X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy
Freundlich, Joel S., Wang, Feng, Tsai, Han-Chun, Kuo, Mack, Shieh, Hong-Ming, Anderson, John W., Nkrumah, Louis J., Valderramos, Juan-Carlos, Yu, Min, Kumar, T.R. Santha, Valderramos, Stephanie G., Jacobs, William R., Schiehser, Guy A., Jacobus, David P., Fidock, David A., Sacchettini, James C.
Published in The Journal of biological chemistry (31.08.2007)
Published in The Journal of biological chemistry (31.08.2007)
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Journal Article
Novel Triazine JPC-2067-B Inhibits Toxoplasma gondii In Vitro and In Vivo
Mui, Ernest J, Schiehser, Guy A, Milhous, Wilbur K, Hsu, Honghue, Roberts, Craig W, Kirisits, Michael, Muench, Stephen, Rice, David, Dubey, J.P, Fowble, Joseph W, Rathod, Pradipsinh K, Queener, Sherry F, Liu, Susan R, Jacobus, David P, McLeod, Rima
Published in PLoS neglected tropical diseases (01.03.2008)
Published in PLoS neglected tropical diseases (01.03.2008)
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Journal Article
Role of Specific Cytochrome P450 Isoforms in the Conversion of Phenoxypropoxybiguanide Analogs in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines
DIAZ, Damaris S, KOZAR, Michael. P, SMITH, Kirsten S, ASHER, Constance O, SOUSA, Jason C, SCHIEHSER, Guy A, JACOBUS, David. P, MILHOUS, Wilbur. K, SKILLMAN, Donald. R, SHEARER, Todd. W
Published in Drug metabolism and disposition (01.02.2008)
Published in Drug metabolism and disposition (01.02.2008)
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In vitro efficacy of next-generation dihydrotriazines and biguanides against babesiosis and malaria parasites
Vydyam, Pratap, Chand, Meenal, Gihaz, Shalev, Renard, Isaline, Heffernan, Gavin D, Jacobus, Laura R, Jacobus, David P, Saionz, Kurt W, Shah, Raju, Shieh, Hong-Ming, Terpinski, Jacek, Zhao, Wenyi, Cornillot, Emmanuel, Ben Mamoun, Choukri
Published in Antimicrobial agents and chemotherapy (04.09.2024)
Published in Antimicrobial agents and chemotherapy (04.09.2024)
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Journal Article
Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum
Birrell, Geoffrey W., Challis, Matthew P., De Paoli, Amanda, Anderson, Dovile, Devine, Shane M., Heffernan, Gavin D., Jacobus, David P., Edstein, Michael D., Siddiqui, Ghizal, Creek, Darren J.
Published in Molecular & cellular proteomics (01.02.2020)
Published in Molecular & cellular proteomics (01.02.2020)
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Journal Article
Relevance of Higher-Order Epistasis in Drug Resistance
Lozovsky, Elena R, Daniels, Rachel F, Heffernan, Gavin D, Jacobus, David P, Hartl, Daniel L
Published in Molecular biology and evolution (01.01.2021)
Published in Molecular biology and evolution (01.01.2021)
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Journal Article
Novel Saccharomyces cerevisiae Screen Identifies WR99210 Analogues That Inhibit Mycobacterium tuberculosis Dihydrofolate Reductase
GERUM, A'Lissa B, ULMER, Jonathan E, JACOBUS, David P, JENSEN, Norman P, SHERMAN, David R, SIBLEY, Carol Hopkins
Published in Antimicrobial Agents and Chemotherapy (01.11.2002)
Published in Antimicrobial Agents and Chemotherapy (01.11.2002)
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Journal Article
3,4‐diaminopyridine base effectively treats the weakness of Lambert‐Eaton myasthenia
Sanders, Donald B., Juel, Vern C., Harati, Yadollah, Smith, A. Gordon, Peltier, Amanda C., Marburger, Tessa, Lou, Jau‐Shin, Pascuzzi, Robert M., Richman, David P., Xie, Tai, Demmel, Valentin, Jacobus, Laura R., Aleš, Kathy L., Jacobus, David P.
