Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies
Andrade, E L, Bento, A F, Cavalli, J, Oliveira, S K, Schwanke, R C, Siqueira, J M, Freitas, C S, Marcon, R, Calixto, J B
Published in Brazilian journal of medical and biological research (12.12.2016)
Published in Brazilian journal of medical and biological research (12.12.2016)
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Journal Article
Contribution and interaction of kinin receptors and dynorphin A in a model of trigeminal neuropathic pain in mice
Luiz, A.P, Schroeder, S.D, Rae, G.A, Calixto, J.B, Chichorro, J.G
Published in Neuroscience (06.08.2015)
Published in Neuroscience (06.08.2015)
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Journal Article
Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies
Andrade, E L, Bento, A F, Cavalli, J, Oliveira, S K, Freitas, C S, Marcon, R, Schwanke, R C, Siqueira, J M, Calixto, J B
Published in Brazilian journal of medical and biological research (01.01.2016)
Published in Brazilian journal of medical and biological research (01.01.2016)
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Journal Article
The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε
Dutra, R.C, Bicca, M.A, Segat, G.C, Silva, K.A.B.S, Motta, E.M, Pianowski, L.F, Costa, R, Calixto, J.B
Published in Neuroscience (10.09.2015)
Published in Neuroscience (10.09.2015)
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Journal Article
Genetic deletion or antagonism of kinin B1 and B2 receptors improves cognitive deficits in a mouse model of Alzheimer's disease
Prediger, R.D.S, Medeiros, R, Pandolfo, P, Duarte, F.S, Passos, G.F, Pesquero, J.B, Campos, M.M, Calixto, J.B, Takahashi, R.N
Published in Neuroscience (01.02.2008)
Published in Neuroscience (01.02.2008)
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The selective and competitive N-methyl-D-aspartate receptor antagonist, (−)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid, prevents synaptic toxicity induced by amyloid-β in mice
Bicca, M.A, Figueiredo, C.P, Piermartiri, T.C, Meotti, F.C, Bouzon, Z.L, Tasca, C.I, Medeiros, R, Calixto, J.B
Published in Neuroscience (29.09.2011)
Published in Neuroscience (29.09.2011)
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Journal Article
Modulation of pentylenetetrazol-induced seizures by prostaglandin E2 receptors
Oliveira, M.S, Furian, A.F, Rambo, L.M, Ribeiro, L.R, Royes, L.F.F, Ferreira, J, Calixto, J.B, Mello, C.F
Published in Neuroscience (09.04.2008)
Published in Neuroscience (09.04.2008)
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P.2.h.003 Depressant-like behavior of TNF-alpha in mice
Gadotti, V.M, Kaster, M.P, Calixto, J.B, Santos, A.R.S, Rodrigues, A.L.S
Published in European neuropsychopharmacology (2007)
Published in European neuropsychopharmacology (2007)
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Journal Article
Bradykinin into amygdala induces thermal hyperalgesia in rats
Dalmolin, G.D, Silva, C.R, Bellé, N.A.V, Rubin, M.A, Mello, C.F, Calixto, J.B, Ferreira, J
Published in Neuropeptides (Edinburgh) (01.08.2007)
Published in Neuropeptides (Edinburgh) (01.08.2007)
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Journal Article
TRPA1 antagonists as potential analgesic drugs
Andrade, E L, Meotti, F C, Calixto, J B
Published in Pharmacology & therapeutics (Oxford) (01.02.2012)
Published in Pharmacology & therapeutics (Oxford) (01.02.2012)
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The mechanism of gentisic acid-induced relaxation of the guinea pig isolated trachea: the role of potassium channels and vasoactive intestinal peptide receptors
Cunha, J F, Campestrini, F D, Calixto, J B, Scremin, A, Paulino, N
Published in Brazilian journal of medical and biological research (01.03.2001)
Published in Brazilian journal of medical and biological research (01.03.2001)
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Journal Article
Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist
de Campos, R O, Alves, R V, Ferreira, J, Kyle, D J, Chakravarty, S, Mavunkel, B J, Calixto, J B
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.09.1999)
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.09.1999)
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The mechanisms underlying the relaxant effect of methyl and ethyl gallates in the guinea pig trachea in vitro: contribution of potassium channels
Paulino, N, Pizollatti, M G, Yunes, R A, Filho, V C, Creczynski-Pasa, T B, Calixto, J B
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.09.1999)
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.09.1999)
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Journal Article
Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea
Passos, Giselle F., Fernandes, Elizabeth S., da Cunha, Fernanda M., Ferreira, Juliano, Pianowski, Luiz F., Campos, Maria M., Calixto, João B.
Published in Journal of ethnopharmacology (21.03.2007)
Published in Journal of ethnopharmacology (21.03.2007)
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Journal Article
Non-clinical studies in the process of new drug Development--Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies
Andrade, E.L, Bento, A.F, Cavalli, J, Oliveira, S.K, Schwanke, R.C, Siqueira, J.M, Freitas, C.S, Marcon, R, Calixto, J.B
Published in Brazilian journal of medical and biological research (01.12.2016)
Published in Brazilian journal of medical and biological research (01.12.2016)
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Journal Article