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Population Pharmacokinetic Modeling of Itraconazole and Hydroxyitraconazole for Oral SUBA-Itraconazole and Sporanox Capsule Formulations in Healthy Subjects in Fed and Fasted States
Abuhelwa, Ahmad Y., Foster, David J. R., Mudge, Stuart, Hayes, David, Upton, Richard N.
Published in Antimicrobial agents and chemotherapy (01.09.2015)
Published in Antimicrobial agents and chemotherapy (01.09.2015)
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A physiologically based biopharmaceutics modeling (PBBM) framework for characterizing formulation-dependent food effects: Paving the road towards fed state virtual BE studies for itraconazole amorphous solid dispersions
Rudolph, Niklas, Charbe, Nitin, Plano, David, Shoyaib, Abdullah Al, Pal, Arindom, Boyce, Heather, Zhao, Liang, Wu, Fang, Polli, James, Dressman, Jennifer, Cristofoletti, Rodrigo
Published in European journal of pharmaceutical sciences (01.06.2025)
Published in European journal of pharmaceutical sciences (01.06.2025)
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Drug–drug interaction study with itraconazole supplemented with physiologically based pharmacokinetic modelling to characterize the effect of CYP3A inhibitors on venglustat pharmacokinetics
Li, Li, Zhang, Yan‐Yan, Sharma, Jyoti, Cartot‐Cotton, Sylvaine, Crawford, Nigel, Macha, Sreeraj, Li, Yi, Sahi, Jasminder
Published in British journal of clinical pharmacology (01.08.2025)
Published in British journal of clinical pharmacology (01.08.2025)
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Effect of itraconazole, food, and ethnic origin on the pharmacokinetics of ivosidenib in healthy subjects
Dai, David, Yang, Hua, Nabhan, Salah, Liu, Hua, Hickman, Denice, Liu, Guowen, Zacher, Jeffrey, Vutikullird, Apinya, Prakash, Chandra, Agresta, Samuel, Bowden, Chris, Fan, Bin
Published in European journal of clinical pharmacology (01.08.2019)
Published in European journal of clinical pharmacology (01.08.2019)
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Evaluation of Potential Effects of CYP3A Inhibition and CYP3A Induction on the Pharmacokinetics of Fruquintinib in Healthy Subjects
Gonzalez, Martha, Yang, Zhao, Schelman, William R, Zhou, Xiaofei, Gupta, Neeraj, Chien, Caly
Published in Clinical pharmacology in drug development (01.08.2025)
Published in Clinical pharmacology in drug development (01.08.2025)
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Quantitative prediction of hepatic CYP3A activity using endogenous markers in healthy subjects after administration of CYP3A inhibitors or inducers
Lee, Jieon, Yoon, Seo Hyun, Yi, Sojeong, Kim, Andrew HyoungJin, Kim, Bora, Lee, SeungHwan, Yu, Kyung-Sang, Jang, In-Jin, Cho, Joo-Youn
Published in Drug metabolism and pharmacokinetics (01.08.2019)
Published in Drug metabolism and pharmacokinetics (01.08.2019)
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Novel cathepsin C inhibitor, BI 1291583, intended for treatment of bronchiectasis: Phase I characterization in healthy volunteers
Badorrek, Philipp, Diefenbach, Claudia, Kögler, Harald, Eleftheraki, Anastasia, Seitz, Friedeborg, Hohlfeld, Jens M.
Published in Clinical and translational science (01.08.2024)
Published in Clinical and translational science (01.08.2024)
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Evaluation of drug–drug interactions of a novel potent FLT3 inhibitor SKLB1028 in healthy subjects
Chen, Jingcheng, Wu, Jingxuan, Guo, Nini, Song, Yuqin, Li, Lijun, Wang, Bingyan, Li, Jiangshuo, Hou, Mengyu, Yin, Hang, Zhang, Meijuan, Kong, Yanhong, Wu, Xiaofang, Li, Ran, Wu, Le, Gao, Qiannan, Dong, Ruihua
Published in Clinical and translational science (01.11.2024)
Published in Clinical and translational science (01.11.2024)
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The effect of itraconazole, a strong CYP3A4 inhibitor, on the pharmacokinetics of the first‐in‐class ACKR3/CXCR7 antagonist, ACT‐1004‐1239
Huynh, Christine, Dingemanse, Jasper, Meyer zu Schwabedissen, Henriette E., Fonseca, Marlene, Sidharta, Patricia N.