Published in Muscle & nerve (01.04.2018)
Published in Muscle & nerve (01.04.2018)
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Journal Article
In Vitro Metabolism of Phenoxypropoxybiguanide Analogues in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines
Shearer, Todd. W, Kozar, Michael. P, O'Neil, Michael T, Smith, Philip L, Schiehser, Guy A, Jacobus, David. P, Diaz, Damaris S, Yang, Young-Sun, Milhous, Wilbur. K, Skillman, Donald. R
Published in Journal of medicinal chemistry (21.04.2005)
Published in Journal of medicinal chemistry (21.04.2005)
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Journal Article
In Vivo Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Aotus Monkey-Human Malaria Model
McCallum, Fiona J, Birrell, Geoffrey W, Chavchich, Marina, Harris, Ivor, Obaldia, 3rd, Nicanor, Van Breda, Karin, Heffernan, Gavin D, Jacobus, David P, Shanks, Dennis, Edstein, Michael D
Published in Antimicrobial agents and chemotherapy (21.02.2020)
Published in Antimicrobial agents and chemotherapy (21.02.2020)
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Journal Article
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites
Yu, Min, Kumar, T R Santha, Nkrumah, Louis J, Coppi, Alida, Retzlaff, Silke, Li, Celeste D, Kelly, Brendan J, Moura, Pedro A, Lakshmanan, Viswanathan, Freundlich, Joel S, Valderramos, Juan-Carlos, Vilcheze, Catherine, Siedner, Mark, Tsai, Jennifer H-C, Falkard, Brie, Sidhu, Amar Bir Singh, Purcell, Lisa A, Gratraud, Paul, Kremer, Laurent, Waters, Andrew P, Schiehser, Guy, Jacobus, David P, Janse, Chris J, Ager, Arba, Jacobs, Jr, William R, Sacchettini, James C, Heussler, Volker, Sinnis, Photini, Fidock, David A
Published in Cell host & microbe (11.12.2008)
Published in Cell host & microbe (11.12.2008)
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Journal Article
Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention
Birrell, Geoffrey W, Heffernan, Gavin D, Schiehser, Guy A, Anderson, John, Ager, Arba L, Morales, Pablo, MacKenzie, Donna, van Breda, Karin, Chavchich, Marina, Jacobus, Laura R, Shanks, G Dennis, Jacobus, David P, Edstein, Michael D
Published in Antimicrobial agents and chemotherapy (01.04.2018)
Published in Antimicrobial agents and chemotherapy (01.04.2018)
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Journal Article
Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention
Chavchich, Marina, Birrell, Geoffrey W, Ager, Arba L, MacKenzie, Donna O, Heffernan, Gavin D, Schiehser, Guy A, Jacobus, Laura R, Shanks, G Dennis, Jacobus, David P, Edstein, Michael D
Published in Antimicrobial agents and chemotherapy (01.05.2016)
Published in Antimicrobial agents and chemotherapy (01.05.2016)
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Journal Article
Reliability of the triple‐timed up‐and‐go test
Sanders, Donald B., Guptill, Jeffrey T., Aleš, Kathy L., Hobson‐Webb, Lisa D., Jacobus, David P., Mahmood, Riaz, Massey, Janice M., Pittman, Melissa M., Prather, Kristi, Raja, Shruti M., Yow, Eric, Juel, Vern C.
Published in Muscle & nerve (01.01.2018)
Published in Muscle & nerve (01.01.2018)
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Journal Article
Evaluation of the 2-Aminomethylphenol JPC-2997 in Aotus Monkeys Infected with Plasmodium falciparum
McCallum, Fiona, Harris, Ivor, van Breda, Karin, De, Sai Lata, Stanisic, Danielle I, Good, Michael F, Jacobus, David P, Edstein, Michael D
Published in Antimicrobial agents and chemotherapy (01.03.2016)
Published in Antimicrobial agents and chemotherapy (01.03.2016)
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Journal Article
Validation of the triple timed up‐and‐go test in Lambert‐Eaton myasthenia
Raja, Shruti M., Sanders, Donald B., Juel, Vern C., Harati, Yadollah, Smith, A. Gordon, Pascuzzi, Robert, Richman, David P., Wu, Angie, Aleš, Kathy L., Jacobus, Laura R., Jacobus, David P., Guptill, Jeffrey T.
Published in Muscle & nerve (01.09.2019)
Published in Muscle & nerve (01.09.2019)
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Journal Article
JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium
Birrell, Geoffrey W, Chavchich, Marina, Ager, Arba L, Shieh, Hong-Ming, Heffernan, Gavin D, Zhao, Wenyi, Krasucki, Peter E, Saionz, Kurt W, Terpinski, Jacek, Schiehser, Guy A, Jacobus, Laura R, Shanks, G Dennis, Jacobus, David P, Edstein, Michael D
Published in Antimicrobial agents and chemotherapy (01.01.2015)
Published in Antimicrobial agents and chemotherapy (01.01.2015)
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Journal Article
Novel diaryl ureas with efficacy in a mouse model of malaria
Anderson, John W., Sarantakis, Dimitri, Terpinski, Jacek, Santha Kumar, T.R., Tsai, Han-Chun, Kuo, Mack, Ager, Arba L., Jacobs, William R., Schiehser, Guy A., Ekins, Sean, Sacchettini, James C., Jacobus, David P., Fidock, David A., Freundlich, Joel S.
Published in Bioorganic & medicinal chemistry letters (15.02.2013)
Published in Bioorganic & medicinal chemistry letters (15.02.2013)
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Journal Article
Discrimination of Potent Inhibitors of Toxoplasma gondii Enoyl-Acyl Carrier Protein Reductase by a Thermal Shift Assay
Afanador, Gustavo A, Muench, Stephen P, McPhillie, Martin, Fomovska, Alina, Schön, Arne, Zhou, Ying, Cheng, Gang, Stec, Jozef, Freundlich, Joel S, Shieh, Hong-Ming, Anderson, John W, Jacobus, David P, Fidock, David A, Kozikowski, Alan P, Fishwick, Colin W, Rice, David W, Freire, Ernesto, McLeod, Rima, Prigge, Sean T
Published in Biochemistry (Easton) (23.12.2013)
Published in Biochemistry (Easton) (23.12.2013)
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Journal Article
Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives
Freundlich, Joel S., Anderson, John W., Sarantakis, Dimitri, Shieh, Hong-Ming, Yu, Min, Valderramos, Juan-Carlos, Lucumi, Edinson, Kuo, Mack, Jacobs, William R., Fidock, David A., Schiehser, Guy A., Jacobus, David P., Sacchettini, James C.
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
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