iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer’s Disease
Kondo, Takayuki, Imamura, Keiko, Funayama, Misato, Tsukita, Kayoko, Miyake, Michiyo, Ohta, Akira, Woltjen, Knut, Nakagawa, Masato, Asada, Takashi, Arai, Tetsuaki, Kawakatsu, Shinobu, Izumi, Yuishin, Kaji, Ryuji, Iwata, Nobuhisa, Inoue, Haruhisa
Published in Cell reports (Cambridge) (21.11.2017)
Published in Cell reports (Cambridge) (21.11.2017)
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Aβ Secretion and Plaque Formation Depend on Autophagy
Nilsson, Per, Loganathan, Krishnapriya, Sekiguchi, Misaki, Matsuba, Yukio, Hui, Kelvin, Tsubuki, Satoshi, Tanaka, Motomasa, Iwata, Nobuhisa, Saito, Takashi, Saido, Takaomi C.
Published in Cell reports (Cambridge) (17.10.2013)
Published in Cell reports (Cambridge) (17.10.2013)
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Enhancement of Neprilysin Activity by Natural Polyphenolic Compounds and Their Derivatives in Cultured Neuroglioma Cells
Hori, Yuma, Watanabe, Kaori, Yassen, Asmaa S. A., Shirotani, Keiro, Tanaka, Takashi, Iwata, Nobuhisa
Published in Biological & pharmaceutical bulletin (01.03.2023)
Published in Biological & pharmaceutical bulletin (01.03.2023)
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Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls
Maruyama, Masahiro, Shimada, Hitoshi, Suhara, Tetsuya, Shinotoh, Hitoshi, Ji, Bin, Maeda, Jun, Zhang, Ming-Rong, Trojanowski, John Q., Lee, Virginia M.-Y., Ono, Maiko, Masamoto, Kazuto, Takano, Harumasa, Sahara, Naruhiko, Iwata, Nobuhisa, Okamura, Nobuyuki, Furumoto, Shozo, Kudo, Yukitsuka, Chang, Qing, Saido, Takaomi C., Takashima, Akihiko, Lewis, Jada, Jang, Ming-Kuei, Aoki, Ichio, Ito, Hiroshi, Higuchi, Makoto
Published in Neuron (Cambridge, Mass.) (18.09.2013)
Published in Neuron (Cambridge, Mass.) (18.09.2013)
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Activity-dependent cleavage of dyskinesia-related proline-rich transmembrane protein 2 (PRRT2) by calpain in mouse primary cortical neurons
Hatta, Daisuke, Shirotani, Keiro, Hori, Yuma, Kurotaki, Naohiro, Iwata, Nobuhisa
Published in The FASEB journal (01.01.2020)
Published in The FASEB journal (01.01.2020)
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An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
Kizuka, Yasuhiko, Kitazume, Shinobu, Fujinawa, Reiko, Saito, Takashi, Iwata, Nobuhisa, Saido, Takaomi C, Nakano, Miyako, Yamaguchi, Yoshiki, Hashimoto, Yasuhiro, Staufenbiel, Matthias, Hatsuta, Hiroyuki, Murayama, Shigeo, Manya, Hiroshi, Endo, Tamao, Taniguchi, Naoyuki
Published in EMBO molecular medicine (01.02.2015)
Published in EMBO molecular medicine (01.02.2015)
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Recent Advances in the Modeling of Alzheimer's Disease
Sasaguri, Hiroki, Hashimoto, Shoko, Watamura, Naoto, Sato, Kaori, Takamura, Risa, Nagata, Kenichi, Tsubuki, Satoshi, Ohshima, Toshio, Yoshiki, Atsushi, Sato, Kenya, Kumita, Wakako, Sasaki, Erika, Kitazume, Shinobu, Nilsson, Per, Winblad, Bengt, Saito, Takashi, Iwata, Nobuhisa, Saido, Takaomi C
Published in Frontiers in neuroscience (31.03.2022)
Published in Frontiers in neuroscience (31.03.2022)
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Neprilysin Is Suppressed by Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 1A (DYRK1A) in Down-Syndrome-Derived Fibroblasts
Kawakubo, Takashi, Mori, Ryotaro, Shirotani, Keiro, Iwata, Nobuhisa, Asai, Masashi
Published in Biological & pharmaceutical bulletin (2017)
Published in Biological & pharmaceutical bulletin (2017)
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Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein
Ikemizu, Ayaka, Hatta, Daisuke, Fujimoto, Kohei, Honda, Mikako, Watanabe, Kaori, Ohyama, Kaname, Kuroda, Naotaka, Tanaka, Takashi, Shirotani, Keiro, Iwata, Nobuhisa
Published in Biological & pharmaceutical bulletin (23.02.2024)
Published in Biological & pharmaceutical bulletin (23.02.2024)
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Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yoshiyama, Yasumasa, Higuchi, Makoto, Zhang, Bin, Huang, Shu-Ming, Iwata, Nobuhisa, Saido, Takaomi C., Maeda, Jun, Suhara, Tetsuya, Trojanowski, John Q., Lee, Virginia M.-Y.
