Potent preclinical antitumor activity of MGCD265, an oral Met/VEGFR kinase inhibitor in phase II clinical development, in combination with taxanes or erlotinib
Besterman, J. M., Fournel, M., Dupont, I., Bonfils, C., Dubay, M., Ste-Croix, H., Maroun, C. R.
Published in Journal of clinical oncology (20.05.2010)
Published in Journal of clinical oncology (20.05.2010)
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MGCD265, an oral Met/VEGFR multitargeted receptor tyrosine kinase inhibitor, in combination with erlotinib: Phase I clinical experience
O'Dwyer, P. J., Papadopoulos, K. P., Tolcher, A. W., Teitelbaum, U. R., Harlacker, K., Beeram, M., Sohal, D., Mehran, M., Tawashi, M., Drouin, M. A., Maroun, C. R., Wang, J., Fournel, M., Karam, A., Besterman, J. M., Patnaik, A.
Published in Journal of clinical oncology (20.05.2011)
Published in Journal of clinical oncology (20.05.2011)
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Daily administration of MGCD265 to patients with solid tumors in a dose-escalation phase I study (study 265-101)
Drouin, M. A., Kollmannsberger, C. K., Uronis, H. E., Martell, R. E., Wang, J., Dubay, M., Dupont, I., Besterman, J. M., Hurwitz, H., Shapiro, G.
Published in Journal of clinical oncology (20.05.2010)
Published in Journal of clinical oncology (20.05.2010)
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Journal Article
Phase II study of MGCD0103 in patients with relapsed follicular lymphoma (FL): Study reinitiation and update of clinical efficacy and safety
Martell, R. E., Younes, A., Assouline, S. E., Rizzieri, D., Fox, S., Drouin, M. A., Wilhelm, J., Mehran, M., Besterman, J. M., Van Der Jagt, R. H.
Published in Journal of clinical oncology (20.05.2010)
Published in Journal of clinical oncology (20.05.2010)
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A phase I study of oral administration of MGCD265 in patients with advanced malignancies (study 265-102)
Heath, E. I., LoRusso, P., Kurzrock, R., Falchook, G. S., Maroun, C. R., Drouin, M. A., Juretic, M., Martell, R. E., Besterman, J. M., Wheler, J. J.
Published in Journal of clinical oncology (20.05.2010)
Published in Journal of clinical oncology (20.05.2010)
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Journal Article
Determination of the maximum tolerated dose (MTD) of MGCD265, an oral Met/VEGFR multitargeted receptor tyrosine kinase inhibitor, in combination with docetaxel
Rasco, D. W., Patnaik, A., Amaravadi, R. K., Papadopoulos, K. P., Haas, N. B., Tolcher, A. W., Beeram, M., Harlacker, K., Drouin, M. A., Tawashi, M., Wang, J., Karam, A., Maroun, C. R., Bonfils, C., Mehran, M., Besterman, J. M., O'Dwyer, P. J.
Published in Journal of clinical oncology (20.05.2011)
Published in Journal of clinical oncology (20.05.2011)
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Journal Article
DNA intercalation and inhibition of topoisomerase II
Besterman, J M, Elwell, L P, Cragoe, E J, Andrews, C W, Cory, M
Published in The Journal of biological chemistry (01.02.1989)
Published in The Journal of biological chemistry (01.02.1989)
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Phase I trials of the oral histone deacetylase (HDAC) inhibitor MGCD0103 given either daily or 3x weekly for 14 days every 3 weeks in patients (pts) with advanced solid tumors
Gelmon, K., Tolcher, A., Carducci, M., Reid, G. K., Li, Z., Kalita, A., Callejas, V., Longstreth, J., Besterman, J. M., Siu, L. L.
Published in Journal of clinical oncology (01.06.2005)
Published in Journal of clinical oncology (01.06.2005)
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Journal Article
Pharmacodynamic effect of MGCD0103, an oral isotype-selective histone deacetylase (HDAC) inhibitor, on HDAC enzyme inhibition and histone acetylation induction in phase I clinical trials in patients (pts) with advanced solid tumors or non-Hodgkin’s lymphoma (NHL)
Kalita, A., Maroun, C., Bonfils, C., Gelmon, K., Siu, L. L., Tolcher, A., Carducci, M., Besterman, J. M., Reid, G. K., Li, Z.