Published in Clinical and translational science (01.07.2024)
Published in Clinical and translational science (01.07.2024)
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Posaconazole for the Treatment of Azole-Refractory Oropharyngeal and Esophageal Candidiasis in Subjects with HIV Infection
Skiest, Daniel J., Vazquez, Jose A., Anstead, Gregory M., Graybill, John R., Reynes, Jacques, Ward, Douglas, Hare, Roberta, Boparai, Navdeep, Isaacs, Randi
Published in Clinical infectious diseases (15.02.2007)
Published in Clinical infectious diseases (15.02.2007)
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Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations
Patel, Aarti, Wilson, Robert, Harrell, Andrew W., Taskar, Kunal S., Taylor, Maxine, Tracey, Helen, Riddell, Kylie, Georgiou, Alex, Cahn, Anthony P., Marotti, Miriam, Hessel, Edith M.
Published in Drug metabolism and disposition (01.04.2020)
Published in Drug metabolism and disposition (01.04.2020)
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Disposition and metabolism of [14C]-galunisertib, a TGF-βRI kinase/ALK5 inhibitor, following oral administration in healthy subjects and mechanistic prediction of the effect of itraconazole on galunisertib pharmacokinetics
Cassidy, Kenneth C., Gueorguieva, Ivelina, Miles, Colin, Rehmel, Jessica, Yi, Ping, Ehlhardt, William J.
Published in Xenobiotica (03.04.2018)
Published in Xenobiotica (03.04.2018)
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Effect of CYP3A4 inhibitor and induction on the pharmacokinetics and safety of FHND9041, a novel EGFR T790M inhibitor, in healthy Chinese
Lu, Chang, Cheng, Dongmei, Xie, Yunqiu, Shang, Minghong, Chen, Rongzhen, Zhu, Yongqiang, Gong, Jian, Zhou, Huan
Published in BMC pharmacology & toxicology (07.05.2025)
Published in BMC pharmacology & toxicology (07.05.2025)
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Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone
Grönlund, Juha, Saari, Teijo I., Hagelberg, Nora M., Neuvonen, Pertti J., Olkkola, Klaus T., Laine, Kari
Published in British journal of clinical pharmacology (01.07.2010)
Published in British journal of clinical pharmacology (01.07.2010)
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An open‐label study to explore the optimal design of CYP3A drug–drug interaction clinical trials in healthy Chinese people
Chen, Jingcheng, Li, Jiangshuo, Wu, Jingxuan, Song, Yuqin, Li, Lijun, Zhang, Jianxiong, Dong, Ruihua
Published in Pharmacology research & perspectives (01.08.2024)
Published in Pharmacology research & perspectives (01.08.2024)
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Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers
Woo, Jong Soo, Song, Yun-Kyoung, Hong, Ji-Yeon, Lim, Soo-Jeong, Kim, Chong-Kook
Published in European journal of pharmaceutical sciences (05.02.2008)
Published in European journal of pharmaceutical sciences (05.02.2008)
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A clinical drug–drug interaction study to evaluate the effect of a proton-pump inhibitor, a combined P-glycoprotein/cytochrome 450 enzyme (CYP)3A4 inhibitor, and a CYP2C9 inhibitor on the pharmacokinetics of vismodegib
Malhi, Vikram, Colburn, Dawn, Williams, Sarah J., Hop, Cornelis E. C. A., Dresser, Mark J., Chandra, Priya, Graham, Richard A.
Published in Cancer chemotherapy and pharmacology (01.07.2016)
Published in Cancer chemotherapy and pharmacology (01.07.2016)
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Pharmacokinetics of Itraconazole and Hydroxyitraconazole in Healthy Subjects after Single and Multiple Doses of a Novel Formulation
Mouton, J. W., van Peer, A., de Beule, K., Van Vliet, A., Donnelly, J. P., Soons, P. A.
Published in Antimicrobial Agents and Chemotherapy (01.12.2006)
Published in Antimicrobial Agents and Chemotherapy (01.12.2006)
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