Target Engagement of a Phosphodiesterase 2A Inhibitor Affecting Long-Term Memory in the Rat
Gu, Guibao, Scott, Trevor, Yan, Yingzhuo, Warren, Noelle, Zhang, Adia, Tabatabaei, Ali, Xu, Hao, Aertgeerts, Kathleen, Gomez, Laurent, Morse, Andrew, Li, Yu-Wen, Breitenbucher, J Guy, Massari, Eben, Vivian, Jeffrey, Danks, Anne
Published in The Journal of pharmacology and experimental therapeutics (01.09.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2019)
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Journal Article
Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase
Keith, John M., Jones, William, Pierce, Joan M., Seierstad, Mark, Palmer, James A., Webb, Michael, Karbarz, Mark, Scott, Brian P., Wilson, Sandy J., Luo, Lin, Wennerholm, Michelle, Chang, Leon, Rizzolio, Michele, Rynberg, Raymond, Chaplan, Sandra, Guy Breitenbucher, J.
Published in Bioorganic & medicinal chemistry letters (15.10.2020)
Published in Bioorganic & medicinal chemistry letters (15.10.2020)
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Journal Article
Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders
Gomez, Laurent, Massari, Mark Eben, Vickers, Troy, Freestone, Graeme, Vernier, William, Ly, Kiev, Xu, Rui, McCarrick, Margaret, Marrone, Tami, Metz, Markus, Yan, Yingzhou G, Yoder, Zachary W, Lemus, Robert, Broadbent, Nicola J, Barido, Richard, Warren, Noelle, Schmelzer, Kara, Neul, David, Lee, Dong, Andersen, Carsten B, Sebring, Kristen, Aertgeerts, Kathleen, Zhou, Xianbo, Tabatabaei, Ali, Peters, Marco, Breitenbucher, J. Guy
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Journal Article
Checkpoint Kinase Inhibitors: SAR and Radioprotective Properties of a Series of 2-Arylbenzimidazoles
Arienti, Kristen L, Brunmark, Anders, Axe, Frank U, McClure, Kelly, Lee, Alice, Blevitt, Jon, Neff, Danielle K, Huang, Liming, Crawford, Shelby, Pandit, Chennagiri R, Karlsson, Lars, Breitenbucher, J. Guy
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
Activation of TRPA1 by Farnesyl Thiosalicylic Acid
Maher, Michael, Ao, Hong, Banke, Tue, Nasser, Nadia, Wu, Nyan-Tsz, Breitenbucher, J Guy, Chaplan, Sandra R, Wickenden, Alan D
Published in Molecular pharmacology (01.04.2008)
Published in Molecular pharmacology (01.04.2008)
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Journal Article
Identification and Biological Evaluation of 4-(3-Trifluoromethylpyridin-2-yl)piperazine-1-carboxylic Acid (5-Trifluoromethylpyridin-2-yl)amide, a High Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist
Swanson, Devin M, Dubin, Adrienne E, Shah, Chandra, Nasser, Nadia, Chang, Leon, Dax, Scott L, Jetter, Michele, Breitenbucher, J. Guy, Liu, Changlu, Mazur, Curt, Lord, Brian, Gonzales, Lisa, Hoey, Kenway, Rizzolio, Michele, Bogenstaetter, Michael, Codd, Ellen E, Lee, Doo H, Zhang, Sui-Po, Chaplan, Sandra R, Carruthers, Nicholas I
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
Discovery of a novel series of selective HCN1 blockers
McClure, Kelly J., Maher, Michael, Wu, Nancy, Chaplan, Sandra R., Eckert, William A., Lee, Dong H., Wickenden, Alan D., Hermann, Michelle, Allison, Brett, Hawryluk, Natalie, Breitenbucher, J. Guy, Grice, Cheryl A.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
PDE2 inhibition: Potential for the treatment of cognitive disorders
Gomez, Laurent, Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Journal Article
Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites
Tichenor, Mark S., Keith, John M., Jones, William M., Pierce, Joan M., Merit, Jeff, Hawryluk, Natalie, Seierstad, Mark, Palmer, James A., Webb, Michael, Karbarz, Mark J., Wilson, Sandy J., Wennerholm, Michelle L., Woestenborghs, Filip, Beerens, Dominiek, Luo, Lin, Brown, Sean M., Boeck, Marlies De, Chaplan, Sandra R., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4- d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist
Maher, Michael P., Bhattacharya, Anindya, Ao, Hong, Swanson, Nadia, Wu, Nyan-Tsz, Freedman, Jamie, Kansagara, Mena, Scott, Brian, Li, Dong H., Eckert, William A., Liu, Yi, Sepassi, Kia, Rizzolio, Michele, Fitzgerald, Anne, Liu, Jing, Branstetter, Bryan J., Rech, Jason C., Lebsack, Alec D., Breitenbucher, J. Guy, Wickenden, Alan D., Chaplan, Sandra R.
