Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases
Harris, Philip A, Berger, Scott B, Jeong, Jae U, Nagilla, Rakesh, Bandyopadhyay, Deepak, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Eidam, Patrick M, Finger, Joshua N, Hoffman, Sandra J, Kang, James, Kasparcova, Viera, King, Bryan W, Lehr, Ruth, Lan, Yunfeng, Leister, Lara K, Lich, John D, MacDonald, Thomas T, Miller, Nathan A, Ouellette, Michael T, Pao, Christina S, Rahman, Attiq, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Schaeffer, Michelle C, Sehon, Clark A, Singhaus, Robert R, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Vossenkämper, Anna, Ward, Paris, Wisnoski, David D, Zhang, Daohua, Marquis, Robert W, Gough, Peter J, Bertin, John
Published in Journal of medicinal chemistry (23.02.2017)
Published in Journal of medicinal chemistry (23.02.2017)
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DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors
Harris, Philip A, King, Bryan W, Bandyopadhyay, Deepak, Berger, Scott B, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Finger, Joshua N, Grady, LaShadric C, Hoffman, Sandra J, Jeong, Jae U, Kang, James, Kasparcova, Viera, Lakdawala, Ami S, Lehr, Ruth, McNulty, Dean E, Nagilla, Rakesh, Ouellette, Michael T, Pao, Christina S, Rendina, Alan R, Schaeffer, Michelle C, Summerfield, Jennifer D, Swift, Barbara A, Totoritis, Rachel D, Ward, Paris, Zhang, Aming, Zhang, Daohua, Marquis, Robert W, Bertin, John, Gough, Peter J
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
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Structure Activity Relationships of 5-, 6-, and 7-Methyl-Substituted Azepan-3-one Cathepsin K Inhibitors
Yamashita, Dennis S, Marquis, Robert W, Xie, Ren, Nidamarthy, Sirishkumar D, Oh, Hye-Ja, Jeong, Jae U, Erhard, Karl F, Ward, Keith W, Roethke, Theresa J, Smith, Brian R, Cheng, H-Y, Geng, Xiaoliu, Lin, Fan, Offen, Priscilla H, Wang, Bing, Nevins, Neysa, Head, Martha S, Haltiwanger, R. Curtis, Narducci Sarjeant, Amy A, Liable-Sands, Louise M, Zhao, Baoguang, Smith, Ward W, Janson, Cheryl A, Gao, Enoch, Tomaszek, Thaddeus, McQueney, Michael, James, Ian E, Gress, Catherine J, Zembryki, Denise L, Lark, Michael W, Veber, Daniel F
Published in Journal of medicinal chemistry (09.03.2006)
Published in Journal of medicinal chemistry (09.03.2006)
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Oncologic Outcome and Morbidity in the Elderly Rectal Cancer Patients After Preoperative Chemoradiotherapy and Total Mesorectal Excision: A Multi-institutional and Case-matched Control Study
Sung, Soo-Y, Jang, Hong S, Kim, Sung H, Jeong, Jae U, Jeong, Songmi, Song, Jin H, Chung, Mi J, Cho, Hyeon M, Kim, Hyung J, Kim, Jun-Gi, Lee, In K, Lee, Jong H
Published in Annals of surgery (01.01.2019)
Published in Annals of surgery (01.01.2019)
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Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer
Harris, Philip A, Marinis, Jill M, Lich, John D, Berger, Scott B, Chirala, Anirudh, Cox, Julie A, Eidam, Patrick M, Finger, Joshua N, Gough, Peter J, Jeong, Jae U, Kang, James, Kasparcova, Viera, Leister, Lara K, Mahajan, Mukesh K, Miller, George, Nagilla, Rakesh, Ouellette, Michael T, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Sun, Helen H, Thorpe, James H, Totoritis, Rachel D, Wang, Wei, Wu, Dongling, Zhang, Daohua, Bertin, John, Marquis, Robert W
Published in ACS medicinal chemistry letters (13.06.2019)
Published in ACS medicinal chemistry letters (13.06.2019)
