Acalabrutinib Versus Ibrutinib in Previously Treated Chronic Lymphocytic Leukemia: Results of the First Randomized Phase III Trial
Byrd, John C, Hillmen, Peter, Ghia, Paolo, Kater, Arnon P, Chanan-Khan, Asher, Furman, Richard R, O'Brien, Susan, Yenerel, Mustafa Nuri, Illés, Arpad, Kay, Neil, Garcia-Marco, Jose A, Mato, Anthony, Pinilla-Ibarz, Javier, Seymour, John F, Lepretre, Stephane, Stilgenbauer, Stephan, Robak, Tadeusz, Rothbaum, Wayne, Izumi, Raquel, Hamdy, Ahmed, Patel, Priti, Higgins, Kara, Sohoni, Sophia, Jurczak, Wojciech
Published in Journal of clinical oncology (01.11.2021)
Published in Journal of clinical oncology (01.11.2021)
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Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia
Byrd, John C, Harrington, Bonnie, O’Brien, Susan, Jones, Jeffrey A, Schuh, Anna, Devereux, Steve, Chaves, Jorge, Wierda, William G, Awan, Farrukh T, Brown, Jennifer R, Hillmen, Peter, Stephens, Deborah M, Ghia, Paolo, Barrientos, Jacqueline C, Pagel, John M, Woyach, Jennifer, Johnson, Dave, Huang, Jane, Wang, Xiaolin, Kaptein, Allard, Lannutti, Brian J, Covey, Todd, Fardis, Maria, McGreivy, Jesse, Hamdy, Ahmed, Rothbaum, Wayne, Izumi, Raquel, Diacovo, Thomas G, Johnson, Amy J, Furman, Richard R
Published in The New England journal of medicine (28.01.2016)
Published in The New England journal of medicine (28.01.2016)
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Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial
Wang, Michael, Rule, Simon, Zinzani, Pier Luigi, Goy, Andre, Casasnovas, Olivier, Smith, Stephen D, Damaj, Gandhi, Doorduijn, Jeanette, Lamy, Thierry, Morschhauser, Franck, Panizo, Carlos, Shah, Bijal, Davies, Andrew, Eek, Richard, Dupuis, Jehan, Jacobsen, Eric, Kater, Arnon P, Le Gouill, Steven, Oberic, Lucie, Robak, Taduesz, Covey, Todd, Dua, Richa, Hamdy, Ahmed, Huang, Xin, Izumi, Raquel, Patel, Priti, Rothbaum, Wayne, Slatter, J Greg, Jurczak, Wojciech
Published in The Lancet (British edition) (17.02.2018)
Published in The Lancet (British edition) (17.02.2018)
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Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies
ADVANI, Ranjana H, BUGGY, Joseph J, SUKBUNTHERNG, Juthamas, IZUMI, Raquel, HAMDY, Ahmed, HEDRICK, Eric, FOWLER, Nathan H, SHARMAN, Jeff P, SMITH, Sonali M, BOYD, Thomas E, GRANT, Barbara, KOLIBABA, Kathryn S, FURMAN, Richard R, RODRIGUEZ, Sara, CHANG, Betty Y
Published in Journal of clinical oncology (01.01.2013)
Published in Journal of clinical oncology (01.01.2013)
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Phase II study of acalabrutinib in ibrutinib-intolerant patients with relapsed/refractory chronic lymphocytic leukemia
Rogers, Kerry A., Thompson, Philip A., Allan, John N., Coleman, Morton, Sharman, Jeff P., Cheson, Bruce D., Jones, Daniel, Izumi, Raquel, Frigault, Melanie M., Quah, Cheng, Raman, Rakesh K., Patel, Priti, Wang, Min Hui, Kipps, Thomas J.
