First-in-Human Study of MANP: A Novel ANP (Atrial Natriuretic Peptide) Analog in Human Hypertension
Chen, Horng H., Wan, Siu-Hin, Iyer, Seethalakshmi R., Cannone, Valentina, Sangaralingham, S. Jeson, Nuetel, Joel, Burnett, John C.
Published in Hypertension (Dallas, Tex. 1979) (01.12.2021)
Published in Hypertension (Dallas, Tex. 1979) (01.12.2021)
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Angiotensin (1–12) in Humans With Normal Blood Pressure and Primary Hypertension
Ferrario, Carlos M., Iyer, Seethalakshmi R., Burnett, John C., Ahmad, Sarfaraz, Wright, Kendra N., VonCannon, Jessica L., Saha, Amit, Groban, Leanne
Published in Hypertension (Dallas, Tex. 1979) (03.03.2021)
Published in Hypertension (Dallas, Tex. 1979) (03.03.2021)
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Long-term blood pressure lowering and cGMP-activating actions of the novel ANP analog MANP
Chen, Yang, Schaefer, Jacob J, Iyer, Seethalakshmi R, Harders, Gerald E, Pan, Shuchong, Sangaralingham, S Jeson, Chen, Horng H, Redfield, Margaret M, Burnett, Jr, John C
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.04.2020)
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.04.2020)
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Evidence for Angiotensin II as a Naturally Existing Suppressor for the Guanylyl Cyclase A Receptor and Cyclic GMP Generation
Ma, Xiao, Iyer, Seethalakshmi R, Ma, Xiaoyu, Reginauld, Shawn H, Chen, Yang, Pan, Shuchong, Zheng, Ye, Moroni, Dante G, Yu, Yue, Zhang, Lianwen, Cannone, Valentina, Chen, Horng H, Ferrario, Carlos M, Sangaralingham, S Jeson, Burnett, Jr, John C
Published in International journal of molecular sciences (10.05.2023)
Published in International journal of molecular sciences (10.05.2023)
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Journal Article
CRRL269: a novel designer and renal-enhancing pGC-A peptide activator
Chen, Yang, Harty, Gail J, Huntley, Brenda K, Iyer, Seethalakshmi R, Heublein, Denise M, Harders, Gerald E, Meems, Laura, Pan, Shuchong, Sangaralingham, S Jeson, Ichiki, Tomoko, Burnett, Jr, John C
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.03.2018)
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.03.2018)
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Journal Article
Design, Synthesis, and Actions of an Innovative Bispecific Designer Peptide
Meems, Laura M G, Andersen, Ingrid A, Pan, Shuchong, Harty, Gail, Chen, Yang, Zheng, Ye, Harders, Gerald E, Ichiki, Tomoki, Heublein, Denise M, Iyer, Seethalakshmi R, Sangaralingham, S Jeson, McCormick, Daniel J, Burnett, Jr, John C
Published in Hypertension (Dallas, Tex. 1979) (01.04.2019)
Published in Hypertension (Dallas, Tex. 1979) (01.04.2019)
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Journal Article
Soluble Neprilysin in the General Population: Clinical Determinants and Its Relationship to Cardiovascular Disease
Reddy, Yogesh N V, Iyer, Seethalakshmi R, Scott, Christopher G, Rodeheffer, Richard J, Bailey, Kent, Jenkins, Gregory, Batzler, Anthony, Redfield, Margaret M, Burnett, Jr, John C, Pereira, Naveen L
Published in Journal of the American Heart Association (06.08.2019)
Published in Journal of the American Heart Association (06.08.2019)
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Journal Article
MANP Activation Of The cGMP Inhibits Aldosterone Via PDE2 And CYP11B2 In H295R Cells And In Mice
Chen, Yang, Iyer, Seethalakshmi R., Nikolaev, Viacheslav O., Naro, Fabio, Pellegrini, Manuela, Cardarelli, Silvia, Ma, Xiao, Lee, Hon-Chi, Burnett, John C.
Published in Hypertension (Dallas, Tex. 1979) (01.08.2022)
Published in Hypertension (Dallas, Tex. 1979) (01.08.2022)
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Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor
Hansen, Lasse H., Madsen, Thomas Daugbjerg, Goth, Christoffer K., Clausen, Henrik, Chen, Yang, Dzhoyashvili, Nina, Iyer, Seethalakshmi R., Sangaralingham, S. Jeson, Burnett, John C., Rehfeld, Jens F., Vakhrushev, Sergey Y., Schjoldager, Katrine T., Goetze, Jens P.
