Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor
McKinzie, David L, Winneroski, Leonard L, Green, Steven J, Hembre, Erik J, Erickson, Jon A, Willis, Brian A, Monk, Scott A, Aluise, Christopher D, Baker, Thomas K, Lopez, Jose E, Hendle, Jörg, Beck, James P, Brier, Richard A, Boggs, Leonard N, Borders, Anthony R, Cocke, Patrick J, Garcia-Losada, Pablo, Lowe, Stephen L, Mathes, Brian M, May, Patrick C, Porter, Warren J, Stout, Stephanie L, Timm, David E, Watson, Brian M, Yang, Zhixiang, Mergott, Dustin J
Published in Journal of medicinal chemistry (24.06.2021)
Published in Journal of medicinal chemistry (24.06.2021)
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Discovery of potent small-molecule inhibitors of lipoprotein(a) formation
Diaz, Nuria, Perez, Carlos, Escribano, Ana Maria, Sanz, Gema, Priego, Julian, Lafuente, Celia, Barberis, Mario, Calle, Luis, Espinosa, Juan Felix, Priest, Birgit T., Zhang, Hong Y., Nosie, Amanda K., Haas, Joseph V., Cannady, Ellen, Borel, Anthony, Schultze, Albert E., Sauder, J. Michael, Hendle, Jörg, Weichert, Ken, Nicholls, Stephen J., Michael, Laura F.
Published in Nature (London) (23.05.2024)
Published in Nature (London) (23.05.2024)
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Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints
Winneroski, Leonard L., Erickson, Jon A., Green, Steven J., Lopez, Jose E., Stout, Stephanie L., Porter, Warren J., Timm, David E., Audia, James E., Barberis, Mario, Beck, James P., Boggs, Leonard N., Borders, Anthony R., Boyer, Robert D., Brier, Richard A., Hembre, Erik J., Hendle, Jörg, Garcia-Losada, Pablo, Minguez, Jose Miguel, Mathes, Brian M., May, Patrick C., Monk, Scott A., Rankovic, Zoran, Shi, Yuan, Watson, Brian M., Yang, Zhixiang, Mergott, Dustin J.
Published in Bioorganic & medicinal chemistry (01.01.2020)
Published in Bioorganic & medicinal chemistry (01.01.2020)
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LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants
Westendorf, Kathryn, Žentelis, Stefanie, Wang, Lingshu, Foster, Denisa, Vaillancourt, Peter, Wiggin, Matthew, Lovett, Erica, van der Lee, Robin, Hendle, Jörg, Pustilnik, Anna, Sauder, J. Michael, Kraft, Lucas, Hwang, Yuri, Siegel, Robert W., Chen, Jinbiao, Heinz, Beverly A., Higgs, Richard E., Kallewaard, Nicole L., Jepson, Kevin, Goya, Rodrigo, Smith, Maia A., Collins, David W., Pellacani, Davide, Xiang, Ping, de Puyraimond, Valentine, Ricicova, Marketa, Devorkin, Lindsay, Pritchard, Caitlin, O’Neill, Aoise, Dalal, Kush, Panwar, Pankaj, Dhupar, Harveer, Garces, Fabian A., Cohen, Courtney A., Dye, John M., Huie, Kathleen E., Badger, Catherine V., Kobasa, Darwyn, Audet, Jonathan, Freitas, Joshua J., Hassanali, Saleema, Hughes, Ina, Munoz, Luis, Palma, Holly C., Ramamurthy, Bharathi, Cross, Robert W., Geisbert, Thomas W., Menachery, Vineet, Lokugamage, Kumari, Borisevich, Viktoriya, Lanz, Iliana, Anderson, Lisa, Sipahimalani, Payal, Corbett, Kizzmekia S., Yang, Eun Sung, Zhang, Yi, Shi, Wei, Zhou, Tongqing, Choe, Misook, Misasi, John, Kwong, Peter D., Sullivan, Nancy J., Graham, Barney S., Fernandez, Tara L., Hansen, Carl L., Falconer, Ester, Mascola, John R., Jones, Bryan E., Barnhart, Bryan C.
