Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2
Zhu, Yan, Poyurovsky, Masha V., Li, Yingchun, Biderman, Lynn, Stahl, Joachim, Jacq, Xavier, Prives, Carol
Published in Molecular cell (14.08.2009)
Published in Molecular cell (14.08.2009)
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Journal Article
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
Colland, Frédéric, Formstecher, Etienne, Jacq, Xavier, Reverdy, Céline, Planquette, Cécile, Conrath, Susan, Trouplin, Virginie, Bianchi, Julie, Aushev, Vasily N, Camonis, Jacques, Calabrese, Alessandra, Borg-Capra, Catherine, Sippl, Wolfgang, Collura, Vincent, Boissy, Guillaume, Rain, Jean-Christophe, Guedat, Philippe, Delansorne, Rémi, Daviet, Laurent
Published in Molecular cancer therapeutics (01.08.2009)
Published in Molecular cancer therapeutics (01.08.2009)
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Journal Article
Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry
Zhu, Yan, Regunath, Kausik, Jacq, Xavier, Prives, Carol
Published in Genes & development (15.08.2013)
Published in Genes & development (15.08.2013)
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Journal Article
Functional proteomics mapping of a human signaling pathway
Colland, Frédéric, Jacq, Xavier, Trouplin, Virginie, Mougin, Christelle, Groizeleau, Caroline, Hamburger, Alexandre, Meil, Alain, Wojcik, Jérôme, Legrain, Pierre, Gauthier, Jean-Michel
Published in Genome research (01.07.2004)
Published in Genome research (01.07.2004)
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Journal Article
USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF
Jurisic, Anamarija, Sung, Pei‐Ju, Wappett, Mark, Daubriac, Julien, Lobb, Ian T., Kung, Wei‐Wei, Crawford, Nyree, Page, Natalie, Cassidy, Eamon, Feutren‐Burton, Stephanie, Rountree, J. S. Shane, Helm, Matthew D., O'Dowd, Colin R., Kennedy, Richard D., Gavory, Gerald, Cranston, Aaron N., Longley, Daniel B., Jacq, Xavier, Harrison, Timothy
Published in Clinical and translational medicine (01.04.2024)
Published in Clinical and translational medicine (01.04.2024)
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Journal Article
Nucleotide Binding by the MDM2 RING Domain Facilitates Arf-Independent MDM2 Nucleolar Localization
Poyurovsky, Masha V., Jacq, Xavier, Ma, Charles, Karni-Schmidt, Orit, Parker, Peter J., Chalfie, Martin, Manley, James L., Prives, Carol
Published in Molecular cell (01.10.2003)
Published in Molecular cell (01.10.2003)
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Journal Article
Deubiquitylating enzymes and drug discovery: emerging opportunities
Harrigan, Jeanine A, Jacq, Xavier, Martin, Niall M, Jackson, Stephen P
Published in Nature reviews. Drug discovery (01.01.2018)
Published in Nature reviews. Drug discovery (01.01.2018)
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Journal Article
Discovery of 4‑{4-[(3R)‑3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}‑1H‑indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity
Foote, Kevin M, Blades, Kevin, Cronin, Anna, Fillery, Shaun, Guichard, Sylvie S, Hassall, Lorraine, Hickson, Ian, Jacq, Xavier, Jewsbury, Philip J, McGuire, Thomas M, Nissink, J. Willem M, Odedra, Rajesh, Page, Ken, Perkins, Paula, Suleman, Abid, Tam, Kin, Thommes, Pia, Broadhurst, Rebecca, Wood, Christine
Published in Journal of medicinal chemistry (14.03.2013)
Published in Journal of medicinal chemistry (14.03.2013)
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Journal Article
Abstract 6057: Discovery of a novel function for USP7 inhibitors: Reprogramming the tumor microenvironment
Jacq, Xavier, Jurisic, Anamarija, Daubriac, Julien, Lobb, Ian T., Wappett, Mark, Cranston, Aaron, Sung, Peggy, Gavory, Gerald, O'Dowd, Colin, Harisson, Tim
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells
Ward, Jennifer A, McLellan, Lauren, Stockley, Martin, Gibson, Karl R, Whitlock, Gavin A, Knights, Charlotte, Harrigan, Jeanine A, Jacq, Xavier, Tate, Edward W
Published in ACS chemical biology (16.12.2016)
Published in ACS chemical biology (16.12.2016)
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Journal Article
A population-based analysis of germline BAP1 mutations in melanoma
O'Shea, Sally J, Robles-Espinoza, Carla Daniela, McLellan, Lauren, Harrigan, Jeanine, Jacq, Xavier, Hewinson, James, Iyer, Vivek, Merchant, Will, Elliott, Faye, Harland, Mark, Bishop, D Timothy, Newton-Bishop, Julia A, Adams, David J
Published in Human molecular genetics (15.02.2017)
Published in Human molecular genetics (15.02.2017)
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Journal Article
OR26-3 USP19 Deubiquitinating Enzyme Functions as a Novel Co-Chaperone of Hsp90 to Regulate Glucocorticoid Receptor Levels
Bedard, Nathalie, Coyne, Erin, Huynh, Julie, Jacq, Xavier, Rozycka, Ewelina, Schorova, Lenka, Young, Jason, Wing, Simon
Published in Journal of the Endocrine Society (01.11.2022)
Published in Journal of the Endocrine Society (01.11.2022)
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Journal Article
Synthesis and Biological Evaluation of 9-Oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile Analogues as Potential Inhibitors of Deubiquitinating Enzymes
Colombo, Matteo, Vallese, Stefania, Peretto, Ilaria, Jacq, Xavier, Rain, Jean-Christophe, Colland, Frédéric, Guedat, Philippe
Published in ChemMedChem (06.04.2010)
Published in ChemMedChem (06.04.2010)
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Journal Article
Deubiquitylating Enzymes and DNA Damage Response Pathways
Jacq, Xavier, Kemp, Mark, Martin, Niall M. B., Jackson, Stephen P.
Published in Cell biochemistry and biophysics (01.09.2013)
Published in Cell biochemistry and biophysics (01.09.2013)
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Journal Article
Abstract LB-049: Targeting the ubiquitin-proteasome system by small molecule inhibition of the DUBome
Harrison, Tim, Jacq, Xavier, O'Dowd, Colin, Gavory, Gerald, Barker, Oliver, Bell, Christina, Burkamp, Frank, Burton, Stephanie, Cassidy, Eamon, Helm, Matthew, Hewitt, Peter, Page, Natalie, Rountree, Shane, Rozycka, Ewelina, Shepherd, Steven, Whitehead, Steven, Wappett, Mark
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
UCHL1 Is a New Therapeutic Target in Lymphoid Malignancies, Independent of ATM and TP53 status
Smith, Edward, Agathanggelou, Angelo, Pratt, Guy, Moss, Paul, Wei, Wenbin, Harrigan, Leanine, Jacq, Xavier, Stankovic, Tatjana
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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