Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation
Thomenius, Michael J, Totman, Jennifer, Harvey, Darren, Mitchell, Lorna H, Riera, Thomas V, Cosmopoulos, Kat, Grassian, Alexandra R, Klaus, Christine, Foley, Megan, Admirand, Elizabeth A, Jahic, Haris, Majer, Christina, Wigle, Tim, Jacques, Suzanne L, Gureasko, Jodi, Brach, Dorothy, Lingaraj, Trupti, West, Kip, Smith, Sherri, Rioux, Nathalie, Waters, Nigel J, Tang, Cuyue, Raimondi, Alejandra, Munchhof, Michael, Mills, James E, Ribich, Scott, Porter Scott, Margaret, Kuntz, Kevin W, Janzen, William P, Moyer, Mikel, Smith, Jesse J, Chesworth, Richard, Copeland, Robert A, Boriack-Sjodin, P Ann
Published in PloS one (01.06.2018)
Published in PloS one (01.06.2018)
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KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients
Gajiwala, Ketan S, Wu, Joe C, Christensen, James, Deshmukh, Gayatri D, Diehl, Wade, DiNitto, Jonathan P, English, Jessie M, Greig, Michael J, He, You-Ai, Jacques, Suzanne L, Lunney, Elizabeth A, McTigue, Michele, Molina, David, Quenzer, Terri, Wells, Peter A, Yu, Xiu, Zhang, Yan, Zou, Aihua, Emmett, Mark R, Marshall, Alan G, Zhang, Hui-Min, Demetri, George D
Published in Proceedings of the National Academy of Sciences - PNAS (03.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (03.02.2009)
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Structure of the Catalytic Domain of Human Polo-like Kinase 1
Kothe, Michael, Kohls, Darcy, Low, Simon, Coli, Rocco, Cheng, Alan C, Jacques, Suzanne L, Johnson, Theresa L, Lewis, Cristina, Loh, Christine, Nonomiya, Jim, Sheils, Alissa L, Verdries, Kimberly A, Wynn, Thomas A, Kuhn, Cyrille, Ding, Yuan-Hua
Published in Biochemistry (Easton) (22.05.2007)
Published in Biochemistry (Easton) (22.05.2007)
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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
Chan-Penebre, Elayne, Kuplast, Kristy G, Majer, Christina R, Boriack-Sjodin, P Ann, Wigle, Tim J, Johnston, L Danielle, Rioux, Nathalie, Munchhof, Michael J, Jin, Lei, Jacques, Suzanne L, West, Kip A, Lingaraj, Trupti, Stickland, Kimberly, Ribich, Scott A, Raimondi, Alejandra, Scott, Margaret Porter, Waters, Nigel J, Pollock, Roy M, Smith, Jesse J, Barbash, Olena, Pappalardi, Melissa, Ho, Thau F, Nurse, Kelvin, Oza, Khyati P, Gallagher, Kathleen T, Kruger, Ryan, Moyer, Mikel P, Copeland, Robert A, Chesworth, Richard, Duncan, Kenneth W
Published in Nature chemical biology (01.06.2015)
Published in Nature chemical biology (01.06.2015)
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Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
Drew, Allison E., Moradei, Oscar, Jacques, Suzanne L., Rioux, Nathalie, Boriack-Sjodin, Ann P., Allain, Christina, Scott, Margaret Porter, Jin, Lei, Raimondi, Alejandra, Handler, Jessica L., Ott, Heidi M., Kruger, Ryan G., McCabe, Michael T., Sneeringer, Christopher, Riera, Thomas, Shapiro, Gideon, Waters, Nigel J., Mitchell, Lorna H., Duncan, Kenneth W., Moyer, Mikel P., Copeland, Robert A., Smith, Jesse, Chesworth, Richard, Ribich, Scott A.
