Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis
Todorović, Viktor, Su, Zhi, Putman, C. Brent, Kakavas, Stevan J., Salte, Katherine M., McDonald, Heath A., Wetter, Joseph B., Paulsboe, Stephanie E., Sun, Qi, Gerstein, Clare E., Medina, Limary, Sielaff, Bernhard, Sadhukhan, Ramkrishna, Stockmann, Henning, Richardson, Paul L., Qiu, Wei, Argiriadi, Maria A., Henry, Rodger F., Herold, J. Martin, Shotwell, J. Brad, McGaraughty, Steve P., Honore, Prisca, Gopalakrishnan, Sujatha M., Sun, Chaohong C., Scott, Victoria E.
Published in Scientific reports (24.06.2019)
Published in Scientific reports (24.06.2019)
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Journal Article
Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines
Liu, Feng, Barsyte-Lovejoy, Dalia, Allali-Hassani, Abdellah, He, Yunlong, Herold, J. Martin, Chen, Xin, Yates, Christopher M, Frye, Stephen V, Brown, Peter J, Huang, Jing, Vedadi, Masoud, Arrowsmith, Cheryl H, Jin, Jian
Published in Journal of medicinal chemistry (08.09.2011)
Published in Journal of medicinal chemistry (08.09.2011)
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Journal Article
Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
Ma, Anqi, Yu, Wenyu, Li, Fengling, Bleich, Rachel M, Herold, J. Martin, Butler, Kyle V, Norris, Jacqueline L, Korboukh, Victoria, Tripathy, Ashutosh, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V, Vedadi, Masoud, Brown, Peter J, Jin, Jian
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Journal Article
Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wasney, Gregory A, Dong, Aiping, Barsyte, Dalia, Kozieradzki, Ivona, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Frye, Stephen V, Arrowsmith, Cheryl H, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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Journal Article
Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines
Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wigle, Tim J, Wasney, Gregory A, Dong, Aiping, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Norris, Jacqueline L, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
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Journal Article
Screening for Inhibitors of Low-Affinity Epigenetic Peptide-Protein Interactions: An AlphaScreen™-Based Assay for Antagonists of Methyl-Lysine Binding Proteins
Wigle, Tim J., Herold, J. Martin, Senisterra, Guillermo A., Vedadi, Masoud, Kireev, Dmitri B., Arrowsmith, Cheryl H., Frye, Stephen V., Janzen, William P.
Published in Journal of biomolecular screening (01.01.2010)
Published in Journal of biomolecular screening (01.01.2010)
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Journal Article
Identification of Non-Peptide Malignant Brain Tumor (MBT) Repeat Antagonists by Virtual Screening of Commercially Available Compounds
Kireev, Dmitri, Wigle, Tim J, Norris-Drouin, Jacqueline, Herold, J. Martin, Janzen, William P, Frye, Stephen V
Published in Journal of medicinal chemistry (11.11.2010)
Published in Journal of medicinal chemistry (11.11.2010)
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Journal Article
Assessment of free energy predictors for ligand binding to a methyllysine histone code reader
Gao, Cen, Herold, J. Martin, Kireev, Dmitri
Published in Journal of computational chemistry (05.03.2012)
Published in Journal of computational chemistry (05.03.2012)
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Journal Article
Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712
Breinlinger, Eric, Van Epps, Stacy, Friedman, Michael, Argiriadi, Maria, Chien, Ellen, Chhor, Gekleng, Cowart, Marlon, Dunstan, Theresa, Graff, Candace, Hardee, David, Herold, J. Martin, Little, Andrew, McCarthy, Richard, Parmentier, Julie, Perham, Matthew, Qiu, Wei, Schrimpf, Michael, Vargo, Thomas, Webster, Matthew P., Wu, Fei, Bennett, Dawn, Edmunds, Jeremy
Published in Journal of medicinal chemistry (26.10.2023)
Published in Journal of medicinal chemistry (26.10.2023)
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Journal Article
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
