Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury
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Published in Nature medicine (01.12.1999)
Published in Nature medicine (01.12.1999)
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Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein–Protein Interaction
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Published in Journal of medicinal chemistry (27.04.2017)
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Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4
Ashton, Trent D., Dans, Madeline G., Favuzza, Paola, Ngo, Anna, Lehane, Adele M., Zhang, Xinxin, Qiu, Deyun, Chandra Maity, Bikash, De, Nirupam, Schindler, Kyra A., Yeo, Tomas, Park, Heekuk, Uhlemann, Anne-Catrin, Churchyard, Alisje, Baum, Jake, Fidock, David A., Jarman, Kate E., Lowes, Kym N., Baud, Delphine, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Sleebs, Brad E.
Published in Journal of medicinal chemistry (09.03.2023)
Published in Journal of medicinal chemistry (09.03.2023)
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Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3
Calic, Petar P.S., Ashton, Trent D., Mansouri, Mahta, Loi, Katie, Jarman, Kate E., Qiu, Deyun, Lehane, Adele M., Roy, Sayantan, Rao, Gunturu P., Maity, Bikash, Wittlin, Sergio, Crespo, Benigno, Gamo, Franciso-Javier, Deni, Ioanna, Fidock, David A., Chowdury, Mrittika, de Koning-Ward, Tania F., Cowman, Alan F., Jackson, Paul F., Baud, Delphine, Brand, Stephen, Laleu, Benoît, Sleebs, Brad E.
Published in European journal of medicinal chemistry (05.10.2024)
Published in European journal of medicinal chemistry (05.10.2024)
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Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein
Nguyen, William, Boulet, Coralie, Dans, Madeline G., Loi, Katie, Jarman, Kate E., Watson, Gabrielle M., Tham, Wai-Hong, Fairhurst, Kate J., Yeo, Tomas, Fidock, David A., Wittlin, Sergio, Chowdury, Mrittika, de Koning-Ward, Tania F., Chen, Gong, Yan, Dandan, Charman, Susan A., Baud, Delphine, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Gilson, Paul R., Sleebs, Brad E.
Published in European journal of medicinal chemistry (15.04.2024)
Published in European journal of medicinal chemistry (15.04.2024)
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Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4
Ashton, Trent D., Calic, Petar P. S., Dans, Madeline G., Ooi, Zi Kang, Zhou, Qingmiao, Palandri, Josephine, Loi, Katie, Jarman, Kate E., Qiu, Deyun, Lehane, Adele M., Maity, Bikash Chandra, De, Nirupam, Giannangelo, Carlo, MacRaild, Christopher A., Creek, Darren J., Mao, Emma Y., Gancheva, Maria R., Wilson, Danny W., Chowdury, Mrittika, de Koning-Ward, Tania F., Famodimu, Mufuliat T., Delves, Michael J., Pollard, Harry, Sutherland, Colin J., Baud, Delphine, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Sleebs, Brad E.
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b
Awalt, Jon Kyle, Su, Wenyin, Nguyen, William, Loi, Katie, Jarman, Kate E., Penington, Jocelyn S., Ramesh, Saishyam, Fairhurst, Kate J., Yeo, Tomas, Park, Heekuk, Uhlemann, Anne-Catrin, Chandra Maity, Bikash, De, Nirupam, Mukherjee, Partha, Chakraborty, Arnish, Churchyard, Alisje, Famodimu, Mufuliat T., Delves, Michael J., Baum, Jake, Mittal, Nimisha, Winzeler, Elizabeth A., Papenfuss, Anthony T., Chowdury, Mrittika, de Koning-Ward, Tania F., Maier, Alexander G., van Dooren, Giel G., Baud, Delphine, Brand, Stephen, Fidock, David A., Jackson, Paul F., Cowman, Alan F., Dans, Madeline G., Sleebs, Brad E.
Published in European journal of medicinal chemistry (03.10.2024)
Published in European journal of medicinal chemistry (03.10.2024)
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Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4
Ashton, Trent D, Calic, Petar P S, Dans, Madeline G, Ooi, Zi Kang, Zhou, Qingmiao, Loi, Katie, Jarman, Kate E, Palandri, Josephine, Qiu, Deyun, Lehane, Adele M, Maity, Bikash, De, Nirupam, Famodimu, Mufuliat T, Delves, Michael J, Mao, Emma Y, Gancheva, Maria R, Wilson, Danny W, Chowdury, Mrittika, de Koning-Ward, Tania F, Baud, Delphine, Brand, Stephen, Jackson, Paul F, Cowman, Alan F, Sleebs, Brad E
Published in ChemMedChem (30.08.2024)
Published in ChemMedChem (30.08.2024)
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Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity
Bailey, Brodie L., Nguyen, William, Ngo, Anna, Goodman, Christopher D., Gancheva, Maria R., Favuzza, Paola, Sanz, Laura M., Gamo, Francisco-Javier, Lowes, Kym N., McFadden, Geoffrey I., Wilson, Danny W., Laleu, Benoît, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Sleebs, Brad E.
