Search Results - "JACOB M. HOFFMAN" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model

Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model

by Bilodeau, Mark T., Balitza, Adrienne E., Hoffman, Jacob M., Manley, Peter J., Barnett, Stanley F., Defeo-Jones, Deborah, Haskell, Kathleen, Jones, Raymond E., Leander, Karen, Robinson, Ronald G., Smith, Anthony M., Huber, Hans E., Hartman, George D.
Published in Bioorganic & medicinal chemistry (01.06.2008)

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Update: Causes and symptoms of sudden cardiac death in young athletes

Update: Causes and symptoms of sudden cardiac death in young athletes

by Asif, Irfan M., Yim, Eugene S, Hoffman, Jacob M., Froelicher, Vic
Published in The Physician and sportsmedicine (01.02.2015)

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Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogs of 3-aminopyridin-2(1H)-one

Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogs of 3-aminopyridin-2(1H)-one

by Saari, Walfred S, Wai, John S, Fisher, Thorsten E, Thomas, Craig M, Hoffman, Jacob M, Rooney, Clarence S, Smith, Anthony M, Jones, James H, Bamberger, Dona L
Published in Journal of medicinal chemistry (01.10.1992)

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2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors

2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors

by Saari, Walfred S, Hoffman, Jacob M, Wai, John S, Fisher, Thorsten E, Rooney, Clarence S, Smith, Anthony M, Thomas, Craig M, Goldman, Mark E, O'Brien, Julie A
Published in Journal of medicinal chemistry (01.09.1991)

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Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogs

Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogs

by Hoffman, Jacob M, Smith, Anthony M, Rooney, Clarence S, Fisher, Thorsten E, Wai, John S, Thomas, Craig M, Bamberger, Dona L, Barnes, James L, Williams, Theresa M
Published in Journal of medicinal chemistry (16.04.1993)

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Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogs

Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogs

by Hoffman, Jacob M, Wai, John S, Thomas, Craig M, Levin, Rhonda B, O'Brien, Julie A, Goldman, Mark E
Published in Journal of medicinal chemistry (01.10.1992)

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Inhibitors of gastric acid secretion: antisecretory 2-pyridylurea derivatives

Inhibitors of gastric acid secretion: antisecretory 2-pyridylurea derivatives

by Bolhofer, William A, Deana, Albert A, Habecker, Charles N, Hoffman, Jacob M, Gould, Norman P, Pietruszkiewicz, Adolph M, Prugh, John D, Torchiana, Mary Lou, Cragoe, Edward J, Hirschmann, Ralph
Published in Journal of medicinal chemistry (01.04.1983)

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Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3-aminopyridin-2(1H)-one

Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3-aminopyridin-2(1H)-one

by Wai, John S, Williams, Theresa M, Bamberger, Dona L, Fisher, Thorsten E, Hoffman, Jacob M, Hudcosky, Ronald J, MacTough, Suzanne C, Rooney, Clarence S, Saari, Walfred S
Published in Journal of medicinal chemistry (1993)

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Topically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides

Topically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides

by Graham, Samuel L, Hoffman, Jacob M, Gautheron, Pierre, Michelson, Stuart R, Scholz, Thomas H, Schwam, Harvey, Shepard, Kenneth L, Smith, Anthony M, Smith, Robert L
Published in Journal of medicinal chemistry (01.02.1990)

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A PRACTICAL SYNTHESIS OF 5-(CHLOROMETHYL)FURO[2,3-B]PYRIDINE, A KEY INTERMEDIATE FOR THE HIV PROTEASE INHIBITOR, L-754,394

A PRACTICAL SYNTHESIS OF 5-(CHLOROMETHYL)FURO[2,3-B]PYRIDINE, A KEY INTERMEDIATE FOR THE HIV PROTEASE INHIBITOR, L-754,394

by BHUPATHY, M, CONLON, DA, WELLS, KM, NELSON, REIDER, PJ, ROSSEN, K, SAGER, JW, VOLANTE, RP, DORSEY, BD, HOFFMAN, JM, JOSEPH, SA, MCDANIEL, SL
Published in Journal of heterocyclic chemistry (01.07.1995)

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Antiaromaticity in the parent cyclopentadienyl cation. Reaction of 5-iodocyclopentadiene with silver ion

Antiaromaticity in the parent cyclopentadienyl cation. Reaction of 5-iodocyclopentadiene with silver ion

by Breslow, Ronald, Hoffman, Jacob M
Published in Journal of the American Chemical Society (01.03.1972)

