Design and synthesis of cell potent BACE-1 inhibitors: Structure–activity relationship of P1′ substituents
Sealy, Jennifer M., Truong, Anh P., Tso, Luke, Probst, Gary D., Aquino, Jose, Hom, Roy K., Jagodzinska, Barbara M., Dressen, Darren, Wone, David W.G., Brogley, Louis, John, Varghese, Tung, Jay S., Pleiss, Michael A., Tucker, John A., Konradi, Andrei W., Dappen, Michael S., Toth, Gergely, Pan, Hu, Ruslim, Lany, Miller, Jim, Bova, Michael P., Sinha, Sukanto, Quinn, Kevin P., Sauer, John-Michael
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
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Journal Article
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region
Probst, Gary D., Bowers, Simeon, Sealy, Jennifer M., Stupi, Brian, Dressen, Darren, Jagodzinska, Barbara M., Aquino, Jose, Gailunas, Andrea, Truong, Anh P., Tso, Luke, Xu, Ying-Zi, Hom, Roy K., John, Varghese, Tung, Jay S., Pleiss, Michael A., Tucker, John A., Konradi, Andrei W., Sham, Hing L., Jagodzinski, Jacek, Toth, Gergely, Brecht, Eric, Yao, Nanhua, Pan, Hu, Lin, May, Artis, Dean R., Ruslim, Lany, Bova, Michael P., Sinha, Sukanto, Yednock, Ted A., Gauby, Shawn, Zmolek, Wes, Quinn, Kevin P., Sauer, John-Michael
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
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Journal Article
Facile synthesis of aryl and benzyl substituted 2-methylquinazolin-4(3H)-one ring by microfluidic flow reaction chemistry
Wi, Dongwook, Campagna, Jesus, Cohn, Whitaker, Lee, Jessica, Cole, Terran, Jagodzinska, Barbara, John, Varghese
Published in Tetrahedron letters (24.03.2024)
Published in Tetrahedron letters (24.03.2024)
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Journal Article
A therapeutic small molecule enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice
Wei, Xiaofei, Campagna, Jesus J, Jagodzinska, Barbara, Wi, Dongwook, Cohn, Whitaker, Lee, Jessica T, Zhu, Chunni, Huang, Christine S, Molnár, László, Houser, Carolyn R, John, Varghese, Mody, Istvan
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2024)
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Journal Article
Evaluation of an Allosteric BACE Inhibitor Peptide to Identify Mimetics that Can Interact with the Loop F Region of the Enzyme and Prevent APP Cleavage
Campagna, Jesus, Vadivel, Kanagasabai, Jagodzinska, Barbara, Jun, Michael, Bilousova, Tina, Spilman, Patricia, John, Varghese
Published in Journal of molecular biology (25.05.2018)
Published in Journal of molecular biology (25.05.2018)
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Journal Article
Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2
Bilousova, Tina, Elias, Chris, Miyoshi, Emily, Alam, Mohammad Parvez, Zhu, Chunni, Campagna, Jesus, Vadivel, Kanagasabai, Jagodzinska, Barbara, Gylys, Karen Hoppens, John, Varghese
Published in Biochemical and biophysical research communications (23.05.2018)
Published in Biochemical and biophysical research communications (23.05.2018)
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Journal Article
APP COMPOUNDS TO PROMOTE NORMAL PROCESSING OF APP
BREDESEN DALE E, JAGODZINSKA BARBARA, SPILMAN PATRICIA R, JOHN VARGHESE
Year of Publication 08.12.2022
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Year of Publication 08.12.2022
Patent
Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease
Bilousova, Tina, Simmons, Bryan J, Knapp, Rachel R, Elias, Chris J, Campagna, Jesus, Melnik, Mikhail, Chandra, Sujyoti, Focht, Samantha, Zhu, Chunni, Vadivel, Kanagasabai, Jagodzinska, Barbara, Cohn, Whitaker, Spilman, Patricia, Gylys, Karen H, Garg, Neil K, John, Varghese
Published in ACS chemical biology (19.06.2020)
Published in ACS chemical biology (19.06.2020)
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Journal Article
A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model
Campagna, Jesus, Spilman, Patricia, Jagodzinska, Barbara, Bai, Dongsheng, Hatami, Asa, Zhu, Chunni, Bilousova, Tina, Jun, Michael, Elias, Chris Jean, Pham, Johnny, Cole, Gregory, LaDu, Mary Jo, Jung, Michael E., Bredesen, Dale E., John, Varghese
Published in Scientific reports (04.12.2018)
Published in Scientific reports (04.12.2018)
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Journal Article
근이영양증을 치료하기 위한 조성물 및 방법
PARFENOVA LIUBOV, CROSBIE RACHELLE H, CAMPAGNA JESUS, MOKHONOVA EKATERINA, SHU CYNTHIA, JAGODZINSKA BARBARA, JOHN VARGHESE
Year of Publication 16.05.2023
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Year of Publication 16.05.2023
Patent
Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimerșs Disease
Bilousova, Tina, Simmons, Bryan J., Knapp, Rachel R., Elias, Chris J., Campagna, Jesus, Melnik, Mikhail, Chandra, Sujyoti, Focht, Samantha, Zhu, Chunni, Vadivel, Kanagasabai, Jagodzinska, Barbara, Cohn, Whitaker, Spilman, Patricia, Gylys, Karen H., Garg, Neil K., John, Varghese
Published in ACS chemical biology (14.05.2020)
Published in ACS chemical biology (14.05.2020)
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Journal Article
근육량 및 산화 대사를 증가시키기 위한 조성물 및 방법
CAMPAGNA JESUS, SPENCER MELISSA, LIU JIAN, JAGODZINSKA BARBARA, KRAMEROVA IRINA, JOHN VARGHESE
Year of Publication 14.12.2021
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Year of Publication 14.12.2021
Patent
PURIFICATION AND CHARACTERIZATION OF SUBPOPULATIONS OF EXTRACELLULAR VESICLES FROM AD AND PD BRAIN AND THEIR SUPPRESSION BY NSMASE2 INHIBITORS
Bilousova, Tina, Elias, Chris Jean, Melnik, Mikhail, Miyoshi, Emily, Campagna, Jesus J., Simmons, Bryan, Hatami, Asa, Zhu, Chunni, Jun, Michael, Cohn, Whitaker, Jagodzinska, Barbara, Vadivel, Kanagasabai, Spilman, Patricia, Garg, Neil, Gylys, Karen H., John, Varghese
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article
P4‐057: PURIFICATION AND CHARACTERIZATION OF SUBPOPULATIONS OF EXTRACELLULAR VESICLES FROM AD AND PD BRAIN AND THEIR SUPPRESSION BY NSMASE2 INHIBITORS
Bilousova, Tina, Elias, Chris Jean, Melnik, Mikhail, Miyoshi, Emily, Campagna, Jesus J., Simmons, Bryan, Hatami, Asa, Zhu, Chunni, Jun, Michael, Cohn, Whitaker, Jagodzinska, Barbara, Vadivel, Kanagasabai, Spilman, Patricia, Garg, Neil, Gylys, Karen H., John, Varghese
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article
APP 의 정상 가공을 촉진하는 화합물
BREDESEN DALE E, JAGODZINSKA BARBARA, SPILMAN PATRICIA R, JOHN VARGHESE
Year of Publication 18.01.2019
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Year of Publication 18.01.2019
Patent