3-Substituted Quinolines as RORγt Inverse Agonists
Tanis, Virginia M., Venkatesan, Hariharan, Cummings, Maxwell D., Albers, Michael, Kent Barbay, J., Herman, Krystal, Kummer, David A., Milligan, Cynthia, Nelen, Marina I., Nishimura, Rachel, Schlueter, Thomas, Scott, Brian, Spurlino, John, Wolin, Ronald, Woods, Craig, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi
Published in Bioorganic & medicinal chemistry letters (15.06.2019)
Published in Bioorganic & medicinal chemistry letters (15.06.2019)
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Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a receptor antagonists
Barbay, J. Kent, Gong, Yong, Buntinx, Mieke, Li, Jian, Claes, Concha, Hornby, Pamela J., Van Lommen, Guy, Van Wauwe, Jean, He, Wei
Published in Bioorganic & medicinal chemistry (15.04.2008)
Published in Bioorganic & medicinal chemistry (15.04.2008)
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Journal Article
Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists
Gong, Yong, Barbay, J. Kent, Buntinx, Mieke, Li, Jian, Wauwe, Jean Van, Claes, Concha, Lommen, Guy Van, Hornby, Pamela J., He, Wei
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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Journal Article
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Bacani, Genesis M., Wei, Jianmei, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Chang, Leon, Clancy, Kathleen W., Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, Jiejun, Rui, Haopeng, Sepassi, Kia, Gaudiano, Marcello, Bekkers, Mariette, Cornelissen, Ivo, Packman, Kathryn, Seierstad, Mark, Xiouras, Christos, Bembenek, Scott D., Alexander, Richard, Milligan, Cynthia, Balasubramanian, Sriram, Lebsack, Alec D., Venable, Jennifer D., Philippar, Ulrike, Edwards, James P., Hirst, Gavin
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Journal Article
6-Substituted quinolines as RORγt inverse agonists
Barbay, J. Kent, Cummings, Maxwell D., Abad, Marta, Castro, Glenda, Kreutter, Kevin D., Kummer, David A., Maharoof, Umar, Milligan, Cynthia, Nishimura, Rachel, Pierce, Joan, Schalk-Hihi, Celine, Spurlino, John, Tanis, Virginia M., Urbanski, Maud, Venkatesan, Hariharan, Wang, Aihua, Woods, Craig, Wolin, Ronald, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
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Journal Article
Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity
Tichenor, Mark S, Wiener, John J. M, Rao, Navin L, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D, Bacani, Genesis M, Wei, Jianmei, Chang, Leon, Murrey, Heather E, Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J, Wu, JieJun, Seierstad, Mark, Bembenek, Scott D, Leonard, Kristi A, Lebsack, Alec D, Venable, Jennifer D, Edwards, James P
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
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Journal Article
Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists
Shook, Brian C., Chakravarty, Devraj, Barbay, J. Kent, Wang, Aihua, Leonard, Kristi, Alford, Vernon, Powell, Mark T., Rassnick, Stefanie, Scannevin, Robert H., Carroll, Karen, Wallace, Nathaniel, Crooke, Jeffrey, Ault, Mark, Lampron, Lisa, Westover, Lori, Rhodes, Kenneth, Jackson, Paul F.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Journal Article
