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Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases
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Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation
Poor, Stephen H, Qiu, Yubin, Fassbender, Elizabeth S, Shen, Siyuan, Woolfenden, Amber, Delpero, Andrea, Kim, Yong, Buchanan, Natasha, Gebuhr, Thomas C, Hanks, Shawn M, Meredith, Erik L, Jaffee, Bruce D, Dryja, Thaddeus P
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Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models
Crowley, Maura A, Delgado, Omar, Will-Orrego, Adrian, Buchanan, Natasha M, Anderson, Karen, Jaffee, Bruce D, Dryja, Thaddeus P, Liao, Sha-Mei
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Long-acting protein drugs for the treatment of ocular diseases
Ghosh, Joy G., Nguyen, Andrew A., Bigelow, Chad E., Poor, Stephen, Qiu, Yubin, Rangaswamy, Nalini, Ornberg, Richard, Jackson, Brittany, Mak, Howard, Ezell, Tucker, Kenanova, Vania, de la Cruz, Elisa, Carrion, Ana, Etemad-Gilbertson, Bijan, Caro, Roxana Garcia, Zhu, Kan, George, Vinney, Bai, Jirong, Sharma-Nahar, Radhika, Shen, Siyuan, Wang, Yiqin, Subramanian, Kulandayan K., Fassbender, Elizabeth, Maker, Michael, Hanks, Shawn, Vrouvlianis, Joanna, Leehy, Barrett, Long, Debby, Prentiss, Melissa, Kansara, Viral, Jaffee, Bruce, Dryja, Thaddeus P., Roguska, Michael
Published in Nature communications (23.03.2017)
Published in Nature communications (23.03.2017)
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Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1
Liao, Sha-Mei, Zheng, Wei, Zhu, Jiang, Lewis, Casey A, Delgado, Omar, Crowley, Maura A, Buchanan, Natasha M, Jaffee, Bruce D, Dryja, Thaddeus P
Published in Molecular vision (2017)
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Published in Molecular vision (2017)
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Amount of Mononuclear Phagocyte Infiltrate Does Not Predict Area of Experimental Choroidal Neovascularization (CNV)
Will-Orrego, Adrian, Qiu, Yubin, Fassbender, Elizabeth S, Shen, Siyuan, Aranda, Jorge, Kotagiri, Namrata, Maker, Michael, Liao, Sha-Mei, Jaffee, Bruce D, Poor, Stephen H
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Nonclinical Safety Evaluation of scAAV8- RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa
MacLachlan, Timothy K, Milton, Mark N, Turner, Oliver, Tukov, Francis, Choi, Vivian W, Penraat, Jan, Delmotte, Marie-Hélène, Michaut, Lydia, Jaffee, Bruce D, Bigelow, Chad E
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Pharmacologic Uncoupling of Angiogenesis and Inflammation during Initiation of Pathological Corneal Neovascularization
Sivak, Jeremy M., Ostriker, Allison C., Woolfenden, Amber, Demirs, John, Cepeda, Rosemarie, Long, Debby, Anderson, Karen, Jaffee, Bruce
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Lack of involvement of CEP adducts in TLR activation and in angiogenesis
Gounarides, John, Cobb, Jennifer S, Zhou, Jing, Cook, Frank, Yang, Xuemei, Yin, Hong, Meredith, Erik, Rao, Chang, Huang, Qian, Xu, YongYao, Anderson, Karen, De Erkenez, Andrea, Liao, Sha-Mei, Crowley, Maura, Buchanan, Natasha, Poor, Stephen, Qiu, Yubin, Fassbender, Elizabeth, Shen, Siyuan, Woolfenden, Amber, Jensen, Amy, Cepeda, Rosemarie, Etemad-Gilbertson, Bijan, Giza, Shelby, Mogi, Muneto, Jaffee, Bruce, Azarian, Sassan
Published in PloS one (24.10.2014)
Published in PloS one (24.10.2014)
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Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
Dinchuk, Joseph E, Car, Bruce D, Focht, Richard J, Johnston, Jennifer J, Jaffee, Bruce D, Covington, Maryanne B, Contel, Nancy R, Eng, Vicki M, Collins, Robert J, Czerniak, Philip M, Gorry, Stewart A, Trzaskos, James M
Published in Nature (London) (23.11.1995)
Published in Nature (London) (23.11.1995)
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AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice
Choi, Vivian W, Bigelow, Chad E, McGee, Terri L, Gujar, Akshata N, Li, Hui, Hanks, Shawn M, Vrouvlianis, Joanna, Maker, Michael, Leehy, Barrett, Zhang, Yiqin, Aranda, Jorge, Bounoutas, George, Demirs, John T, Yang, Junzheng, Ornberg, Richard, Wang, Yu, Martin, Wendy, Stout, Kelly R, Argentieri, Gregory, Grosenstein, Paul, Diaz, Danielle, Turner, Oliver, Jaffee, Bruce D, Police, Seshidhar R, Dryja, Thaddeus P
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Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy
DeSilva, Dimuthu R, Jones, Elizabeth A, Favata, Margaret F, Jaffee, Bruce D, Magolda, Ronald L, Trzaskos, James M, Scherle, Peggy A
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Participation of Rip2 in Lipopolysaccharide Signaling Is Independent of Its Kinase Activity
Lu, Chafen, Wang, Anlai, Dorsch, Marion, Tian, Jane, Nagashima, Kumiko, Coyle, Anthony J., Jaffee, Bruce, Ocain, Timothy D., Xu, Yajun
Published in The Journal of biological chemistry (22.04.2005)
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Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo
Xue, Chu-Biao, Voss, Matthew E, Nelson, David J, Duan, James J.-W, Cherney, Robert J, Jacobson, Irina C, He, Xiaohua, Roderick, John, Chen, Lihua, Corbett, Ronald L, Wang, Li, Meyer, Dayton T, Kennedy, Kenneth, DeGrado, William F, Hardman, Karl D, Teleha, Christopher A, Jaffee, Bruce D, Liu, Rui-Qin, Copeland, Robert A, Covington, Maryanne B, Christ, David D, Trzaskos, James M, Newton, Robert C, Magolda, Ronald L, Wexler, Ruth R, Decicco, Carl P
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Published in Journal of medicinal chemistry (02.08.2001)
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Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release
Xue, Chu-Biao, He, Xiaohua, Corbett, Ronald L, Roderick, John, Wasserman, Zelda R, Liu, Rui-Qin, Jaffee, Bruce D, Covington, Maryanne B, Qian, Mingxin, Trzaskos, James M, Newton, Robert C, Magolda, Ronald L, Wexler, Ruth R, Decicco, Carl P
Published in Journal of medicinal chemistry (11.10.2001)
Published in Journal of medicinal chemistry (11.10.2001)
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