Structure–Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists
Selfridge, Brandon R, Wang, Xiaohui, Zhang, Yingning, Yin, Hang, Grace, Peter M, Watkins, Linda R, Jacobson, Arthur E, Rice, Kenner C
Published in Journal of medicinal chemistry (25.06.2015)
Published in Journal of medicinal chemistry (25.06.2015)
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Journal Article
Functional Activity of Enantiomeric Oximes and Diastereomeric Amines and Cyano Substituents at C9 in 3-Hydroxy- N -phenethyl-5-phenylmorphans
Roth, Hudson G, Das, Madhurima, Sulima, Agnieszka, Luo, Dan, Kaska, Sophia, Prisinzano, Thomas E, Kerr, Andrew T, Jacobson, Arthur E, Rice, Kenner C
Published in Molecules (Basel, Switzerland) (23.04.2024)
Published in Molecules (Basel, Switzerland) (23.04.2024)
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Journal Article
Potent MOR Agonists from 2'-Hydroxy-5,9-dimethyl- N -phenethyl Substituted-6,7-benzomorphans and from C8-Hydroxy, Methylene and Methyl Derivatives of N -Phenethylnormetazocine
Das, Madhurima, Ward, George W, Sulima, Agnieszka, Luo, Dan, Prisinzano, Thomas Edward, Imler, Gregory H, Kerr, Andrew T, Jacobson, Arthur E, Rice, Kenner C
Published in Molecules (Basel, Switzerland) (22.11.2023)
Published in Molecules (Basel, Switzerland) (22.11.2023)
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Journal Article
A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted N -Phenethyl-5-(3-hydroxy)phenylmorphans
Chambers, Dana R, Sulima, Agnieszka, Luo, Dan, Prisinzano, Thomas E, Jacobson, Arthur E, Rice, Kenner C
Published in Molecules (Basel, Switzerland) (14.07.2023)
Published in Molecules (Basel, Switzerland) (14.07.2023)
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Journal Article
Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans
Lutz, Joshua A, Sulima, Agnieszka, Gutman, Eugene S, Bow, Eric W, Luo, Dan, Kaska, Sophia, Prisinzano, Thomas E, Paronis, Carol A, Bergman, Jack, Imler, Gregory H, Kerr, Andrew T, Jacobson, Arthur E, Rice, Kenner C
Published in Molecules (Basel, Switzerland) (15.06.2023)
Published in Molecules (Basel, Switzerland) (15.06.2023)
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Journal Article
Synthesis and Pharmacological Evaluation of Enantiopure N-Substituted Ortho-c Oxide-Bridged 5-Phenylmorphans
Li, Fuying, Kopajtic, Theresa A, Katz, Jonathan L, Luo, Dan, Prisinzano, Thomas E, Imler, Gregory H, Deschamps, Jeffrey R, Jacobson, Arthur E, Rice, Kenner C
Published in Molecules (Basel, Switzerland) (12.12.2022)
Published in Molecules (Basel, Switzerland) (12.12.2022)
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Journal Article
A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists
Chambers, Dana R, Sulima, Agnieszka, Luo, Dan, Prisinzano, Thomas E, Goldberg, Alexander, Xie, Bing, Shi, Lei, Paronis, Carol A, Bergman, Jack, Nassehi, Nima, Selley, Dana E, Imler, Gregory H, Jacobson, Arthur E, Rice, Kenner C
Published in Molecules (Basel, Switzerland) (30.09.2022)
Published in Molecules (Basel, Switzerland) (30.09.2022)
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Journal Article
Design, Synthesis, and In Vivo Evaluation of C1-Linked 4,5-Epoxymorphinan Haptens for Heroin Vaccines
Sulima, Agnieszka, Li, Fuying, Morgan, Jeffrey Brian, Truong, Phong, Antoline, Joshua F G, Oertel, Therese, Barrientos, Rodell C, Torres, Oscar B, Beck, Zoltan, Imler, Gregory H, Deschamps, Jeffrey R, Matyas, Gary R, Jacobson, Arthur E, Rice, Kenner C
Published in Molecules (Basel, Switzerland) (25.02.2022)
Published in Molecules (Basel, Switzerland) (25.02.2022)
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Journal Article
Novel chimeric monoclonal antibodies that block fentanyl effects and alter fentanyl biodistribution in mice
Ban, Bhupal, Barrientos, Rodell C., Oertel, Therese, Komla, Essie, Whalen, Connor, Sopko, Megan, You, Yingjian, Banerjee, Partha, Sulima, Agnieszka, Jacobson, Arthur E., Rice, Kenner C., Matyas, Gary R., Yusibov, Vidadi
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Journal Article
The Intriguing Effects of Substituents in the N -Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of "Tail Wags Dog" Experiments
Wang, Meining, Irvin, Thomas C, Herdman, Christine A, Hanna, Ramsey D, Hassan, Sergio A, Lee, Yong-Sok, Kaska, Sophia, Crowley, Rachel Saylor, Prisinzano, Thomas E, Withey, Sarah L, Paronis, Carol A, Bergman, Jack, Inan, Saadet, Geller, Ellen B, Adler, Martin W, Kopajtic, Theresa A, Katz, Jonathan L, Chadderdon, Aaron M, Traynor, John R, Jacobson, Arthur E, Rice, Kenner C
Published in Molecules (Basel, Switzerland) (06.06.2020)
Published in Molecules (Basel, Switzerland) (06.06.2020)
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Journal Article
Role of efficacy as a determinant of locomotor activation by mu‐opioid receptor (MOR) ligands in female and male mice. II. Effects of novel MOR‐selective phenylmorphans with high‐to‐low MOR efficacy
Santos, Edna J., Nassehi, Nima, Bow, Eric W., Chambers, Dana R., Gutman, Eugene S., Jacobson, Arthur E., Lutz, Joshua A., Marsh, Samuel A., Rice, Kenner C., Sulima, Agnieszka, Selley, Dana E., Negus, S. Stevens
Published in Pharmacology research & perspectives (01.08.2023)
Published in Pharmacology research & perspectives (01.08.2023)
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Journal Article
Effect of Preexisting Immunity to Tetanus Toxoid on the Efficacy of Tetanus Toxoid-Conjugated Heroin Vaccine in Mice
Komla, Essie, Torres, Oscar B., Jalah, Rashmi, Sulima, Agnieszka, Beck, Zoltan, Alving, Carl R., Jacobson, Arthur E., Rice, Kenner C., Matyas, Gary R.