Published in The Journal of biological chemistry (23.08.2019)
Published in The Journal of biological chemistry (23.08.2019)
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Journal Article
Sex-based differences in metabolic protection by the ANP genetic variant rs5068 in the general population
Ichiki, Tomoko, Cannone, Valentina, Scott, Christopher G, Iyer, Seethalakshmi R, Sangaralingham, S Jeson, Bailey, Kent R, Goetze, Jens P, Tsuji, Yoshihisa, Rodeheffer, Richard J, Burnett, Jr, John C
Published in American journal of physiology. Heart and circulatory physiology (01.09.2023)
Published in American journal of physiology. Heart and circulatory physiology (01.09.2023)
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Journal Article
Atrial Natriuretic Peptide and Treatment With Sacubitril/Valsartan in Heart Failure With Reduced Ejection Fraction
Murphy, Sean P., Prescott, Margaret F., Camacho, Alexander, Iyer, Seethalakshmi R., Maisel, Alan S., Felker, G. Michael, Butler, Javed, Piña, Ileana L., Ibrahim, Nasrien E., Abbas, Cheryl, Burnett, John C., Solomon, Scott D., Januzzi, James L.
Published in JACC. Heart failure (01.02.2021)
Published in JACC. Heart failure (01.02.2021)
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Journal Article
C53: A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti-fibrotic actions in human cardiac and renal fibroblasts
Chen, Yang, Zheng, Ye, Iyer, Seethalakshmi R., Harders, Gerald E., Pan, Shuchong, Chen, Horng H., Ichiki, Tomoko, Burnett, John C., Sangaralingham, S. Jeson
Published in Journal of molecular and cellular cardiology (01.05.2019)
Published in Journal of molecular and cellular cardiology (01.05.2019)
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Journal Article
CRRL269: A Novel Particulate Guanylyl Cyclase A Receptor Peptide Activator for Acute Kidney Injury
Chen, Yang, Harty, Gail J, Zheng, Ye, Iyer, Seethalakshmi R, Sugihara, Shinobu, Sangaralingham, S Jeson, Ichiki, Tomoko, Grande, Joseph P, Lee, Hon-Chi, Wang, Xiaoli, Burnett, John C
Published in Circulation research (10.05.2019)
Published in Circulation research (10.05.2019)
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Journal Article
Design, Synthesis, and Actions of an Innovative Bispecific Designer Peptide: NPA7
Meems, Laura M.G, Andersen, Ingrid A, Pan, Shuchong, Harty, Gail, Chen, Yang, Zheng, Ye, Harders, Gerald E, Ichiki, Tomoki, Heublein, Denise M, Iyer, Seethalakshmi R, Sangaralingham, S Jeson, McCormick, Daniel J, Burnett, John C
Published in Hypertension (Dallas, Tex. 1979) (01.04.2019)
Published in Hypertension (Dallas, Tex. 1979) (01.04.2019)
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Journal Article
Annexin A1 is a Potential Novel Biomarker of Congestion in Acute Heart Failure
Adel, FADI W., RIKHI, ARUNA, WAN, SIU-HIN, IYER, SEETHALAKSHMI R., CHAKRABORTY, HRISHIKESH, MCNULTY, STEVEN, TANG, W.H. WILSON, FELKER, G. MICHAEL, GIVERTZ, MICHAEL M., CHEN, HORNG H.
Published in Journal of cardiac failure (01.08.2020)
Published in Journal of cardiac failure (01.08.2020)
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Journal Article
Correction: Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor
Hansen, Lasse H., Madsen, Thomas Daugbjerg, Goth, Christoffer K., Clausen, Henrik, Chen, Yang, Dzoyashvili, Nina, Iyer, Seethalakshmi R., Sangaralingham, S. Jeson, Burnett, John C., Rehfeld, Jens F., Vakhrushev, Sergey Y., Schjoldager, Katrine T., Goetze, Jens P.
Published in The Journal of biological chemistry (29.11.2019)
Published in The Journal of biological chemistry (29.11.2019)
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Journal Article
Circulating Neprilysin in Patients With Heart Failure and Preserved Ejection Fraction
Lyle, Melissa A., Iyer, Seethalakshmi R., Redfield, Margaret M., Reddy, Yogesh N.V., Felker, G. Michael, Cappola, Thomas P., Hernandez, Adrian F., Scott, Christopher G., Burnett, John C., Pereira, Naveen L.
Published in JACC. Heart failure (01.01.2020)
Published in JACC. Heart failure (01.01.2020)
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Journal Article
CRRL269
Chen, Yang, Harty, Gail J, Zheng, Ye, Iyer, Seethalakshmi R, Sugihara, Shinobu, Sangaralingham, S Jeson, Ichiki, Tomoko, Grande, Joseph P, Lee, Hon-Chi, Wang, Xiaoli, Burnett, Jr, John C
Published in Circulation research (10.05.2019)
Published in Circulation research (10.05.2019)
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Journal Article
Prognostic Value of Urinary and Plasma C-Type Natriuretic Peptide in Acute Decompensated Heart Failure
Ma, Xiao, Chen, Yang, Reginauld, Shawn H., Scott, Christopher G., Iyer, Seethalakshmi R., Schaefer, Jacob J., Ichiki, Tomoko, Chen, Horng H., Rule, Andrew D., Burnett, John C., Sangaralingham, S. Jeson
Published in JACC. Heart failure (01.09.2021)
Published in JACC. Heart failure (01.09.2021)
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Journal Article