Published in Haematologica (Roma) (01.09.2021)
Published in Haematologica (Roma) (01.09.2021)
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Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial
O'Brien, Susan, Prof, Furman, Richard R, MD, Coutre, Steven E, Prof, Sharman, Jeff P, MD, Burger, Jan A, MD, Blum, Kristie A, MD, Grant, Barbara, MD, Richards, Donald A, MD, Coleman, Morton, Prof, Wierda, William G, MD, Jones, Jeffrey A, MD, Zhao, Weiqiang, MD, Heerema, Nyla A, Prof, Johnson, Amy J, PhD, Izumi, Raquel, PhD, Hamdy, Ahmed, MD, Chang, Betty Y, PhD, Graef, Thorsten, MD, Clow, Fong, ScD, Buggy, Joseph J, PhD, James, Danelle F, MD, Byrd, John C, Prof
Published in The lancet oncology (01.01.2014)
Published in The lancet oncology (01.01.2014)
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The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia
Herman, Sarah E M, Montraveta, Arnau, Niemann, Carsten U, Mora-Jensen, Helena, Gulrajani, Michael, Krantz, Fanny, Mantel, Rose, Smith, Lisa L, McClanahan, Fabienne, Harrington, Bonnie K, Colomer, Dolors, Covey, Todd, Byrd, John C, Izumi, Raquel, Kaptein, Allard, Ulrich, Roger, Johnson, Amy J, Lannutti, Brian J, Wiestner, Adrian, Woyach, Jennifer A
Published in Clinical cancer research (01.06.2017)
Published in Clinical cancer research (01.06.2017)
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Acalabrutinib plus Obinutuzumab in Treatment-Naïve and Relapsed/Refractory Chronic Lymphocytic Leukemia
Woyach, Jennifer A, Blachly, James S, Rogers, Kerry A, Bhat, Seema A, Jianfar, Mojgan, Lozanski, Gerard, Weiss, David M, Andersen, Barbara L, Gulrajani, Michael, Frigault, Melanie M, Hamdy, Ahmed, Izumi, Raquel, Munugalavadla, Veerendra, Quah, Cheng, Wang, Min-Hui, Byrd, John C
Published in Cancer discovery (01.03.2020)
Published in Cancer discovery (01.03.2020)
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Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment
Rebstock, Anne-Sophie, Wiedmann, Mareike, Stelte-Ludwig, Beatrix, Wong, Harvey, Johnson, Amy J, Izumi, Raquel, Hamdy, Ahmed, Lerchen, Hans-Georg
Published in Frontiers in pharmacology (01.03.2024)
Published in Frontiers in pharmacology (01.03.2024)
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Discovery of VIP236, an αvβ3-Targeted Small-Molecule–Drug Conjugate with Neutrophil Elastase-Mediated Activation of 7-Ethyl Camptothecin Payload for Treatment of Solid Tumors
Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Heroult, Melanie, Zubov, Dmitry, Gericke, Kersten Matthias, Wong, Harvey, Frigault, Melanie M, Johnson, Amy J, Izumi, Raquel, Hamdy, Ahmed
Published in Cancers (01.09.2023)
Published in Cancers (01.09.2023)
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The highly selective Bruton tyrosine kinase inhibitor acalabrutinib leaves macrophage phagocytosis intact
Pinney, Jonathan J, Blick-Nitko, Sara K, Baran, Andrea M, Peterson, Derick R, Whitehead, Hannah E, Izumi, Raquel, Munugalavadla, Veerendra, Van DerMeid, Karl R, Barr, Paul M, Zent, Clive S, Elliott, Michael R, Chu, Charles C
Published in Haematologica (Roma) (01.06.2022)
Published in Haematologica (Roma) (01.06.2022)
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Preclinical Evaluation of the Novel BTK Inhibitor Acalabrutinib in Canine Models of B-Cell Non-Hodgkin Lymphoma
Harrington, Bonnie K, Gardner, Heather L, Izumi, Raquel, Hamdy, Ahmed, Rothbaum, Wayne, Coombes, Kevin R, Covey, Todd, Kaptein, Allard, Gulrajani, Michael, Van Lith, Bart, Krejsa, Cecile, Coss, Christopher C, Russell, Duncan S, Zhang, Xiaoli, Urie, Bridget K, London, Cheryl A, Byrd, John C, Johnson, Amy J, Kisseberth, William C
Published in PloS one (19.07.2016)
Published in PloS one (19.07.2016)