Published in Vaccines (Basel) (01.06.2021)
Published in Vaccines (Basel) (01.06.2021)
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Journal Article
Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvant
Torres, Oscar B, Matyas, Gary R, Rao, Mangala, Peachman, Kristina K, Jalah, Rashmi, Beck, Zoltan, Michael, Nelson L, Rice, Kenner C, Jacobson, Arthur E, Alving, Carl R
Published in npj vaccines (02.05.2017)
Published in npj vaccines (02.05.2017)
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Journal Article
Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist
Vardanyan, Marina, Melemedjian, Ohannes K., Price, Theodore J., Ossipov, Michael H., Lai, Josephine, Roberts, Ed, Boos, Terrence L., Deschamps, Jeffrey R., Jacobson, Arthur E., Rice, Kenner C., Porreca, Frank
Published in Pain (Amsterdam) (01.11.2010)
Published in Pain (Amsterdam) (01.11.2010)
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Journal Article
Bivalent Conjugate Vaccine Induces Dual Immunogenic Response That Attenuates Heroin and Fentanyl Effects in Mice
Barrientos, Rodell C, Whalen, Connor, Torres, Oscar B, Sulima, Agnieszka, Bow, Eric W, Komla, Essie, Beck, Zoltan, Jacobson, Arthur E, Rice, Kenner C, Matyas, Gary R
Published in Bioconjugate chemistry (17.11.2021)
Published in Bioconjugate chemistry (17.11.2021)
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Journal Article
Enhancing Protective Antibodies against Opioids through Antigen Display on Virus-like Particles
Shafieichaharberoud, Fatemeh, Lang, Shuyao, Whalen, Connor, Rivera Quiles, Cristina, Purcell, Lillie, Talbot, Cameron, Wang, Pengfei, Norton, Elizabeth B., Mazei-Robison, Michelle, Sulima, Agnieszka, Jacobson, Arthur E., Rice, Kenner C., Matyas, Gary R., Huang, Xuefei
Published in Bioconjugate chemistry (21.02.2024)
Published in Bioconjugate chemistry (21.02.2024)
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Journal Article
Novel Vaccine That Blunts Fentanyl Effects and Sequesters Ultrapotent Fentanyl Analogues
Barrientos, Rodell C, Bow, Eric W, Whalen, Connor, Torres, Oscar B, Sulima, Agnieszka, Beck, Zoltan, Jacobson, Arthur E, Rice, Kenner C, Matyas, Gary R
Published in Molecular pharmaceutics (08.09.2020)
Published in Molecular pharmaceutics (08.09.2020)
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Journal Article
A Stable Heroin Analogue That Can Serve as a Vaccine Hapten to Induce Antibodies That Block the Effects of Heroin and Its Metabolites in Rodents and That Cross-React Immunologically with Related Drugs of Abuse
Sulima, Agnieszka, Jalah, Rashmi, Antoline, Joshua F. G, Torres, Oscar B, Imler, Gregory H, Deschamps, Jeffrey R, Beck, Zoltan, Alving, Carl R, Jacobson, Arthur E, Rice, Kenner C, Matyas, Gary R
Published in Journal of medicinal chemistry (11.01.2018)
Published in Journal of medicinal chemistry (11.01.2018)
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Journal Article
Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids
Cai, Ning-Sheng, Quiroz, César, Bonaventura, Jordi, Bonifazi, Alessandro, Cole, Thomas O, Purks, Julia, Billing, Amy S, Massey, Ebonie, Wagner, Michael, Wish, Eric D, Guitart, Xavier, Rea, William, Lam, Sherry, Moreno, Estefanía, Casadó-Anguera, Verònica, Greenblatt, Aaron D, Jacobson, Arthur E, Rice, Kenner C, Casadó, Vicent, Newman, Amy H, Winkelman, John W, Michaelides, Michael, Weintraub, Eric, Volkow, Nora D, Belcher, Annabelle M, Ferré, Sergi
Published in The Journal of clinical investigation (01.07.2019)
Published in The Journal of clinical investigation (01.07.2019)
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