Published in Journal of clinical oncology (01.06.2005)
Published in Journal of clinical oncology (01.06.2005)
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Journal Article
Modulation of the Multidrug-Resistance Phenotype by New Tropane Alkaloid Aromatic Esters from Erythroxylum pervillei
SILVA, Gloria L., CUI, Baoliang, CHáVEZ, Daniel, YOU, Min, CHAI, Hee-Byung, RASOANAIVO, Philippe, LYNN, Sean M., O'NEILL, Melanie J., LEWIS, Jane A., BESTERMAN, Jeffrey M., MONKS, Anne, FARNSWORTH, Norman R., CORDELL, Geoffrey A., PEZZUTO, John M., KINGHORN, A. Douglas
Published in Journal of natural products (Washington, D.C.) (01.12.2001)
Published in Journal of natural products (Washington, D.C.) (01.12.2001)
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Down-regulation of Human DNA-(Cytosine-5) Methyltransferase Induces Cell Cycle Regulators p16ink4A and p21 super(WAF/Cip1) by Distinct Mechanisms
Fournel, M, Sapieha, P, Beaulieu, N, Besterman, J M, MacLeod, A R
Published in The Journal of biological chemistry (20.08.1999)
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Published in The Journal of biological chemistry (20.08.1999)
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Structurally Simple Trichostatin A-Like Straight Chain Hydroxamates as Potent Histone Deacetylase Inhibitors
Woo, Soon Hyung, Frechette, Sylvie, Khalil, Elie Abou, Bouchain, Giliane, Vaisburg, Arkadii, Bernstein, Naomy, Moradei, Oscar, Leit, Silvana, Allan, Martin, Fournel, Marielle, Trachy-Bourget, Marie-Claude, Li, Zuomei, Besterman, Jeffrey M, Delorme, Daniel
Published in Journal of medicinal chemistry (20.06.2002)
Published in Journal of medicinal chemistry (20.06.2002)
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Journal Article
Development of Potential Antitumor Agents. Synthesis and Biological Evaluation of a New Set of Sulfonamide Derivatives as Histone Deacetylase Inhibitors
Bouchain, Giliane, Leit, Silvana, Frechette, Sylvie, Khalil, Elie Abou, Lavoie, Rico, Moradei, Oscar, Woo, Soon Hyung, Fournel, Marielle, Yan, Pu T, Kalita, Ann, Trachy-Bourget, Marie-Claude, Beaulieu, Carole, Li, Zuomei, Robert, Marie-France, MacLeod, A. Robert, Besterman, Jeffrey M, Delorme, Daniel
Published in Journal of medicinal chemistry (27.02.2003)
Published in Journal of medicinal chemistry (27.02.2003)
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Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks
DAVIS, Alison J, GELMON, Karen A, AYERS, Debbie, FIRBY, Patricia, BESTERMAN, Jeffrey M, REID, Gregory K, EISENHAUER, Elizabeth A, SIU, Lillian L, MOORE, Malcolm J, BRITTEN, Carolyn D, MISTRY, Nisha, KLAMUT, Henry, D'ALOISIO, Susan, MACLEAN, Martha, WAINMAN, Nancy
Published in Investigational new drugs (01.02.2003)
Published in Investigational new drugs (01.02.2003)
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(2-Amino-phenyl)-amides of ω-substituted alkanoic acids as new histone deacetylase inhibitors
Vaisburg, Arkadii, Bernstein, Naomy, Frechette, Sylvie, Allan, Martin, Abou-Khalil, Elie, Leit, Silvana, Moradei, Oscar, Bouchain, Giliane, Wang, James, Woo, Soon Hyung, Fournel, Marielle, Yan, Pu T., Trachy-Bourget, Marie-Claude, Kalita, Ann, Beaulieu, Carole, Li, Zuomei, MacLeod, A.Robert, Besterman, Jeffrey M., Delorme, Daniel
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
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Journal Article
Specific inhibition of DNA polymerase β by its 14 kDa domain: role of single- and double-stranded DNA binding and 5′-phosphate recognition
Husain, Intisar, Morton, Bradley S., Beard, William A., Singhal, Rakesh K., Prasad, Rajendra, Wilson, Samuel H., Besterman, Jeffrey M.
Published in Nucleic acids research (11.05.1995)
Published in Nucleic acids research (11.05.1995)
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Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: Demonstration of tumor-type specificity and implications for cancer chemotherapy
Husain, I, Mohler, J L, Seigler, H F, Besterman, J M
Published in Cancer research (Chicago, Ill.) (01.01.1994)
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Published in Cancer research (Chicago, Ill.) (01.01.1994)
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