Published in Cell Reports (17.05.2022)
Published in Cell Reports (17.05.2022)
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SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
Buchanan, Sean G, Hendle, Jorg, Lee, Patrick S, Smith, Christopher R, Bounaud, Pierre-Yves, Jessen, Katti A, Tang, Crystal M, Huser, Nanni H, Felce, Jeremy D, Froning, Karen J, Peterman, Marshall C, Aubol, Brandon E, Gessert, Steve F, Sauder, J Michael, Schwinn, Kenneth D, Russell, Marijane, Rooney, Isabelle A, Adams, Jason, Leon, Barbara C, Do, Tuan H, Blaney, Jeff M, Sprengeler, Paul A, Thompson, Devon A, Smyth, Lydia, Pelletier, Laura A, Atwell, Shane, Holme, Kevin, Wasserman, Stephen R, Emtage, Spencer, Burley, Stephen K, Reich, Siegfried H
Published in Molecular cancer therapeutics (01.12.2009)
Published in Molecular cancer therapeutics (01.12.2009)
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Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant
Atwell, Shane, Brouillette, Christie G., Conners, Kris, Emtage, Spencer, Gheyi, Tarun, Guggino, William B., Hendle, Jorg, Hunt, John F., Lewis, Hal A., Lu, Frances, Protasevich, Irina I., Rodgers, Logan A., Romero, Rich, Wasserman, Stephen R., Weber, Patricia C., Wetmore, Diana, Zhang, Feiyu F., Zhao, Xun
Published in Protein engineering, design and selection (01.05.2010)
Published in Protein engineering, design and selection (01.05.2010)
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Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors
Antonysamy, Stephen S., Aubol, Brandon, Blaney, Jeff, Browner, Michelle F., Giannetti, Anthony M., Harris, Seth F., Hébert, Normand, Hendle, Jörg, Hopkins, Stephanie, Jefferson, Elizabeth, Kissinger, Charles, Leveque, Vincent, Marciano, David, McGee, Ethel, Nájera, Isabel, Nolan, Brian, Tomimoto, Masaki, Torres, Eduardo, Wright, Tobi
Published in Bioorganic & medicinal chemistry (01.05.2008)
Published in Bioorganic & medicinal chemistry (01.05.2008)
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The 1.59 Å resolution crystal structure of TM0096, a flavin mononucleotide binding protein from Thermotoga maritima
Park, Frances, Gajiwala, Ketan, Noland, Brian, Wu, Lydia, He, Dongmei, Molinari, Janessa, Loomis, Kim, Pagarigan, Barbra, Kearins, Peggy, Christopher, Jon, Peat, Tom, Badger, John, Hendle, Jorg, Lin, Johann, Buchanan, Sean
Published in Proteins, structure, function, and bioinformatics (15.05.2004)
Published in Proteins, structure, function, and bioinformatics (15.05.2004)
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The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates
Jones, Bryan E, Brown-Augsburger, Patricia L, Corbett, Kizzmekia S, Westendorf, Kathryn, Davies, Julian, Cujec, Thomas P, Wiethoff, Christopher M, Blackbourne, Jamie L, Heinz, Beverly A, Foster, Denisa, Higgs, Richard E, Balasubramaniam, Deepa, Wang, Lingshu, Zhang, Yi, Yang, Eun Sung, Bidshahri, Roza, Kraft, Lucas, Hwang, Yuri, Žentelis, Stefanie, Jepson, Kevin R, Goya, Rodrigo, Smith, Maia A, Collins, David W, Hinshaw, Samuel J, Tycho, Sean A, Pellacani, Davide, Xiang, Ping, Muthuraman, Krithika, Sobhanifar, Solmaz, Piper, Marissa H, Triana, Franz J, Hendle, Jorg, Pustilnik, Anna, Adams, Andrew C, Berens, Shawn J, Baric, Ralph S, Martinez, David R, Cross, Robert W, Geisbert, Thomas W, Borisevich, Viktoriya, Abiona, Olubukola, Belli, Hayley M, de Vries, Maren, Mohamed, Adil, Dittmann, Meike, Samanovic, Marie I, Mulligan, Mark J, Goldsmith, Jory A, Hsieh, Ching-Lin, Johnson, Nicole V, Wrapp, Daniel, McLellan, Jason S, Barnhart, Bryan C, Graham, Barney S, Mascola, John R, Hansen, Carl L, Falconer, Ester
Published in Science Translational Medicine (12.05.2021)