Published in Scientific reports (21.12.2017)
Published in Scientific reports (21.12.2017)
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CARM1 Preferentially Methylates H3R17 over H3R26 through a Random Kinetic Mechanism
Jacques, Suzanne L, Aquino, Katrina P, Gureasko, Jodi, Boriack-Sjodin, P. Ann, Porter Scott, Margaret, Copeland, Robert A, Riera, Thomas V
Published in Biochemistry (Easton) (22.03.2016)
Published in Biochemistry (Easton) (22.03.2016)
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Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound
Mitchell, Lorna H., Drew, Allison E., Ribich, Scott A., Rioux, Nathalie, Swinger, Kerren K., Jacques, Suzanne L., Lingaraj, Trupti, Boriack-Sjodin, P. Ann, Waters, Nigel J., Wigle, Tim J., Moradei, Oscar, Jin, Lei, Riera, Tom, Porter-Scott, Margaret, Moyer, Mikel P., Smith, Jesse J., Chesworth, Richard, Copeland, Robert A.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates
Boriack-Sjodin, P. Ann, Jin, Lei, Jacques, Suzanne L, Drew, Allison, Sneeringer, Chris, Scott, Margaret Porter, Moyer, Mikel P, Ribich, Scott, Moradei, Oscar, Copeland, Robert A
Published in ACS chemical biology (18.03.2016)
Published in ACS chemical biology (18.03.2016)
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Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis
LEGER, Andrew J, JACQUES, Suzanne L, BADAR, Jehangir, KANEIDER, Nicole C, DERIAN, Claudia K, ANDRADE-GORDON, Patricia, COVIC, Lidija, KULIOPULOS, Athan
Published in Circulation (New York, N.Y.) (07.03.2006)
Published in Circulation (New York, N.Y.) (07.03.2006)
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Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor
Mitchell, Lorna H, Boriack-Sjodin, P. Ann, Smith, Sherri, Thomenius, Michael, Rioux, Nathalie, Munchhof, Michael, Mills, James E, Klaus, Christine, Totman, Jennifer, Riera, Thomas V, Raimondi, Alejandra, Jacques, Suzanne L, West, Kip, Foley, Megan, Waters, Nigel J, Kuntz, Kevin W, Wigle, Tim J, Scott, Margaret Porter, Copeland, Robert A, Smith, Jesse J, Chesworth, Richard
Published in ACS medicinal chemistry letters (11.02.2016)
Published in ACS medicinal chemistry letters (11.02.2016)
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Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance
DiNitto, Jonathan P, Deshmukh, Gayatri D, Zhang, Yan, Jacques, Suzanne L, Coli, Rocco, Worrall, Joseph W, Diehl, Wade, English, Jessie M, Wu, Joe C
Published in Journal of biochemistry (Tokyo) (01.04.2010)
Published in Journal of biochemistry (Tokyo) (01.04.2010)
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Enhanced selectivity profile of pyrazole-urea based DFG-out p38α inhibitors
Liu, Hu, Kuhn, Cyrille, Feru, Frederic, Jacques, Suzanne L., Deshmukh, Gayatri D., Ye, Ping, Rennie, Glen R., Johnson, Theresa, Kazmirski, Steven, Low, Simon, Coli, Rocco, Ding, Yuan-hua, Cheng, Alan C., Tecle, Haile, English, Jessie M., Stanton, Robert, Wu, Joe C.
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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Substrate-Assisted Catalysis of the PAR1 Thrombin Receptor
Jacques, Suzanne L., LeMasurier, Meredith, Sheridan, Paul J., Seeley, Stacy K., Kuliopulos, Athan
Published in The Journal of biological chemistry (29.12.2000)
Published in The Journal of biological chemistry (29.12.2000)
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Abstract 1768: Identification of a potent, orally-available SMARCA2/4 inhibitor with in vitro and in vivo activity in preclinical models of SMARCA4-mutant NSCLC
Drew, Allison E., Jacques, Suzanne L., Eichinger, Lindsey W., Pantano, Chloe, Motwani, Vinny, Tang, Cuyue, Farrow, Neil, Brach, Dorothy, Howe, Selene, Raimondi, Alejandra, Dransfield, Daniel T., Duncan, Kenneth W., Stickland, Kim, Huang, Liyue, Lampe, John
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 2924: Aberrant SWI/SNF complexes lacking SMARCA2 or SMARCA4 differentially affect cell state and response to a novel SMARCA2/4 inhibitor
Eichinger, Lindsey W., Pantano, Chloe, Motwani, Vinny, Brach, Dorothy, Howe, Selene, Raimondi, Alejandra, Dransfield, Daniel T., Duncan, Kenneth W., Stickland, Kim, Tang, Cuyue, Farrow, Neil A., Lampe, John, Jacques, Suzanne L., Drew, Allison E.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 97: CARM1 preferentially methylates H3R17 over H3R26 through a random kinetic mechanism
Jacques, Suzanne L., Aquino, Katrina P., Gureasko, Jodi, Boriack-Sjodin, P Ann, Copeland, Robert A., Riera, Thomas V.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract 2437: Crystal structures of CARM1 bound to sinefungin and diverse peptide substrates
Boriack-Sjodin, Ann, Jin, Lei, Jacques, Suzanne L., Drew, Allison, Porter Scott, Margaret, Ribich, Scott, Moradei, Oscar
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract 589: Discovery of NTX-001, a potent Cbl-b inhibitor with antitumor activity in syngeneic models
Csibi-Levin, Fred, Leit, Silvana, Laughton, David L., Baker, Tom, Jacques, Suzanne L., Browning, Beth, Toms, Angela V., Garside, Samantha, D'Archivio, Simon, Kopycka, Katarzyna, Zhu, Xiaohua, Jordan, Allan M., Thomson, Stuart, Loh, Christine, Tummino, Peter, Ciccone, David N.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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