Appraisal of ICH E14/S7B Q&As adopted in February 2022 using thorough QT/QTc study data for α4-integrin antagonist carotegrast methyl in Japanese healthy subjects
Kambayashi, Ryuichi, Goto, Ai, Izumi-Nakaseko, Hiroko, Oikawa, Ichiro, Ikeda, Naoki, Matsuda, Kazuki, Takei, Yoshinori, Matsumoto, Akio, Kumagai, Yuji, Sugiyama, Atsushi
Published in Journal of pharmacological sciences (01.11.2022)
Published in Journal of pharmacological sciences (01.11.2022)
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Journal Article
Impact of head-up tilt on expiratory negative airway pressure ventilation-induced cardiovascular hemodynamics in the halothane-anesthetized intact microminipigs
Goto, Ai, Kambayashi, Ryuichi, Hagiwara-Nagasawa, Mihoko, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Kawai, Shinichi, Matsumoto, Akio, Lurie, Keith G., Sugiyama, Atsushi
Published in Heart and vessels (01.10.2022)
Published in Heart and vessels (01.10.2022)
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Journal Article
Analysis of clinically-reported, memantine-induced cardiovascular adverse responses using the halothane-anesthetized dogs: Reverse translational study
Kambayashi, Ryuichi, Goto, Ai, Hagiwara-Nagasawa, Mihoko, Izumi-Nakaseko, Hiroko, Shinozaki, Makoto, Kawai, Shinichi, Matsumoto, Akio, Takei, Yoshinori, Sugiyama, Atsushi
Published in Journal of pharmacological sciences (01.04.2022)
Published in Journal of pharmacological sciences (01.04.2022)
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Journal Article
In vivo analysis of acute eletropharmacological effects of proton pump inhibitors using halothane-anesthetized dogs: a translational study of cardiovascular adverse events
Kambayashi, Ryuichi, Goto, Ai, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Sugiyama, Atsushi
Published in Journal of toxicological sciences (2023)
Published in Journal of toxicological sciences (2023)
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Journal Article
Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones
Hagiwara-Nagasawa, Mihoko, Kambayashi, Ryuichi, Goto, Ai, Nunoi, Yoshio, Izumi-Nakaseko, Hiroko, Chiba, Koki, Wada, Takeshi, Takei, Yoshinori, Matsumoto, Akio, Sugiyama, Atsushi
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.04.2021)
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.04.2021)
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Journal Article
Roles of IK,ACh for perpetuating atrial fibrillation: Effects of atrial-selective K+ channel inhibitor AVE0118 and class I drugs on the persistent atrial fibrillation canine model
Kambayashi, Ryuichi, Goto, Ai, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Matsumoto, Akio, Kawai, Shinichi, Sugiyama, Atsushi
Published in Journal of pharmacological sciences (01.08.2022)
Published in Journal of pharmacological sciences (01.08.2022)
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Journal Article
Simultaneous analyses of hemodynamic and electrophysiological effects of oseltamivir along with its pharmacokinetic profile using the canine paroxysmal atrial fibrillation model
Kambayashi, Ryuichi, Goto, Ai, Onozato, Mayu, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Matsumoto, Akio, Kawai, Shinichi, Fukushima, Takeshi, Sugiyama, Atsushi
Published in Journal of pharmacological sciences (01.01.2022)
Published in Journal of pharmacological sciences (01.01.2022)
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Journal Article
Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors
Chiba, Koki, Kambayashi, Ryuichi, Onozato, Mayu, Goto, Ai, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Matsumoto, Akio, Tanaka, Koichiro, Kanda, Yasunari, Fukushima, Takeshi, Sugiyama, Atsushi
Published in Journal of pharmacological sciences (01.11.2022)
Published in Journal of pharmacological sciences (01.11.2022)
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Journal Article
Characterization of the electrocardiogram of microminipig in comparison with that of Clawn miniature swine: impacts of miniaturization of body size on electrocardiographic indices
GOTO, Ai, KAMBAYASHI, Ryuichi, SAITO, Hiroyuki, AKIE, Yasuki, IZUMI-NAKASEKO, Hiroko, TAKEI, Yoshinori, SUGIYAMA, Atsushi
Published in Journal of Veterinary Medical Science (2023)
Published in Journal of Veterinary Medical Science (2023)
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Journal Article
In vivo comparison of dl-sotalol-induced electrocardiographic responses among halothane anesthesia, isoflurane anesthesia with nitrous oxide, and conscious state
Saito, Hiroyuki, Kambayashi, Ryuichi, Hagiwara-Nagasawa, Mihoko, Nunoi, Yoshio, Goto, Ai, Izumi-Nakaseko, Hiroko, Kawai, Shinichi, Takei, Yoshinori, Matsumoto, Akio, Hoshiai, Kiyotaka, Akie, Yasuki, Sugiyama, Atsushi
Published in Journal of pharmacological sciences (01.01.2021)