Published in Science Translational Medicine (12.05.2021)
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A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase
Atwell, Shane, Adams, Jason M., Badger, John, Buchanan, Michelle D., Feil, Ingeborg K., Froning, Karen J., Gao, Xia, Hendle, Jörg, Keegan, Kevin, Leon, Barbara C., Müller-Dieckmann, Hans J., Nienaber, Vicki L., Noland, Brian W., Post, Kai, Rajashankar, K.R., Ramos, Aurora, Russell, Marijane, Burley, Stephen K., Buchanan, Sean G.
Published in The Journal of biological chemistry (31.12.2004)
Published in The Journal of biological chemistry (31.12.2004)
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1.8 and 1.9 Å resolution structures of the Penicillium amagasakiense and Aspergillus niger glucose oxidases as a basis for modelling substrate complexes
Wohlfahrt, Gerd, Witt, Susanne, Hendle, Jörg, Schomburg, Dietmar, Kalisz, Henryk M., Hecht, Hans-Jürgen
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.1999)
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.1999)
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Structural Studies of Salmonella typhimurium ArnB (PmrH) Aminotransferase : A 4-Amino-4-Deoxy-L-Arabinose Lipopolysaccharide-Modifying Enzyme
Noland, Brian W., Newman, Janet M., Hendle, Jörg, Badger, John, Christopher, Jon A., Tresser, Jason, Buchanan, Michelle D., Wright, Tobi A., Rutter, Marc E., Sanderson, Wendy E., Müller-Dieckmann, Hans-Joachim, Gajiwala, Ketan S., Buchanan, Sean G.
Published in Structure (London) (01.11.2002)
Published in Structure (London) (01.11.2002)
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Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA
Cheung, Timothy C., Atwell, Shane, Bafetti, Lisa, Cuenca, Paulina Delgado, Froning, Karen, Hendle, Jorg, Hickey, Michael, Ho, Carolyn, Huang, Jiawen, Lieu, Ricky, Lim, Stacie, Lippner, David, Obungu, Victor, Ward-Kavanagh, Lindsay, Weichert, Kenneth, Ware, Carl F., Vendel, Andrew C.
Published in Structure (London) (03.08.2023)
Published in Structure (London) (03.08.2023)
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Reliable quality-control methods for protein crystal structures
Badger, John, Hendle, Jörg
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2002)
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2002)
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Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop
Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, Young, Jasmine
Published in Structure (London) (05.04.2016)
Published in Structure (London) (05.04.2016)
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Idea2Data: Toward a New Paradigm for Drug Discovery
Nicolaou, Christos A, Humblet, Christine, Hu, Hong, Martin, Eva M, Dorsey, Frank C, Castle, Thomas M, Burton, Keith Ian, Hu, Haitao, Hendle, Jorg, Hickey, Michael J, Duerksen, Joel, Wang, Jibo, Erickson, Jon A
Published in ACS medicinal chemistry letters (14.03.2019)
Published in ACS medicinal chemistry letters (14.03.2019)
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X-ray crystallographic characterization and phasing of an NtrC homologue
Sallai, László, Hendle, Jörg, Tucker, Paul A.
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2003)
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2003)
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X-ray crystallographic characterization and phasing of an NtrC homologue
Sallai, László, Hendle, Jörg, Tucker, Paul A.
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2003)
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2003)
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