James, Lindsey I, Barsyte-Lovejoy, Dalia, Zhong, Nan, Krichevsky, Liubov, Korboukh, Victoria K, Herold, J Martin, MacNevin, Christopher J, Norris, Jacqueline L, Sagum, Cari A, Tempel, Wolfram, Marcon, Edyta, Guo, Hongbo, Gao, Cen, Huang, Xi-Ping, Duan, Shili, Emili, Andrew, Greenblatt, Jack F, Kireev, Dmitri B, Jin, Jian, Janzen, William P, Brown, Peter J, Bedford, Mark T, Arrowsmith, Cheryl H, Frye, Stephen V
Published in Nature chemical biology (01.03.2013)
Published in Nature chemical biology (01.03.2013)
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Journal Article
Small-Molecule Ligands of Methyl-Lysine Binding Proteins: Optimization of Selectivity for L3MBTL3
James, Lindsey I, Korboukh, Victoria K, Krichevsky, Liubov, Baughman, Brandi M, Herold, J. Martin, Norris, Jacqueline L, Jin, Jian, Kireev, Dmitri B, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V
Published in Journal of medicinal chemistry (26.09.2013)
Published in Journal of medicinal chemistry (26.09.2013)
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Journal Article
Small-Molecule Ligands of Methyl-Lysine Binding Proteins
Herold, J. Martin, Wigle, Tim J, Norris, Jacqueline L, Lam, Robert, Korboukh, Victoria K, Gao, Cen, Ingerman, Lindsey A, Kireev, Dmitri B, Senisterra, Guillermo, Vedadi, Masoud, Tripathy, Ashutosh, Brown, Peter J, Arrowsmith, Cheryl H, Jin, Jian, Janzen, William P, Frye, Stephen V
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Journal Article
Structure–activity relationships of methyl-lysine reader antagonists
Herold, J. Martin, James, Lindsey Ingerman, Korboukh, Victoria K., Gao, Cen, Coil, Kaitlyn E., Bua, Dennis J., Norris, Jacqueline L., Kireev, Dmitri B., Brown, Peter J., Jin, Jian, Janzen, William P., Gozani, Or, Frye, Stephen V.
Published in MedChemComm (01.01.2012)
Published in MedChemComm (01.01.2012)
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Journal Article
PRIMARY CARBOXAMIDES AS BTK INHIBITORS
NOEL S WILSON, ANIL VASUDEVAN, STACY A VAN EPPS, JII WAN, MICHAEL M FRIEDMAN, AUGUSTINE OSUMA, RAYMOND HUNTLEY, GAGANDEEP K SOMAL, J MARTIN HEROLD, XU XIANGDONG, GRIER A WALLACE, WANG LU, HEATHER M DAVIS, MICHAEL Z HOEMANN, GEORGE SHEPPARD, DOMINIQUE BONAFOUX, KRISTINE E FRANK, JENNIFER VAN CAMP
Year of Publication 07.01.2021
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Year of Publication 07.01.2021
Patent
INHIBITOR OF TYROSINE KINASE 2 MEDIATED SIGNAL TRANSDUCTION
MARIA A ARGIRIADI, ELLEN YULIN TSAI CHIEN, LIU HUAQING, STACY A VAN EPPS, MICHAEL M FRIEDMAN, MATTHEW P WEBSTER, DAVID A SCHIEDLER, J MARTIN HEROLD, ANDREW J LITTLE, MICHAEL R SCHRIMPF, DAVID J HARDEE, MARLON D COWART, THOMAS R VARGO, MATTHEW H KATCHER, MARC J SCANIO, KRISTINE E FRANK, THERESA A DUNSTAN, ERIC C BREINLINGER, WEI QIU
Year of Publication 07.11.2019
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Year of Publication 07.11.2019
Patent
INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING
MARIA A ARGIRIADI, ELLEN YULIN TSAI CHIEN, LIU HUAQING, STACY A VAN EPPS, MICHAEL M FRIEDMAN, MATTHEW P WEBSTER, DAVID A SCHIEDLER, J MARTIN HEROLD, ANDREW J LITTLE, MICHAEL R SCHRIMPF, DAVID J HARDEE, MARLON D COWART, THOMAS R VARGO, MATTHEW H KATCHER, MARC J SCANIO, KRISTINE E FRANK, THERESA A DUNSTAN, ERIC C BREINLINGER, WEI QIU
Year of Publication 19.09.2019
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Year of Publication 19.09.2019
Patent
PRIMARY CARBOXAMIDES AS BTK INHIBITORS
NOEL S WILSON, ANIL VASUDEVAN, STACY A VAN EPPS, JII WAN, MICHAEL M FRIEDMAN, AUGUSTINE OSUMA, RAYMOND HUNTLEY, GAGANDEEP K SOMAL, J MARTIN HEROLD, XU XIANGDONG, GRIER A WALLACE, WANG LU, HEATHER M DAVIS, MICHAEL Z HOEMANN, GEORGE SHEPPARD, DOMINIQUE BONAFOUX, KRISTINE E FRANK, JENNIFER VAN CAMP
Year of Publication 25.07.2019
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Year of Publication 25.07.2019
Patent
Drug discovery toward antagonists of methyl-lysine binding proteins
Herold, J Martin, Ingerman, Lindsey A, Gao, Cen, Frye, Stephen V
Published in Current chemical genomics (2011)
Published in Current chemical genomics (2011)
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Journal Article