Published in Journal of pharmacological sciences (01.01.2021)
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Journal Article
Cardiovascular safety pharmacology of ivermectin assessed using the isoflurane-anesthetized beagle dogs: ICH S7B follow-up study
Suzuki, Nobuyuki, Kambayashi, Ryuichi, Goto, Ai, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Naito, Atsuhiko T, Sugiyama, Atsushi
Published in Journal of toxicological sciences (2023)
Published in Journal of toxicological sciences (2023)
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Journal Article
Both osmolality-dependent and independent mechanisms are associated with acute hyperglycemia-induced cardiovascular adverse reactions: Analysis of the mutual interactions leading to cardiovascular phenotypes in dogs
Kambayashi, Ryuichi, Izumi-Nakaseko, Hiroko, Goto, Ai, Takei, Yoshinori, Matsumoto, Akio, Lorch, Ulrike, Täubel, Jörg, Sugiyama, Atsushi
Published in Journal of toxicological sciences (2023)
Published in Journal of toxicological sciences (2023)
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Journal Article
Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs
Goto, Ai, Hagiwara-Nagasawa, Mihoko, Kambayashi, Ryuichi, Nunoi, Yoshio, Izumi-Nakaseko, Hiroko, Kawai, Shinichi, Takei, Yoshinori, Matsumoto, Akio, Sugiyama, Atsushi
Published in Heart and vessels (01.03.2021)
Published in Heart and vessels (01.03.2021)
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Journal Article
In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs
Saito, Hiroyuki, Kambayashi, Ryuichi, Goto, Ai, Hagiwara-Nagasawa, Mihoko, Hoshiai, Kiyotaka, Nunoi, Yoshio, Izumi-Nakaseko, Hiroko, Akie, Yasuki, Takei, Yoshinori, Matsumoto, Akio, Sugiyama, Atsushi
Published in Journal of pharmacological sciences (01.03.2021)
Published in Journal of pharmacological sciences (01.03.2021)
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Journal Article
Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes
Goto, Ai, Sakamoto, Kengo, Hagiwara-Nagasawa, Mihoko, Kambayashi, Ryuichi, Chiba, Koki, Nunoi, Yoshio, Izumi-Nakaseko, Hiroko, Matsumoto, Akio, Sugiyama, Atsushi
Published in Journal of pharmacological sciences (01.04.2020)
Published in Journal of pharmacological sciences (01.04.2020)
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Journal Article
In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys
Goto, Ai, Sakamoto, Kengo, Hagiwara-Nagasawa, Mihoko, Kambayashi, Ryuichi, Chiba, Koki, Nunoi, Yoshio, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Matsumoto, Akio, Sugiyama, Atsushi
Published in Journal of pharmacological sciences (01.08.2020)
Published in Journal of pharmacological sciences (01.08.2020)
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Journal Article
Cardiohemodynamic and Arrhythmogenic Effects of the Anti-Atrial Fibrillatory Compound Vanoxerine in Halothane-Anesthetized Dogs
Hagiwara-Nagasawa, Mihoko, Kambayashi, Ryuichi, Goto, Ai, Nunoi, Yoshio, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Matsumoto, Akio, Sugiyama, Atsushi
Published in Cardiovascular toxicology (01.03.2021)
Published in Cardiovascular toxicology (01.03.2021)
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Journal Article
Analysis of electropharmacological effects of AVE0118 on the atria of chronic atrioventricular block dogs: characterization of anti-atrial fibrillatory action by atrial repolarization-delaying agent
Kambayashi, Ryuichi, Hagiwara-Nagasawa, Mihoko, Ichikawa, Tomoaki, Goto, Ai, Chiba, Koki, Nunoi, Yoshio, Izumi-Nakaseko, Hiroko, Matsumoto, Akio, Takahara, Akira, Sugiyama, Atsushi
Published in Heart and vessels (01.09.2020)
Published in Heart and vessels (01.09.2020)
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Journal Article
Magnitude of mitral valve closure plays a pivotal role in enhancing the forward blood flow during cardiac massage in dogs with ventricular fibrillation
GOTO, Ai, KAMBAYASHI, Ryuichi, IZUMI-NAKASEKO, Hiroko, TAKEI, Yoshinori, KAWAI, Shinichi, MATSUMOTO, Akio, LURIE, Keith G., SUGIYAMA, Atsushi
Published in Journal of Veterinary Medical Science (2022)
Published in Journal of Veterinary Medical Science (2022)
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Journal Article
Effects of Cardiac Massage and β-Blocker Pretreatment on the Success Rate of Cardiopulmonary Resuscitation Assessed by the Canine Ischemia/Reperfusion-Induced Ventricular Fibrillation Model
Wada, Takeshi, Hagiwara-Nagasawa, Mihoko, Kambayashi, Ryuichi, Goto, Ai, Chiba, Koki, Nunoi, Yoshio, Izumi-Nakaseko, Hiroko, Koga, Tadashi, Matsumoto, Akio, Nakazato, Yuji, Lurie, Keith G., Sugiyama, Atsushi
Published in Circulation Journal (24.09.2021)
Published in Circulation Journal (24.09.2021)
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Journal Article