Published in Bioorganic chemistry (01.10.2021)
Published in Bioorganic chemistry (01.10.2021)
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7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex
Nguyen, William, Dans, Madeline G, Currie, Iain, Awalt, Jon Kyle, Bailey, Brodie L, Lumb, Chris, Ngo, Anna, Favuzza, Paola, Palandri, Josephine, Ramesh, Saishyam, Penington, Jocelyn, Jarman, Kate E, Mukherjee, Partha, Chakraborty, Arnish, Maier, Alexander G, van Dooren, Giel G, Papenfuss, Tony, Wittlin, Sergio, Churchyard, Alisje, Baum, Jake, Winzeler, Elizabeth A, Baud, Delphine, Brand, Stephen, Jackson, Paul F, Cowman, Alan F, Sleebs, Brad E
Published in ACS infectious diseases (10.03.2023)
Published in ACS infectious diseases (10.03.2023)
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Microwave-assisted Sonogashira-type cross couplings of various heterocyclic methylthioethers
Shook, Brian C., Chakravarty, Devraj, Jackson, Paul F.
Published in Tetrahedron letters (04.03.2009)
Published in Tetrahedron letters (04.03.2009)
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Journal Article
7‑N‑Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc 1 Complex
Nguyen, William, Dans, Madeline G., Currie, Iain, Awalt, Jon Kyle, Bailey, Brodie L., Lumb, Chris, Ngo, Anna, Favuzza, Paola, Palandri, Josephine, Ramesh, Saishyam, Penington, Jocelyn, Jarman, Kate E., Mukherjee, Partha, Chakraborty, Arnish, Maier, Alexander G., van Dooren, Giel G., Papenfuss, Tony, Wittlin, Sergio, Churchyard, Alisje, Baum, Jake, Winzeler, Elizabeth A., Baud, Delphine, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Sleebs, Brad E.
Published in ACS infectious diseases (10.03.2023)
Published in ACS infectious diseases (10.03.2023)
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Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate
Lim, Heng-Keang, Chen, Jie, Sensenhauser, Carlo, Cook, Kevin, Preston, Robert, Thomas, Tynisha, Shook, Brian, Jackson, Paul F, Rassnick, Stefanie, Rhodes, Kenneth, Gopaul, Vedwatee, Salter, Rhys, Silva, Jose, Evans, David C
Published in Chemical research in toxicology (18.07.2011)
Published in Chemical research in toxicology (18.07.2011)
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In Vivo Characterization of a Dual Adenosine A2A/A1 Receptor Antagonist in Animal Models of Parkinson’s Disease
Shook, Brian C, Rassnick, Stefanie, Osborne, Melville C, Davis, Scott, Westover, Lori, Boulet, Jamie, Hall, Daniel, Rupert, Kenneth C, Heintzelman, Geoffrey R, Hansen, Kristin, Chakravarty, Devraj, Bullington, James L, Russell, Ronald, Branum, Shawn, Wells, Kenneth M, Damon, Sandra, Youells, Scott, Li, Xun, Beauchamp, Derek A, Palmer, David, Reyes, Mayra, Demarest, Keith, Tang, Yuting, Rhodes, Kenneth, Jackson, Paul F
Published in Journal of medicinal chemistry (25.11.2010)
Published in Journal of medicinal chemistry (25.11.2010)
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Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists
Shook, Brian C., Chakravarty, Devraj, Barbay, J. Kent, Wang, Aihua, Leonard, Kristi, Alford, Vernon, Powell, Mark T., Rassnick, Stefanie, Scannevin, Robert H., Carroll, Karen, Wallace, Nathaniel, Crooke, Jeffrey, Ault, Mark, Lampron, Lisa, Westover, Lori, Rhodes, Kenneth, Jackson, Paul F.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Journal Article
JNJ-40255293, a Novel Adenosine A2A/A1 Antagonist with Efficacy in Preclinical Models of Parkinson’s Disease
Atack, John R, Shook, Brian C, Rassnick, Stefanie, Jackson, Paul F, Rhodes, Kenneth, Drinkenburg, Wilhelmus H, Ahnaou, Abdallah, te Riele, Paula, Langlois, Xavier, Hrupka, Brian, De Haes, Patrick, Hendrickx, Herman, Aerts, Nancy, Hens, Koen, Wellens, Annemie, Vermeire, Jef, Megens, Anton A. H. P
Published in ACS chemical neuroscience (15.10.2014)
Published in ACS chemical neuroscience (15.10.2014)
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Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs)
Zhang, Yue-Mei, Fan, Xiaodong, Yang, Shyh-Ming, Scannevin, Robert H., Burke, Sharon L., Rhodes, Kenneth J., Jackson, Paul F.
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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