Published in Neuron (Cambridge, Mass.) (01.02.2007)
Published in Neuron (Cambridge, Mass.) (01.02.2007)
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Alterations of ATG4A and LC3B in neurons derived from Alzheimer's disease patients
Shirotani, Keiro, Watanabe, Kaori, Hatta, Daisuke, Kutoku, Yumiko, Ohsawa, Yutaka, Sunada, Yoshihide, Kondo, Takayuki, Inoue, Haruhisa, Iwata, Nobuhisa
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.04.2023)
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.04.2023)
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Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease
Yahata, Naoki, Asai, Masashi, Kitaoka, Shiho, Takahashi, Kazutoshi, Asaka, Isao, Hioki, Hiroyuki, Kaneko, Takeshi, Maruyama, Kei, Saido, Takaomi C, Nakahata, Tatsutoshi, Asada, Takashi, Yamanaka, Shinya, Iwata, Nobuhisa, Inoue, Haruhisa
Published in PloS one (30.09.2011)
Published in PloS one (30.09.2011)
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Proline-rich transmembrane protein 2 knock-in mice present dopamine-dependent motor deficits
Hatta, Daisuke, Kanamoto, Kaito, Makiya, Shiho, Watanabe, Kaori, Kishino, Tatsuya, Kinoshita, Akira, Yoshiura, Koh-Ichiro, Kurotaki, Naohiro, Shirotani, Keiro, Iwata, Nobuhisa
Published in Journal of biochemistry (Tokyo) (30.11.2023)
Published in Journal of biochemistry (Tokyo) (30.11.2023)
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Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography
Maeda, Jun, Ji, Bin, Irie, Toshiaki, Tomiyama, Takami, Maruyama, Masahiro, Okauchi, Takashi, Staufenbiel, Matthias, Iwata, Nobuhisa, Ono, Maiko, Saido, Takaomi C, Suzuki, Kazutoshi, Mori, Hiroshi, Higuchi, Makoto, Suhara, Tetsuya
Published in The Journal of neuroscience (10.10.2007)
Published in The Journal of neuroscience (10.10.2007)
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Paradigm shift from diagnosing patients based on common symptoms to categorizing patients into subtypes with different pathogenic mechanisms to guide treatment for Alzheimer's disease
Shirotani, Keiro, Asai, Masashi, Iwata, Nobuhisa
Published in Journal of biochemistry (Tokyo) (01.06.2017)
Published in Journal of biochemistry (Tokyo) (01.06.2017)
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Local Action of Neprilysin Exacerbates Pressure Overload Induced Cardiac Remodeling
Nakagawa, Hitoshi, Kumazawa, Takuya, Onoue, Kenji, Nakada, Yasuki, Nakano, Tomoya, Ishihara, Satomi, Minamino, Naoto, Hosoda, Hiroshi, Iwata, Nobuhisa, Ueda, Tomoya, Seno, Ayako, Nishida, Taku, Soeda, Tsunenari, Okayama, Satoshi, Watanabe, Makoto, Kawakami, Rika, Saito, Yoshihiko
Published in Hypertension (Dallas, Tex. 1979) (01.06.2021)
Published in Hypertension (Dallas, Tex. 1979) (01.06.2021)
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Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice
Iwata, Nobuhisa, Sekiguchi, Misaki, Hattori, Yoshino, Takahashi, Akane, Asai, Masashi, Ji, Bin, Higuchi, Makoto, Staufenbiel, Matthias, Muramatsu, Shin-ichi, Saido, Takaomi C.
Published in Scientific reports (18.03.2013)
Published in Scientific reports (18.03.2013)
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Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer’s Disease
Asai, Masashi, Kinjo, Aimi, Kimura, Shoko, Mori, Ryotaro, Kawakubo, Takashi, Shirotani, Keiro, Yagishita, Sosuke, Maruyama, Kei, Iwata, Nobuhisa
Published in Biological & pharmaceutical bulletin (2016)
Published in Biological & pharmaceutical bulletin (2016)
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