Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor
Yingling, Jonathan M, McMillen, William T, Yan, Lei, Huang, Huocong, Sawyer, J Scott, Graff, Jeremy, Clawson, David K, Britt, Karen S, Anderson, Bryan D, Beight, Douglas W, Desaiah, Durisala, Lahn, Michael M, Benhadji, Karim A, Lallena, Maria J, Holmgaard, Rikke B, Xu, Xiaohong, Zhang, Faming, Manro, Jason R, Iversen, Philip W, Iyer, Chandrasekar V, Brekken, Rolf A, Kalos, Michael D, Driscoll, Kyla E
Published in Oncotarget (23.01.2018)
Published in Oncotarget (23.01.2018)
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Rapid and recurrent neutrophil mobilization regulated by T134, a CXCR4 peptide antagonist
Iyer, Chandrasekar V, Evans, Robert J, Lou, Qinyuan, Lin, Datian, Wang, Jian, Kohn, Wayne, Yan, Liang Zeng, Pulley, Shon, Peng, Sheng-Bin
Published in Experimental hematology (01.09.2008)
Published in Experimental hematology (01.09.2008)
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Abstract 3316: LY3962673, an oral, highly potent, mutant-selective, and non-covalent KRAS G12D inhibitor demonstrates robust anti-tumor activity in KRAS G12D models
Gong, Xueqian, Gao, Hong, Bender, Mark H., Ming, Wenyu, Zhang, Youyan, Stewart, Trent R., Yu, Chun Ping, Xu, Wei Guo, You, Aurthur Xintian, Bian, Wen Ting, Li, Binghui, Wang, Tao, Bian, Huimin, Tandon, Manuj, Capen, Andrew, Cavitt, Rachel N., Anderson, Bryan D., Bocchinfuso, Wayne, Klippel, Anke, Iyer, Chandrasekar
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract B115: Preclinical characterization of LY3962673, an orally bioavailable, highly potent, and selective KRAS G12D inhibitor
Iyer, Chandrasekar, Li, Binghui, Stewart, Trent R, Wang, Tao, Capen, Andrew, Cavitt, Rachel, Anderson, Bryan D, Bocchinfuso, Wayne, Zhao, Gaiying, Rodriguez, Michael J, Carballares, Santiago, Cooke, Andrew, Bondi, Robert, Burns, Lee, Kelamangalath, Lakshmi, Wallace, Ross, Kolakowski, Gabrielle, Henry, James R, Si, Chong
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Abstract B116: Preclinical characterization of orally bioavailable, highly potent pan-KRAS inhibitors with selectivity over HRAS and NRAS
Vallejo, Lourdes Prieto, Iyer, Chandrasekar, Goggin, Noelle, Li, Binghui, Yang, Peiyi, Bian, Huimin, Podoll, Jessica, Grotegut, Stefan, Tandon, Manuj, Anderson, Bryan D, Capen, Andrew, Xiao, Min, Wang, Tao, Stewart, Trent R, Aronow, Sean, Bume, Desta, Garcia, Isabel Rojo, Si, Chong, Cooke, Andrew, Bondi, Robert, Kelamangalath, Lakshmi, Wallace, Ross, Kolakowski, Gabrielle, LeBrun, Lauire, Henry, James R, Kercher, Tim
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Abstract 955: LY3200882, a novel, highly selective TGFβRI small molecule inhibitor
Pei, Huaxing, Parthasarathy, Saravanan, Joseph, Sajan, McMillen, William, Xu, Xiaohong, Castaneda, Stephen, Inigo, Ivan, Britt, Karen, Anderson, Bryan, Zhao, Gaiying, Sawyer, Scott, Beight, Douglas, Kaoudi, Talbi, Iyer, Chandrasekar, Bian, Huimin, Pappas, Amy, Surguladze, David, Schaer, David, Benhadji, Karim, Kalos, Michael, Driscoll, Kyla
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Compuestos de 7,8-dihidro-4h-pirazol[4,3-c]azepin-6-ona
SHAHDA, Safi, BRANDHUBER, Barbara Jean, LALLENA JIMENO, Maria Jose, IYER, Chandrasekar Venkataraman, LUMERAS AMADOR, Wenceslao
Year of Publication 01.04.2024
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Year of Publication 01.04.2024
Patent
7,8-dihydro-4h-pyrazolo(4,3-c)azepine-6-one compounds
SHAHDA, Safi, BRANDHUBER, Barbara Jean, LALLENA JIMENO, Maria Jose, IYER, Chandrasekar Venkataraman, LUMERAS AMADOR, Wenceslao
Year of Publication 02.11.2023
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Year of Publication 02.11.2023
Patent
7,8-DIHYDRO-4H-PYRAZOLO[4,3-C]AZEPINE-6-ONE COMPOUNDS
SHAHDA, Safi, BRANDHUBER, Barbara Jean, LALLENA JIMENO, Maria Jose, IYER, Chandrasekar Venkataraman, LUMERAS AMADOR, Wenceslao
Year of Publication 13.09.2023
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Year of Publication 13.09.2023
Patent