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Chronic Metabotropic Glutamate Receptor 5 Inhibition Corrects Local Alterations of Brain Activity and Improves Cognitive Performance in Fragile X Mice
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Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities
Morgenthaler, Martin, Schweizer, Eliane, Hoffmann-Röder, Anja, Benini, Fausta, Martin, Rainer E., Jaeschke, Georg, Wagner, Björn, Fischer, Holger, Bendels, Stefanie, Zimmerli, Daniel, Schneider, Josef, Diederich, François, Kansy, Manfred, Müller, Klaus
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CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor
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Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity
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Published in The Journal of pharmacology and experimental therapeutics (01.11.2005)
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Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2‑Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl‑1H‑imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases
Jaeschke, Georg, Kolczewski, Sabine, Spooren, Will, Vieira, Eric, Bitter-Stoll, Nadia, Boissin, Patrick, Borroni, Edilio, Büttelmann, Bernd, Ceccarelli, Simona, Clemann, Nicole, David, Beatrice, Funk, Christoph, Guba, Wolfgang, Harrison, Anthony, Hartung, Thomas, Honer, Michael, Huwyler, Jörg, Kuratli, Martin, Niederhauser, Urs, Pähler, Axel, Peters, Jens-Uwe, Petersen, Ann, Prinssen, Eric, Ricci, Antonio, Rueher, Daniel, Rueher, Marianne, Schneider, Manfred, Spurr, Paul, Stoll, Theodor, Tännler, Daniel, Wichmann, Jürgen, Porter, Richard H, Wettstein, Joseph G, Lindemann, Lothar
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Published in Journal of the American Chemical Society (22.05.2002)
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Resolution of racemic carboxylic acid derivatives by Ti-TADDOLate mediated esterification reactions—A general method for the preparation of enantiopure compounds
Seebach, Dieter, Jaeschke, Georg, Gottwald, Konstanze, Matsuda, Keiji, Formisano, Roberto, Chaplin, David A, Breuning, Matthias, Bringmann, Gerhard
Published in Tetrahedron (02.06.1997)
Published in Tetrahedron (02.06.1997)
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Scharf, Sebastian H, Jaeschke, Georg, Wettstein, Joseph G, Lindemann, Lothar
Published in Current opinion in pharmacology (01.02.2015)
Published in Current opinion in pharmacology (01.02.2015)
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Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice
Michalon, Aubin, Sidorov, Michael, Ballard, Theresa M., Ozmen, Laurence, Spooren, Will, Wettstein, Joseph G., Jaeschke, Georg, Bear, Mark F., Lindemann, Lothar
Published in Neuron (Cambridge, Mass.) (12.04.2012)
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Obst-Sander, Ulrike, Ricci, Antonio, Kuhn, Bernd, Friess, Thomas, Koldewey, Philipp, Kuglstatter, Andreas, Hewings, David, Goergler, Annick, Steiner, Sandra, Rueher, Daniel, Imhoff, Marie-Paule, Raschetti, Noemi, Marty, Hans-Peter, Dietzig, Aline, Rynn, Caroline, Ehler, Andreas, Burger, Dominique, Kornacker, Martin, Schaffland, Jeannine Petrig, Herting, Frank, Pao, William, Bischoff, James R., Martoglio, Bruno, Alice Nagel, Yvonne, Jaeschke, Georg
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