Published in European journal of pharmacology (01.08.2011)
Published in European journal of pharmacology (01.08.2011)
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Journal Article
Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands
LEE-DUTRA, Alice, ARIENTI, Kristen L, BREITENBUCHER, J. Guy, BUZARD, Daniel J, HACK, Michael D, KHATUYA, Haripada, DESAI, Pragnya J, NGUYEN, Steven, THURMOND, Robin L, KARLSSON, Lars, EDWARDS, James P
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
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Journal Article
Identification and synthesis of 2,7-diamino-thiazolo[5,4- d]pyrimidine derivatives as TRPV1 antagonists
Lebsack, Alec D., Branstetter, Bryan J., Hack, Michael D., Xiao, Wei, Peterson, Matthew L., Nasser, Nadia, Maher, Michael P., Ao, Hong, Bhattacharya, Anindya, Kansagara, Mena, Scott, Brian P., Luo, Lin, Rynberg, Raymond, Rizzolio, Michele, Chaplan, Sandra R., Wickenden, Alan D., Guy Breitenbucher, J.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Journal Article
Mathematical and Structural Characterization of Strong Nonadditive Structure–Activity Relationship Caused by Protein Conformational Changes
Gomez, Laurent, Xu, Rui, Sinko, William, Selfridge, Brandon, Vernier, William, Ly, Kiev, Truong, Richard, Metz, Markus, Marrone, Tami, Sebring, Kristen, Yan, Yingzhou, Appleton, Brent, Aertgeerts, Kathleen, Massari, Mark Eben, Breitenbucher, J. Guy
Published in Journal of medicinal chemistry (13.09.2018)
Published in Journal of medicinal chemistry (13.09.2018)
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Journal Article
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties
Dyck, Brian, Branstetter, Bryan, Gharbaoui, Tawfik, Hudson, Andrew R, Breitenbucher, J. Guy, Gomez, Laurent, Botrous, Iriny, Marrone, Tami, Barido, Richard, Allerston, Charles K, Cedervall, E. Peder, Xu, Rui, Sridhar, Vandana, Barker, Ryan, Aertgeerts, Kathleen, Schmelzer, Kara, Neul, David, Lee, Dong, Massari, Mark Eben, Andersen, Carsten B, Sebring, Kristen, Zhou, Xianbo, Petroski, Robert, Limberis, James, Augustin, Martin, Chun, Lawrence E, Edwards, Thomas E, Peters, Marco, Tabatabaei, Ali
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Journal Article
Novel non-benzimidazole chk2 kinase inhibitors
McClure, Kelly J., Huang, Liming, Arienti, Kristen L., Axe, Frank U., Brunmark, Anders, Blevitt, Jon, Guy Breitenbucher, J.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Journal Article
Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors
Katz, Bradley A., Elrod, Kyle, Verner, Erik, Mackman, Richard L., Luong, Christine, Shrader, William D., Sendzik, Martin, Spencer, Jeffrey R., Sprengeler, Paul A., Kolesnikov, Aleks, Tai, Vincent W.-F., Hui, Hon C., Guy Breitenbucher, J., Allen, Darin, Janc, James W.
Published in Journal of molecular biology (23.05.2003)
Published in Journal of molecular biology (23.05.2003)
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Journal Article
Design and Synthesis of Novel and Selective Glycine Transporter‑1 (GlyT1) Inhibitors with Memory Enhancing Properties
Santora, Vincent J, Almos, Theresa A, Barido, Richard, Basinger, Jillian, Bellows, Chris L, Bookser, Brett C, Breitenbucher, J. Guy, Broadbent, Nicola J, Cabebe, Clifford, Chai, Chih-Kun, Chen, Mi, Chow, Stephine, Chung, De Michael, Crickard, Lindsay, Danks, Anne M, Freestone, Graeme C, Gitnick, Dany, Gupta, Varsha, Hoffmaster, Christine, Hudson, Andrew R, Kaplan, Alan P, Kennedy, Michael R, Lee, Dong, Limberis, James, Ly, Kiev, Mak, Chi Ching, Masatsugu, Brittany, Morse, Andrew C, Na, Jim, Neul, David, Nikpur, John, Peters, Marco, Petroski, Robert E, Renick, Joel, Sebring, Kristen, Sevidal, Samantha, Tabatabaei, Ali, Wen, Jenny, Yan, Yingzhuo, Yoder, Zachary W, Zook, Douglas
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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Journal Article
Preclinical Characterization of the FAAH Inhibitor JNJ-42165279
Keith, John M, Jones, William M, Tichenor, Mark, Liu, Jing, Seierstad, Mark, Palmer, James A, Webb, Michael, Karbarz, Mark, Scott, Brian P, Wilson, Sandy J, Luo, Lin, Wennerholm, Michelle L, Chang, Leon, Rizzolio, Michele, Rynberg, Raymond, Chaplan, Sandra R, Breitenbucher, J. Guy
Published in ACS medicinal chemistry letters (10.12.2015)
Published in ACS medicinal chemistry letters (10.12.2015)
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Journal Article
Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties
Hudson, Andrew R., Santora, Vincent J., Petroski, Robert E., Almos, Theresa A., Anderson, Gary, Barido, Richard, Basinger, Jillian, Bellows, Chris L., Bookser, Brett C., Broadbent, Nicola J., Cabebe, Clifford, Chai, Chih-Kun, Chen, Mi, Chow, Stephine, Chung, De Michael, Heger, Lindsay, Danks, Anne M., Freestone, Graeme C., Gitnick, Dany, Gupta, Varsha, Hoffmaster, Christine, Kaplan, Alan P., Kennedy, Michael R., Lee, Dong, Limberis, James, Ly, Kiev, Mak, Chi Ching, Masatsugu, Brittany, Morse, Andrew C., Na, Jim, Neul, David, Nikpur, John, Renick, Joel, Sebring, Kristen, Sevidal, Samantha, Tabatabaei, Ali, Wen, Jenny, Xia, Shouzhen, Yan, Yingzhuo, Yoder, Zachary W., Zook, Douglas, Peters, Marco, Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (15.07.2020)
Published in Bioorganic & medicinal chemistry letters (15.07.2020)
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