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A Small Molecule–Drug Conjugate (SMDC) Consisting of a Modified Camptothecin Payload Linked to an αVß3 Binder for the Treatment of Multiple Cancer Types
Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Kopitz, Charlotte, Heroult, Melanie, Zubov, Dmitry, Willuda, Joerg, Schlange, Thomas, Kahnert, Antje, Wong, Harvey, Izumi, Raquel, Hamdy, Ahmed
Published in Cancers (13.01.2022)
Published in Cancers (13.01.2022)
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A Peptide from Autoantigen La Blocks Poliovirus and Hepatitis C Virus Cap-Independent Translation and Reveals a Single Tyrosine Critical for La RNA Binding and Translation Stimulation
IZUMI, Raquel E, DAS, Saumitra, BARAT, Bhaswati, RAYCHAUDHURI, Santanu, DASGUPTA, Asim
Published in Journal of Virology (01.04.2004)
Published in Journal of Virology (01.04.2004)
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Nucleolin stimulates viral internal ribosome entry site-mediated translation
Izumi, Raquel E, Valdez, Benigno, Banerjee, Rajeev, Srivastava, Meera, Dasgupta, Asim
Published in Virus research (01.07.2001)
Published in Virus research (01.07.2001)
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Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile
Barf, Tjeerd, Covey, Todd, Izumi, Raquel, van de Kar, Bas, Gulrajani, Michael, van Lith, Bart, van Hoek, Maaike, de Zwart, Edwin, Mittag, Diana, Demont, Dennis, Verkaik, Saskia, Krantz, Fanny, Pearson, Paul G, Ulrich, Roger, Kaptein, Allard
Published in The Journal of pharmacology and experimental therapeutics (01.11.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2017)
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Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial
Sharman, Jeff P, Egyed, Miklos, Jurczak, Wojciech, Skarbnik, Alan, Pagel, John M, Flinn, Ian W, Kamdar, Manali, Munir, Talha, Walewska, Renata, Corbett, Gillian, Fogliatto, Laura Maria, Herishanu, Yair, Banerji, Versha, Coutre, Steven, Follows, George, Walker, Patricia, Karlsson, Karin, Ghia, Paolo, Janssens, Ann, Cymbalista, Florence, Woyach, Jennifer A, Salles, Gilles, Wierda, William G, Izumi, Raquel, Munugalavadla, Veerendra, Patel, Priti, Wang, Min Hui, Wong, Sofia, Byrd, John C
Published in The Lancet (British edition) (18.04.2020)
Published in The Lancet (British edition) (18.04.2020)
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Comparison of the CXCR5-Antibody Drug Conjugate (ADC; VIP924) to a CD19-ADC and a CD79b-ADC in a Humanized Rec-1 Mantle Cell Lymphoma (MCL) Mouse Model
Schomber, Tibor, Stelte-Ludwig, Beatrix, Rebstock, Anne-Sophie, v Ahsen, Oliver, Johnson, Amy J, Izumi, Raquel, Hamdy, Ahmed
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia: updated phase 2 results
Byrd, John C., Wierda, William G., Schuh, Anna, Devereux, Stephen, Chaves, Jorge M., Brown, Jennifer R., Hillmen, Peter, Martin, Peter, Awan, Farrukh T., Stephens, Deborah M., Ghia, Paolo, Barrientos, Jacqueline, Pagel, John M., Woyach, Jennifer A., Burke, Kathleen, Covey, Todd, Gulrajani, Michael, Hamdy, Ahmed, Izumi, Raquel, Frigault, Melanie M., Patel, Priti, Rothbaum, Wayne, Wang, Min Hui, O'Brien, Susan, Furman, Richard R.
Published in Blood (09.04.2020)
Published in Blood (09.04.2020)
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VIP943 Is a Novel CD123 Antibody Drug Conjugate with in Vitro and In Vivo Efficacy in Acute Myeloid Leukemia (AML) Models
Stelte-Ludwig, Beatrix, Clemens, George, Schomber, Tibor, Frigault, Melanie M., Johnson, Amy J., Lerchen, Hans-Georg, Izumi, Raquel, Hamdy, Ahmed
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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