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HETEROCYCLIC AMIDES AS KINASE INHIBITORS
NICOLAS S GEORGE, DAUGAN ALAIN CLAUDE-MARIE, NICOLAS ERIC FAUCHER, NIALL ANDREW ANDERSON, JAE U JEONG, BRYAN W KING, DAVID DUFF WISNOSKI, FREDERIC G DONCHE, CLARK A SEHON, GEMMA VICTORIA WHITE, PHILIP ANTHONY HARRIS, DEEPAK BANDYOPADHYAY, PATRICK M EIDAM
Year of Publication 16.09.2021
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Year of Publication 16.09.2021
Patent
HETEROCYCLIC AMIDES AS KINASE INHIBITORS
NICOLAS S GEORGE, DAUGAN ALAIN CLAUDE-MARIE, NICOLAS ERIC FAUCHER, NIALL ANDREW ANDERSON, JAE U JEONG, BRYAN W KING, DAVID DUFF WISNOSKI, FREDERIC G DONCHE, CLARK A SEHON, GEMMA VICTORIA WHITE, PHILIP ANTHONY HARRIS, DEEPAK BANDYOPADHYAY, PATRICK M EIDAM
Year of Publication 10.09.2020
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Year of Publication 10.09.2020
Patent
HETEROCYCLIC AMIDES AS KINASE INHIBITORS
JOSHI M RAMANJULU, ROBERT W MARQUIS JR, KANG JIANXING, LARA KATHRYN LEISTER, BRYAN WAYNE KING, JAE U JEONG, RAHMAN ATTIQ, ROBERT SINGHAUS JR, LAKDAWALA SHAH AMI, CLARK A SEHON, ZHANG DAOHUA, PHILIP ANTHONY HARRIS, DEEPAK BANDYOPADHYAY, PATRICK M EIDAM, PETER J GOUGH
Year of Publication 27.09.2018
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Year of Publication 27.09.2018
Patent
HETEROCYCLIC AMIDES AS KINASE INHIBITORS
JOSHI M RAMANJULU, ROBERT W MARQUIS JR, KANG JIANXING, LARA KATHRYN LEISTER, BRYAN WAYNE KING, JAE U JEONG, RAHMAN ATTIQ, ROBERT SINGHAUS JR, LAKDAWALA SHAH AMI, CLARK A SEHON, ZHANG DAOHUA, PHILIP ANTHONY HARRIS, DEEPAK BANDYOPADHYAY, PATRICK M EIDAM, PETER J GOUGH
Year of Publication 19.07.2018
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Year of Publication 19.07.2018
Patent
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase
Harris, Philip A, Faucher, Nicolas, George, Nicolas, Eidam, Patrick M, King, Bryan W, White, Gemma V, Anderson, Niall A, Bandyopadhyay, Deepak, Beal, Allison M, Beneton, Veronique, Berger, Scott B, Campobasso, Nino, Campos, Sebastien, Capriotti, Carol A, Cox, Julie A, Daugan, Alain, Donche, Frederic, Fouchet, Marie-Hélène, Finger, Joshua N, Geddes, Brad, Gough, Peter J, Grondin, Pascal, Hoffman, Bonnie L, Hoffman, Sandra J, Hutchinson, Susan E, Jeong, Jae U, Jigorel, Emilie, Lamoureux, Pauline, Leister, Lara K, Lich, John D, Mahajan, Mukesh K, Meslamani, Jamel, Mosley, Julie E, Nagilla, Rakesh, Nassau, Pamela M, Ng, Sze-Ling, Ouellette, Michael T, Pasikanti, Kishore K, Potvain, Florent, Reilly, Michael A, Rivera, Elizabeth J, Sautet, Stéphane, Schaeffer, Michelle C, Sehon, Clark A, Sun, Helen, Thorpe, James H, Totoritis, Rachel D, Ward, Paris, Wellaway, Natalie, Wisnoski, David D, Woolven, James M, Bertin, John, Marquis, Robert W
Published in Journal of medicinal chemistry (23.05.2019)
Published in Journal of medicinal chemistry (23.05.2019)
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Combined NK Cell Therapy and Radiation Therapy Exhibit Long-Term Therapeutic and Antimetastatic Effects in a Human Triple Negative Breast Cancer Model
Kim, Kyung Won, Jeong, Jae-UK, Lee, Kyung-Hwa, Uong, Tung Nguyen Thanh, Rhee, Joon Haeng, Ahn, Sung-Ja, Kim, Sang-Ki, Cho, Duck, Quang Nguyen, Huy Phuoc, Pham, Chanh Tin, Yoon, Mee Sun
Published in International journal of radiation oncology, biology, physics (01.09.2020)
Published in International journal of radiation oncology, biology, physics (01.09.2020)
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