Design and Characterization of Optimized Adenosine A2A/A1 Receptor Antagonists for the Treatment of Parkinson's Disease
Shook, Brian C, Rassnick, Stefanie, Wallace, Nathaniel, Crooke, Jeffrey, Ault, Mark, Chakravarty, Devraj, Barbay, J. Kent, Wang, Aihua, Powell, Mark T, Leonard, Kristi, Alford, Vernon, Scannevin, Robert H, Carroll, Karen, Lampron, Lisa, Westover, Lori, Lim, Heng-Keang, Russell, Ronald, Branum, Shawn, Wells, Kenneth M, Damon, Sandra, Youells, Scott, Li, Xun, Beauchamp, Derek A, Rhodes, Kenneth, Jackson, Paul F
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
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Journal Article
Optimization of arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists
Shook, Brian C, Rassnick, Stefanie, Chakravarty, Devraj, Wallace, Nathaniel, Ault, Mark, Crooke, Jeffrey, Barbay, J Kent, Wang, Aihua, Leonard, Kristi, Powell, Mark T, Alford, Vernon, Hall, Daniel, Rupert, Kenneth C, Heintzelman, Geoffrey R, Hansen, Kristen, Bullington, James L, Scannevin, Robert H, Carroll, Karen, Lampron, Lisa, Westover, Lori, Russell, Ronald, Branum, Shawn, Wells, Kenneth, Damon, Sandra, Youells, Scott, Beauchamp, Derek, Li, Xun, Rhodes, Kenneth, Jackson, Paul F
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Journal Article
Synthesis and SAR of pyridazinone-substituted phenylalanine amide α4 integrin antagonists
YONG GONG, BARBAY, J. Kent, KIMBALL, Edward S, SANTULLI, Rosemary J, FISHER, M. Carolyn, DYATKIN, Alexey B, MISKOWSKI, Tamara A, HORNBY, Pamela J, WEI HE
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
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Journal Article
Design and Characterization of Optimized Adenosine A(2A)/A(1) Receptor Antagonists for the Treatment of Parkinson's Disease
Shook, Brian C., Rassnick, Stefanie, Wallace, Nathaniel, Crooke, Jeffrey, Ault, Mark, Chakravarty, Devraj, Barbay, J. Kent, Wang, Aihua, Powell, Mark T., Leonard, Kristi, Alford, Vernon, Scannevin, Robert H., Carroll, Karen, Lampron, Lisa, Westover, Lori, Lim, Heng-Keang, Russell, Ronald, Branum, Shawn, Wells, Kenneth M., Damon, Sandra, Youells, Scott, Li, Xun, Beauchamp, Derek A., Rhodes, Kenneth, Jackson, Paul F.
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
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Journal Article
Substituted thieno[2,3-d]pyrimidines as adenosine A(2A) receptor antagonists
Shook, Brian C., Chakravarty, Devraj, Barbay, J. Kent, Wang, Aihua, Leonard, Kristi, Alford, Vernon, Powell, Mark T., Rassnick, Stefanie, Scannevin, Robert H., Carroll, Karen, Wallace, Nathaniel, Crooke, Jeffrey, Ault, Mark, Lampron, Lisa, Westover, Lori, Rhodes, Kenneth, Jackson, Paul F.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Journal Article
Design and Characterization of Optimized Adenosine A 2A /A 1 Receptor Antagonists for the Treatment of Parkinson's Disease
Shook, Brian C., Rassnick, Stefanie, Wallace, Nathaniel, Crooke, Jeffrey, Ault, Mark, Chakravarty, Devraj, Barbay, J. Kent, Wang, Aihua, Powell, Mark T., Leonard, Kristi, Alford, Vernon, Scannevin, Robert H., Carroll, Karen, Lampron, Lisa, Westover, Lori, Lim, Heng-Keang, Russell, Ronald, Branum, Shawn, Wells, Kenneth M., Damon, Sandra, Youells, Scott, Li, Xun, Beauchamp, Derek A., Rhodes, Kenneth, Jackson, Paul F.