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Synthesis of 3-nitro-5-acylpyridines by condensation of sodium nitromalonaldehyde/tosyl chloride with 2-amino-1-acylolefins. Evidence for the intermediacy of 3-chloro-2-nitroacrolein

Synthesis of 3-nitro-5-acylpyridines by condensation of sodium nitromalonaldehyde/tosyl chloride with 2-amino-1-acylolefins. Evidence for the intermediacy of 3-chloro-2-nitroacrolein

by Hoffman, Jacob M, Phillips, Brian T, Cochran, David W
Published in Journal of organic chemistry (01.01.1984)

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Solvolytic Cope rearrangements

Solvolytic Cope rearrangements

by Breslow, Ronald, Hoffman, Jacob M
Published in Journal of the American Chemical Society (01.03.1972)

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Allosteric inhibitors of Aktl and Akt2 : A naphthyridinone with efficacy in an A2780 tumor xenograft model

Allosteric inhibitors of Aktl and Akt2 : A naphthyridinone with efficacy in an A2780 tumor xenograft model

by BILODEAU, Mark T, BALITZA, Adrienne E, SMITH, Anthony M, HUBER, Hans E, HARTMAN, George D, HOFFMAN, Jacob M, MANLEY, Peter J, BARNETT, Stanley F, DEFEO-JONES, Deborah, HASKELL, Kathleen, JONES, Raymond E, LEANDER, Karen, ROBINSON, Ronald G
Published in Bioorganic & medicinal chemistry letters (2008)

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Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

by NUNBERG, J. H, SCHLEIF, W. A, BOOTS, E. J, O'BRIEN, J. A, QUINTERO, J. C, HOFFMAN, J. M, EMINI, E. A, GOLDMAN, M. E
Published in Journal of Virology (01.09.1991)

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Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogs related to cimetidine and tiotidine

Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogs related to cimetidine and tiotidine

by Hoffman, Jacob M, Pietruszkiewicz, Adolph M, Habecker, Charles N, Phillips, Brian T, Bolhofer, William A, Cragoe, Edward J, Torchiana, Mary Lou, Lumma, William C, Baldwin, John J
Published in Journal of medicinal chemistry (01.02.1983)

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A deuterium isotope effect on the inhibition of gastric secretion by N,N-dimethyl-N'-[2-(diisopropylamino)ethyl]-N'-(4,6-dimethyl-2-pyridyl)urea. Synthesis of metabolites

A deuterium isotope effect on the inhibition of gastric secretion by N,N-dimethyl-N'-[2-(diisopropylamino)ethyl]-N'-(4,6-dimethyl-2-pyridyl)urea. Synthesis of metabolites

by Hoffman, Jacob M, Habecker, Charles N, Pietruszkiewicz, Adolph M, Bolhofer, William A, Cragoe, Edward J, Torchiana, Mary Lou, Hirschmann, Ralph
Published in Journal of medicinal chemistry (01.11.1983)

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Pyridinone Derivatives: Specific Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors with Antiviral Activity

Pyridinone Derivatives: Specific Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors with Antiviral Activity

by Goldman, Mark E., Nunberg, Jack H., O'Brien, Julie A., Quintero, Julio C., Schleif, William A., Freund, Kurt F., Gaul, S. Lee, Saari, Walfred S., Wai, John S., Hoffman, Jacob M., Anderson, Paul S., Hupe, Donald J., Emini, Emilio A., Stern, Andrew M.
Published in Proceedings of the National Academy of Sciences - PNAS (01.08.1991)

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Structure-activity, theoretical, and x-ray studies on the intramolecular interactions in a series of novel histamine H2 receptor antagonists

Structure-activity, theoretical, and x-ray studies on the intramolecular interactions in a series of novel histamine H2 receptor antagonists

by Lumma, William C, Baldwin, John J, Bicking, John B, Bolhofer, William A, Hoffman, Jacob M, Phillips, Brian T, Robb, Charles M, Torchiana, Mary Lou, Schlegel, H. B
Published in Journal of medicinal chemistry (01.08.1984)

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Inhibition of gastric acid secretion by 1,8-naphthyridin-2(1H)-ones

Inhibition of gastric acid secretion by 1,8-naphthyridin-2(1H)-ones

by Bolhofer, William A, Hoffman, Jacob M, Habecker, Charles N, Pietruszkiewicz, Adolph M, Cragoe, Edward J, Torchiana, Mary Lou
Published in Journal of medicinal chemistry (01.03.1979)

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