α-Methyl Polyamines: Efficient Synthesis and Tolerance Studies in Vivo and in Vitro. First Evidence for Dormant Stereospecificity of Polyamine Oxidase
Järvinen, Aki J, Cerrada-Gimenez, Marc, Grigorenko, Nikolay A, Khomutov, Alex R, Vepsäläinen, Jouko J, Sinervirta, Riitta M, Keinänen, Tuomo A, Alhonen, Leena I, Jänne, Juhani E
Published in Journal of medicinal chemistry (12.01.2006)
Published in Journal of medicinal chemistry (12.01.2006)
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Genetic Manipulation of Polyamine Catabolism in Rodents
Jänne, Juhani, Alhonen, Leena, Pietilä, Marko, Keinänen, Tuomo A, Uimari, Anne, Hyvönen, Mervi T, Pirinen, Eija, Järvinen, Aki
Published in Journal of biochemistry (Tokyo) (01.02.2006)
Published in Journal of biochemistry (Tokyo) (01.02.2006)
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Alpha-methylated polyamines as potential drugs and experimental tools in enzymology
Keinänen, Tuomo A, Järvinen, Aki, Uimari, Anne, Vepsäläinen, Jouko, Khomutov, Alex R, Grigorenko, Nikolay A, Hyvönen, Mervi T, Cerrada-Gimenez, Marc, Alhonen, Leena, Jänne, Juhani
Published in Mini reviews in medicinal chemistry (01.08.2007)
Published in Mini reviews in medicinal chemistry (01.08.2007)
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Synthesis of novel optical isomers of α-methylpolyamines
Grigorenko, Nikolay A., Khomutov, Alex R., Keinänen, Tuomo A., Järvinen, Aki, Alhonen, Leena, Jänne, Juhani, Vepsäläinen, Jouko
Published in Tetrahedron (05.03.2007)
Published in Tetrahedron (05.03.2007)
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Animal disease models generated by genetic engineering of polyamine metabolism
Jänne, Juhani, Alhonen, Leena, Keinänen, Tuomo A., Pietilä, Marko, Uimari, Anne, Pirinen, Eija, Hyvönen, Mervi T., Järvinen, Aki
Published in Journal of cellular and molecular medicine (01.10.2005)
Published in Journal of cellular and molecular medicine (01.10.2005)
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Metabolic Stability of α-Methylated Polyamine Derivatives and Their Use as Substitutes for the Natural Polyamines
Järvinen, Aki, Grigorenko, Nikolay, Khomutov, Alex R., Hyvönen, Mervi T., Uimari, Anne, Vepsäläinen, Jouko, Sinervirta, Riitta, Keinänen, Tuomo A., Vujcic, Slavoljub, Alhonen, Leena, Porter, Carl W., Jänne, Juhani
Published in The Journal of biological chemistry (25.02.2005)
Published in The Journal of biological chemistry (25.02.2005)
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Guide Molecule-driven Stereospecific Degradation of α-Methylpolyamines by Polyamine Oxidase
Järvinen, Aki, Keinänen, Tuomo A., Grigorenko, Nikolay A., Khomutov, Alex R., Uimari, Anne, Vepsäläinen, Jouko, Närvänen, Ale, Alhonen, Leena, Jänne, Juhani
Published in The Journal of biological chemistry (24.02.2006)
Published in The Journal of biological chemistry (24.02.2006)
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Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues
Niiranen, Kirsi, Pietilä, Marko, Pirttilä, Terhi J, Järvinen, Aki, Halmekytö, Maria, Korhonen, Veli-Pekka, Keinänen, Tuomo A, Alhonen, Leena, Jänne, Juhani
Published in The Journal of biological chemistry (12.07.2002)
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Published in The Journal of biological chemistry (12.07.2002)
Journal Article
Targeted Disruption of Spermidine/SpermineN1-Acetyltransferase Gene in Mouse Embryonic Stem Cells
Niiranen, Kirsi, Pietilä, Marko, Pirttilä, Terhi J., Järvinen, Aki, Halmekytö, Maria, Korhonen, Veli-Pekka, Keinänen, Tuomo A., Alhonen, Leena, Jänne, Juhani
Published in The Journal of biological chemistry (12.07.2002)
Published in The Journal of biological chemistry (12.07.2002)
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Journal Article
Targeted Disruption of Spermidine/SpermineN 1-Acetyltransferase Gene in Mouse Embryonic Stem Cells
Niiranen, Kirsi, Pietilä, Marko, Pirttilä, Terhi J., Järvinen, Aki, Halmekytö, Maria, Korhonen, Veli-Pekka, Keinänen, Tuomo A., Alhonen, Leena, Jänne, Juhani
Published in The Journal of biological chemistry (12.07.2002)
Published in The Journal of biological chemistry (12.07.2002)
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Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase-overexpressing transgenic rats
Lukkarinen, Jouko A., Kauppinen, Risto A., Gröhn, Olli H. J., Oja, Joni M. E., Sinervirta, Riitta, Järvinen, Aki, Alhonen, Leena I., Jänne, Juhani
Published in The European journal of neuroscience (01.06.1998)
Published in The European journal of neuroscience (01.06.1998)
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Journal Article
Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase-overexpressing transgenic rats: ODC transgenic rats are focal ischaemia resistant
Lukkarinen, Jouko A., Kauppinen, Risto A., Gröhn, Olli H. J., Oja, Joni M. E., Sinervirta, Riitta, Järvinen, Aki, Alhonen, Leena I., Jänne, Juhani
Published in The European journal of neuroscience (01.06.1998)
Published in The European journal of neuroscience (01.06.1998)
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Journal Article