saul, Harbin, Alicia, Wang, Jing, Hamman, Brian D, Crews, Craig M
Published in Nature communications (10.01.2019)
Published in Nature communications (10.01.2019)
Get full text
Journal Article
Targeting the C481S Ibrutinib-Resistance Mutation in Bruton’s Tyrosine Kinase Using PROTAC-Mediated Degradation
Buhimschi, Alexandru D, Armstrong, Haley A, Toure, Momar, Jaime-Figueroa, Saul, Chen, Timothy L, Lehman, Amy M, Woyach, Jennifer A, Johnson, Amy J, Byrd, John C, Crews, Craig M
Published in Biochemistry (Easton) (03.07.2018)
Published in Biochemistry (Easton) (03.07.2018)
Get full text
Journal Article
Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras
Samarasinghe, Kusal T.G., Jaime-Figueroa, Saul, Burgess, Michael, Nalawansha, Dhanusha A., Dai, Katherine, Hu, Zhenyi, Bebenek, Adrian, Holley, Scott A., Crews, Craig M.
Published in Cell chemical biology (20.05.2021)
Published in Cell chemical biology (20.05.2021)
Get full text
Journal Article
Mutant-selective degradation by BRAF-targeting PROTACs
Alabi, Shanique, Jaime-Figueroa, Saul, Yao, Zhan, Gao, Yijun, Hines, John, Samarasinghe, Kusal T G, Vogt, Lea, Rosen, Neal, Crews, Craig M
Published in Nature communications (10.02.2021)
Published in Nature communications (10.02.2021)
Get full text
Journal Article
Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury
Chase, Davis H., Bebenek, Adrian M., Nie, Pengju, Jaime‐Figueroa, Saul, Butrin, Arseniy, Castro, Danielle A., Hines, John, Linhares, Brian M., Crews, Craig M.
Published in Angewandte Chemie (02.04.2024)
Published in Angewandte Chemie (02.04.2024)
Get full text
Journal Article
Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors
Jaime-Figueroa, Saul, De Vicente, Javier, Hermann, Johannes, Jahangir, Alam, Jin, Sue, Kuglstatter, Andreas, Lynch, Stephen M., Menke, John, Niu, Linghao, Patel, Vaishali, Shao, Ada, Soth, Michael, Vu, Minh Diem, Yee, Calvin
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Get full text
Journal Article
Novel Practical Deprotection of N-Boc Compounds Using Fluorinated Alcohols
Choy, Jason, Jaime-Figueroa, Saul, Jiang, Laurence, Wagner, Paul
Published in Synthetic communications (22.10.2008)
Published in Synthetic communications (22.10.2008)
Get full text
Journal Article
급속 진행형 섬유육종 폴리펩티드의 표적화 분해를 위한 다중 고리 화합물 및 방법
DONG HANQING, ZIMMERMAN KURT, WANG JING, JAIME FIGUEROA SAUL, HORNBERGER KEITH R, QIAN YIMIN, CREWS CRAIG M, CREW ANDREW P
Year of Publication 18.06.2021
Get full text
Year of Publication 18.06.2021
Patent
Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties
Jaime-Figueroa, Saul, Buhimschi, Alexandru D., Toure, Momar, Hines, John, Crews, Craig M.
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
Get full text
Journal Article
Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead
Bondeson, Daniel P., Smith, Blake E., Burslem, George M., Buhimschi, Alexandru D., Hines, John, Jaime-Figueroa, Saul, Wang, Jing, Hamman, Brian D., Ishchenko, Alexey, Crews, Craig M.
Published in Cell chemical biology (18.01.2018)
Published in Cell chemical biology (18.01.2018)
Get full text
Journal Article
급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법
DONG HANQING, WANG JING, JAIME FIGUEROA SAUL, HORNBERGER KEITH R, QIAN YIMIN, CREWS CRAIG M, CREW ANDREW P
Year of Publication 02.09.2019
Get full text
Year of Publication 02.09.2019
Patent
Modulares PROTAC-Design zum Abbau von onkogenem BCR-ABL
Lai, Ashton C., Toure, Momar, Hellerschmied, Doris, Salami, Jemilat, Jaime-Figueroa, Saul, Ko, Eunhwa, Hines, John, Crews, Craig M.
Published in Angewandte Chemie (11.01.2016)
Published in Angewandte Chemie (11.01.2016)
Get full text
Journal Article
Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs)
Chen, Po-Han, Hu, Zhenyi, An, Elvira, Okeke, Ifunanya, Zheng, Sijin, Luo, Xuanmeng, Gong, Angela, Jaime-Figueroa, Saul, Crews, Craig M
Published in ACS chemical biology (17.12.2021)
Published in ACS chemical biology (17.12.2021)
Get full text
Journal Article