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
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Journal Article
Synthesis and biological evaluation of novel pyridazinone-based alpha(4) integrin receptor antagonists
Gong, Yong, Barbay, J. Kent, Dyatkin, Alexey B., Miskowski, Tamara A., Kimball, Edward S., Prouty, Stephen M., Fisher, M. Carolyn, Santulli, Rosemary J., Schneider, Craig R., Wallace, Nathaniel H., Ballentine, Scott A., Hageman, William E., Masucci, John A., Maryanoff, Bruce E., Damiano, Bruce P., Andrade-Gordon, Patricia, Hlasta, Dennis J., Hornby, Pamela J., He, Wei
Published in Journal of medicinal chemistry (01.06.2006)
Published in Journal of medicinal chemistry (01.06.2006)
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Journal Article
Optimization of arylindenopyrimidines as potent adenosine A2A/A1 antagonists
SHOOK, Brian C, RASSNICK, Stefanie, ALFORD, Vernon, HALL, Daniel, RUPERT, Kenneth C, HEINTZELMAN, Geoffrey R, HANSEN, Kristen, BULLINGTON, James L, SCANNEVIN, Robert H, CARROLL, Karen, LAMPRON, Lisa, WESTOVER, Lori, CHAKRAVARTY, Devraj, RUSSELL, Ronald, BRANUM, Shawn, WELLS, Kenneth, DAMON, Sandra, YOUELLS, Scott, BEAUCHAMP, Derek, XUN LI, RHODES, Kenneth, JACKSON, Paul F, WALLACE, Nathaniel, AULT, Mark, CROOKE, Jeffrey, BARBAY, J. Kent, AIHUA WANG, LEONARD, Kristi, POWELL, Mark T
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Journal Article
Synthesis and Biological Evaluation of Novel Pyridazinone-Based α4 Integrin Receptor Antagonists
Gong, Yong, Barbay, J. Kent, Dyatkin, Alexey B, Miskowski, Tamara A, Kimball, Edward S, Prouty, Stephen M, Fisher, M. Carolyn, Santulli, Rosemary J, Schneider, Craig R, Wallace, Nathaniel H, Ballentine, Scott A, Hageman, William E, Masucci, John A, Maryanoff, Bruce E, Damiano, Bruce P, Andrade-Gordon, Patricia, Hlasta, Dennis J, Hornby, Pamela J, He, Wei
Published in Journal of medicinal chemistry (01.06.2006)
Published in Journal of medicinal chemistry (01.06.2006)
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Journal Article
Optimization of arylindenopyrimidines as potent adenosine A 2A/A 1 antagonists
Shook, Brian C., Rassnick, Stefanie, Chakravarty, Devraj, Wallace, Nathaniel, Ault, Mark, Crooke, Jeffrey, Barbay, J. Kent, Wang, Aihua, Leonard, Kristi, Powell, Mark T., Alford, Vernon, Hall, Daniel, Rupert, Kenneth C., Heintzelman, Geoffrey R., Hansen, Kristen, Bullington, James L., Scannevin, Robert H., Carroll, Karen, Lampron, Lisa, Westover, Lori, Russell, Ronald, Branum, Shawn, Wells, Kenneth, Damon, Sandra, Youells, Scott, Beauchamp, Derek, Li, Xun, Rhodes, Kenneth, Jackson, Paul F.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
Synthesis and SAR of pyridazinone-substituted phenylalanine amide α 4 integrin antagonists
Gong, Yong, Kent Barbay, J., Kimball, Edward S., Santulli, Rosemary J., Carolyn Fisher, M., Dyatkin, Alexey B., Miskowski, Tamara A., Hornby, Pamela J., He, Wei
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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Journal Article
Aminomethyl substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists
Shook, Brian C., Charavarty, Devraj, Barbay, J. Kent, Wang, Aihua, Leonard, Kristi, Alford, Vernon, Powell, Mark, Beauchamp, Derek A., Rassnick, Stefanie, Scannevin, Robert, Carroll, Karen, Wallace, Nathaniel, Crooke, Jeffrey, Ault, Mark, Lampron, Lisa, Westover, Lori, Rhodes, Kenneth, Jackson, Paul F.
Published in MedChemComm (2011)
Published in MedChemComm (2011)
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Journal Article
Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists
Gong, Yong, Barbay, J Kent, Dyatkin, Alexey B, Miskowski, Tamara A, Kimball, Edward S, Prouty, Stephen M, Fisher, M Carolyn, Santulli, Rosemary J, Schneider, Craig R, Wallace, Nathaniel H, Ballentine, Scott A, Hageman, William E, Masucci, John A, Maryanoff, Bruce E, Damiano, Bruce P, Andrade-Gordon, Patricia, Hlasta, Dennis J, Hornby, Pamela J, He, Wei
Published in Journal of medicinal chemistry (01.06.2006)
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Published in Journal of medicinal chemistry (01.06.2006)
Journal Article